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Martin K Bakht Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea
Laboratory of Molecular Imaging and Therapy, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
Department of Biological Sciences, University of Windsor, Windsor, Ontario, Canada

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Iulian Derecichei Department of Biological Sciences, University of Windsor, Windsor, Ontario, Canada

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Yinan Li Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada

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Rosa-Maria Ferraiuolo Department of Biological Sciences, University of Windsor, Windsor, Ontario, Canada

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Mark Dunning Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK

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So Won Oh Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea

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Abdulkadir Hussein Department of Mathematics and Statistics, University of Windsor, Windsor, Ontario, Canada

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Hyewon Youn Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea
Laboratory of Molecular Imaging and Therapy, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
Tumor Microenvironment Global Core Research Center, Seoul National University, Seoul, Korea
Cancer Imaging Center, Seoul National University Hospital, Seoul, Korea

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Keith F Stringer Department of Biological Sciences, University of Windsor, Windsor, Ontario, Canada
Department of Pathology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA

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Chang Wook Jeong Department of Urology, Seoul National University College of Medicine, Seoul, Korea

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Gi Jeong Cheon Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea
Laboratory of Molecular Imaging and Therapy, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea

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Cheol Kwak Department of Urology, Seoul National University College of Medicine, Seoul, Korea

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Keon Wook Kang Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea
Laboratory of Molecular Imaging and Therapy, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea

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Alastair D Lamb Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK
Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK

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Yuzhuo Wang Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada
Department of Experimental Therapeutics, BC Cancer Research Centre, Vancouver, British Columbia, Canada

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Xuesen Dong Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada

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Lisa A Porter Department of Biological Sciences, University of Windsor, Windsor, Ontario, Canada

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Introduction The main treatment protocol for patients suffering from castration-resistant prostate cancer (CRPC) is androgen receptor pathway inhibition (ARPI). Selection pressure and lineage plasticity of ARPI can lead to neuroendocrine (NE

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Zhi Long Department of Urology, Third Xiangya Hospital, Institute of Prostate Disease, Central South University, Changsha, China
Department of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia, Canada

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Yinan Li Department of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia, Canada

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Yu Gan Department of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia, Canada
Department of Urology, Xiangya Hospital, Central South University, Changsha, China

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Dongyu Zhao Center for Bioinformatics and Computational Biology, Houston Methodist Research Institute, Houston, Texas, USA
Department of Cardiothoracic Surgeries, Weill Cornell Medical College, Cornell University, New York, New York, USA
Institute for Academic Medicine, Houston Methodist Hospital, Houston, Texas, USA

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Guangyu Wang Center for Bioinformatics and Computational Biology, Houston Methodist Research Institute, Houston, Texas, USA
Department of Cardiothoracic Surgeries, Weill Cornell Medical College, Cornell University, New York, New York, USA
Institute for Academic Medicine, Houston Methodist Hospital, Houston, Texas, USA

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Ning Xie Department of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia, Canada

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Jessica M Lovnicki Department of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia, Canada

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Ladan Fazli Department of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia, Canada

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Qi Cao Department of Urology and Robert H. Lurie Comprehensive Cancer Cancer, Northwestern University Reinberg School of Medicine, Chicago, Illinois, USA

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Kaifu Chen Center for Bioinformatics and Computational Biology, Houston Methodist Research Institute, Houston, Texas, USA
Department of Cardiothoracic Surgeries, Weill Cornell Medical College, Cornell University, New York, New York, USA
Institute for Academic Medicine, Houston Methodist Hospital, Houston, Texas, USA

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Xuesen Dong Department of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia, Canada

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in fully developed prostate in males, and whether HOXA10 regulates signal pathways during prostate cancer (PCa) development or tumor progression into the castrate-resistant stage. PCa is the most commonly diagnosed cancer in males. The primary

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Laisa Teleni School of Nursing, Faculty of Health Sciences and Medicine, West Moreton Hospital and Health Service, Department of Pharmacy, Oncology Pharmacy, Department of Nutrition and Dietetics, Department of Urology, Australian Prostate Cancer Research Centre – Queensland, Department of Diabetes and Endocrinology, School of Medicine, Division of Cancer Services, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia
School of Nursing, Faculty of Health Sciences and Medicine, West Moreton Hospital and Health Service, Department of Pharmacy, Oncology Pharmacy, Department of Nutrition and Dietetics, Department of Urology, Australian Prostate Cancer Research Centre – Queensland, Department of Diabetes and Endocrinology, School of Medicine, Division of Cancer Services, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia

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Raymond J Chan School of Nursing, Faculty of Health Sciences and Medicine, West Moreton Hospital and Health Service, Department of Pharmacy, Oncology Pharmacy, Department of Nutrition and Dietetics, Department of Urology, Australian Prostate Cancer Research Centre – Queensland, Department of Diabetes and Endocrinology, School of Medicine, Division of Cancer Services, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia
School of Nursing, Faculty of Health Sciences and Medicine, West Moreton Hospital and Health Service, Department of Pharmacy, Oncology Pharmacy, Department of Nutrition and Dietetics, Department of Urology, Australian Prostate Cancer Research Centre – Queensland, Department of Diabetes and Endocrinology, School of Medicine, Division of Cancer Services, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia

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Alexandre Chan School of Nursing, Faculty of Health Sciences and Medicine, West Moreton Hospital and Health Service, Department of Pharmacy, Oncology Pharmacy, Department of Nutrition and Dietetics, Department of Urology, Australian Prostate Cancer Research Centre – Queensland, Department of Diabetes and Endocrinology, School of Medicine, Division of Cancer Services, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia
School of Nursing, Faculty of Health Sciences and Medicine, West Moreton Hospital and Health Service, Department of Pharmacy, Oncology Pharmacy, Department of Nutrition and Dietetics, Department of Urology, Australian Prostate Cancer Research Centre – Queensland, Department of Diabetes and Endocrinology, School of Medicine, Division of Cancer Services, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia

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Elisabeth A Isenring School of Nursing, Faculty of Health Sciences and Medicine, West Moreton Hospital and Health Service, Department of Pharmacy, Oncology Pharmacy, Department of Nutrition and Dietetics, Department of Urology, Australian Prostate Cancer Research Centre – Queensland, Department of Diabetes and Endocrinology, School of Medicine, Division of Cancer Services, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia
School of Nursing, Faculty of Health Sciences and Medicine, West Moreton Hospital and Health Service, Department of Pharmacy, Oncology Pharmacy, Department of Nutrition and Dietetics, Department of Urology, Australian Prostate Cancer Research Centre – Queensland, Department of Diabetes and Endocrinology, School of Medicine, Division of Cancer Services, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia

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Ian Vela School of Nursing, Faculty of Health Sciences and Medicine, West Moreton Hospital and Health Service, Department of Pharmacy, Oncology Pharmacy, Department of Nutrition and Dietetics, Department of Urology, Australian Prostate Cancer Research Centre – Queensland, Department of Diabetes and Endocrinology, School of Medicine, Division of Cancer Services, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia
School of Nursing, Faculty of Health Sciences and Medicine, West Moreton Hospital and Health Service, Department of Pharmacy, Oncology Pharmacy, Department of Nutrition and Dietetics, Department of Urology, Australian Prostate Cancer Research Centre – Queensland, Department of Diabetes and Endocrinology, School of Medicine, Division of Cancer Services, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia

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Warrick J Inder School of Nursing, Faculty of Health Sciences and Medicine, West Moreton Hospital and Health Service, Department of Pharmacy, Oncology Pharmacy, Department of Nutrition and Dietetics, Department of Urology, Australian Prostate Cancer Research Centre – Queensland, Department of Diabetes and Endocrinology, School of Medicine, Division of Cancer Services, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia
School of Nursing, Faculty of Health Sciences and Medicine, West Moreton Hospital and Health Service, Department of Pharmacy, Oncology Pharmacy, Department of Nutrition and Dietetics, Department of Urology, Australian Prostate Cancer Research Centre – Queensland, Department of Diabetes and Endocrinology, School of Medicine, Division of Cancer Services, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia

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Alexandra L McCarthy School of Nursing, Faculty of Health Sciences and Medicine, West Moreton Hospital and Health Service, Department of Pharmacy, Oncology Pharmacy, Department of Nutrition and Dietetics, Department of Urology, Australian Prostate Cancer Research Centre – Queensland, Department of Diabetes and Endocrinology, School of Medicine, Division of Cancer Services, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia
School of Nursing, Faculty of Health Sciences and Medicine, West Moreton Hospital and Health Service, Department of Pharmacy, Oncology Pharmacy, Department of Nutrition and Dietetics, Department of Urology, Australian Prostate Cancer Research Centre – Queensland, Department of Diabetes and Endocrinology, School of Medicine, Division of Cancer Services, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia
School of Nursing, Faculty of Health Sciences and Medicine, West Moreton Hospital and Health Service, Department of Pharmacy, Oncology Pharmacy, Department of Nutrition and Dietetics, Department of Urology, Australian Prostate Cancer Research Centre – Queensland, Department of Diabetes and Endocrinology, School of Medicine, Division of Cancer Services, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia

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Introduction Prostate cancer (PCa) is the second most commonly diagnosed cancer in men after lung cancers. According to the International Agency for Research on Cancer, more than 1.1 million cases were diagnosed in 2012, with highest incidence rates

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David Adler Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany

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Anne Offermann Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany

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Martin Braun Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany

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Roopika Menon Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany

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Isabella Syring Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany

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Michael Nowak Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany

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Rebecca Halbach Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany

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Wenzel Vogel Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany

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Christian Ruiz Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany

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Tobias Zellweger Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany

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Cyrill A Rentsch Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany

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Maria Svensson Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany

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Ove Andren Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany

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Lukas Bubendorf Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany

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Saskia Biskup Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany

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Stefan Duensing Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany

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Jutta Kirfel Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany

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Sven Perner Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany
Department of Prostate Cancer Research

Institute of Pathology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Institute for Pathology University Hospital Basel, Basel, Switzerland

Department of Urology St. Claraspital, Basel, Switzerland

Department of Urology University Hospital Basel, Basel, Switzerland

Department of Urology University Hospital of Örebro, Örebro, Sweden

School of Health and Medical Sciences Örebro University, Örebro, Sweden

Center for Genomics and Transcriptomics CeGaT GmbH, Tuebingen, Germany

Clinic for Urology and Pediatric Urology University Hospital of Bonn, Sigmund‐Freud Strasse 25, 53127 Bonn, Germany

Section of Molecular Urooncology Department of Urology, School of Medicine, University of Heidelberg, Heidelberg, Germany

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Introduction Prostate cancer (PCa) is a clinically heterogeneous disease and a leading cause of cancer death worldwide, thus unraveling the molecular basis of this disease is of great importance. Therefore, a notable effort has been made recently by

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Valeria Coppola Department of Hematology, Department of Experimental Oncology, Oncology and Molecular Medicine, Istituto Superiore Sanità, viale Regina Elena 299, 00161 Rome, Italy

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Ruggero De Maria Department of Hematology, Department of Experimental Oncology, Oncology and Molecular Medicine, Istituto Superiore Sanità, viale Regina Elena 299, 00161 Rome, Italy
Department of Hematology, Department of Experimental Oncology, Oncology and Molecular Medicine, Istituto Superiore Sanità, viale Regina Elena 299, 00161 Rome, Italy

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Désirée Bonci Department of Hematology, Department of Experimental Oncology, Oncology and Molecular Medicine, Istituto Superiore Sanità, viale Regina Elena 299, 00161 Rome, Italy

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deregulated in tumours. Prostate cancer: a complex scenario for miR action In developed western countries, prostate cancer is the most common malignant tumour in men, and is the second highest cause of cancer mortality after lung tumours ( Gronberg

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Hira Lal Goel Department of Cancer Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA

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Jing Li Department of Cancer Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA

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Sophia Kogan Department of Cancer Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA

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Lucia R Languino Department of Cancer Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA

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Introduction Prostate cancer develops through a series of defined states: prostatic intraepithelial neoplasia (PIN), high-grade PIN lesions, invasive cancer, and an androgen-independent state ( Scher & Heller 2000 , Culig & Bartsch 2006 , Dehm

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Lisa D Berman-Booty Department of Cancer Biology, Kimmel Cancer Center, Departments of Urology, Radiation Oncology, Thomas Jefferson University, 233 South 10th Street, BLSB 1008, Philadelphia, Pennsylvania 19107, USA
Department of Cancer Biology, Kimmel Cancer Center, Departments of Urology, Radiation Oncology, Thomas Jefferson University, 233 South 10th Street, BLSB 1008, Philadelphia, Pennsylvania 19107, USA

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Karen E Knudsen Department of Cancer Biology, Kimmel Cancer Center, Departments of Urology, Radiation Oncology, Thomas Jefferson University, 233 South 10th Street, BLSB 1008, Philadelphia, Pennsylvania 19107, USA
Department of Cancer Biology, Kimmel Cancer Center, Departments of Urology, Radiation Oncology, Thomas Jefferson University, 233 South 10th Street, BLSB 1008, Philadelphia, Pennsylvania 19107, USA
Department of Cancer Biology, Kimmel Cancer Center, Departments of Urology, Radiation Oncology, Thomas Jefferson University, 233 South 10th Street, BLSB 1008, Philadelphia, Pennsylvania 19107, USA
Department of Cancer Biology, Kimmel Cancer Center, Departments of Urology, Radiation Oncology, Thomas Jefferson University, 233 South 10th Street, BLSB 1008, Philadelphia, Pennsylvania 19107, USA

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Introduction Prostate cancer is the second most common cancer in men worldwide ( Ferlay et al . 2010 ). With >90% of prostate cancers initially diagnosed as acinar adenocarcinomas ( Fine 2012 , Humphrey 2012 ), neuroendocrine carcinomas of the

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Cindy H Chau Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA

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Cathee Till SWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

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Douglas K Price Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA

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Phyllis J Goodman SWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

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Marian L Neuhouser Cancer Prevention Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

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Michael N Pollak Department of Oncology and Medicine, McGill University, Montreal, Canada

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Ian M Thompson CHRISTUS Santa Rosa Hospital Medical Center, San Antonio, Texas, USA

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William D Figg Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA

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Introduction Prostate cancer is the most common non-cutaneous malignancy and the second leading cause of cancer deaths among men in the United States (US), with approximately 248,530 new cases and about 34,130 men expected to die of the

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Delila Gasi Tandefelt Departments of Pathology, Urology, Erasmus University Medical Centre, PO Box 2040, 2000 CA Rotterdam, The Netherlands

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Joost Boormans Departments of Pathology, Urology, Erasmus University Medical Centre, PO Box 2040, 2000 CA Rotterdam, The Netherlands

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Karin Hermans Departments of Pathology, Urology, Erasmus University Medical Centre, PO Box 2040, 2000 CA Rotterdam, The Netherlands

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Jan Trapman Departments of Pathology, Urology, Erasmus University Medical Centre, PO Box 2040, 2000 CA Rotterdam, The Netherlands

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Introduction Prostate cancer is the most frequent malignancy and the second most common cause of cancer-related death in men in the USA and in other countries with a Western lifestyle ( Siegel et al . 2013 ). Almost all prostate cancers are

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Gail S Prins Department of Urology, University of Illinois at Chicago, 820 South Wood St, MC 955, Chicago, Illinois 60612, USA

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Introduction Prostate cancer is the most common solid cancer in males and is the second leading cause of cancer deaths in American men ( Jemal et al . 2008 ). While rates today are markedly higher than rates observed three decades ago, the most

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