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Changmeng Cai
Changmeng Cai
Hematology Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
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Steven P Balk
Steven P Balk
Hematology Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
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Geng L Holcomb I Coleman IM Lucas J True LD Nelson PS 2010 Variability in the androgen response of prostate epithelium to 5alpha-reductase inhibition: implications for prostate cancer chemoprevention . Cancer Research 70 1286 – 1295
Wen-Lung Ma
Wen-Lung Ma
Sex Hormone Research Center, George Whipple Lab for Cancer Research, Chawnshang Chang Liver Cancer Center, Department of Gastroenterology, Graduate Institute of Clinical Medical Science, China Medical University/Hospital, Taichung 404, Taiwan, Republic of China
Sex Hormone Research Center, George Whipple Lab for Cancer Research, Chawnshang Chang Liver Cancer Center, Department of Gastroenterology, Graduate Institute of Clinical Medical Science, China Medical University/Hospital, Taichung 404, Taiwan, Republic of China
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Sex Hormone Research Center, George Whipple Lab for Cancer Research, Chawnshang Chang Liver Cancer Center, Department of Gastroenterology, Graduate Institute of Clinical Medical Science, China Medical University/Hospital, Taichung 404, Taiwan, Republic of China
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Hsueh-Chou Lai
Hsueh-Chou Lai
Sex Hormone Research Center, George Whipple Lab for Cancer Research, Chawnshang Chang Liver Cancer Center, Department of Gastroenterology, Graduate Institute of Clinical Medical Science, China Medical University/Hospital, Taichung 404, Taiwan, Republic of China
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Shuyuan Yeh
Shuyuan Yeh
Sex Hormone Research Center, George Whipple Lab for Cancer Research, Chawnshang Chang Liver Cancer Center, Department of Gastroenterology, Graduate Institute of Clinical Medical Science, China Medical University/Hospital, Taichung 404, Taiwan, Republic of China
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Xiujun Cai
Xiujun Cai
Sex Hormone Research Center, George Whipple Lab for Cancer Research, Chawnshang Chang Liver Cancer Center, Department of Gastroenterology, Graduate Institute of Clinical Medical Science, China Medical University/Hospital, Taichung 404, Taiwan, Republic of China
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Chawnshang Chang
Chawnshang Chang
Sex Hormone Research Center, George Whipple Lab for Cancer Research, Chawnshang Chang Liver Cancer Center, Department of Gastroenterology, Graduate Institute of Clinical Medical Science, China Medical University/Hospital, Taichung 404, Taiwan, Republic of China
Sex Hormone Research Center, George Whipple Lab for Cancer Research, Chawnshang Chang Liver Cancer Center, Department of Gastroenterology, Graduate Institute of Clinical Medical Science, China Medical University/Hospital, Taichung 404, Taiwan, Republic of China
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Sex Hormone Research Center, George Whipple Lab for Cancer Research, Chawnshang Chang Liver Cancer Center, Department of Gastroenterology, Graduate Institute of Clinical Medical Science, China Medical University/Hospital, Taichung 404, Taiwan, Republic of China
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physiological and pathological functions in organisms by translocating to the nucleus upon binding to androgens ( Chang et al . 1988 ), where it binds to specific DNA sequences known as androgen response elements (AREs; Claessens et al . 2001 ) in conjunction
Hema Parmar
Hema Parmar
University of California, 3rd and Parnassus, Department of Anatomy, HSW 1323, San Francisco, CA 94143, USA
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Gerald R Cunha
Gerald R Cunha
University of California, 3rd and Parnassus, Department of Anatomy, HSW 1323, San Francisco, CA 94143, USA
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mesenchymal cells in the androgen response of the embryonic mammary gland. Cell 19 465 –471. Earp HS , Dawson TL, Li X & Yu H 1995 Heterodimerization and functional interaction between EGF receptor family members
S Prekovic
S Prekovic
Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands
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T Van den Broeck
T Van den Broeck
Laboratory of Molecular Endocrinology, KU Leuven, Leuven, Belgium
Department of Urology, University Hospitals Leuven, Leuven, Belgium
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Department of Urology, University Hospitals Leuven, Leuven, Belgium
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S Linder
S Linder
Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands
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M E van Royen
M E van Royen
Department of Pathology, Erasmus MC, Rotterdam, The Netherlands
Erasmus Optical Imaging Centre, Erasmus MC, Rotterdam, The Netherlands
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Erasmus Optical Imaging Centre, Erasmus MC, Rotterdam, The Netherlands
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A B Houtsmuller
A B Houtsmuller
Department of Pathology, Erasmus MC, Rotterdam, The Netherlands
Erasmus Optical Imaging Centre, Erasmus MC, Rotterdam, The Netherlands
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Erasmus Optical Imaging Centre, Erasmus MC, Rotterdam, The Netherlands
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F Handle
F Handle
Laboratory of Molecular Endocrinology, KU Leuven, Leuven, Belgium
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S Joniau
S Joniau
Department of Urology, University Hospitals Leuven, Leuven, Belgium
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W Zwart
W Zwart
Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands
Department of Biomedical Engineering, Laboratory of Chemical Biology and Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, The Netherlands
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Department of Biomedical Engineering, Laboratory of Chemical Biology and Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, The Netherlands
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F Claessens
F Claessens
Laboratory of Molecular Endocrinology, KU Leuven, Leuven, Belgium
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androgen response elements and drive the growth of prostate cancer when the AR is inhibited by enzalutamide. E, element. Truncated ARs could very well serve as markers of response and resistance to therapy in advanced PCa ( Antonarakis et al
Varadha Balaji Venkadakrishnan
Varadha Balaji Venkadakrishnan
Department of Cancer Biology, Cleveland Clinic, Cleveland, Ohio, USA
Department of Biological, Geological and Environmental Sciences, Cleveland State University, Cleveland, Ohio, USA
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Department of Biological, Geological and Environmental Sciences, Cleveland State University, Cleveland, Ohio, USA
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Salma Ben-Salem
Salma Ben-Salem
Department of Cancer Biology, Cleveland Clinic, Cleveland, Ohio, USA
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Hannelore V Heemers
Hannelore V Heemers
Department of Cancer Biology, Cleveland Clinic, Cleveland, Ohio, USA
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Differential AR action in CaP. Canonical AR signaling (left panel). Androgens bind to and activate AR. Activated AR homodimerizes, relocates to the nucleus and binds to androgen response elements (AREs) where it interacts with coregulators to transcribe target
Honglin Chen
Honglin Chen
Department of Medical Microbiology and Immunology, Division of Basic Sciences, Department of Urology, Veterans Affairs Northern California Health Care System, University of California Davis, 3147 Tupper Hall, Davis, California 95616, USA
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Stephen J Libertini
Stephen J Libertini
Department of Medical Microbiology and Immunology, Division of Basic Sciences, Department of Urology, Veterans Affairs Northern California Health Care System, University of California Davis, 3147 Tupper Hall, Davis, California 95616, USA
Department of Medical Microbiology and Immunology, Division of Basic Sciences, Department of Urology, Veterans Affairs Northern California Health Care System, University of California Davis, 3147 Tupper Hall, Davis, California 95616, USA
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Department of Medical Microbiology and Immunology, Division of Basic Sciences, Department of Urology, Veterans Affairs Northern California Health Care System, University of California Davis, 3147 Tupper Hall, Davis, California 95616, USA
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Michael George
Michael George
Department of Medical Microbiology and Immunology, Division of Basic Sciences, Department of Urology, Veterans Affairs Northern California Health Care System, University of California Davis, 3147 Tupper Hall, Davis, California 95616, USA
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Satya Dandekar
Satya Dandekar
Department of Medical Microbiology and Immunology, Division of Basic Sciences, Department of Urology, Veterans Affairs Northern California Health Care System, University of California Davis, 3147 Tupper Hall, Davis, California 95616, USA
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Clifford G Tepper
Clifford G Tepper
Department of Medical Microbiology and Immunology, Division of Basic Sciences, Department of Urology, Veterans Affairs Northern California Health Care System, University of California Davis, 3147 Tupper Hall, Davis, California 95616, USA
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Bushra Al-Bataina
Bushra Al-Bataina
Department of Medical Microbiology and Immunology, Division of Basic Sciences, Department of Urology, Veterans Affairs Northern California Health Care System, University of California Davis, 3147 Tupper Hall, Davis, California 95616, USA
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Hsing-Jien Kung
Hsing-Jien Kung
Department of Medical Microbiology and Immunology, Division of Basic Sciences, Department of Urology, Veterans Affairs Northern California Health Care System, University of California Davis, 3147 Tupper Hall, Davis, California 95616, USA
Department of Medical Microbiology and Immunology, Division of Basic Sciences, Department of Urology, Veterans Affairs Northern California Health Care System, University of California Davis, 3147 Tupper Hall, Davis, California 95616, USA
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Department of Medical Microbiology and Immunology, Division of Basic Sciences, Department of Urology, Veterans Affairs Northern California Health Care System, University of California Davis, 3147 Tupper Hall, Davis, California 95616, USA
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Paramita M Ghosh
Paramita M Ghosh
Department of Medical Microbiology and Immunology, Division of Basic Sciences, Department of Urology, Veterans Affairs Northern California Health Care System, University of California Davis, 3147 Tupper Hall, Davis, California 95616, USA
Department of Medical Microbiology and Immunology, Division of Basic Sciences, Department of Urology, Veterans Affairs Northern California Health Care System, University of California Davis, 3147 Tupper Hall, Davis, California 95616, USA
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Department of Medical Microbiology and Immunology, Division of Basic Sciences, Department of Urology, Veterans Affairs Northern California Health Care System, University of California Davis, 3147 Tupper Hall, Davis, California 95616, USA
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Maria Mudryj
Maria Mudryj
Department of Medical Microbiology and Immunology, Division of Basic Sciences, Department of Urology, Veterans Affairs Northern California Health Care System, University of California Davis, 3147 Tupper Hall, Davis, California 95616, USA
Department of Medical Microbiology and Immunology, Division of Basic Sciences, Department of Urology, Veterans Affairs Northern California Health Care System, University of California Davis, 3147 Tupper Hall, Davis, California 95616, USA
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Department of Medical Microbiology and Immunology, Division of Basic Sciences, Department of Urology, Veterans Affairs Northern California Health Care System, University of California Davis, 3147 Tupper Hall, Davis, California 95616, USA
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-dependent transcription factor, AR mediates androgen-regulated gene expression. Androgen-bound AR is stabilized and translocated into the nucleus to regulate the expression of target genes by binding to androgen response elements (AREs) or by interacting with other
Mark A White
Mark A White
Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, Texas, USA
Department of Biology and Biochemistry, University of Houston, Houston, Texas, USA
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Department of Biology and Biochemistry, University of Houston, Houston, Texas, USA
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Efrosini Tsouko
Efrosini Tsouko
Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, Texas, USA
Department of Biology and Biochemistry, University of Houston, Houston, Texas, USA
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Department of Biology and Biochemistry, University of Houston, Houston, Texas, USA
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Chenchu Lin
Chenchu Lin
Department of Cancer Systems Imaging, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA
The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, Texas, USA
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The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, Texas, USA
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Kimal Rajapakshe
Kimal Rajapakshe
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
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Jeffrey M Spencer
Jeffrey M Spencer
Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, Texas, USA
Department of Biology and Biochemistry, University of Houston, Houston, Texas, USA
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Department of Biology and Biochemistry, University of Houston, Houston, Texas, USA
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Sandi R Wilkenfeld
Sandi R Wilkenfeld
Department of Cancer Systems Imaging, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA
The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, Texas, USA
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The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, Texas, USA
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Sheiva S Vakili
Sheiva S Vakili
Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, Texas, USA
Department of Biology and Biochemistry, University of Houston, Houston, Texas, USA
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Department of Biology and Biochemistry, University of Houston, Houston, Texas, USA
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Thomas L Pulliam
Thomas L Pulliam
Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, Texas, USA
Department of Biology and Biochemistry, University of Houston, Houston, Texas, USA
Department of Cancer Systems Imaging, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA
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Department of Biology and Biochemistry, University of Houston, Houston, Texas, USA
Department of Cancer Systems Imaging, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA
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Dominik Awad
Dominik Awad
Department of Cancer Systems Imaging, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA
The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, Texas, USA
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The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, Texas, USA
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Fotis Nikolos
Fotis Nikolos
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
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Rajasekhara Reddy Katreddy
Rajasekhara Reddy Katreddy
Department of Biology and Biochemistry, University of Houston, Houston, Texas, USA
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Benny Abraham Kaipparettu
Benny Abraham Kaipparettu
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, USA
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Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, USA
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Arun Sreekumar
Arun Sreekumar
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, USA
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Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, USA
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Xiaoliu Zhang
Xiaoliu Zhang
Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, Texas, USA
Department of Biology and Biochemistry, University of Houston, Houston, Texas, USA
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Department of Biology and Biochemistry, University of Houston, Houston, Texas, USA
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Edwin Cheung
Edwin Cheung
Biology and Pharmacology, Genome Institute of Singapore, A*STAR, Singapore, Singapore
Faculty of Health Sciences, University of Macau, Taipa, Macau, China
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Faculty of Health Sciences, University of Macau, Taipa, Macau, China
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Cristian Coarfa
Cristian Coarfa
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
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Daniel E Frigo
Daniel E Frigo
Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, Texas, USA
Department of Biology and Biochemistry, University of Houston, Houston, Texas, USA
Department of Cancer Systems Imaging, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA
Department of Genitourinary Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA
Molecular Medicine Program, The Houston Methodist Research Institute, Houston, Texas, USA
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Department of Biology and Biochemistry, University of Houston, Houston, Texas, USA
Department of Cancer Systems Imaging, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA
Department of Genitourinary Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA
Molecular Medicine Program, The Houston Methodist Research Institute, Houston, Texas, USA
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). To confirm that the identified AR-binding region contained a functional androgen response element (ARE) and thus primary AR target, we cloned out the genomic region surrounding the identified binding site and tested its ability to confer androgen
Gerard A Tarulli
Gerard A Tarulli
Dame Roma Mitchell Cancer Research Laboratories (DRMCRL) Faculty of Health Sciences, School of Medicine, The University of Adelaide, Adelaide, South Australia 5005, Australia
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Lisa M Butler
Lisa M Butler
Dame Roma Mitchell Cancer Research Laboratories (DRMCRL) Faculty of Health Sciences, School of Medicine, The University of Adelaide, Adelaide, South Australia 5005, Australia
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Wayne D Tilley
Wayne D Tilley
Dame Roma Mitchell Cancer Research Laboratories (DRMCRL) Faculty of Health Sciences, School of Medicine, The University of Adelaide, Adelaide, South Australia 5005, Australia
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Theresa E Hickey
Theresa E Hickey
Dame Roma Mitchell Cancer Research Laboratories (DRMCRL) Faculty of Health Sciences, School of Medicine, The University of Adelaide, Adelaide, South Australia 5005, Australia
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mammary stem/progenitor cells . Breast Cancer Research 6 R605 – R615 . ( doi:10.1186/bcr920 ). Dürnberger H Kratochwil K 1980 Specificity of tissue interaction and origin of mesenchymal cells in the androgen response of the embryonic mammary
KeeMing Chia
KeeMing Chia
Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
St Vincent’s Clinical School, Faculty of Medicine, UNSW Sydney, Darlinghurst, New South Wales, Australia
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St Vincent’s Clinical School, Faculty of Medicine, UNSW Sydney, Darlinghurst, New South Wales, Australia
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Heloisa Milioli
Heloisa Milioli
Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
St Vincent’s Clinical School, Faculty of Medicine, UNSW Sydney, Darlinghurst, New South Wales, Australia
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St Vincent’s Clinical School, Faculty of Medicine, UNSW Sydney, Darlinghurst, New South Wales, Australia
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Neil Portman
Neil Portman
Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
St Vincent’s Clinical School, Faculty of Medicine, UNSW Sydney, Darlinghurst, New South Wales, Australia
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St Vincent’s Clinical School, Faculty of Medicine, UNSW Sydney, Darlinghurst, New South Wales, Australia
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Geraldine Laven-Law
Geraldine Laven-Law
Dame Roma Mitchell Cancer Research Laboratories, Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia
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Rhiannon Coulson
Rhiannon Coulson
Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
St Vincent’s Clinical School, Faculty of Medicine, UNSW Sydney, Darlinghurst, New South Wales, Australia
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St Vincent’s Clinical School, Faculty of Medicine, UNSW Sydney, Darlinghurst, New South Wales, Australia
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Aliza Yong
Aliza Yong
Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
St Vincent’s Clinical School, Faculty of Medicine, UNSW Sydney, Darlinghurst, New South Wales, Australia
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St Vincent’s Clinical School, Faculty of Medicine, UNSW Sydney, Darlinghurst, New South Wales, Australia
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Davendra Segara
Davendra Segara
St Vincent’s Clinical School, Faculty of Medicine, UNSW Sydney, Darlinghurst, New South Wales, Australia
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Andrew Parker
Andrew Parker
St Vincent’s Clinical School, Faculty of Medicine, UNSW Sydney, Darlinghurst, New South Wales, Australia
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Catherine E Caldon
Catherine E Caldon
Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
St Vincent’s Clinical School, Faculty of Medicine, UNSW Sydney, Darlinghurst, New South Wales, Australia
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St Vincent’s Clinical School, Faculty of Medicine, UNSW Sydney, Darlinghurst, New South Wales, Australia
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Niantao Deng
Niantao Deng
Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
St Vincent’s Clinical School, Faculty of Medicine, UNSW Sydney, Darlinghurst, New South Wales, Australia
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St Vincent’s Clinical School, Faculty of Medicine, UNSW Sydney, Darlinghurst, New South Wales, Australia
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Alexander Swarbrick
Alexander Swarbrick
Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
St Vincent’s Clinical School, Faculty of Medicine, UNSW Sydney, Darlinghurst, New South Wales, Australia
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St Vincent’s Clinical School, Faculty of Medicine, UNSW Sydney, Darlinghurst, New South Wales, Australia
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Wayne D Tilley
Wayne D Tilley
Dame Roma Mitchell Cancer Research Laboratories, Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia
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Theresa E Hickey
Theresa E Hickey
Dame Roma Mitchell Cancer Research Laboratories, Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia
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Elgene Lim
Elgene Lim
Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
St Vincent’s Clinical School, Faculty of Medicine, UNSW Sydney, Darlinghurst, New South Wales, Australia
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St Vincent’s Clinical School, Faculty of Medicine, UNSW Sydney, Darlinghurst, New South Wales, Australia
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, pathways involved in E2F, G2/M checkpoint, androgen response and estrogen response were enriched in the downregulated gene set ( Fig. 2C ). A heat map of the top 50 differential genes revealed C-X-C motif chemokine ligand 8 ( CXCL8 ) and connective tissue
Anton Neschadim
Anton Neschadim
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Laura B Pritzker
Laura B Pritzker
Armour Therapeutics Inc., Rna Diagnostics Inc., Departments of Laboratory Medicine and Pathobiology, Surgery, Pathology and Laboratory Medicine, Departments of Medicine, Laboratory Medicine and Pathobiology, Centre for Innovation, Division of Advanced Diagnostics – Infection and Immunity, Department of Biomedical Sciences, Departments of Surgery and Medical Imaging, Division of Urology, Prostate Centre, Ontario Cancer Institute, 124 Orchard View Boulevard, Toronto, Ontario, Canada
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Kenneth P H Pritzker
Kenneth P H Pritzker
Armour Therapeutics Inc., Rna Diagnostics Inc., Departments of Laboratory Medicine and Pathobiology, Surgery, Pathology and Laboratory Medicine, Departments of Medicine, Laboratory Medicine and Pathobiology, Centre for Innovation, Division of Advanced Diagnostics – Infection and Immunity, Department of Biomedical Sciences, Departments of Surgery and Medical Imaging, Division of Urology, Prostate Centre, Ontario Cancer Institute, 124 Orchard View Boulevard, Toronto, Ontario, Canada
Armour Therapeutics Inc., Rna Diagnostics Inc., Departments of Laboratory Medicine and Pathobiology, Surgery, Pathology and Laboratory Medicine, Departments of Medicine, Laboratory Medicine and Pathobiology, Centre for Innovation, Division of Advanced Diagnostics – Infection and Immunity, Department of Biomedical Sciences, Departments of Surgery and Medical Imaging, Division of Urology, Prostate Centre, Ontario Cancer Institute, 124 Orchard View Boulevard, Toronto, Ontario, Canada
Armour Therapeutics Inc., Rna Diagnostics Inc., Departments of Laboratory Medicine and Pathobiology, Surgery, Pathology and Laboratory Medicine, Departments of Medicine, Laboratory Medicine and Pathobiology, Centre for Innovation, Division of Advanced Diagnostics – Infection and Immunity, Department of Biomedical Sciences, Departments of Surgery and Medical Imaging, Division of Urology, Prostate Centre, Ontario Cancer Institute, 124 Orchard View Boulevard, Toronto, Ontario, Canada
Armour Therapeutics Inc., Rna Diagnostics Inc., Departments of Laboratory Medicine and Pathobiology, Surgery, Pathology and Laboratory Medicine, Departments of Medicine, Laboratory Medicine and Pathobiology, Centre for Innovation, Division of Advanced Diagnostics – Infection and Immunity, Department of Biomedical Sciences, Departments of Surgery and Medical Imaging, Division of Urology, Prostate Centre, Ontario Cancer Institute, 124 Orchard View Boulevard, Toronto, Ontario, Canada
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Armour Therapeutics Inc., Rna Diagnostics Inc., Departments of Laboratory Medicine and Pathobiology, Surgery, Pathology and Laboratory Medicine, Departments of Medicine, Laboratory Medicine and Pathobiology, Centre for Innovation, Division of Advanced Diagnostics – Infection and Immunity, Department of Biomedical Sciences, Departments of Surgery and Medical Imaging, Division of Urology, Prostate Centre, Ontario Cancer Institute, 124 Orchard View Boulevard, Toronto, Ontario, Canada
Armour Therapeutics Inc., Rna Diagnostics Inc., Departments of Laboratory Medicine and Pathobiology, Surgery, Pathology and Laboratory Medicine, Departments of Medicine, Laboratory Medicine and Pathobiology, Centre for Innovation, Division of Advanced Diagnostics – Infection and Immunity, Department of Biomedical Sciences, Departments of Surgery and Medical Imaging, Division of Urology, Prostate Centre, Ontario Cancer Institute, 124 Orchard View Boulevard, Toronto, Ontario, Canada
Armour Therapeutics Inc., Rna Diagnostics Inc., Departments of Laboratory Medicine and Pathobiology, Surgery, Pathology and Laboratory Medicine, Departments of Medicine, Laboratory Medicine and Pathobiology, Centre for Innovation, Division of Advanced Diagnostics – Infection and Immunity, Department of Biomedical Sciences, Departments of Surgery and Medical Imaging, Division of Urology, Prostate Centre, Ontario Cancer Institute, 124 Orchard View Boulevard, Toronto, Ontario, Canada
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Donald R Branch
Donald R Branch
Armour Therapeutics Inc., Rna Diagnostics Inc., Departments of Laboratory Medicine and Pathobiology, Surgery, Pathology and Laboratory Medicine, Departments of Medicine, Laboratory Medicine and Pathobiology, Centre for Innovation, Division of Advanced Diagnostics – Infection and Immunity, Department of Biomedical Sciences, Departments of Surgery and Medical Imaging, Division of Urology, Prostate Centre, Ontario Cancer Institute, 124 Orchard View Boulevard, Toronto, Ontario, Canada
Armour Therapeutics Inc., Rna Diagnostics Inc., Departments of Laboratory Medicine and Pathobiology, Surgery, Pathology and Laboratory Medicine, Departments of Medicine, Laboratory Medicine and Pathobiology, Centre for Innovation, Division of Advanced Diagnostics – Infection and Immunity, Department of Biomedical Sciences, Departments of Surgery and Medical Imaging, Division of Urology, Prostate Centre, Ontario Cancer Institute, 124 Orchard View Boulevard, Toronto, Ontario, Canada
Armour Therapeutics Inc., Rna Diagnostics Inc., Departments of Laboratory Medicine and Pathobiology, Surgery, Pathology and Laboratory Medicine, Departments of Medicine, Laboratory Medicine and Pathobiology, Centre for Innovation, Division of Advanced Diagnostics – Infection and Immunity, Department of Biomedical Sciences, Departments of Surgery and Medical Imaging, Division of Urology, Prostate Centre, Ontario Cancer Institute, 124 Orchard View Boulevard, Toronto, Ontario, Canada
Armour Therapeutics Inc., Rna Diagnostics Inc., Departments of Laboratory Medicine and Pathobiology, Surgery, Pathology and Laboratory Medicine, Departments of Medicine, Laboratory Medicine and Pathobiology, Centre for Innovation, Division of Advanced Diagnostics – Infection and Immunity, Department of Biomedical Sciences, Departments of Surgery and Medical Imaging, Division of Urology, Prostate Centre, Ontario Cancer Institute, 124 Orchard View Boulevard, Toronto, Ontario, Canada
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Armour Therapeutics Inc., Rna Diagnostics Inc., Departments of Laboratory Medicine and Pathobiology, Surgery, Pathology and Laboratory Medicine, Departments of Medicine, Laboratory Medicine and Pathobiology, Centre for Innovation, Division of Advanced Diagnostics – Infection and Immunity, Department of Biomedical Sciences, Departments of Surgery and Medical Imaging, Division of Urology, Prostate Centre, Ontario Cancer Institute, 124 Orchard View Boulevard, Toronto, Ontario, Canada
Armour Therapeutics Inc., Rna Diagnostics Inc., Departments of Laboratory Medicine and Pathobiology, Surgery, Pathology and Laboratory Medicine, Departments of Medicine, Laboratory Medicine and Pathobiology, Centre for Innovation, Division of Advanced Diagnostics – Infection and Immunity, Department of Biomedical Sciences, Departments of Surgery and Medical Imaging, Division of Urology, Prostate Centre, Ontario Cancer Institute, 124 Orchard View Boulevard, Toronto, Ontario, Canada
Armour Therapeutics Inc., Rna Diagnostics Inc., Departments of Laboratory Medicine and Pathobiology, Surgery, Pathology and Laboratory Medicine, Departments of Medicine, Laboratory Medicine and Pathobiology, Centre for Innovation, Division of Advanced Diagnostics – Infection and Immunity, Department of Biomedical Sciences, Departments of Surgery and Medical Imaging, Division of Urology, Prostate Centre, Ontario Cancer Institute, 124 Orchard View Boulevard, Toronto, Ontario, Canada
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Alastair J S Summerlee
Alastair J S Summerlee
Armour Therapeutics Inc., Rna Diagnostics Inc., Departments of Laboratory Medicine and Pathobiology, Surgery, Pathology and Laboratory Medicine, Departments of Medicine, Laboratory Medicine and Pathobiology, Centre for Innovation, Division of Advanced Diagnostics – Infection and Immunity, Department of Biomedical Sciences, Departments of Surgery and Medical Imaging, Division of Urology, Prostate Centre, Ontario Cancer Institute, 124 Orchard View Boulevard, Toronto, Ontario, Canada
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John Trachtenberg
John Trachtenberg
Armour Therapeutics Inc., Rna Diagnostics Inc., Departments of Laboratory Medicine and Pathobiology, Surgery, Pathology and Laboratory Medicine, Departments of Medicine, Laboratory Medicine and Pathobiology, Centre for Innovation, Division of Advanced Diagnostics – Infection and Immunity, Department of Biomedical Sciences, Departments of Surgery and Medical Imaging, Division of Urology, Prostate Centre, Ontario Cancer Institute, 124 Orchard View Boulevard, Toronto, Ontario, Canada
Armour Therapeutics Inc., Rna Diagnostics Inc., Departments of Laboratory Medicine and Pathobiology, Surgery, Pathology and Laboratory Medicine, Departments of Medicine, Laboratory Medicine and Pathobiology, Centre for Innovation, Division of Advanced Diagnostics – Infection and Immunity, Department of Biomedical Sciences, Departments of Surgery and Medical Imaging, Division of Urology, Prostate Centre, Ontario Cancer Institute, 124 Orchard View Boulevard, Toronto, Ontario, Canada
Armour Therapeutics Inc., Rna Diagnostics Inc., Departments of Laboratory Medicine and Pathobiology, Surgery, Pathology and Laboratory Medicine, Departments of Medicine, Laboratory Medicine and Pathobiology, Centre for Innovation, Division of Advanced Diagnostics – Infection and Immunity, Department of Biomedical Sciences, Departments of Surgery and Medical Imaging, Division of Urology, Prostate Centre, Ontario Cancer Institute, 124 Orchard View Boulevard, Toronto, Ontario, Canada
Armour Therapeutics Inc., Rna Diagnostics Inc., Departments of Laboratory Medicine and Pathobiology, Surgery, Pathology and Laboratory Medicine, Departments of Medicine, Laboratory Medicine and Pathobiology, Centre for Innovation, Division of Advanced Diagnostics – Infection and Immunity, Department of Biomedical Sciences, Departments of Surgery and Medical Imaging, Division of Urology, Prostate Centre, Ontario Cancer Institute, 124 Orchard View Boulevard, Toronto, Ontario, Canada
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Armour Therapeutics Inc., Rna Diagnostics Inc., Departments of Laboratory Medicine and Pathobiology, Surgery, Pathology and Laboratory Medicine, Departments of Medicine, Laboratory Medicine and Pathobiology, Centre for Innovation, Division of Advanced Diagnostics – Infection and Immunity, Department of Biomedical Sciences, Departments of Surgery and Medical Imaging, Division of Urology, Prostate Centre, Ontario Cancer Institute, 124 Orchard View Boulevard, Toronto, Ontario, Canada
Armour Therapeutics Inc., Rna Diagnostics Inc., Departments of Laboratory Medicine and Pathobiology, Surgery, Pathology and Laboratory Medicine, Departments of Medicine, Laboratory Medicine and Pathobiology, Centre for Innovation, Division of Advanced Diagnostics – Infection and Immunity, Department of Biomedical Sciences, Departments of Surgery and Medical Imaging, Division of Urology, Prostate Centre, Ontario Cancer Institute, 124 Orchard View Boulevard, Toronto, Ontario, Canada
Armour Therapeutics Inc., Rna Diagnostics Inc., Departments of Laboratory Medicine and Pathobiology, Surgery, Pathology and Laboratory Medicine, Departments of Medicine, Laboratory Medicine and Pathobiology, Centre for Innovation, Division of Advanced Diagnostics – Infection and Immunity, Department of Biomedical Sciences, Departments of Surgery and Medical Imaging, Division of Urology, Prostate Centre, Ontario Cancer Institute, 124 Orchard View Boulevard, Toronto, Ontario, Canada
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Joshua D Silvertown
Joshua D Silvertown
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-relaxin and anti-androgen therapies in prostate cancer (red) are depicted along with the key signaling mediators and impacted cellular functions. Akt/PKB, protein kinase B; ARE, androgen response element; C-Raf, rapidly accelerated fibrosarcoma kinase; CRE
