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H H Milioli Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales, Australia
St Vincent’s Clinical School, UNSW Sydney, Sydney, New South Wales, Australia

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S Alexandrou Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales, Australia

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E Lim Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales, Australia
St Vincent’s Clinical School, UNSW Sydney, Sydney, New South Wales, Australia

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C E Caldon Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales, Australia
St Vincent’s Clinical School, UNSW Sydney, Sydney, New South Wales, Australia

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refractory to standard chemotherapies. As a result, biomarkers of therapeutic resistance and therapeutic targets are required to identify and treat these patients. Cyclins E/CDK complexes are acutely responsive to estrogen and anti-estrogens ( Caldon et al

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Joseph M Shulan
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Leonid Vydro
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Arthur B Schneider
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Dan V Mihailescu Division of Endocrinology, Diabetes and Metabolism, University of Illinois at Chicago, Chicago, Illinois, USA

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( NCRP 2009 ). While several studies have attempted to identify biomarkers that are predictive of the likelihood of malignancy in patients with thyroid nodules in the general population, the data correlating these factors in radiation-induced thyroid

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Fei Han Institute of Toxicology, College of Preventive Medicine, Army Medical University, Chongqing, China

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Wen-bin Liu Institute of Toxicology, College of Preventive Medicine, Army Medical University, Chongqing, China

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Jian-jun Li Department of Oncology, Southwest Hospital, Army Medical University, Chongqing, China

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Ming-qian Zhang Department of Emergency, Yan’an Hospital, Kunming Medical University, Kunming, Yunnan Province, China

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Jun-tang Yang Institute of Toxicology, College of Preventive Medicine, Army Medical University, Chongqing, China

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Xi Zhang Institute of Toxicology, College of Preventive Medicine, Army Medical University, Chongqing, China

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Xiang-lin Hao Institute of Toxicology, College of Preventive Medicine, Army Medical University, Chongqing, China

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Li Yin Institute of Toxicology, College of Preventive Medicine, Army Medical University, Chongqing, China

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Cheng-yi Mao Department of Pathology, Daping Hospital, Army Medical University, Chongqing, China

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Xiao Jiang Institute of Toxicology, College of Preventive Medicine, Army Medical University, Chongqing, China

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Jia Cao Institute of Toxicology, College of Preventive Medicine, Army Medical University, Chongqing, China

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Jin-yi Liu Institute of Toxicology, College of Preventive Medicine, Army Medical University, Chongqing, China

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, identification of new prognostic biomarkers and chemotherapeutic indicators is of great importance to improve therapeutic methods and prolong the survival of patients with ovarian cancer. Sox30, a member of Sox transcription factor, is always considered to be

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Yuanliang Yan Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China

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Qiuju Liang Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China

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Yuanhong Liu Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China

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Shangjun Zhou Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China

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Zhijie Xu Department of Pathology, Xiangya Hospital, Central South University, Changsha, China

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death, which could be mitigated via ICI-based combination therapies ( Wang et al. 2021 , Viscardi et al. 2022 ). Despite these encouraging benefits, only a few BC patients have achieved a durable response to ICIs in clinical practice. Biomarkers

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Balázs Győrffy Research Laboratory of Pediatrics and Nephrology, Laboratory of Functional Genomics, 2nd Department of Pathology, Center for Biological Sequence Analysis, Children's Hospital, Hungarian Academy of Sciences, Budapest, Hungary
Research Laboratory of Pediatrics and Nephrology, Laboratory of Functional Genomics, 2nd Department of Pathology, Center for Biological Sequence Analysis, Children's Hospital, Hungarian Academy of Sciences, Budapest, Hungary

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András Lánczky Research Laboratory of Pediatrics and Nephrology, Laboratory of Functional Genomics, 2nd Department of Pathology, Center for Biological Sequence Analysis, Children's Hospital, Hungarian Academy of Sciences, Budapest, Hungary

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Zoltán Szállási Research Laboratory of Pediatrics and Nephrology, Laboratory of Functional Genomics, 2nd Department of Pathology, Center for Biological Sequence Analysis, Children's Hospital, Hungarian Academy of Sciences, Budapest, Hungary
Research Laboratory of Pediatrics and Nephrology, Laboratory of Functional Genomics, 2nd Department of Pathology, Center for Biological Sequence Analysis, Children's Hospital, Hungarian Academy of Sciences, Budapest, Hungary

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related to patient outcome. To date, only two biomarkers have been approved by the Food and Drug Administration (FDA) for monitoring patients with EOC: CA125 ( MUC16 ; Gadducci et al . 1995 , 2004 , Cooper et al . 2002 , Riedinger et al . 2006

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Kjell Oberg Department of Endocrine Oncology, University Hospital, Entrance 78, SE-751 85 Uppsala, Sweden

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commonly present late in the disease course with imageable metastases identified per chance or when studies are ordered for symptoms attributable to tumour growth rather than hormone production ( Metz & Jensen 2008 , Vinik et al . 2009 ). Biomarker

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Jennifer W Carlisle Winship Cancer Institute of Emory University, Atlanta, Georgia, USA
Department of Hematology and Oncology, Emory University School of Medicine, Atlanta, Georgia, USA

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Caroline S Jansen Winship Cancer Institute of Emory University, Atlanta, Georgia, USA
Department of Urology, Emory University School of Medicine, Atlanta, Georgia, USA
Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, USA

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Mehmet Asim Bilen Winship Cancer Institute of Emory University, Atlanta, Georgia, USA
Department of Hematology and Oncology, Emory University School of Medicine, Atlanta, Georgia, USA

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Haydn Kissick Winship Cancer Institute of Emory University, Atlanta, Georgia, USA
Department of Urology, Emory University School of Medicine, Atlanta, Georgia, USA
Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA
Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, USA

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functioning as a biomarker of response to immunotherapy. Examples of successful use of this tactic and the potential impact of COVID-19 on this approach is reviewed subsequently. Expression of programmed cell death protein 1 (PD-1) on T cells during chronic

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Jacques Amar Department of Arterial Hypertension, Toulouse University, Hôpital Rangueil, Toulouse, France
INSERM UMR1048, I2MC, Toulouse, France

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Jeremy Brunel Department of Arterial Hypertension, Toulouse University, Hôpital Rangueil, Toulouse, France

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Catherine Cardot Bauters Service d’Endocrinologie, Hôpital Claude Huriez, CHU Lille, Lille, France

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Virginie Jacques Laboratory of Biochemistry and Molecular Biology, IFB-CHU, Toulouse, France
Laboratory of Biochemistry and Molecular Biology, IFB-CHU, Toulouse, France

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Clément Delmas INSERM UMR1048, I2MC, Toulouse, France
Department of Cardiology Toulouse University, Hôpital Rangueil, Toulouse, France

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Marie-Françoise Odou Service de Biochimie et Biologie Moléculaire ‘Hormonologie, Métabolisme-Nutrition, Oncologie’, CHU Lille, Lille, France
Univ. Lille, Inserm, CHU Lille, U1286 – Infinite – Institute for Translational Research in Inflammation, Lille, France

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Frédérique Savagner Laboratory of Biochemistry and Molecular Biology, IFB-CHU, Toulouse, France
Laboratory of Biochemistry and Molecular Biology, IFB-CHU, Toulouse, France

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. Discussion The main finding of the study was that 2CDel322–325 polymorphism was a biomarker of the risk of CIC in patients with PPGL. Some studies have previously identified such a relationship between one SNP and acute events ( Kim & Jeong 2020 , Li et

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Mark Kidd Wren Laboratories, 35 NE Industrial Road, Branford, Connecticut 06405, USA

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Ignat Drozdov Wren Laboratories, 35 NE Industrial Road, Branford, Connecticut 06405, USA

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Irvin Modlin Wren Laboratories, 35 NE Industrial Road, Branford, Connecticut 06405, USA

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Introduction Biomarker assessment of gastroenteropancreatic neuroendocrine tumor (GEP–NET) disease has been difficult since the default is provided by a monoanalyte measurement, chromogranin A, which has well-described limitations ( Lawrence et al

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Louis de Mestier
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Clarisse Dromain Department of Hepato-Gastroenterology and Digestive Oncology, Department of Radiology, Department of Radiology, Department of Pathology, Integrated Research Cancer Institute in Villejuif, Department of Nuclear Medicine, Department of Medical Oncology, Department of Digestive Oncology, Department of Nuclear Medicine, Department of Biology and Pathology, Robert-Debré University Hospital, Avenue du Général Koenig, 51092 Reims Cedex, France

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Gaspard d'Assignies Department of Hepato-Gastroenterology and Digestive Oncology, Department of Radiology, Department of Radiology, Department of Pathology, Integrated Research Cancer Institute in Villejuif, Department of Nuclear Medicine, Department of Medical Oncology, Department of Digestive Oncology, Department of Nuclear Medicine, Department of Biology and Pathology, Robert-Debré University Hospital, Avenue du Général Koenig, 51092 Reims Cedex, France

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Jean-Yves Scoazec Department of Hepato-Gastroenterology and Digestive Oncology, Department of Radiology, Department of Radiology, Department of Pathology, Integrated Research Cancer Institute in Villejuif, Department of Nuclear Medicine, Department of Medical Oncology, Department of Digestive Oncology, Department of Nuclear Medicine, Department of Biology and Pathology, Robert-Debré University Hospital, Avenue du Général Koenig, 51092 Reims Cedex, France

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Nathalie Lassau Department of Hepato-Gastroenterology and Digestive Oncology, Department of Radiology, Department of Radiology, Department of Pathology, Integrated Research Cancer Institute in Villejuif, Department of Nuclear Medicine, Department of Medical Oncology, Department of Digestive Oncology, Department of Nuclear Medicine, Department of Biology and Pathology, Robert-Debré University Hospital, Avenue du Général Koenig, 51092 Reims Cedex, France

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Rachida Lebtahi Department of Hepato-Gastroenterology and Digestive Oncology, Department of Radiology, Department of Radiology, Department of Pathology, Integrated Research Cancer Institute in Villejuif, Department of Nuclear Medicine, Department of Medical Oncology, Department of Digestive Oncology, Department of Nuclear Medicine, Department of Biology and Pathology, Robert-Debré University Hospital, Avenue du Général Koenig, 51092 Reims Cedex, France

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Hedia Brixi
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Emmanuel Mitry Department of Hepato-Gastroenterology and Digestive Oncology, Department of Radiology, Department of Radiology, Department of Pathology, Integrated Research Cancer Institute in Villejuif, Department of Nuclear Medicine, Department of Medical Oncology, Department of Digestive Oncology, Department of Nuclear Medicine, Department of Biology and Pathology, Robert-Debré University Hospital, Avenue du Général Koenig, 51092 Reims Cedex, France

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Rosine Guimbaud Department of Hepato-Gastroenterology and Digestive Oncology, Department of Radiology, Department of Radiology, Department of Pathology, Integrated Research Cancer Institute in Villejuif, Department of Nuclear Medicine, Department of Medical Oncology, Department of Digestive Oncology, Department of Nuclear Medicine, Department of Biology and Pathology, Robert-Debré University Hospital, Avenue du Général Koenig, 51092 Reims Cedex, France

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Frédéric Courbon Department of Hepato-Gastroenterology and Digestive Oncology, Department of Radiology, Department of Radiology, Department of Pathology, Integrated Research Cancer Institute in Villejuif, Department of Nuclear Medicine, Department of Medical Oncology, Department of Digestive Oncology, Department of Nuclear Medicine, Department of Biology and Pathology, Robert-Debré University Hospital, Avenue du Général Koenig, 51092 Reims Cedex, France

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Michèle d'Herbomez Department of Hepato-Gastroenterology and Digestive Oncology, Department of Radiology, Department of Radiology, Department of Pathology, Integrated Research Cancer Institute in Villejuif, Department of Nuclear Medicine, Department of Medical Oncology, Department of Digestive Oncology, Department of Nuclear Medicine, Department of Biology and Pathology, Robert-Debré University Hospital, Avenue du Général Koenig, 51092 Reims Cedex, France

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Guillaume Cadiot
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hypoxia metabolism and might be a potential biomarker of response to antiangiogenic therapy, as reported for sunitinib-treated metastatic renal cell carcinoma ( Hugonnet et al . 2011 ; Fig. 5 ). Figure 5 Axial 18 FMISO-PET views, obtained in a man with

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