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Cesar Luiz Boguszewski Department of Internal Medicine, Endocrine Division (SEMPR), University Hospital, Federal University of Parana, Curitiba, Brazil

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Margaret Cristina da Silva Boguszewski Department of Pediatrics, Endocrine Division (SEMPR), University Hospital, Federal University of Parana, Curitiba, Brazil

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Wouter W de Herder Department of Internal Medicine, Sector of Endocrinology, Erasmus Medical Center, Rotterdam, The Netherlands

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that metastases could be suppressed after hypophysectomy led to treatment of advanced cancers in humans, particularly those of the breast and prostate, with surgical ablation of the pituitary, mainly in the 1950s and early1960s ( Bailey 1956 ). At that

Article Type:
Review Article
Collections:
Growth Hormone in Endocrine Cancers
DOI:
https://doi.org/10.1530/ERC-22-0400
Volume/Issue:
Volume 30: Issue 4
Free access
Marta García-Goñi Department of Endocrinology and Nutrition, University of Navarra, Pamplona, Spain

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Beatriz Vázquez Gutiérrez Department of Endocrinology and Nutrition, University of Navarra, Pamplona, Spain

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Miguel F Sanmamed Department of Oncology, University of Navarra, Pamplona, Spain

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Salvador Martín-Algarra Department of Oncology, University of Navarra, Pamplona, Spain
IdiSNA (Instituto de investigación en la Salud de Navarra), Pamplona, Spain

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José Luis Pérez-Gracia Department of Oncology, University of Navarra, Pamplona, Spain
IdiSNA (Instituto de investigación en la Salud de Navarra), Pamplona, Spain

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María Olmedo Department of Oncology, University of Navarra, Pamplona, Spain

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Estefanía Chumbiauca Department of Endocrinology and Nutrition, University of Navarra, Pamplona, Spain

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Nerea Martín-Calvo IdiSNA (Instituto de investigación en la Salud de Navarra), Pamplona, Spain
Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain
CIBER de Fisiopatología de la Obesidad y la Nutrición, Pamplona, Spain

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Juan C Galofré Department of Endocrinology and Nutrition, University of Navarra, Pamplona, Spain
Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain

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Introduction Targeted cancer immunotherapy to enhance T-cell activation has revolutionized the management of cancer ( Kichenadasse et al. 2020 ). Among the array of cancer immunotherapies currently available ( Waldman et al. 2020 ), immune

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-24-0064
Volume/Issue:
Volume 31: Issue 10
Restricted access
Rosalinda M Savoy Department of Urology, VA Northern California Health Care System, University of California Davis School of Medicine, University of California, 4860 Y Street, Suite 3500, Sacramento, California 95817, USA

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Paramita M Ghosh Department of Urology, VA Northern California Health Care System, University of California Davis School of Medicine, University of California, 4860 Y Street, Suite 3500, Sacramento, California 95817, USA
Department of Urology, VA Northern California Health Care System, University of California Davis School of Medicine, University of California, 4860 Y Street, Suite 3500, Sacramento, California 95817, USA

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the opposing roles of FlnA in cancer progression depending on its localization. Reports in the literature have proposed blocking FlnA expression as a means of cancer therapy; however, we and others showed that completely eliminating FlnA will have

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-13-0364
Volume/Issue:
Volume 20: Issue 6
Free access
Nicola Normanno
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Massimo Di Maio
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Ermelinda De Maio
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Antonella De Luca
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Andrea de Matteis
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Antonio Giordano
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Francesco Perrone
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Introduction It has long been established that estrogen is involved in the pathogenesis of breast carcinoma, and that it sustains the growth of breast cancer cells that express the receptor for this hormone. Indeed, approximately 70

Article Type:
Review Article
DOI:
https://doi.org/10.1677/erc.1.00857
Volume/Issue:
Volume 12: Issue 4
Free access
Avaniyapuram Kannan Murugan Division of Molecular Endocrinology, Department of Molecular Oncology, King Faisal, Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

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Abeer Al-Amr Department of Microbiology, College of Science, Female Campus, King Saud University, Riyadh, Saudi Arabia

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Mysoon M Al-Ansari Department of Microbiology, College of Science, Female Campus, King Saud University, Riyadh, Saudi Arabia
Department of Molecular Oncology, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

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Pulicat S Manogaran Department of Stem Cell Tissue Re-Engineering Program, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

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Hindi Al-Hindi Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

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Ali S Alzahrani Division of Molecular Endocrinology, Department of Molecular Oncology, King Faisal, Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
Department of Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

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Introduction Thyroid cancer is one of the most common endocrine malignancies ( Haroon Al Rasheed & Xu 2019 ). The incidence of thyroid cancer has dramatically increased during the past 4 decades worldwide, particularly in the United States

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-20-0242
Volume/Issue:
Volume 28: Issue 4
Restricted access
Jonathan W Nyce ACGT Biotechnology, Collegeville, Pennsylvania, USA

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suppression mechanism that may fundamentally control cancer risk in humans’ ( Nyce 2018 ), published in the November 2018 issue of Endocrine-Related Cancer . As we define in some detail in Supplementary Section 1 (see section on supplementary data given at

Article Type:
Article Commentary
DOI:
https://doi.org/10.1530/ERC-18-0468
Volume/Issue:
Volume 26: Issue 2
Open access
Hira Lal Goel Department of Cancer Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA

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Jing Li Department of Cancer Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA

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Sophia Kogan Department of Cancer Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA

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Lucia R Languino Department of Cancer Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA

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Introduction Prostate cancer develops through a series of defined states: prostatic intraepithelial neoplasia (PIN), high-grade PIN lesions, invasive cancer, and an androgen-independent state ( Scher & Heller 2000 , Culig & Bartsch 2006 , Dehm

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-08-0019
Volume/Issue:
Volume 15: Issue 3
Free access
Deborah J Thompson Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Tracy A O'Mara Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Dylan M Glubb Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Jodie N Painter Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Timothy Cheng Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Elizabeth Folkerd Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Deborah Doody Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Joe Dennis Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Penelope M Webb Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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for the Australian National Endometrial Cancer Study Group (ANECS) Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Maggie Gorman Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Lynn Martin Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Shirley Hodgson Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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for the National Study of Endometrial Cancer Genetics Group (NSECG) Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Kyriaki Michailidou Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Jonathan P Tyrer Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Mel J Maranian Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Per Hall Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Kamila Czene Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Hatef Darabi Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Jingmei Li Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Peter A Fasching Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Alexander Hein Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Matthias W Beckmann Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Arif B Ekici Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Thilo Dörk Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Peter Hillemanns Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Matthias Dürst Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Ingo Runnebaum Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Hui Zhao Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Jeroen Depreeuw Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Stefanie Schrauwen Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Frederic Amant Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Ellen L Goode Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Brooke L Fridley Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Sean C Dowdy Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Stacey J Winham Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Helga B Salvesen Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Jone Trovik Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Tormund S Njolstad Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Henrica M J Werner Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Katie Ashton Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Tony Proietto Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Geoffrey Otton Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Luis Carvajal-Carmona Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Emma Tham Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Tao Liu Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Miriam Mints Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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for RENDOCAS Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Rodney J Scott Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Mark McEvoy Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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John Attia Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Elizabeth G Holliday Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Grant W Montgomery Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Nicholas G Martin Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Dale R Nyholt Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Anjali K Henders Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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John L Hopper Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Nadia Traficante Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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for the AOCS Group Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Matthias Ruebner Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Anthony J Swerdlow Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Barbara Burwinkel Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Hermann Brenner Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Alfons Meindl Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Hiltrud Brauch Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Annika Lindblom Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Diether Lambrechts Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Jenny Chang-Claude Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Fergus J Couch Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Graham G Giles Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Vessela N Kristensen Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Angela Cox Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Manjeet K Bolla Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Qin Wang Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Stig E Bojesen Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Mitul Shah Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Robert Luben Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Kay-Tee Khaw Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Paul D P Pharoah Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Alison M Dunning Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Ian Tomlinson Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Mitch Dowsett Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Douglas F Easton Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Amanda B Spurdle Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Introduction Established risk factors for endometrial cancer include high BMI ( IARC 2002 ), early menarche, late menopause, nulliparity, estrogen-only hormone replacement therapy (HRT) ( Beral et al . 2005 ) and tamoxifen use ( Cuzick et al

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-15-0386
Volume/Issue:
Volume 23: Issue 2
Open access
Tracy A O'Mara Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Dylan M Glubb Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Jodie N Painter Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Timothy Cheng Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Joe Dennis Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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The Australian National Endometrial Cancer Study Group (ANECS) Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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John Attia Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Elizabeth G Holliday Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Mark McEvoy Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Rodney J Scott Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Katie Ashton Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Tony Proietto Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Geoffrey Otton Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Mitul Shah Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Shahana Ahmed Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Catherine S Healey Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Maggie Gorman Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Lynn Martin Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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National Study of Endometrial Cancer Genetics Group (NSECG) Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Shirley Hodgson Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Peter A Fasching Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Alexander Hein Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Matthias W Beckmann Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Arif B Ekici Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Per Hall Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Kamila Czene Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Hatef Darabi Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Jingmei Li Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Matthias Dürst Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Ingo Runnebaum Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Peter Hillemanns Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Thilo Dörk Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Diether Lambrechts Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Jeroen Depreeuw Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Daniela Annibali Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Frederic Amant Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Hui Zhao Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Ellen L Goode Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Sean C Dowdy Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Brooke L Fridley Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Stacey J Winham Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Helga B Salvesen Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Tormund S Njølstad Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Jone Trovik Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Henrica M J Werner Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Emma Tham Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Tao Liu Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Miriam Mints Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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RENDOCAS Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Manjeet K Bolla Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Kyriaki Michailidou Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Jonathan P Tyrer Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Qin Wang Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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John L Hopper Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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AOCS Group Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Julian Peto Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Anthony J Swerdlow Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Barbara Burwinkel Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Hermann Brenner Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Alfons Meindl Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Hiltrud Brauch Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Annika Lindblom Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Jenny Chang-Claude Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Fergus J Couch Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Graham G Giles Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Vessela N Kristensen Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Angela Cox Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Paul D P Pharoah Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Alison M Dunning Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Ian Tomlinson Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Douglas F Easton Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia
Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Deborah J Thompson Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Amanda B Spurdle Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Department of Public Health and Primary Care, Hunter Medical Research Institute, School of Medicine and Public Health, Hunter Area Pathology Service, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Department of Oncology, Department of Clinical Genetics, Division of Hematology/Oncology, Department of Gynecology and Obstetrics, Institute of Human Genetics, Department of Medical Epidemiology and Biostatistics, Department of Gynaecology, Hannover Medical School, Gynaecology Research Unit, Vesalius Research Center, Laboratory for Translational Genetics, Division of Gynecologic Oncology, Department of Health Sciences Research, Division of Gynecologic Oncology, Department of Biostatistics, Department of Clinical Science, Department of Obstetrics and Gynecology, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Melbourne School of Population and Global Health, Peter MacCallum Cancer Center, London School of Hygiene and Tropical Medicine, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Division of Tumor Genetics, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The KG Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Sheffield Cancer Research, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia

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Introduction Endometrial cancer is the most commonly diagnosed gynaecological malignancy in developed countries ( http://globocan.iarc.fr/ ). Excessive endogenous and exogenous estrogen exposure or estrogen exposure unopposed by progesterone

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-15-0319
Volume/Issue:
Volume 22: Issue 5
Free access
Marilina Romeo Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy
Unit of Endocrinology, Department of Medical Specialties, Azienda Ospedaliero-Universitaria of Modena, Modena, Italy

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Giorgia Spaggiari Unit of Endocrinology, Department of Medical Specialties, Azienda Ospedaliero-Universitaria of Modena, Modena, Italy
Unit of Andrology and Sexual Medicine, Unit of Endocrinology, Department of Medical Specialties, Azienda Ospedaliero-Universitaria of Modena, Modena, Italy

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Chiara Furini Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy
Unit of Endocrinology, Department of Medical Specialties, Azienda Ospedaliero-Universitaria of Modena, Modena, Italy

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Antonio R M Granata Unit of Endocrinology, Department of Medical Specialties, Azienda Ospedaliero-Universitaria of Modena, Modena, Italy
Unit of Andrology and Sexual Medicine, Unit of Endocrinology, Department of Medical Specialties, Azienda Ospedaliero-Universitaria of Modena, Modena, Italy

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Angela Toss Department of Oncology and Hematology, Azienda Ospedaliero-Universitaria of Modena, Modena, Italy
Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy

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Manuela Simoni Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy
Unit of Endocrinology, Department of Medical Specialties, Azienda Ospedaliero-Universitaria of Modena, Modena, Italy
Unit of Andrology and Sexual Medicine, Unit of Endocrinology, Department of Medical Specialties, Azienda Ospedaliero-Universitaria of Modena, Modena, Italy

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Daniele Santi Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy
Unit of Endocrinology, Department of Medical Specialties, Azienda Ospedaliero-Universitaria of Modena, Modena, Italy
Unit of Andrology and Sexual Medicine, Unit of Endocrinology, Department of Medical Specialties, Azienda Ospedaliero-Universitaria of Modena, Modena, Italy

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Introduction The fight against cancer has largely influenced the scientific research in recent decades, leading to important achievements in both diagnostic and treatment paths and significant increase in patients’ survival. Cancer diagnosis

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-22-0401
Volume/Issue:
Volume 30: Issue 6
Free access