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Introduction MicroRNAs (miRs) have emerged as an important class of short endogenous RNAs that act as post-transcriptional regulators of gene expression by base-pairing with their target mRNAs. A majority of identified miRs are
INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
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INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
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INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
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INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
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INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
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INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
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, transcriptomics, and/or proteomics) can be useful in identifying diagnostic and prognostic tools in cancer ( Ludwig & Weinstein 2005 ). Among these approaches, profiling of microRNAs (miRNAs), a class of small non-coding RNAs, has shown great promise for the
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MicroRNAs (miRNAs or miRs) have emerged as an important class of short endogenous RNAs that act as post-transcriptional regulators of gene expression via sequence-specific interactions with the 3′-untranslated regions of cognate mRNA targets. In
Freemasons Foundation Centre for Men's Health, The University of Adelaide Adelaide, South Australia Australia
Royal Brisbane Hospital, University of Queensland Centre for Clinical Research Level 6, Building 71/918, Herston, Brisbane, Queensland, QLD 4006 Australia
Department of Urology Royal Brisbane and Women's Hospital Brisbane, Queensland Australia
Queensland Institute of Medical Research Herston, Brisbane, Queensland Australia
School of Population Health, The University of Queensland Brisbane, Queensland Australia
Department of Endocrinology Princess Alexandra Hospital Brisbane, Queensland Australia
Dame Roma Mitchell Cancer Research Laboratories and Adelaide Prostate Cancer Research Centre School of Medicine, The University of Adelaide Level 4 Hanson Institute Building, DX Number 650 801, Adelaide, South Australia, SA 5005 Australia
Freemasons Foundation Centre for Men's Health, The University of Adelaide Adelaide, South Australia Australia
Royal Brisbane Hospital, University of Queensland Centre for Clinical Research Level 6, Building 71/918, Herston, Brisbane, Queensland, QLD 4006 Australia
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Freemasons Foundation Centre for Men's Health, The University of Adelaide Adelaide, South Australia Australia
Royal Brisbane Hospital, University of Queensland Centre for Clinical Research Level 6, Building 71/918, Herston, Brisbane, Queensland, QLD 4006 Australia
Department of Urology Royal Brisbane and Women's Hospital Brisbane, Queensland Australia
Queensland Institute of Medical Research Herston, Brisbane, Queensland Australia
School of Population Health, The University of Queensland Brisbane, Queensland Australia
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Dame Roma Mitchell Cancer Research Laboratories and Adelaide Prostate Cancer Research Centre School of Medicine, The University of Adelaide Level 4 Hanson Institute Building, DX Number 650 801, Adelaide, South Australia, SA 5005 Australia
Freemasons Foundation Centre for Men's Health, The University of Adelaide Adelaide, South Australia Australia
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Freemasons Foundation Centre for Men's Health, The University of Adelaide Adelaide, South Australia Australia
Royal Brisbane Hospital, University of Queensland Centre for Clinical Research Level 6, Building 71/918, Herston, Brisbane, Queensland, QLD 4006 Australia
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Dame Roma Mitchell Cancer Research Laboratories and Adelaide Prostate Cancer Research Centre School of Medicine, The University of Adelaide Level 4 Hanson Institute Building, DX Number 650 801, Adelaide, South Australia, SA 5005 Australia
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Freemasons Foundation Centre for Men's Health, The University of Adelaide Adelaide, South Australia Australia
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Dame Roma Mitchell Cancer Research Laboratories and Adelaide Prostate Cancer Research Centre School of Medicine, The University of Adelaide Level 4 Hanson Institute Building, DX Number 650 801, Adelaide, South Australia, SA 5005 Australia
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Freemasons Foundation Centre for Men's Health, The University of Adelaide Adelaide, South Australia Australia
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Dame Roma Mitchell Cancer Research Laboratories and Adelaide Prostate Cancer Research Centre School of Medicine, The University of Adelaide Level 4 Hanson Institute Building, DX Number 650 801, Adelaide, South Australia, SA 5005 Australia
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). Biomarkers that could identify patients with clinically significant PCa would be ideal but are currently lacking. Aberrant microRNA (miRNA) expression is a common feature of many diseases, including PCa ( Selth et al . 2012 ), and there has been widespread
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Pathology and Laboratory Medicine, University of Louisville, Louisville, Kentucky, USA
The Brown Cancer Center, University of Louisville, Louisville, Kentucky, USA
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The Brown Cancer Center, University of Louisville, Louisville, Kentucky, USA
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The Brown Cancer Center, University of Louisville, Louisville, Kentucky, USA
Center for Integrative Environmental Health Sciences (CIEHS), University of Louisville, Louisville, Kentucky, USA
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marks primary microRNAs for processing . Nature 519 482 – 485 . ( https://doi.org/10.1038/nature14281 ) Alarcon CR Goodarzi H Lee H Liu X Tavazoie S & Tavazoie SF 2015b HNRNPA2B1 is a mediator of m(6)A-dependent nuclear RNA processing
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Introduction The discovery of microRNAs (miRNAs or miRs) in the early 1990s has opened a new era understanding posttranscriptional regulation of genes by small RNAs ( Lee et al . 1993 ). miRs are small noncoding RNAs known to repress target
Human Cancer Genetics Program, Division of Pathology, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA
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Introduction MicroRNAs (miRNAs or miRs) are non-protein coding genes thought to regulate the expression of up to 30% of human genes, either inhibiting mRNA translation or inducing its degradation ( Lewis et al . 2005 ). Besides a crucial
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Hereditary Endocrine Cancer Group, Department of Pathology, Laboratory of Pathology and Oncology, Department of Medical Oncology, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Human Genetics Group, Department of Obstetrics and Gynecology, Human Cancer Genetics Programme, Spanish National Cancer Research Center, Melchor Fernández Almagro 3, 28029 Madrid, Spain
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Hereditary Endocrine Cancer Group, Department of Pathology, Laboratory of Pathology and Oncology, Department of Medical Oncology, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Human Genetics Group, Department of Obstetrics and Gynecology, Human Cancer Genetics Programme, Spanish National Cancer Research Center, Melchor Fernández Almagro 3, 28029 Madrid, Spain
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Hereditary Endocrine Cancer Group, Department of Pathology, Laboratory of Pathology and Oncology, Department of Medical Oncology, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Human Genetics Group, Department of Obstetrics and Gynecology, Human Cancer Genetics Programme, Spanish National Cancer Research Center, Melchor Fernández Almagro 3, 28029 Madrid, Spain
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Hereditary Endocrine Cancer Group, Department of Pathology, Laboratory of Pathology and Oncology, Department of Medical Oncology, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Human Genetics Group, Department of Obstetrics and Gynecology, Human Cancer Genetics Programme, Spanish National Cancer Research Center, Melchor Fernández Almagro 3, 28029 Madrid, Spain
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Hereditary Endocrine Cancer Group, Department of Pathology, Laboratory of Pathology and Oncology, Department of Medical Oncology, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Human Genetics Group, Department of Obstetrics and Gynecology, Human Cancer Genetics Programme, Spanish National Cancer Research Center, Melchor Fernández Almagro 3, 28029 Madrid, Spain
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contributing factor in ovarian tumors ( Izutsu et al . 2008 ) and melanoma cells ( Akasaka et al . 2009 ). Recent studies suggest an important role of microRNAs, specifically, Cochrane et al . (2009 , 2010) demonstrated that miR-200c had a binding site in
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various malignancies, including PTC ( Khatami & Tavangar 2018 , Rappa et al. 2019 , Toraih et al. 2021 ). Special attention was paid to small non-coding RNAs, micro-RNAs (miRNAs), and small lipid bilayer-enclosed extracellular vesicles (EVs), both
Cancer Genetics, Department of Endocrinology, Kolling Institute of Medical Research
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Cancer Genetics, Department of Endocrinology, Kolling Institute of Medical Research
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microRNA-mediated regulation. Autophagy: the mechanism Cellular homoeostasis is a complex process dependent on close regulation of synthesis and degradation of both structural and functional elements. The ubiquitin–proteasome pathway is one such mechanism