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Introduction MicroRNAs (miRs) have emerged as an important class of short endogenous RNAs that act as post-transcriptional regulators of gene expression by base-pairing with their target mRNAs. A majority of identified miRs are

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Sandra Lassalle INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Véronique Hofman INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Marius Ilie INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Christelle Bonnetaud INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Marie-Pierre Puisségur INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Patrick Brest INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Céline Loubatier INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Nicolas Guevara INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Olivier Bordone INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Bruno Cardinaud INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Kévin Lebrigand INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Géraldine Rios INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Joseph Santini INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Brigitte Franc INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Bernard Mari INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Abir Al Ghuzlan INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Philippe Vielh INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Pascal Barbry INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Paul Hofman INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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, transcriptomics, and/or proteomics) can be useful in identifying diagnostic and prognostic tools in cancer ( Ludwig & Weinstein 2005 ). Among these approaches, profiling of microRNAs (miRNAs), a class of small non-coding RNAs, has shown great promise for the

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Alfredo Fusco Istituto di Endocrinologia ed Oncologia Sperimentale, del CNR c/o Dipartimento di Biologia e Patologia, Cellulare e Molecolare, Facoltá di Medicina e Chirurgia di Napoli, Universitá degli Studi di Napoli ‘Federico II’ via Pansini 5, 80131 Naples, Italy

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MicroRNAs (miRNAs or miRs) have emerged as an important class of short endogenous RNAs that act as post-transcriptional regulators of gene expression via sequence-specific interactions with the 3′-untranslated regions of cognate mRNA targets. In

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Luke A Selth Dame Roma Mitchell Cancer Research Laboratories and Adelaide Prostate Cancer Research Centre School of Medicine, The University of Adelaide Level 4 Hanson Institute Building, DX Number 650 801, Adelaide, South Australia, SA 5005 Australia

Freemasons Foundation Centre for Men's Health, The University of Adelaide Adelaide, South Australia Australia

Royal Brisbane Hospital, University of Queensland Centre for Clinical Research Level 6, Building 71/918, Herston, Brisbane, Queensland, QLD 4006 Australia

Department of Urology Royal Brisbane and Women's Hospital Brisbane, Queensland Australia

Queensland Institute of Medical Research Herston, Brisbane, Queensland Australia

School of Population Health, The University of Queensland Brisbane, Queensland Australia

Department of Endocrinology Princess Alexandra Hospital Brisbane, Queensland Australia
Dame Roma Mitchell Cancer Research Laboratories and Adelaide Prostate Cancer Research Centre School of Medicine, The University of Adelaide Level 4 Hanson Institute Building, DX Number 650 801, Adelaide, South Australia, SA 5005 Australia

Freemasons Foundation Centre for Men's Health, The University of Adelaide Adelaide, South Australia Australia

Royal Brisbane Hospital, University of Queensland Centre for Clinical Research Level 6, Building 71/918, Herston, Brisbane, Queensland, QLD 4006 Australia

Department of Urology Royal Brisbane and Women's Hospital Brisbane, Queensland Australia

Queensland Institute of Medical Research Herston, Brisbane, Queensland Australia

School of Population Health, The University of Queensland Brisbane, Queensland Australia

Department of Endocrinology Princess Alexandra Hospital Brisbane, Queensland Australia

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Matthew J Roberts Dame Roma Mitchell Cancer Research Laboratories and Adelaide Prostate Cancer Research Centre School of Medicine, The University of Adelaide Level 4 Hanson Institute Building, DX Number 650 801, Adelaide, South Australia, SA 5005 Australia

Freemasons Foundation Centre for Men's Health, The University of Adelaide Adelaide, South Australia Australia

Royal Brisbane Hospital, University of Queensland Centre for Clinical Research Level 6, Building 71/918, Herston, Brisbane, Queensland, QLD 4006 Australia

Department of Urology Royal Brisbane and Women's Hospital Brisbane, Queensland Australia

Queensland Institute of Medical Research Herston, Brisbane, Queensland Australia

School of Population Health, The University of Queensland Brisbane, Queensland Australia

Department of Endocrinology Princess Alexandra Hospital Brisbane, Queensland Australia
Dame Roma Mitchell Cancer Research Laboratories and Adelaide Prostate Cancer Research Centre School of Medicine, The University of Adelaide Level 4 Hanson Institute Building, DX Number 650 801, Adelaide, South Australia, SA 5005 Australia

Freemasons Foundation Centre for Men's Health, The University of Adelaide Adelaide, South Australia Australia

Royal Brisbane Hospital, University of Queensland Centre for Clinical Research Level 6, Building 71/918, Herston, Brisbane, Queensland, QLD 4006 Australia

Department of Urology Royal Brisbane and Women's Hospital Brisbane, Queensland Australia

Queensland Institute of Medical Research Herston, Brisbane, Queensland Australia

School of Population Health, The University of Queensland Brisbane, Queensland Australia

Department of Endocrinology Princess Alexandra Hospital Brisbane, Queensland Australia

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Clement W K Chow Dame Roma Mitchell Cancer Research Laboratories and Adelaide Prostate Cancer Research Centre School of Medicine, The University of Adelaide Level 4 Hanson Institute Building, DX Number 650 801, Adelaide, South Australia, SA 5005 Australia

Freemasons Foundation Centre for Men's Health, The University of Adelaide Adelaide, South Australia Australia

Royal Brisbane Hospital, University of Queensland Centre for Clinical Research Level 6, Building 71/918, Herston, Brisbane, Queensland, QLD 4006 Australia

Department of Urology Royal Brisbane and Women's Hospital Brisbane, Queensland Australia

Queensland Institute of Medical Research Herston, Brisbane, Queensland Australia

School of Population Health, The University of Queensland Brisbane, Queensland Australia

Department of Endocrinology Princess Alexandra Hospital Brisbane, Queensland Australia
Dame Roma Mitchell Cancer Research Laboratories and Adelaide Prostate Cancer Research Centre School of Medicine, The University of Adelaide Level 4 Hanson Institute Building, DX Number 650 801, Adelaide, South Australia, SA 5005 Australia

Freemasons Foundation Centre for Men's Health, The University of Adelaide Adelaide, South Australia Australia

Royal Brisbane Hospital, University of Queensland Centre for Clinical Research Level 6, Building 71/918, Herston, Brisbane, Queensland, QLD 4006 Australia

Department of Urology Royal Brisbane and Women's Hospital Brisbane, Queensland Australia

Queensland Institute of Medical Research Herston, Brisbane, Queensland Australia

School of Population Health, The University of Queensland Brisbane, Queensland Australia

Department of Endocrinology Princess Alexandra Hospital Brisbane, Queensland Australia

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Villis R Marshall Dame Roma Mitchell Cancer Research Laboratories and Adelaide Prostate Cancer Research Centre School of Medicine, The University of Adelaide Level 4 Hanson Institute Building, DX Number 650 801, Adelaide, South Australia, SA 5005 Australia

Freemasons Foundation Centre for Men's Health, The University of Adelaide Adelaide, South Australia Australia

Royal Brisbane Hospital, University of Queensland Centre for Clinical Research Level 6, Building 71/918, Herston, Brisbane, Queensland, QLD 4006 Australia

Department of Urology Royal Brisbane and Women's Hospital Brisbane, Queensland Australia

Queensland Institute of Medical Research Herston, Brisbane, Queensland Australia

School of Population Health, The University of Queensland Brisbane, Queensland Australia

Department of Endocrinology Princess Alexandra Hospital Brisbane, Queensland Australia
Dame Roma Mitchell Cancer Research Laboratories and Adelaide Prostate Cancer Research Centre School of Medicine, The University of Adelaide Level 4 Hanson Institute Building, DX Number 650 801, Adelaide, South Australia, SA 5005 Australia

Freemasons Foundation Centre for Men's Health, The University of Adelaide Adelaide, South Australia Australia

Royal Brisbane Hospital, University of Queensland Centre for Clinical Research Level 6, Building 71/918, Herston, Brisbane, Queensland, QLD 4006 Australia

Department of Urology Royal Brisbane and Women's Hospital Brisbane, Queensland Australia

Queensland Institute of Medical Research Herston, Brisbane, Queensland Australia

School of Population Health, The University of Queensland Brisbane, Queensland Australia

Department of Endocrinology Princess Alexandra Hospital Brisbane, Queensland Australia

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Suhail A R Doi Dame Roma Mitchell Cancer Research Laboratories and Adelaide Prostate Cancer Research Centre School of Medicine, The University of Adelaide Level 4 Hanson Institute Building, DX Number 650 801, Adelaide, South Australia, SA 5005 Australia

Freemasons Foundation Centre for Men's Health, The University of Adelaide Adelaide, South Australia Australia

Royal Brisbane Hospital, University of Queensland Centre for Clinical Research Level 6, Building 71/918, Herston, Brisbane, Queensland, QLD 4006 Australia

Department of Urology Royal Brisbane and Women's Hospital Brisbane, Queensland Australia

Queensland Institute of Medical Research Herston, Brisbane, Queensland Australia

School of Population Health, The University of Queensland Brisbane, Queensland Australia

Department of Endocrinology Princess Alexandra Hospital Brisbane, Queensland Australia
Dame Roma Mitchell Cancer Research Laboratories and Adelaide Prostate Cancer Research Centre School of Medicine, The University of Adelaide Level 4 Hanson Institute Building, DX Number 650 801, Adelaide, South Australia, SA 5005 Australia

Freemasons Foundation Centre for Men's Health, The University of Adelaide Adelaide, South Australia Australia

Royal Brisbane Hospital, University of Queensland Centre for Clinical Research Level 6, Building 71/918, Herston, Brisbane, Queensland, QLD 4006 Australia

Department of Urology Royal Brisbane and Women's Hospital Brisbane, Queensland Australia

Queensland Institute of Medical Research Herston, Brisbane, Queensland Australia

School of Population Health, The University of Queensland Brisbane, Queensland Australia

Department of Endocrinology Princess Alexandra Hospital Brisbane, Queensland Australia

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Andrew D Vincent Dame Roma Mitchell Cancer Research Laboratories and Adelaide Prostate Cancer Research Centre School of Medicine, The University of Adelaide Level 4 Hanson Institute Building, DX Number 650 801, Adelaide, South Australia, SA 5005 Australia

Freemasons Foundation Centre for Men's Health, The University of Adelaide Adelaide, South Australia Australia

Royal Brisbane Hospital, University of Queensland Centre for Clinical Research Level 6, Building 71/918, Herston, Brisbane, Queensland, QLD 4006 Australia

Department of Urology Royal Brisbane and Women's Hospital Brisbane, Queensland Australia

Queensland Institute of Medical Research Herston, Brisbane, Queensland Australia

School of Population Health, The University of Queensland Brisbane, Queensland Australia

Department of Endocrinology Princess Alexandra Hospital Brisbane, Queensland Australia

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Lisa M Butler Dame Roma Mitchell Cancer Research Laboratories and Adelaide Prostate Cancer Research Centre School of Medicine, The University of Adelaide Level 4 Hanson Institute Building, DX Number 650 801, Adelaide, South Australia, SA 5005 Australia

Freemasons Foundation Centre for Men's Health, The University of Adelaide Adelaide, South Australia Australia

Royal Brisbane Hospital, University of Queensland Centre for Clinical Research Level 6, Building 71/918, Herston, Brisbane, Queensland, QLD 4006 Australia

Department of Urology Royal Brisbane and Women's Hospital Brisbane, Queensland Australia

Queensland Institute of Medical Research Herston, Brisbane, Queensland Australia

School of Population Health, The University of Queensland Brisbane, Queensland Australia

Department of Endocrinology Princess Alexandra Hospital Brisbane, Queensland Australia
Dame Roma Mitchell Cancer Research Laboratories and Adelaide Prostate Cancer Research Centre School of Medicine, The University of Adelaide Level 4 Hanson Institute Building, DX Number 650 801, Adelaide, South Australia, SA 5005 Australia

Freemasons Foundation Centre for Men's Health, The University of Adelaide Adelaide, South Australia Australia

Royal Brisbane Hospital, University of Queensland Centre for Clinical Research Level 6, Building 71/918, Herston, Brisbane, Queensland, QLD 4006 Australia

Department of Urology Royal Brisbane and Women's Hospital Brisbane, Queensland Australia

Queensland Institute of Medical Research Herston, Brisbane, Queensland Australia

School of Population Health, The University of Queensland Brisbane, Queensland Australia

Department of Endocrinology Princess Alexandra Hospital Brisbane, Queensland Australia

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Martin F Lavin Dame Roma Mitchell Cancer Research Laboratories and Adelaide Prostate Cancer Research Centre School of Medicine, The University of Adelaide Level 4 Hanson Institute Building, DX Number 650 801, Adelaide, South Australia, SA 5005 Australia

Freemasons Foundation Centre for Men's Health, The University of Adelaide Adelaide, South Australia Australia

Royal Brisbane Hospital, University of Queensland Centre for Clinical Research Level 6, Building 71/918, Herston, Brisbane, Queensland, QLD 4006 Australia

Department of Urology Royal Brisbane and Women's Hospital Brisbane, Queensland Australia

Queensland Institute of Medical Research Herston, Brisbane, Queensland Australia

School of Population Health, The University of Queensland Brisbane, Queensland Australia

Department of Endocrinology Princess Alexandra Hospital Brisbane, Queensland Australia
Dame Roma Mitchell Cancer Research Laboratories and Adelaide Prostate Cancer Research Centre School of Medicine, The University of Adelaide Level 4 Hanson Institute Building, DX Number 650 801, Adelaide, South Australia, SA 5005 Australia

Freemasons Foundation Centre for Men's Health, The University of Adelaide Adelaide, South Australia Australia

Royal Brisbane Hospital, University of Queensland Centre for Clinical Research Level 6, Building 71/918, Herston, Brisbane, Queensland, QLD 4006 Australia

Department of Urology Royal Brisbane and Women's Hospital Brisbane, Queensland Australia

Queensland Institute of Medical Research Herston, Brisbane, Queensland Australia

School of Population Health, The University of Queensland Brisbane, Queensland Australia

Department of Endocrinology Princess Alexandra Hospital Brisbane, Queensland Australia

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Wayne D Tilley Dame Roma Mitchell Cancer Research Laboratories and Adelaide Prostate Cancer Research Centre School of Medicine, The University of Adelaide Level 4 Hanson Institute Building, DX Number 650 801, Adelaide, South Australia, SA 5005 Australia

Freemasons Foundation Centre for Men's Health, The University of Adelaide Adelaide, South Australia Australia

Royal Brisbane Hospital, University of Queensland Centre for Clinical Research Level 6, Building 71/918, Herston, Brisbane, Queensland, QLD 4006 Australia

Department of Urology Royal Brisbane and Women's Hospital Brisbane, Queensland Australia

Queensland Institute of Medical Research Herston, Brisbane, Queensland Australia

School of Population Health, The University of Queensland Brisbane, Queensland Australia

Department of Endocrinology Princess Alexandra Hospital Brisbane, Queensland Australia
Dame Roma Mitchell Cancer Research Laboratories and Adelaide Prostate Cancer Research Centre School of Medicine, The University of Adelaide Level 4 Hanson Institute Building, DX Number 650 801, Adelaide, South Australia, SA 5005 Australia

Freemasons Foundation Centre for Men's Health, The University of Adelaide Adelaide, South Australia Australia

Royal Brisbane Hospital, University of Queensland Centre for Clinical Research Level 6, Building 71/918, Herston, Brisbane, Queensland, QLD 4006 Australia

Department of Urology Royal Brisbane and Women's Hospital Brisbane, Queensland Australia

Queensland Institute of Medical Research Herston, Brisbane, Queensland Australia

School of Population Health, The University of Queensland Brisbane, Queensland Australia

Department of Endocrinology Princess Alexandra Hospital Brisbane, Queensland Australia

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Robert A Gardiner Dame Roma Mitchell Cancer Research Laboratories and Adelaide Prostate Cancer Research Centre School of Medicine, The University of Adelaide Level 4 Hanson Institute Building, DX Number 650 801, Adelaide, South Australia, SA 5005 Australia

Freemasons Foundation Centre for Men's Health, The University of Adelaide Adelaide, South Australia Australia

Royal Brisbane Hospital, University of Queensland Centre for Clinical Research Level 6, Building 71/918, Herston, Brisbane, Queensland, QLD 4006 Australia

Department of Urology Royal Brisbane and Women's Hospital Brisbane, Queensland Australia

Queensland Institute of Medical Research Herston, Brisbane, Queensland Australia

School of Population Health, The University of Queensland Brisbane, Queensland Australia

Department of Endocrinology Princess Alexandra Hospital Brisbane, Queensland Australia
Dame Roma Mitchell Cancer Research Laboratories and Adelaide Prostate Cancer Research Centre School of Medicine, The University of Adelaide Level 4 Hanson Institute Building, DX Number 650 801, Adelaide, South Australia, SA 5005 Australia

Freemasons Foundation Centre for Men's Health, The University of Adelaide Adelaide, South Australia Australia

Royal Brisbane Hospital, University of Queensland Centre for Clinical Research Level 6, Building 71/918, Herston, Brisbane, Queensland, QLD 4006 Australia

Department of Urology Royal Brisbane and Women's Hospital Brisbane, Queensland Australia

Queensland Institute of Medical Research Herston, Brisbane, Queensland Australia

School of Population Health, The University of Queensland Brisbane, Queensland Australia

Department of Endocrinology Princess Alexandra Hospital Brisbane, Queensland Australia

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). Biomarkers that could identify patients with clinically significant PCa would be ideal but are currently lacking. Aberrant microRNA (miRNA) expression is a common feature of many diseases, including PCa ( Selth et al . 2012 ), and there has been widespread

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Belinda J Petri Department of Biochemistry & Molecular Genetics, University of Louisville School of Medicine Louisville, Kentucky, USA

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Kellianne M Piell Department of Biochemistry & Molecular Genetics, University of Louisville School of Medicine Louisville, Kentucky, USA

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Ali E Wilt Department of Biochemistry & Molecular Genetics, University of Louisville School of Medicine Louisville, Kentucky, USA

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Alexa D Howser Department of Biochemistry & Molecular Genetics, University of Louisville School of Medicine Louisville, Kentucky, USA

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Laura Winkler Department of Biochemistry & Molecular Genetics, University of Louisville School of Medicine Louisville, Kentucky, USA

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Mattie R Whitworth Department of Biochemistry & Molecular Genetics, University of Louisville School of Medicine Louisville, Kentucky, USA

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Bailey L Valdes Department of Biochemistry & Molecular Genetics, University of Louisville School of Medicine Louisville, Kentucky, USA

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Norman L Lehman Department of Biochemistry & Molecular Genetics, University of Louisville School of Medicine Louisville, Kentucky, USA
Pathology and Laboratory Medicine, University of Louisville, Louisville, Kentucky, USA
The Brown Cancer Center, University of Louisville, Louisville, Kentucky, USA

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Brian F Clem Department of Biochemistry & Molecular Genetics, University of Louisville School of Medicine Louisville, Kentucky, USA
The Brown Cancer Center, University of Louisville, Louisville, Kentucky, USA

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Carolyn M Klinge Department of Biochemistry & Molecular Genetics, University of Louisville School of Medicine Louisville, Kentucky, USA
The Brown Cancer Center, University of Louisville, Louisville, Kentucky, USA
Center for Integrative Environmental Health Sciences (CIEHS), University of Louisville, Louisville, Kentucky, USA

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marks primary microRNAs for processing . Nature 519 482 – 485 . ( https://doi.org/10.1038/nature14281 ) Alarcon CR Goodarzi H Lee H Liu X Tavazoie S & Tavazoie SF 2015b HNRNPA2B1 is a mediator of m(6)A-dependent nuclear RNA processing

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Benjamin Boyerinas The Ben May Department for Cancer Research, The University of Chicago, 924 E 57th Street, Chicago, Illinois 60637, USA

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Sun-Mi Park The Ben May Department for Cancer Research, The University of Chicago, 924 E 57th Street, Chicago, Illinois 60637, USA

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Annika Hau The Ben May Department for Cancer Research, The University of Chicago, 924 E 57th Street, Chicago, Illinois 60637, USA

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Andrea E Murmann The Ben May Department for Cancer Research, The University of Chicago, 924 E 57th Street, Chicago, Illinois 60637, USA

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Marcus E Peter The Ben May Department for Cancer Research, The University of Chicago, 924 E 57th Street, Chicago, Illinois 60637, USA

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Introduction The discovery of microRNAs (miRNAs or miRs) in the early 1990s has opened a new era understanding posttranscriptional regulation of genes by small RNAs ( Lee et al . 1993 ). miRs are small noncoding RNAs known to repress target

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Andrea Vecchione Human Cancer Genetics Program, Division of Pathology, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA
Human Cancer Genetics Program, Division of Pathology, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA

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Carlo M Croce Human Cancer Genetics Program, Division of Pathology, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA

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Introduction MicroRNAs (miRNAs or miRs) are non-protein coding genes thought to regulate the expression of up to 30% of human genes, either inhibiting mRNA translation or inducing its degradation ( Lewis et al . 2005 ). Besides a crucial

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Susanna Leskelä Hereditary Endocrine Cancer Group, Department of Pathology, Laboratory of Pathology and Oncology, Department of Medical Oncology, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Human Genetics Group, Department of Obstetrics and Gynecology, Human Cancer Genetics Programme, Spanish National Cancer Research Center, Melchor Fernández Almagro 3, 28029 Madrid, Spain

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Luis J Leandro-García Hereditary Endocrine Cancer Group, Department of Pathology, Laboratory of Pathology and Oncology, Department of Medical Oncology, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Human Genetics Group, Department of Obstetrics and Gynecology, Human Cancer Genetics Programme, Spanish National Cancer Research Center, Melchor Fernández Almagro 3, 28029 Madrid, Spain

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Marta Mendiola Hereditary Endocrine Cancer Group, Department of Pathology, Laboratory of Pathology and Oncology, Department of Medical Oncology, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Human Genetics Group, Department of Obstetrics and Gynecology, Human Cancer Genetics Programme, Spanish National Cancer Research Center, Melchor Fernández Almagro 3, 28029 Madrid, Spain
Hereditary Endocrine Cancer Group, Department of Pathology, Laboratory of Pathology and Oncology, Department of Medical Oncology, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Human Genetics Group, Department of Obstetrics and Gynecology, Human Cancer Genetics Programme, Spanish National Cancer Research Center, Melchor Fernández Almagro 3, 28029 Madrid, Spain

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Jorge Barriuso Hereditary Endocrine Cancer Group, Department of Pathology, Laboratory of Pathology and Oncology, Department of Medical Oncology, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Human Genetics Group, Department of Obstetrics and Gynecology, Human Cancer Genetics Programme, Spanish National Cancer Research Center, Melchor Fernández Almagro 3, 28029 Madrid, Spain

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Lucía Inglada-Pérez Hereditary Endocrine Cancer Group, Department of Pathology, Laboratory of Pathology and Oncology, Department of Medical Oncology, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Human Genetics Group, Department of Obstetrics and Gynecology, Human Cancer Genetics Programme, Spanish National Cancer Research Center, Melchor Fernández Almagro 3, 28029 Madrid, Spain
Hereditary Endocrine Cancer Group, Department of Pathology, Laboratory of Pathology and Oncology, Department of Medical Oncology, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Human Genetics Group, Department of Obstetrics and Gynecology, Human Cancer Genetics Programme, Spanish National Cancer Research Center, Melchor Fernández Almagro 3, 28029 Madrid, Spain

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Iván Muñoz Hereditary Endocrine Cancer Group, Department of Pathology, Laboratory of Pathology and Oncology, Department of Medical Oncology, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Human Genetics Group, Department of Obstetrics and Gynecology, Human Cancer Genetics Programme, Spanish National Cancer Research Center, Melchor Fernández Almagro 3, 28029 Madrid, Spain
Hereditary Endocrine Cancer Group, Department of Pathology, Laboratory of Pathology and Oncology, Department of Medical Oncology, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Human Genetics Group, Department of Obstetrics and Gynecology, Human Cancer Genetics Programme, Spanish National Cancer Research Center, Melchor Fernández Almagro 3, 28029 Madrid, Spain

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Beatriz Martínez-Delgado Hereditary Endocrine Cancer Group, Department of Pathology, Laboratory of Pathology and Oncology, Department of Medical Oncology, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Human Genetics Group, Department of Obstetrics and Gynecology, Human Cancer Genetics Programme, Spanish National Cancer Research Center, Melchor Fernández Almagro 3, 28029 Madrid, Spain

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Andrés Redondo Hereditary Endocrine Cancer Group, Department of Pathology, Laboratory of Pathology and Oncology, Department of Medical Oncology, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Human Genetics Group, Department of Obstetrics and Gynecology, Human Cancer Genetics Programme, Spanish National Cancer Research Center, Melchor Fernández Almagro 3, 28029 Madrid, Spain

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Javier de Santiago Hereditary Endocrine Cancer Group, Department of Pathology, Laboratory of Pathology and Oncology, Department of Medical Oncology, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Human Genetics Group, Department of Obstetrics and Gynecology, Human Cancer Genetics Programme, Spanish National Cancer Research Center, Melchor Fernández Almagro 3, 28029 Madrid, Spain

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Mercedes Robledo Hereditary Endocrine Cancer Group, Department of Pathology, Laboratory of Pathology and Oncology, Department of Medical Oncology, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Human Genetics Group, Department of Obstetrics and Gynecology, Human Cancer Genetics Programme, Spanish National Cancer Research Center, Melchor Fernández Almagro 3, 28029 Madrid, Spain
Hereditary Endocrine Cancer Group, Department of Pathology, Laboratory of Pathology and Oncology, Department of Medical Oncology, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Human Genetics Group, Department of Obstetrics and Gynecology, Human Cancer Genetics Programme, Spanish National Cancer Research Center, Melchor Fernández Almagro 3, 28029 Madrid, Spain

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David Hardisson Hereditary Endocrine Cancer Group, Department of Pathology, Laboratory of Pathology and Oncology, Department of Medical Oncology, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Human Genetics Group, Department of Obstetrics and Gynecology, Human Cancer Genetics Programme, Spanish National Cancer Research Center, Melchor Fernández Almagro 3, 28029 Madrid, Spain

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Cristina Rodríguez-Antona Hereditary Endocrine Cancer Group, Department of Pathology, Laboratory of Pathology and Oncology, Department of Medical Oncology, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Human Genetics Group, Department of Obstetrics and Gynecology, Human Cancer Genetics Programme, Spanish National Cancer Research Center, Melchor Fernández Almagro 3, 28029 Madrid, Spain
Hereditary Endocrine Cancer Group, Department of Pathology, Laboratory of Pathology and Oncology, Department of Medical Oncology, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Human Genetics Group, Department of Obstetrics and Gynecology, Human Cancer Genetics Programme, Spanish National Cancer Research Center, Melchor Fernández Almagro 3, 28029 Madrid, Spain

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contributing factor in ovarian tumors ( Izutsu et al . 2008 ) and melanoma cells ( Akasaka et al . 2009 ). Recent studies suggest an important role of microRNAs, specifically, Cochrane et al . (2009 , 2010) demonstrated that miR-200c had a binding site in

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Ophélie Delcorte CELL Unit, de Duve Institute, Université Catholique de Louvain, Brussels, Belgium

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Julie Craps FATH & MORF Unit, IREC, Université Catholique de Louvain, Brussels, Belgium

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Siam Mahibullah CELL Unit, de Duve Institute, Université Catholique de Louvain, Brussels, Belgium

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Catherine Spourquet CELL Unit, de Duve Institute, Université Catholique de Louvain, Brussels, Belgium

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Ludovic D’Auria Neurochemistry group, Institute of Neurosciences, Université Catholique de Louvain, Brussels, Belgium

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Patrick Van Der Smissen PICT Platform, de Duve Institute, Université Catholique de Louvain, Brussels, Belgium

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Chantal Dessy FATH & MORF Unit, IREC, Université Catholique de Louvain, Brussels, Belgium

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Etienne Marbaix CELL Unit, de Duve Institute, Université Catholique de Louvain, Brussels, Belgium

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Michel Mourad Surgery and Abdominal Transplantation Division, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium

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Christophe E Pierreux CELL Unit, de Duve Institute, Université Catholique de Louvain, Brussels, Belgium

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various malignancies, including PTC ( Khatami & Tavangar 2018 , Rappa et al. 2019 , Toraih et al. 2021 ). Special attention was paid to small non-coding RNAs, micro-RNAs (miRNAs), and small lipid bilayer-enclosed extracellular vesicles (EVs), both

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Justin S Gundara Cancer Genetics, Department of Endocrinology, Kolling Institute of Medical Research
Cancer Genetics, Department of Endocrinology, Kolling Institute of Medical Research

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JingTing Zhao Cancer Genetics, Department of Endocrinology, Kolling Institute of Medical Research

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Bruce G Robinson Cancer Genetics, Department of Endocrinology, Kolling Institute of Medical Research
Cancer Genetics, Department of Endocrinology, Kolling Institute of Medical Research

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Stan B Sidhu Cancer Genetics, Department of Endocrinology, Kolling Institute of Medical Research
Cancer Genetics, Department of Endocrinology, Kolling Institute of Medical Research

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microRNA-mediated regulation. Autophagy: the mechanism Cellular homoeostasis is a complex process dependent on close regulation of synthesis and degradation of both structural and functional elements. The ubiquitin–proteasome pathway is one such mechanism

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