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Darren Cowzer Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Ronak H Shah Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Joanne F Chou Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Ritika Kundra Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Sippy Punn Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Laura Fiedler Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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April DeMore Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Marinela Capanu Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Michael F Berger Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Department of Pathology and laboratory medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Diane Reidy-Lagunes Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Weill Medical College of Cornell University, New York, New York, USA

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Nitya Raj Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Weill Medical College of Cornell University, New York, New York, USA

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Introduction Pancreatic neuroendocrine neoplasms (panNENs) represent a heterogenous group of tumors with varying clinical behaviors and outcomes with increasing incidence and prevalence ( Dasari et al. 2017 ). Tumors are histologically

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-23-0292
Volume/Issue:
Volume 31: Issue 4
Restricted access
Andreas Venizelos K.G. Jebsen Center for Genome-Directed Cancer Therapy, Department of Clinical Science, University of Bergen, Bergen, Norway
Department of Oncology, Haukeland University Hospital, Bergen, Norway

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Halfdan Sorbye Department of Oncology, Haukeland University Hospital, Bergen, Norway
Department of Clinical Science, University of Bergen, Bergen, Norway

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Hege Elvebakken Department of Oncology, Ålesund Hospital, Møre og Romsdal Hospital Trust, Ålesund, Norway
Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway

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Aurel Perren Institute of Tissue Medicine and Pathology, University of Bern, Bern, Switzerland

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Inger Marie B Lothe Department of Pathology, Oslo University Hospital, Oslo, Norway

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Anne Couvelard Department of Pathology, Université Paris Cité and AP-HP, Bichat Hospital, Paris, France

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Geir Olav Hjortland Department of Oncology, Oslo University Hospital, Oslo, Norway

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Anna Sundlöv Departmentt of Oncology, Skåne University Hospital, Lund, Sweden
Department of Medical Radiation Physics, Lund University, Lund, Sweden

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Johanna Svensson Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden

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Harrish Garresori Department of Oncology, Stavanger University Hospital, Stavanger, Norway

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Christian Kersten Department of Research, Hospital of Southern Norway, Kristiansand, Norway

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Eva Hofsli Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway
Department of Oncology, St. Olavs Hospital, Trondheim, Norway

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Sönke Detlefsen Department of Pathology, Odense University Hospital, Odense, Denmark
Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark

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Lene W Vestermark Department of Oncology, Odense University Hospital, Odense, Denmark

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Morten Ladekarl Department of Oncology, Aarhus University Hospital, Aarhus, Denmark
Department of Oncology, Clinical Cancer Research Center, Aalborg University Hospital, Aalborg, Denmark

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Elizaveta Mitkina Tabaksblat Department of Oncology, Clinical Cancer Research Center, Aalborg University Hospital, Aalborg, Denmark

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Stian Knappskog K.G. Jebsen Center for Genome-Directed Cancer Therapy, Department of Clinical Science, University of Bergen, Bergen, Norway
Department of Oncology, Haukeland University Hospital, Bergen, Norway

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Introduction Neuroendocrine neoplasms (NENs) constitute ~2% of all malignancies and are frequently located in the gastrointestinal (GI) tract and pancreas. High-grade gastroenteropancreatic (HG-GEP) NENs are among the most aggressive cancers

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-23-0057
Volume/Issue:
Volume 30: Issue 10
Open access
Tiago Bordeira Gaspar i3S – Instituto de Investigação e Inovação em Saúde, Porto, Portugal
Ipatimup – Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Porto, Portugal
ICBAS – Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto, Porto, Portugal
FMUP – Faculdade de Medicina da Universidade do Porto, Porto, Portugal

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José Manuel Lopes i3S – Instituto de Investigação e Inovação em Saúde, Porto, Portugal
Ipatimup – Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Porto, Portugal
FMUP – Faculdade de Medicina da Universidade do Porto, Porto, Portugal
Department of Pathology, Centro Hospitalar e Universitário de São João, Porto, Portugal

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Paula Soares i3S – Instituto de Investigação e Inovação em Saúde, Porto, Portugal
Ipatimup – Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Porto, Portugal
FMUP – Faculdade de Medicina da Universidade do Porto, Porto, Portugal

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João Vinagre i3S – Instituto de Investigação e Inovação em Saúde, Porto, Portugal
Ipatimup – Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Porto, Portugal
FMUP – Faculdade de Medicina da Universidade do Porto, Porto, Portugal

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Introduction Pancreatic neuroendocrine neoplasms (PanNENs) are rare entities that constitute the second most common pancreatic malignancy (1–2% of all pancreatic neoplasms) following pancreatic ductal adenocarcinoma (PDAC) ( Lawrence et al

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-22-0166
Volume/Issue:
Volume 29: Issue 12
Free access
T Vandamme Center of Oncological Research (CORE), University of Antwerp, Antwerp, Belgium
Section of Endocrinology, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

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M Beyens Center of Oncological Research (CORE), University of Antwerp, Antwerp, Belgium

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G Boons Center of Oncological Research (CORE), University of Antwerp, Antwerp, Belgium

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A Schepers Center of Medical Genetics, University of Antwerp, Antwerp, Belgium

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K Kamp Section of Endocrinology, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

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K Biermann Department of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands

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P Pauwels Department of Pathology, University of Antwerp, Antwerp, Belgium

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W W De Herder Section of Endocrinology, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

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L J Hofland Section of Endocrinology, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

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M Peeters Center of Oncological Research (CORE), University of Antwerp, Antwerp, Belgium

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G Van Camp Center of Medical Genetics, University of Antwerp, Antwerp, Belgium

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K Op de Beeck Center of Oncological Research (CORE), University of Antwerp, Antwerp, Belgium

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Introduction Neuroendocrine neoplasms of the pancreas (pNENs), originating from the islet cells, are considered rare, although incidence is increasing ( Dasari et al . 2017 ). pNENs can occur as part of genetic syndromes, such as multiple

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-18-0120
Volume/Issue:
Volume 26: Issue 1
Free access
Jennifer R Eads Division of Hematology and Oncology, Abramson Cancer Center, University of Pennsylvania, Pennsylvania, USA

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Thorvardur R Halfdanarson Division of Medical Oncology, Mayo Clinic Cancer Center, Rochester, Minnesota, USA

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Tim Asmis Division of Medical Oncology, University of Ottawa, Ottawa, Ontario, Canada

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Andrew M Bellizzi Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA

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Emily K Bergsland Department of Medicine, University of California, San Francisco, California, USA

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Arvind Dasari Division of Gastrointestinal Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

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Ghassan El-Haddad Department of Diagnostic Imaging and Interventional Radiology, Moffitt Cancer Center and Research Institute, Tampa, Florida, USA

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Michael Frumovitz Division of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

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Joshua Meyer Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA

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Erik Mittra Division of Molecular Imaging and Therapy, Oregon Health & Science University, Portland, Oregon, USA

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Sten Myrehaug Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada

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Eric Nakakura Department of Surgery, University of California, San Francisco, California, USA

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Nitya Raj Department of Medicine, Gastrointestinal Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Heloisa P Soares Division of Oncology, Huntsman Cancer Institute, University of Utah, Salt Lake City, Salt Lake City, Utah, USA

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Brian Untch Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Namrata Vijayvergia Department of Hematology and Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA

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Jennifer A Chan Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA

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Introduction High-grade neuroendocrine neoplasms (NENs) constitute a rare disease entity and account for approximately 10% of all NENs. Given their rarity, there is a paucity of prospective data to guide the optimal diagnosis and management of

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Other
DOI:
https://doi.org/10.1530/ERC-22-0206
Volume/Issue:
Volume 30: Issue 8
Open access
Giulia Vocino Trucco Pathology Unit, SS. Annunziata Hospital, Savigliano, Italy

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Marco Volante Department of Oncology, University of Turin, Orbassano, Turin, Italy

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Introduction: a universal terminology and classification system The World Health Organization (WHO) has recently introduced a universal classification framework for neuroendocrine neoplasms (NENs), proposing a single model for terminology and

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Review Article
DOI:
https://doi.org/10.1530/ERC-24-0004
Volume/Issue:
Volume 31: Issue 8
Restricted access
Shani Avniel-Polak Neuroendocrine Tumor Laboratory, Endocrinology & Metabolism Department, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

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Gil Leibowitz Neuroendocrine Tumor Laboratory, Endocrinology & Metabolism Department, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

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Victoria Doviner Department of Pathology, Shaare Zedek Medical Center, Jerusalem, Israel

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David J Gross Neuroendocrine Tumor Laboratory, Endocrinology & Metabolism Department, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

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Simona Grozinsky-Glasberg Neuroendocrine Tumor Laboratory, Endocrinology & Metabolism Department, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

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Introduction Neuroendocrine neoplasms (NENs) constitute a heterogeneous and rare family of tumors that arise from cells of the diffuse endocrine system dispersed throughout the body, with an increasing annual incidence (~6.9/100,000 people

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-18-0121
Volume/Issue:
Volume 25: Issue 6
Free access
Roberto Valente Digestive and Liver Disease Unit, Sant’ Andrea Hospital, Sapienza University of Rome, Rome, Italy

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Alastair J Hayes Department of General Surgery, Royal Infirmary of Edinburgh, Edinburgh, UK

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Sven-Petter Haugvik Department of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway

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Per Hedenström Unit of Gastroenterology, Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden

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Darko Siuka Department of Gastroenterology, University Medical Centre Ljubljana, Ljubljana, Slovenia

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Emilie Korsæth Department of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway

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Daniel Kämmerer Department of General and Visceral Surgery, Zentralklinik Bad Berka, Bad Berka, Germany

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Stuart M Robinson Department of Hepatopancreatobiliary and Transplantation Surgery, The Freeman Hospital, Newcastle upon Tyne, UK

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Patrick Maisonneuve Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy

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Gianfranco Delle Fave Digestive and Liver Disease Unit, Sant’ Andrea Hospital, Sapienza University of Rome, Rome, Italy

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Bjorn Lindkvist Unit of Gastroenterology, Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden

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Gabriele Capurso Digestive and Liver Disease Unit, Sant’ Andrea Hospital, Sapienza University of Rome, Rome, Italy

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Introduction Pancreatic neuroendocrine neoplasms (PNENs) are a group of tumors which originate from endocrine cells within the pancreas gland. PNENs have heterogeneous clinical behavior owing to their hormone functional status, cellular

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-17-0040
Volume/Issue:
Volume 24: Issue 8
Free access
James C Yao University of Texas MD Anderson Cancer Center, Houston, Texas, USA

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Jonathan Strosberg Department of GI Oncology, Moffitt Cancer Center, Tampa, Florida, USA

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Nicola Fazio European Institute of Oncology, IEO, IRCCS, Milan, Italy

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Marianne E Pavel Department of Medicine 1, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany

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Emily Bergsland UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California, USA

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Philippe Ruszniewski Hôpital Beaujon, University of Paris, Paris, France

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Daniel M Halperin University of Texas MD Anderson Cancer Center, Houston, Texas, USA

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Daneng Li City of Hope Comprehensive Cancer Center and Beckman Research Institute, Duarte, California, USA

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Salvatore Tafuto Sarcomas and Rare Tumours Unit, Istituto Nazionale Tumori, IRCCS Fondazione G. Pascale, Naples, Italy

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Nitya Raj Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Davide Campana Department of Clinical Medicine, Sant’Orsola-Malpighi Hospital, University of Bologna, ENETS Center of Excellence, Bologna, Italy

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Susumu Hijioka National Cancer Center Japan Tsukiji Campus, Department of Hepatobiliary and Pancreatic Oncology, Tokyo, Japan

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Markus Raderer Clinical Division of Oncology, Medical University of Vienna, Vienna, Austria

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Rosine Guimbaud CHU de Toulouse, Toulouse, France

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Pablo Gajate Hospital Universitário Ramón y Cajal, Clinical Oncology Department, Madrid, Spain

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Sara Pusceddu Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

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Albert Reising Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA

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Evgeny Degtyarev Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA

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Mark Shilkrut Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA

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Simantini Eddy Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA

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Simron Singh Sunnybrook Health Sciences Centre, Toronto, Canada

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years ( Yao et al. 2008 ). Neuroendocrine neoplasms (NENs) are comprised of well-differentiated NETs and poorly differentiated neuroendocrine carcinomas (NECs). The World Health Organization classification reported four categories, based on tumor

Article Type:
Research Article
Collections:
Top-cited articles of 2023
DOI:
https://doi.org/10.1530/ERC-20-0382
Volume/Issue:
Volume 28: Issue 3
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Chiara Borga Department of Medicine (DIMED), Surgical Pathology & Cytopathology Unit, University of Padua, Padua, Italy

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Carlo Alberto Dal Pozzo Department of Medicine (DIMED), Surgical Pathology & Cytopathology Unit, University of Padua, Padua, Italy

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Elisabetta Trevellin Department of Medicine (DIMED), Endocrine-Metabolic Laboratory, University of Padua, Padua, Italy

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Francesca Bergamo Medical Oncology Unit 1, Department of Oncology, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy

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Sabina Murgioni Medical Oncology Unit 1, Department of Oncology, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy

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Anna Caterina Milanetto Department of Oncology, Surgery and Gastroenterology (DISCOG), Surgery 1, Pancreatic and Endocrine Digestive Surgical Unit, University of Padua, Padua, Italy

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Claudio Pasquali Department of Oncology, Surgery and Gastroenterology (DISCOG), Surgery 1, Pancreatic and Endocrine Digestive Surgical Unit, University of Padua, Padua, Italy

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Umberto Cillo Department of Oncology, Surgery and Gastroenterology (DISCOG), Hepatobiliary Surgery and Liver Transplant Unit, University of Padua, Padua, Italy

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Giada Munari Department of Medicine (DIMED), Surgical Pathology & Cytopathology Unit, University of Padua, Padua, Italy

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Chiara Martini Department of Medicine (DIMED), Endocrine-Metabolic Laboratory, University of Padua, Padua, Italy

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Eugenio De Carlo Department of Medicine (DIMED), Endocrine-Metabolic Laboratory, University of Padua, Padua, Italy

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Vittorina Zagonel Medical Oncology Unit 1, Department of Oncology, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy

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Vincenza Guzzardo Department of Medicine (DIMED), Surgical Pathology & Cytopathology Unit, University of Padua, Padua, Italy

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Gianmaria Pennelli Department of Medicine (DIMED), Surgical Pathology & Cytopathology Unit, University of Padua, Padua, Italy

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Angelo Paolo Dei Tos Department of Medicine (DIMED), Surgical Pathology & Cytopathology Unit, University of Padua, Padua, Italy

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Roberto Vettor Department of Medicine (DIMED), Endocrine-Metabolic Laboratory, University of Padua, Padua, Italy

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Matteo Fassan Department of Medicine (DIMED), Surgical Pathology & Cytopathology Unit, University of Padua, Padua, Italy
Veneto Institute of Oncology IOV - IRCCS, Padua, Italy

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Introduction Gastrointestinal neuroendocrine neoplasms (GI-NENs) are a heterogeneous group of malignancies that represent an emerging issue both in research and clinical practice due to their increase in incidence ( Patel & Benipal 2019 ) and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-21-0052
Volume/Issue:
Volume 28: Issue 7
Restricted access