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Luca Morandi Department of Biomedical and Neuromotor Sciences, Section of Anatomic Pathology ‘M. Malpighi’ at Bellaria Hospital, University of Bologna, Bologna, Italy

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Alberto Righi Department of Pathology, Rizzoli Institute, (IRCCS), Bologna, Italy

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Francesca Maletta Department of Medical Sciences, University of Turin, Turin, Italy

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Paola Rucci Section of Hygiene and Biostatistics, University of Bologna, Bologna, Italy

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Fabio Pagni Department of Pathology, University of Milano Bicocca, Monza, Italy

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Marco Gallo Oncological Endocrinology Unit, Department of Medical Sciences, AOU Città della Salute e della Scienza di Torino, University of Turin, Turin, Italy

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Sabrina Rossi Department of Pathology, Regional Hospital, Treviso, Italy

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Leonardo Caporali Istituto delle Scienze Neurologiche di Bologna (IRCCS), Bellaria Hospital, Bologna, Italy

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Anna Sapino Institute for Cancer Research and Treatment (IRCCS), Candiolo, Italy

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Ricardo V Lloyd University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA

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Sofia Asioli Department of Biomedical and Neuromotor Sciences, Section of Anatomic Pathology ‘M. Malpighi’ at Bellaria Hospital, University of Bologna, Bologna, Italy

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Introduction Thyroid cancer is the most common type of endocrine malignancy. The vast majority of thyroid tumors originate from thyroid follicular cells and encompasses well-differentiated papillary carcinoma and follicular carcinoma. Its

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Garcilaso Riesco-Eizaguirre Instituto de Investigaciones Biomédicas ‘Alberto Sols’,, Servicio de Endocrinología y Nutrición,, Consejo Superior de Investigaciones Científicas y Universidad Autónoma de Madrid (CSIC-UAM), 28029 Madrid, Spain
Instituto de Investigaciones Biomédicas ‘Alberto Sols’,, Servicio de Endocrinología y Nutrición,, Consejo Superior de Investigaciones Científicas y Universidad Autónoma de Madrid (CSIC-UAM), 28029 Madrid, Spain

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Pilar Santisteban Instituto de Investigaciones Biomédicas ‘Alberto Sols’,, Servicio de Endocrinología y Nutrición,, Consejo Superior de Investigaciones Científicas y Universidad Autónoma de Madrid (CSIC-UAM), 28029 Madrid, Spain

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correlation with the solid variant of papillary carcinoma ( Nikiforov 2002 ). However, the presence of the mutation does not seem to influence the biological behaviour of the tumour or its response to conventional treatment modalities ( Pacini et al . 2000

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A Perren
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S Schmid
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T Locher
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P Saremaslani
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C Bonvin
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P U Heitz
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P Komminoth
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. American Journal of Pathology 156 651 –659. Fukushima T , Suzuki S, Mashiko M, Ohtake T, Endo Y, Takebayashi Y, Sekikawa K, Hagiwara K & Takenoshita S 2003 BRAF mutations in papillary carcinomas of the thyroid. Oncogene

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M Niedziela Department of Pediatric Endocrinology and Diabetes, Poznan University of Medical Sciences, Szpitalna Street 27/33, 60–572 Poznan, Poland

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inaccurate. An adequate (true-positive) diagnosis can be made in more than 90% of undifferentiated, medullary and papillary carcinomas using FNAB ( Kini 1996 ). An FTC cannot be distinguished pre-operatively by FNAB from a hyperplastic nodule, an FA

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Alyaksandr V Nikitski Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

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Marina N Nikiforova Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

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Linwah Yip Division of Endocrine Surgery, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

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Esra Karslioglu-French Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

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Sally E Carty Division of Endocrine Surgery, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

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Yuri E Nikiforov Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

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Introduction The current classification of follicular cell-derived thyroid cancer recognizes (i) well-differentiated cancer types, including papillary carcinoma (PC), follicular carcinoma (FC), and Hurtle cell carcinoma (HCC); (ii) poorly

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G Riesco-Eizaguirre
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P Gutiérrez-Martínez
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M A García-Cabezas
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M Nistal
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P Santisteban
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other patient characteristics, and were subclassified as classic papillary carcinoma or as distinct histological variants based on the histopathological typing of the World Health Organization (2004). DNA isolation, single

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Päivi Siironen
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Ari Ristimäki
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Kirsi Narko
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Stig Nordling
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Johanna Louhimo
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Sture Andersson
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Reijo Haapiainen
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Caj Haglund
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papillary carcinoma. Therefore, 106 patients were included in this study. Papillary thyroid carcinomas were staged according to the TNM classification of 1997 ( Sobin & Wittekind 1997 ). Most of these patients underwent total thyroidectomy (98 of

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Cristina Romei Departments of, Endocrinology and Metabolism, Oncology, Surgery, Department of Internal Medicine, AMBISEN Center, University of Pisa, 56100 Pisa, Italy

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Raffaele Ciampi Departments of, Endocrinology and Metabolism, Oncology, Surgery, Department of Internal Medicine, AMBISEN Center, University of Pisa, 56100 Pisa, Italy

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Pinuccia Faviana Departments of, Endocrinology and Metabolism, Oncology, Surgery, Department of Internal Medicine, AMBISEN Center, University of Pisa, 56100 Pisa, Italy

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Laura Agate Departments of, Endocrinology and Metabolism, Oncology, Surgery, Department of Internal Medicine, AMBISEN Center, University of Pisa, 56100 Pisa, Italy

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Eleonora Molinaro Departments of, Endocrinology and Metabolism, Oncology, Surgery, Department of Internal Medicine, AMBISEN Center, University of Pisa, 56100 Pisa, Italy

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Valeria Bottici Departments of, Endocrinology and Metabolism, Oncology, Surgery, Department of Internal Medicine, AMBISEN Center, University of Pisa, 56100 Pisa, Italy

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Fulvio Basolo Departments of, Endocrinology and Metabolism, Oncology, Surgery, Department of Internal Medicine, AMBISEN Center, University of Pisa, 56100 Pisa, Italy

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Paolo Miccoli Departments of, Endocrinology and Metabolism, Oncology, Surgery, Department of Internal Medicine, AMBISEN Center, University of Pisa, 56100 Pisa, Italy

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Furio Pacini Departments of, Endocrinology and Metabolism, Oncology, Surgery, Department of Internal Medicine, AMBISEN Center, University of Pisa, 56100 Pisa, Italy

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Aldo Pinchera Departments of, Endocrinology and Metabolism, Oncology, Surgery, Department of Internal Medicine, AMBISEN Center, University of Pisa, 56100 Pisa, Italy
Departments of, Endocrinology and Metabolism, Oncology, Surgery, Department of Internal Medicine, AMBISEN Center, University of Pisa, 56100 Pisa, Italy

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Rossella Elisei Departments of, Endocrinology and Metabolism, Oncology, Surgery, Department of Internal Medicine, AMBISEN Center, University of Pisa, 56100 Pisa, Italy

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Fagin JA 1997 Distinct pattern of ret oncogene rearrangements in morphological variants of radiation-induced and sporadic thyroid papillary carcinomas in children . Cancer Research 57 1690 – 1694 . Nikiforova MN Kimura ET Gandhi M Biddinger PW

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Soomin Ahn Department of Pathology, Ewha Womans University School of Medicine, Seoul, Korea

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Tae Hyuk Kim Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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Sun Wook Kim Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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Chang Seok Ki Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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Hye Won Jang Department of Medical Education, Sungkyunkwan University School of Medicine, Seoul, Korea

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Jee Soo Kim Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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Jung Han Kim Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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Jun-Ho Choe Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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Jung Hee Shin Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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Soo Yeon Hahn Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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Young Lyun Oh Department of Pathology and Translational genomics, Sungkyunkwan University School of Medicine, Seoul, Korea

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Jae Hoon Chung Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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Frequency of PD-L1 positivity. PD-L1 immunohistochemistry in tumor Positive Negative (1% ≤ Proportion <5%) (Proportion ≥5%) Total Papillary carcinoma 306 (93.9%) 17 (5.2%) 3 (0.9%) 326

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Shih-Ping Cheng Department of Surgery, Division of Endocrinology and Metabolism, Mackay Junior College of Medicine, Department of Pharmacology, Department of Medical Research, Institute of Statistical Science
Department of Surgery, Division of Endocrinology and Metabolism, Mackay Junior College of Medicine, Department of Pharmacology, Department of Medical Research, Institute of Statistical Science
Department of Surgery, Division of Endocrinology and Metabolism, Mackay Junior College of Medicine, Department of Pharmacology, Department of Medical Research, Institute of Statistical Science

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Chien-Liang Liu Department of Surgery, Division of Endocrinology and Metabolism, Mackay Junior College of Medicine, Department of Pharmacology, Department of Medical Research, Institute of Statistical Science
Department of Surgery, Division of Endocrinology and Metabolism, Mackay Junior College of Medicine, Department of Pharmacology, Department of Medical Research, Institute of Statistical Science

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Ming-Jen Chen Department of Surgery, Division of Endocrinology and Metabolism, Mackay Junior College of Medicine, Department of Pharmacology, Department of Medical Research, Institute of Statistical Science
Department of Surgery, Division of Endocrinology and Metabolism, Mackay Junior College of Medicine, Department of Pharmacology, Department of Medical Research, Institute of Statistical Science
Department of Surgery, Division of Endocrinology and Metabolism, Mackay Junior College of Medicine, Department of Pharmacology, Department of Medical Research, Institute of Statistical Science

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Ming-Nan Chien Department of Surgery, Division of Endocrinology and Metabolism, Mackay Junior College of Medicine, Department of Pharmacology, Department of Medical Research, Institute of Statistical Science
Department of Surgery, Division of Endocrinology and Metabolism, Mackay Junior College of Medicine, Department of Pharmacology, Department of Medical Research, Institute of Statistical Science

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Ching-Hsiang Leung Department of Surgery, Division of Endocrinology and Metabolism, Mackay Junior College of Medicine, Department of Pharmacology, Department of Medical Research, Institute of Statistical Science
Department of Surgery, Division of Endocrinology and Metabolism, Mackay Junior College of Medicine, Department of Pharmacology, Department of Medical Research, Institute of Statistical Science

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Chi-Hsin Lin Department of Surgery, Division of Endocrinology and Metabolism, Mackay Junior College of Medicine, Department of Pharmacology, Department of Medical Research, Institute of Statistical Science

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Yi-Chiung Hsu Department of Surgery, Division of Endocrinology and Metabolism, Mackay Junior College of Medicine, Department of Pharmacology, Department of Medical Research, Institute of Statistical Science

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Jie-Jen Lee Department of Surgery, Division of Endocrinology and Metabolism, Mackay Junior College of Medicine, Department of Pharmacology, Department of Medical Research, Institute of Statistical Science
Department of Surgery, Division of Endocrinology and Metabolism, Mackay Junior College of Medicine, Department of Pharmacology, Department of Medical Research, Institute of Statistical Science
Department of Surgery, Division of Endocrinology and Metabolism, Mackay Junior College of Medicine, Department of Pharmacology, Department of Medical Research, Institute of Statistical Science

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-identification of patient records. Finally, a total of 108 patients comprised our main study cohort. Lesions consisted of 103 papillary carcinomas and five anaplastic carcinomas. Of the 103 papillary carcinomas, ten showed a follicular structure and were diagnosed

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