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Introduction Thyroid cancer is the most common type of endocrine malignancy. The vast majority of thyroid tumors originate from thyroid follicular cells and encompasses well-differentiated papillary carcinoma and follicular carcinoma. Its
Instituto de Investigaciones Biomédicas ‘Alberto Sols’,, Servicio de Endocrinología y Nutrición,, Consejo Superior de Investigaciones Científicas y Universidad Autónoma de Madrid (CSIC-UAM), 28029 Madrid, Spain
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correlation with the solid variant of papillary carcinoma ( Nikiforov 2002 ). However, the presence of the mutation does not seem to influence the biological behaviour of the tumour or its response to conventional treatment modalities ( Pacini et al . 2000
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. American Journal of Pathology 156 651 –659. Fukushima T , Suzuki S, Mashiko M, Ohtake T, Endo Y, Takebayashi Y, Sekikawa K, Hagiwara K & Takenoshita S 2003 BRAF mutations in papillary carcinomas of the thyroid. Oncogene
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inaccurate. An adequate (true-positive) diagnosis can be made in more than 90% of undifferentiated, medullary and papillary carcinomas using FNAB ( Kini 1996 ). An FTC cannot be distinguished pre-operatively by FNAB from a hyperplastic nodule, an FA
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Introduction The current classification of follicular cell-derived thyroid cancer recognizes (i) well-differentiated cancer types, including papillary carcinoma (PC), follicular carcinoma (FC), and Hurtle cell carcinoma (HCC); (ii) poorly
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other patient characteristics, and were subclassified as classic papillary carcinoma or as distinct histological variants based on the histopathological typing of the World Health Organization (2004). DNA isolation, single
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papillary carcinoma. Therefore, 106 patients were included in this study. Papillary thyroid carcinomas were staged according to the TNM classification of 1997 ( Sobin & Wittekind 1997 ). Most of these patients underwent total thyroidectomy (98 of
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Departments of, Endocrinology and Metabolism, Oncology, Surgery, Department of Internal Medicine, AMBISEN Center, University of Pisa, 56100 Pisa, Italy
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Fagin JA 1997 Distinct pattern of ret oncogene rearrangements in morphological variants of radiation-induced and sporadic thyroid papillary carcinomas in children . Cancer Research 57 1690 – 1694 . Nikiforova MN Kimura ET Gandhi M Biddinger PW
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Frequency of PD-L1 positivity. PD-L1 immunohistochemistry in tumor Positive Negative (1% ≤ Proportion <5%) (Proportion ≥5%) Total Papillary carcinoma 306 (93.9%) 17 (5.2%) 3 (0.9%) 326
Department of Surgery, Division of Endocrinology and Metabolism, Mackay Junior College of Medicine, Department of Pharmacology, Department of Medical Research, Institute of Statistical Science
Department of Surgery, Division of Endocrinology and Metabolism, Mackay Junior College of Medicine, Department of Pharmacology, Department of Medical Research, Institute of Statistical Science
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Department of Surgery, Division of Endocrinology and Metabolism, Mackay Junior College of Medicine, Department of Pharmacology, Department of Medical Research, Institute of Statistical Science
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Department of Surgery, Division of Endocrinology and Metabolism, Mackay Junior College of Medicine, Department of Pharmacology, Department of Medical Research, Institute of Statistical Science
Department of Surgery, Division of Endocrinology and Metabolism, Mackay Junior College of Medicine, Department of Pharmacology, Department of Medical Research, Institute of Statistical Science
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Department of Surgery, Division of Endocrinology and Metabolism, Mackay Junior College of Medicine, Department of Pharmacology, Department of Medical Research, Institute of Statistical Science
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Department of Surgery, Division of Endocrinology and Metabolism, Mackay Junior College of Medicine, Department of Pharmacology, Department of Medical Research, Institute of Statistical Science
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Department of Surgery, Division of Endocrinology and Metabolism, Mackay Junior College of Medicine, Department of Pharmacology, Department of Medical Research, Institute of Statistical Science
Department of Surgery, Division of Endocrinology and Metabolism, Mackay Junior College of Medicine, Department of Pharmacology, Department of Medical Research, Institute of Statistical Science
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-identification of patient records. Finally, a total of 108 patients comprised our main study cohort. Lesions consisted of 103 papillary carcinomas and five anaplastic carcinomas. Of the 103 papillary carcinomas, ten showed a follicular structure and were diagnosed