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Valentina Martineti
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Lucia Picariello
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Maria Luisa Brandi
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and 2 from Sigma, USA), according to the manufacturer’s instructions (protein extraction buffer). Proteins (25 μg) were subjected to SDS-PAGE on a 10% (cyclin E, ERβ), 12% (cyclin D1, cdk2, cdk4, ERK1/2 and phospho-ERK1/2) or a 15% (p21CIP1 and p27KIP1

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Nidhi Singh Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA

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Hannelore V Heemers Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA

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transcriptomic data integration and summarize such data at the individual level. Using this tool, they implicated several signaling proteins such as PRKDC, PRKAA2, PTK2, RPS6KA4, and CDK family members within these pathways as possible new therapeutic targets and

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Donata Vitagliano
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Valentina De Falco
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Anna Tamburrino
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Sabrina Coluzzi
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Giancarlo Troncone Dipartimento di Biologia e Patologia Cellulare e Molecolare, Dipartimento di Scienze Biomorfologiche e Funzionali, Istituto Nazionale dei Tumori di Napoli, Division of Medical Oncology, Dipartimento di Endocrinologia e Oncologia Molecolare e Clinica, Department of Medicine and Human Oncology and Pathogenesis Program, Cancer Discovery, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Università Federico II, Via S. Pansini 5, 80131 Napoli, Italy

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Gennaro Chiappetta Dipartimento di Biologia e Patologia Cellulare e Molecolare, Dipartimento di Scienze Biomorfologiche e Funzionali, Istituto Nazionale dei Tumori di Napoli, Division of Medical Oncology, Dipartimento di Endocrinologia e Oncologia Molecolare e Clinica, Department of Medicine and Human Oncology and Pathogenesis Program, Cancer Discovery, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Università Federico II, Via S. Pansini 5, 80131 Napoli, Italy

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Fortunato Ciardiello Dipartimento di Biologia e Patologia Cellulare e Molecolare, Dipartimento di Scienze Biomorfologiche e Funzionali, Istituto Nazionale dei Tumori di Napoli, Division of Medical Oncology, Dipartimento di Endocrinologia e Oncologia Molecolare e Clinica, Department of Medicine and Human Oncology and Pathogenesis Program, Cancer Discovery, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Università Federico II, Via S. Pansini 5, 80131 Napoli, Italy

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Giampaolo Tortora Dipartimento di Biologia e Patologia Cellulare e Molecolare, Dipartimento di Scienze Biomorfologiche e Funzionali, Istituto Nazionale dei Tumori di Napoli, Division of Medical Oncology, Dipartimento di Endocrinologia e Oncologia Molecolare e Clinica, Department of Medicine and Human Oncology and Pathogenesis Program, Cancer Discovery, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Università Federico II, Via S. Pansini 5, 80131 Napoli, Italy

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James A Fagin Dipartimento di Biologia e Patologia Cellulare e Molecolare, Dipartimento di Scienze Biomorfologiche e Funzionali, Istituto Nazionale dei Tumori di Napoli, Division of Medical Oncology, Dipartimento di Endocrinologia e Oncologia Molecolare e Clinica, Department of Medicine and Human Oncology and Pathogenesis Program, Cancer Discovery, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Università Federico II, Via S. Pansini 5, 80131 Napoli, Italy

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Anderson J Ryan Dipartimento di Biologia e Patologia Cellulare e Molecolare, Dipartimento di Scienze Biomorfologiche e Funzionali, Istituto Nazionale dei Tumori di Napoli, Division of Medical Oncology, Dipartimento di Endocrinologia e Oncologia Molecolare e Clinica, Department of Medicine and Human Oncology and Pathogenesis Program, Cancer Discovery, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Università Federico II, Via S. Pansini 5, 80131 Napoli, Italy

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Francesca Carlomagno
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Massimo Santoro
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data analysis software (SABiosciences-Qiagen). The Human Cell Cycle RT 2 Profiler PCR Array measures the expression level of the following cell-cycle-related genes: ANAPC2 , CCND1 , CCNE1 , CDC34 , CDK4 , CDK6 , CDKN1B , CDKN3 , CUL1 , CUL2

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Conleth G Murphy Bons Secours Hospital Cork, Medical Oncology, Cork, Ireland
University College Cork, Medicine, Cork, Ireland

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Maura N Dickler Memorial Sloan-Kettering Cancer Center, Breast Medicine Service, New York, New York, USA
Joan and Sanford I Weill Medical College of Cornell University, Medicine, New York, New York, USA

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–threonine protein kinases ( Morgan 1997 ). Progression through the G1-S phase requires phosphorylation of Rb by the cyclin-dependent kinase CDK4 (or the highly homologous enzyme CDK6) in complex with cyclin D1, D2, or D3 ( Sherr 1995 ). Hyperphosphorylation of Rb

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Jason M D'Antonio Department of Urology, Department of Oncology, Brady Urologic Institute
Department of Urology, Department of Oncology, Brady Urologic Institute

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Donald J Vander Griend Department of Urology, Department of Oncology, Brady Urologic Institute
Department of Urology, Department of Oncology, Brady Urologic Institute

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John T Isaacs Department of Urology, Department of Oncology, Brady Urologic Institute
Department of Urology, Department of Oncology, Brady Urologic Institute

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). Figure 2 Mammalian pre-RC formation and DNA licensing in the context of cell cycle progression. In early G 1 , cyclin D-cdk4/6 phosphorylation of Rb, which permits E2F transcriptional activity, triggers entry into the cell cycle. Pre-RCs form via stepwise

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Varadha Balaji Venkadakrishnan Department of Cancer Biology, Cleveland Clinic, Cleveland, Ohio, USA
Department of Biological, Geological and Environmental Sciences, Cleveland State University, Cleveland, Ohio, USA

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Salma Ben-Salem Department of Cancer Biology, Cleveland Clinic, Cleveland, Ohio, USA

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Hannelore V Heemers Department of Cancer Biology, Cleveland Clinic, Cleveland, Ohio, USA

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Nelfinavir, Everolimus, PHT 427 pT34 c  CDK11B NA Ser/Thr CMGC None pS265, pS271, pS422 c  CDK6 NA Ser/Thr CMGC LEE011 - CDK4/6 NA  CDK7 NA Ser/Thr CMGC Alvocidib, seliciclib, BS-181 pS164 g  CDK9 NA

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Wayne D Tilley Dame Roma Mitchell Cancer Research Laboratories, School of Medicine, Faculty of Health Sciences, The University of Adelaide, Adelaide, Australia

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, transcriptional repression and interference with co-regulators are viable therapeutic approaches to target AR-Vs. The review concludes with an overview of recent preclinical compounds that have been shown to modulate AR-V activity. Cyclin-dependent kinase 9 (CDK

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Hannes Neuwirt
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Martin Puhr
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Ilaria T Cavarretta
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Michael Mitterberger
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Alfred Hobisch Department of Urology, General Hospital Feldkirch,, Innsbruck Medical University, Anichtrasse 35, A-6020 Innsbruck, Austria

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Zoran Culig
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, SOCS-3 significantly diminishes stimulation of cell cycle regulatory proteins cdk2, cdk4, cyclins E and D1 by androgen. Materials and methods Cell culture and chemicals Prostate cancer PC3-AR cells were donated by Dr Andrew Cato (Research Center

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Rosa Visone
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Lucia Russo
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Pierlorenzo Pallante
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Ivana De Martino
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Angelo Ferraro
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Vincenza Leone
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Eleonora Borbone
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Fabio Petrocca
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Hansjuerg Alder
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Carlo Maria Croce
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Alfredo Fusco
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al. 1995 ). In fact, the Cip/Kip family together with INK4 proteins (p16 INK4a , p15 INK4b , p18 INK4c , and p19 INK4d ), belongs to the cyclin-dependent kinase (CDK) inhibitors ( Serrano et al. 1993 , Guan et al. 1994 , Hannon et al. 1994

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Yu-Ling Lu Department of Internal Medicine, New Taipei Municipal TuCheng Hospital, New Taipei City, Taiwan
Department of Internal Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan
Chang Gung University, Taoyuan, Taiwan

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Yu-Tung Huang Center for Big Data Analytics and Statistics, Chang Gung Memorial Hospital, Taoyuan, Taiwan

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Ming-Hsien Wu Department of Internal Medicine, New Taipei Municipal TuCheng Hospital, New Taipei City, Taiwan
Department of Internal Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan
Chang Gung University, Taoyuan, Taiwan

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Ting-Chao Chou Laboratory of Preclinical Pharmacology Core, Memorial Sloan-Kettering Cancer Center, New York, New York, USA

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Richard J Wong Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York, USA

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Shu-Fu Lin Department of Internal Medicine, New Taipei Municipal TuCheng Hospital, New Taipei City, Taiwan
Department of Internal Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan
Chang Gung University, Taoyuan, Taiwan

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EL (Sigma) and 50% ethanol (Sigma) to a concentration of 57.6 mg/mL and stored at −80°C; it was further dissolved at a final concentration of 14.4 mg/mL in water before in vivo use. Antibodies Antibodies against p-CDK1 (Tyr15), p-CHK1 (Ser

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