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and 2 from Sigma, USA), according to the manufacturer’s instructions (protein extraction buffer). Proteins (25 μg) were subjected to SDS-PAGE on a 10% (cyclin E, ERβ), 12% (cyclin D1, cdk2, cdk4, ERK1/2 and phospho-ERK1/2) or a 15% (p21CIP1 and p27KIP1
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transcriptomic data integration and summarize such data at the individual level. Using this tool, they implicated several signaling proteins such as PRKDC, PRKAA2, PTK2, RPS6KA4, and CDK family members within these pathways as possible new therapeutic targets and
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data analysis software (SABiosciences-Qiagen). The Human Cell Cycle RT 2 Profiler PCR Array measures the expression level of the following cell-cycle-related genes: ANAPC2 , CCND1 , CCNE1 , CDC34 , CDK4 , CDK6 , CDKN1B , CDKN3 , CUL1 , CUL2
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Joan and Sanford I Weill Medical College of Cornell University, Medicine, New York, New York, USA
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–threonine protein kinases ( Morgan 1997 ). Progression through the G1-S phase requires phosphorylation of Rb by the cyclin-dependent kinase CDK4 (or the highly homologous enzyme CDK6) in complex with cyclin D1, D2, or D3 ( Sherr 1995 ). Hyperphosphorylation of Rb
Department of Urology, Department of Oncology, Brady Urologic Institute
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Department of Urology, Department of Oncology, Brady Urologic Institute
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). Figure 2 Mammalian pre-RC formation and DNA licensing in the context of cell cycle progression. In early G 1 , cyclin D-cdk4/6 phosphorylation of Rb, which permits E2F transcriptional activity, triggers entry into the cell cycle. Pre-RCs form via stepwise
Department of Biological, Geological and Environmental Sciences, Cleveland State University, Cleveland, Ohio, USA
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Nelfinavir, Everolimus, PHT 427 pT34 c CDK11B NA Ser/Thr CMGC None pS265, pS271, pS422 c CDK6 NA Ser/Thr CMGC LEE011 - CDK4/6 NA CDK7 NA Ser/Thr CMGC Alvocidib, seliciclib, BS-181 pS164 g CDK9 NA
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, transcriptional repression and interference with co-regulators are viable therapeutic approaches to target AR-Vs. The review concludes with an overview of recent preclinical compounds that have been shown to modulate AR-V activity. Cyclin-dependent kinase 9 (CDK
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, SOCS-3 significantly diminishes stimulation of cell cycle regulatory proteins cdk2, cdk4, cyclins E and D1 by androgen. Materials and methods Cell culture and chemicals Prostate cancer PC3-AR cells were donated by Dr Andrew Cato (Research Center
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al. 1995 ). In fact, the Cip/Kip family together with INK4 proteins (p16 INK4a , p15 INK4b , p18 INK4c , and p19 INK4d ), belongs to the cyclin-dependent kinase (CDK) inhibitors ( Serrano et al. 1993 , Guan et al. 1994 , Hannon et al. 1994
Department of Internal Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan
Chang Gung University, Taoyuan, Taiwan
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Department of Internal Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan
Chang Gung University, Taoyuan, Taiwan
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Department of Internal Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan
Chang Gung University, Taoyuan, Taiwan
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EL (Sigma) and 50% ethanol (Sigma) to a concentration of 57.6 mg/mL and stored at −80°C; it was further dissolved at a final concentration of 14.4 mg/mL in water before in vivo use. Antibodies Antibodies against p-CDK1 (Tyr15), p-CHK1 (Ser