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Victoria Byrd Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

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Ted Getz Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

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Roshan Padmanabhan Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA

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Hans Arora Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
Glickman Urological & Kidney Institute, Cleveland Clinic, Cleveland, Ohio, USA

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Charis Eng Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA
Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
CASE Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

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characteristics. Twelve of the 17 cancer patients had a history of breast cancer (71%), seven of thyroid (41%), five of kidney (29%), three of skin (18%), two of endometrial (12%) and one of colon cancer (6%). Five had a history of another type of cancer; all

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-17-0442
Volume/Issue:
Volume 25: Issue 3
Open access
Li Cong
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Jessica Gasser
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Jessica Zhao
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Baofeng Yang
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Fanghong Li
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Allan Z Zhao
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pathogenesis of endometrial cancer ( Akhmedkhanov et al. 2001 , Zhu et al. 2001 ), other adipocytes-derived factors have also contributed to the regulation of cancer cell growth ( Housa et al. 2006 ). For example, both insulin-like growth factor-I (IGF

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-07-0065
Volume/Issue:
Volume 14: Issue 3
Free access
Manami Inoue Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan

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Shoichiro Tsugane Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan

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esophageal adenocarcinoma, colorectal cancer, pancreatic cancer, postmenopausal breast cancer, endometrial cancer, and kidney cancer. Further, it probably increases the risk of gallbladder cancer, and possibly increases the risk of liver cancer. The WCRF

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-12-0142
Volume/Issue:
Volume 19: Issue 5
Free access
S C J P Gielen
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L C M Kühne
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P C Ewing
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L J Blok
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C W Burger
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small (less than 100% endometrium) and one sample was classified by histology as endometrial cancer. From the remaining eight samples RNA was isolated and the quality of RNA was verified. In one of these eight samples the RNA turned out to be degraded

Article Type:
Research Article
DOI:
https://doi.org/10.1677/erc.1.01046
Volume/Issue:
Volume 12: Issue 4
Free access
Douglas A Gibson Queen's Medical Research Institute, MRC Centre for Reproductive Health, The University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Philippa T K Saunders Queen's Medical Research Institute, MRC Centre for Reproductive Health, The University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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most common cancer in women ( http://www.cancerresearchuk.org/cancer-info/cancerstats/incidence/commoncancers/uk-cancer-incidence-statistics-for-common-cancers#Top3 ; accessed August 2013). Endometrial cancer accounts for the majority of these cancers

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-13-0342
Volume/Issue:
Volume 21: Issue 2
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V J Assikis
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V C Jordan
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Research Article
DOI:
https://doi.org/10.1677/erc.0.0203235
Volume/Issue:
Volume 2: Issue 3
Restricted access
Nicola M Bougen The Liggins Institute, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, Cancer Science Institute of Singapore and Department of Pharmacology, University of Auckland, 2-6 Park Avenue, Private Bag 92019, Auckland 1023, New Zealand
The Liggins Institute, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, Cancer Science Institute of Singapore and Department of Pharmacology, University of Auckland, 2-6 Park Avenue, Private Bag 92019, Auckland 1023, New Zealand

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Michael Steiner The Liggins Institute, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, Cancer Science Institute of Singapore and Department of Pharmacology, University of Auckland, 2-6 Park Avenue, Private Bag 92019, Auckland 1023, New Zealand

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Mikhail Pertziger The Liggins Institute, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, Cancer Science Institute of Singapore and Department of Pharmacology, University of Auckland, 2-6 Park Avenue, Private Bag 92019, Auckland 1023, New Zealand

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Arindam Banerjee The Liggins Institute, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, Cancer Science Institute of Singapore and Department of Pharmacology, University of Auckland, 2-6 Park Avenue, Private Bag 92019, Auckland 1023, New Zealand

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Severine E Brunet-Dunand The Liggins Institute, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, Cancer Science Institute of Singapore and Department of Pharmacology, University of Auckland, 2-6 Park Avenue, Private Bag 92019, Auckland 1023, New Zealand

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Tao Zhu The Liggins Institute, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, Cancer Science Institute of Singapore and Department of Pharmacology, University of Auckland, 2-6 Park Avenue, Private Bag 92019, Auckland 1023, New Zealand

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Peter E Lobie The Liggins Institute, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, Cancer Science Institute of Singapore and Department of Pharmacology, University of Auckland, 2-6 Park Avenue, Private Bag 92019, Auckland 1023, New Zealand
The Liggins Institute, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, Cancer Science Institute of Singapore and Department of Pharmacology, University of Auckland, 2-6 Park Avenue, Private Bag 92019, Auckland 1023, New Zealand

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Jo K Perry The Liggins Institute, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, Cancer Science Institute of Singapore and Department of Pharmacology, University of Auckland, 2-6 Park Avenue, Private Bag 92019, Auckland 1023, New Zealand

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, risk of cancer compared with individuals from the same family without the receptor deficiency ( Guevara-Aguirre et al . 2011 , Steuerman et al . 2011 ). While studies investigating hGH expression in human breast and endometrial cancer have

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-12-0042
Volume/Issue:
Volume 19: Issue 5
Free access
Kathleen Van Asten KU Leuven, University Hospitals Leuven, University Hospitals Leuven, Department of Oncology, Leuven, Belgium

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Patrick Neven KU Leuven, University Hospitals Leuven, University Hospitals Leuven, Department of Oncology, Leuven, Belgium
KU Leuven, University Hospitals Leuven, University Hospitals Leuven, Department of Oncology, Leuven, Belgium

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Anneleen Lintermans KU Leuven, University Hospitals Leuven, University Hospitals Leuven, Department of Oncology, Leuven, Belgium

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Hans Wildiers KU Leuven, University Hospitals Leuven, University Hospitals Leuven, Department of Oncology, Leuven, Belgium
KU Leuven, University Hospitals Leuven, University Hospitals Leuven, Department of Oncology, Leuven, Belgium

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Robert Paridaens KU Leuven, University Hospitals Leuven, University Hospitals Leuven, Department of Oncology, Leuven, Belgium
KU Leuven, University Hospitals Leuven, University Hospitals Leuven, Department of Oncology, Leuven, Belgium

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adverse effects that tamoxifen-treated breast cancer patients experience is an increased risk of developing endometrial hyperplasia, polyps, and carcinoma ( Fornander et al . 1989 , Neven et al . 1989 , Rutqvist & Johansson 2007 ). Patients treated

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-13-0269
Volume/Issue:
Volume 21: Issue 1
Free access
Ying Ni Genomic Medicine Institute, Taussig Cancer Institute, Stanley Shalom Zielony Nursing Institute, Division of Medical Oncology, Divisions of Human Genetics, Endocrinology and Metabolism, Comprehensive Cancer Center, Departments of Genetics and Genome Sciences, Epidemiology and Biostatistics, CASE Comprehensive Cancer Center, Lerner Research Institute
Genomic Medicine Institute, Taussig Cancer Institute, Stanley Shalom Zielony Nursing Institute, Division of Medical Oncology, Divisions of Human Genetics, Endocrinology and Metabolism, Comprehensive Cancer Center, Departments of Genetics and Genome Sciences, Epidemiology and Biostatistics, CASE Comprehensive Cancer Center, Lerner Research Institute
Genomic Medicine Institute, Taussig Cancer Institute, Stanley Shalom Zielony Nursing Institute, Division of Medical Oncology, Divisions of Human Genetics, Endocrinology and Metabolism, Comprehensive Cancer Center, Departments of Genetics and Genome Sciences, Epidemiology and Biostatistics, CASE Comprehensive Cancer Center, Lerner Research Institute

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Spencer Seballos Genomic Medicine Institute, Taussig Cancer Institute, Stanley Shalom Zielony Nursing Institute, Division of Medical Oncology, Divisions of Human Genetics, Endocrinology and Metabolism, Comprehensive Cancer Center, Departments of Genetics and Genome Sciences, Epidemiology and Biostatistics, CASE Comprehensive Cancer Center, Lerner Research Institute

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Shireen Ganapathi Genomic Medicine Institute, Taussig Cancer Institute, Stanley Shalom Zielony Nursing Institute, Division of Medical Oncology, Divisions of Human Genetics, Endocrinology and Metabolism, Comprehensive Cancer Center, Departments of Genetics and Genome Sciences, Epidemiology and Biostatistics, CASE Comprehensive Cancer Center, Lerner Research Institute

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Danielle Gurin Genomic Medicine Institute, Taussig Cancer Institute, Stanley Shalom Zielony Nursing Institute, Division of Medical Oncology, Divisions of Human Genetics, Endocrinology and Metabolism, Comprehensive Cancer Center, Departments of Genetics and Genome Sciences, Epidemiology and Biostatistics, CASE Comprehensive Cancer Center, Lerner Research Institute

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Benjamin Fletcher Genomic Medicine Institute, Taussig Cancer Institute, Stanley Shalom Zielony Nursing Institute, Division of Medical Oncology, Divisions of Human Genetics, Endocrinology and Metabolism, Comprehensive Cancer Center, Departments of Genetics and Genome Sciences, Epidemiology and Biostatistics, CASE Comprehensive Cancer Center, Lerner Research Institute

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Joanne Ngeow Genomic Medicine Institute, Taussig Cancer Institute, Stanley Shalom Zielony Nursing Institute, Division of Medical Oncology, Divisions of Human Genetics, Endocrinology and Metabolism, Comprehensive Cancer Center, Departments of Genetics and Genome Sciences, Epidemiology and Biostatistics, CASE Comprehensive Cancer Center, Lerner Research Institute
Genomic Medicine Institute, Taussig Cancer Institute, Stanley Shalom Zielony Nursing Institute, Division of Medical Oncology, Divisions of Human Genetics, Endocrinology and Metabolism, Comprehensive Cancer Center, Departments of Genetics and Genome Sciences, Epidemiology and Biostatistics, CASE Comprehensive Cancer Center, Lerner Research Institute

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Rebecca Nagy Genomic Medicine Institute, Taussig Cancer Institute, Stanley Shalom Zielony Nursing Institute, Division of Medical Oncology, Divisions of Human Genetics, Endocrinology and Metabolism, Comprehensive Cancer Center, Departments of Genetics and Genome Sciences, Epidemiology and Biostatistics, CASE Comprehensive Cancer Center, Lerner Research Institute
Genomic Medicine Institute, Taussig Cancer Institute, Stanley Shalom Zielony Nursing Institute, Division of Medical Oncology, Divisions of Human Genetics, Endocrinology and Metabolism, Comprehensive Cancer Center, Departments of Genetics and Genome Sciences, Epidemiology and Biostatistics, CASE Comprehensive Cancer Center, Lerner Research Institute

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Richard T Kloos Genomic Medicine Institute, Taussig Cancer Institute, Stanley Shalom Zielony Nursing Institute, Division of Medical Oncology, Divisions of Human Genetics, Endocrinology and Metabolism, Comprehensive Cancer Center, Departments of Genetics and Genome Sciences, Epidemiology and Biostatistics, CASE Comprehensive Cancer Center, Lerner Research Institute
Genomic Medicine Institute, Taussig Cancer Institute, Stanley Shalom Zielony Nursing Institute, Division of Medical Oncology, Divisions of Human Genetics, Endocrinology and Metabolism, Comprehensive Cancer Center, Departments of Genetics and Genome Sciences, Epidemiology and Biostatistics, CASE Comprehensive Cancer Center, Lerner Research Institute

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Matthew D Ringel Genomic Medicine Institute, Taussig Cancer Institute, Stanley Shalom Zielony Nursing Institute, Division of Medical Oncology, Divisions of Human Genetics, Endocrinology and Metabolism, Comprehensive Cancer Center, Departments of Genetics and Genome Sciences, Epidemiology and Biostatistics, CASE Comprehensive Cancer Center, Lerner Research Institute
Genomic Medicine Institute, Taussig Cancer Institute, Stanley Shalom Zielony Nursing Institute, Division of Medical Oncology, Divisions of Human Genetics, Endocrinology and Metabolism, Comprehensive Cancer Center, Departments of Genetics and Genome Sciences, Epidemiology and Biostatistics, CASE Comprehensive Cancer Center, Lerner Research Institute

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Thomas LaFramboise Genomic Medicine Institute, Taussig Cancer Institute, Stanley Shalom Zielony Nursing Institute, Division of Medical Oncology, Divisions of Human Genetics, Endocrinology and Metabolism, Comprehensive Cancer Center, Departments of Genetics and Genome Sciences, Epidemiology and Biostatistics, CASE Comprehensive Cancer Center, Lerner Research Institute
Genomic Medicine Institute, Taussig Cancer Institute, Stanley Shalom Zielony Nursing Institute, Division of Medical Oncology, Divisions of Human Genetics, Endocrinology and Metabolism, Comprehensive Cancer Center, Departments of Genetics and Genome Sciences, Epidemiology and Biostatistics, CASE Comprehensive Cancer Center, Lerner Research Institute
Genomic Medicine Institute, Taussig Cancer Institute, Stanley Shalom Zielony Nursing Institute, Division of Medical Oncology, Divisions of Human Genetics, Endocrinology and Metabolism, Comprehensive Cancer Center, Departments of Genetics and Genome Sciences, Epidemiology and Biostatistics, CASE Comprehensive Cancer Center, Lerner Research Institute

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Charis Eng Genomic Medicine Institute, Taussig Cancer Institute, Stanley Shalom Zielony Nursing Institute, Division of Medical Oncology, Divisions of Human Genetics, Endocrinology and Metabolism, Comprehensive Cancer Center, Departments of Genetics and Genome Sciences, Epidemiology and Biostatistics, CASE Comprehensive Cancer Center, Lerner Research Institute
Genomic Medicine Institute, Taussig Cancer Institute, Stanley Shalom Zielony Nursing Institute, Division of Medical Oncology, Divisions of Human Genetics, Endocrinology and Metabolism, Comprehensive Cancer Center, Departments of Genetics and Genome Sciences, Epidemiology and Biostatistics, CASE Comprehensive Cancer Center, Lerner Research Institute
Genomic Medicine Institute, Taussig Cancer Institute, Stanley Shalom Zielony Nursing Institute, Division of Medical Oncology, Divisions of Human Genetics, Endocrinology and Metabolism, Comprehensive Cancer Center, Departments of Genetics and Genome Sciences, Epidemiology and Biostatistics, CASE Comprehensive Cancer Center, Lerner Research Institute
Genomic Medicine Institute, Taussig Cancer Institute, Stanley Shalom Zielony Nursing Institute, Division of Medical Oncology, Divisions of Human Genetics, Endocrinology and Metabolism, Comprehensive Cancer Center, Departments of Genetics and Genome Sciences, Epidemiology and Biostatistics, CASE Comprehensive Cancer Center, Lerner Research Institute
Genomic Medicine Institute, Taussig Cancer Institute, Stanley Shalom Zielony Nursing Institute, Division of Medical Oncology, Divisions of Human Genetics, Endocrinology and Metabolism, Comprehensive Cancer Center, Departments of Genetics and Genome Sciences, Epidemiology and Biostatistics, CASE Comprehensive Cancer Center, Lerner Research Institute

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. 2002 , 2004 ). It was noticed that a rare subset of individuals with germline SDHB or SDHD mutations in the European–American pheochromocytoma registry had renal cancers and papillary thyroid cancer (PTC) ( Neumann et al . 2004 , Vanharanta et

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-14-0537
Volume/Issue:
Volume 22: Issue 2
Open access
P Hadji Department of Endocrinology, Reproductive Medicine and Osteoporosis, Philipps-University of Marburg, Baldingerstrasse, 35033 Marburg, Germany

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1983 ). Tamoxifen therapy not only reduced breast cancer recurrence and mortality but was also associated with an increased incidence of thromboembolic events and endometrial cancer, as well as other bothersome AEs, including vaginal discharge, fluid

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-07-0193
Volume/Issue:
Volume 15: Issue 1
Free access