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Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
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Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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of life reported by growth hormone (GH)-treated patients ( Tamhane et al. 2018 ). Moreover, the metabolic effects of GHT in children, such as a decrease in body fat and an increase in fat-free mass, may have improving effects on health risks later
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Departments of, Radiation Oncology, Neurosurgery, Medicine, IPSEN
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medical therapy for a variety of neuroendocrine tumors with regard to reduction in pathologic hormone secretion and inhibition of tumor growth. Acromegaly is an uncommon disorder characterized by excess secretion of GH, resulting in excessive growth of
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Department of Endocrinology, Program on Developmental Endocrinology and Genetics, Helmholtz Zentrum München, Department of Molecular and Human Genetics, Department of Pediatric Endocrinology and Diabetes, Department of Clinical Genetics, Endocrinology and Diabetology Unit, Department of Endocrinology, Department of Paediatric Endocrinology, INSERM U 693, Pediatric Endocrinology Unit, Mater Medical Research Institute, Department of Endocrinology, Endocrinology and Diabetes Unit, Section of Endocrinology, Service d'Anatomie et Cytologie Pathologiques, INSERM Unité 1016, Institute of Pediatric Endocrinology, Burdenko Neurosurgery Institute, Department of Neurosurgery, Laboratorio Sabin, Section of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology and Diabetes, Department of Endocrinology, Clinical Center of Endocrinology and Gerontology, Department of Clinical Biochemistry, Skeletal Clinical Studies Unit, Laboratory of Pathology, National Institute of Neurological Disorders and Stroke, Department of Neurosurgery, Department of Pediatrics, Texas Children's Hospital, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium
Department of Endocrinology, Program on Developmental Endocrinology and Genetics, Helmholtz Zentrum München, Department of Molecular and Human Genetics, Department of Pediatric Endocrinology and Diabetes, Department of Clinical Genetics, Endocrinology and Diabetology Unit, Department of Endocrinology, Department of Paediatric Endocrinology, INSERM U 693, Pediatric Endocrinology Unit, Mater Medical Research Institute, Department of Endocrinology, Endocrinology and Diabetes Unit, Section of Endocrinology, Service d'Anatomie et Cytologie Pathologiques, INSERM Unité 1016, Institute of Pediatric Endocrinology, Burdenko Neurosurgery Institute, Department of Neurosurgery, Laboratorio Sabin, Section of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology and Diabetes, Department of Endocrinology, Clinical Center of Endocrinology and Gerontology, Department of Clinical Biochemistry, Skeletal Clinical Studies Unit, Laboratory of Pathology, National Institute of Neurological Disorders and Stroke, Department of Neurosurgery, Department of Pediatrics, Texas Children's Hospital, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium
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Department of Endocrinology, Program on Developmental Endocrinology and Genetics, Helmholtz Zentrum München, Department of Molecular and Human Genetics, Department of Pediatric Endocrinology and Diabetes, Department of Clinical Genetics, Endocrinology and Diabetology Unit, Department of Endocrinology, Department of Paediatric Endocrinology, INSERM U 693, Pediatric Endocrinology Unit, Mater Medical Research Institute, Department of Endocrinology, Endocrinology and Diabetes Unit, Section of Endocrinology, Service d'Anatomie et Cytologie Pathologiques, INSERM Unité 1016, Institute of Pediatric Endocrinology, Burdenko Neurosurgery Institute, Department of Neurosurgery, Laboratorio Sabin, Section of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology and Diabetes, Department of Endocrinology, Clinical Center of Endocrinology and Gerontology, Department of Clinical Biochemistry, Skeletal Clinical Studies Unit, Laboratory of Pathology, National Institute of Neurological Disorders and Stroke, Department of Neurosurgery, Department of Pediatrics, Texas Children's Hospital, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium
Department of Endocrinology, Program on Developmental Endocrinology and Genetics, Helmholtz Zentrum München, Department of Molecular and Human Genetics, Department of Pediatric Endocrinology and Diabetes, Department of Clinical Genetics, Endocrinology and Diabetology Unit, Department of Endocrinology, Department of Paediatric Endocrinology, INSERM U 693, Pediatric Endocrinology Unit, Mater Medical Research Institute, Department of Endocrinology, Endocrinology and Diabetes Unit, Section of Endocrinology, Service d'Anatomie et Cytologie Pathologiques, INSERM Unité 1016, Institute of Pediatric Endocrinology, Burdenko Neurosurgery Institute, Department of Neurosurgery, Laboratorio Sabin, Section of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology and Diabetes, Department of Endocrinology, Clinical Center of Endocrinology and Gerontology, Department of Clinical Biochemistry, Skeletal Clinical Studies Unit, Laboratory of Pathology, National Institute of Neurological Disorders and Stroke, Department of Neurosurgery, Department of Pediatrics, Texas Children's Hospital, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium
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Introduction Pituitary gigantism is a rare condition associated with hypersecretion of growth hormone (GH) by a pituitary tumor or hyperplasia before the complete fusion of growth plates, leading to pathological tall stature ( Eugster & Pescovitz
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after radio-therapy ( Littley et al. 1989 c ). The difference in the development of the anterior pituitary hormone deficiencies, with growth hormone (GH) being most frequently affected, suggests that selective hypothalamic neuronal and
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Department of Medicine, Department of Applied Biomedical Science, Neuroendocrine Clinic, Faculty of Medicine and Surgery, Mater Dei Hospital, University of Malta, Block A, Level 0, Msida MSD2080, Malta
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Martinez-Fuentes AJ Frawley LS Garcia-Navarro S Gracia-Navarro F 1999 Growth hormone (GH) releasing factor differentially activates cyclic adenosine 3′,5′-monophosphate- and inositol phosphate-dependant pathways to stimulate GH release in two
Institute of Endocrinology and Metabolism and Felsenstein Medical Research Center, Sackler School of Medicine, Department of Internal Medicine E, Department of Endocrinology, Department of Neurosurgery, Rabin Medical Center, Beilinson Campus, Petach Tikva 49100, Israel
Institute of Endocrinology and Metabolism and Felsenstein Medical Research Center, Sackler School of Medicine, Department of Internal Medicine E, Department of Endocrinology, Department of Neurosurgery, Rabin Medical Center, Beilinson Campus, Petach Tikva 49100, Israel
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Institute of Endocrinology and Metabolism and Felsenstein Medical Research Center, Sackler School of Medicine, Department of Internal Medicine E, Department of Endocrinology, Department of Neurosurgery, Rabin Medical Center, Beilinson Campus, Petach Tikva 49100, Israel
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Institute of Endocrinology and Metabolism and Felsenstein Medical Research Center, Sackler School of Medicine, Department of Internal Medicine E, Department of Endocrinology, Department of Neurosurgery, Rabin Medical Center, Beilinson Campus, Petach Tikva 49100, Israel
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Institute of Endocrinology and Metabolism and Felsenstein Medical Research Center, Sackler School of Medicine, Department of Internal Medicine E, Department of Endocrinology, Department of Neurosurgery, Rabin Medical Center, Beilinson Campus, Petach Tikva 49100, Israel
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Institute of Endocrinology and Metabolism and Felsenstein Medical Research Center, Sackler School of Medicine, Department of Internal Medicine E, Department of Endocrinology, Department of Neurosurgery, Rabin Medical Center, Beilinson Campus, Petach Tikva 49100, Israel
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Institute of Endocrinology and Metabolism and Felsenstein Medical Research Center, Sackler School of Medicine, Department of Internal Medicine E, Department of Endocrinology, Department of Neurosurgery, Rabin Medical Center, Beilinson Campus, Petach Tikva 49100, Israel
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(GH5) did not respond to any of these doses. Since adenoma cell cultures are contaminated with fibroblasts, it was essential to confirm that reduction in viable cell numbers was not due to the inhibition of fibroblasts growth. Therefore, cell viability
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E 1998 Comparison between insulin-induced hypoglycemia and growth hormone (GH)-releasing hormone+arginine as provocative tests for the diagnosis of GH deficiency in adults . Journal of Clinical Endocrinology and Metabolism 83 1615 – 1618
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Department of Medicine, Department of Medicine II, Department of Biomedical Science and Pathology and Laboratory Medicine, Department of Pathology and Laboratory Medicine, Pituitary Center, Cedars-Sinai Medical Center, Academic Affairs, Room 2015, 8700 Beverly Boulevard, Los Angeles, California 90048, USA
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) . PNAS 80 6451 – 6455 . doi:10.1073/pnas.80.21.6451 . Hinkle PM Shanshala ED II Yan ZF 1991 Epidermal growth factor decreases the concentration of thyrotropin-releasing hormone (TRH) receptors and TRH responses in pituitary GH4C1 cells
Department of Biotechnological and Applied Clinical Sciences, Department of Neurological Sciences, Endocrinology, CNRS, AP‐HM, Endocrinology and Diabetology Unit, Endocrinology, Department of Neurology and Psychiatry, INSERM, AP‐HM, Department of Radiology, University of L'Aquila, Via Vetoio, Coppito 2, 67100 L'Aquila, Italy
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Department of Biotechnological and Applied Clinical Sciences, Department of Neurological Sciences, Endocrinology, CNRS, AP‐HM, Endocrinology and Diabetology Unit, Endocrinology, Department of Neurology and Psychiatry, INSERM, AP‐HM, Department of Radiology, University of L'Aquila, Via Vetoio, Coppito 2, 67100 L'Aquila, Italy
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Department of Biotechnological and Applied Clinical Sciences, Department of Neurological Sciences, Endocrinology, CNRS, AP‐HM, Endocrinology and Diabetology Unit, Endocrinology, Department of Neurology and Psychiatry, INSERM, AP‐HM, Department of Radiology, University of L'Aquila, Via Vetoio, Coppito 2, 67100 L'Aquila, Italy
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Department of Biotechnological and Applied Clinical Sciences, Department of Neurological Sciences, Endocrinology, CNRS, AP‐HM, Endocrinology and Diabetology Unit, Endocrinology, Department of Neurology and Psychiatry, INSERM, AP‐HM, Department of Radiology, University of L'Aquila, Via Vetoio, Coppito 2, 67100 L'Aquila, Italy
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Department of Biotechnological and Applied Clinical Sciences, Department of Neurological Sciences, Endocrinology, CNRS, AP‐HM, Endocrinology and Diabetology Unit, Endocrinology, Department of Neurology and Psychiatry, INSERM, AP‐HM, Department of Radiology, University of L'Aquila, Via Vetoio, Coppito 2, 67100 L'Aquila, Italy
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germline inactivating mutations being associated with somatic loss of heterozygosity in the corresponding tumours. A particular preponderance of growth hormone (GH)-secreting PA (GH-PA) in the setting of germline AIP mutations ( AIP mut ) has been
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recommend retesting patients for GHD after the completion of linear growth before considering treatment with GH through adulthood ( Holm et al . 1996 , Couto-Silva et al . 2000 , Growth Hormone Research Society 2000 , Gleeson et al . 2004 ). The