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Yu Wang Genomic Medicine Institute

Department of Anatomic Pathology Cleveland Clinic, Cleveland, Ohio 44195, USA

Department of Urology Stanford University School of Medicine, Stanford, California 94305, USA

Taussig Cancer Institute

Stanley Shalom Zielony Institute for Nursing Excellence Cleveland Clinic, Cleveland, Ohio 44195, USA

Department of Genetics and Genome Sciences

CASE Comprehensive Cancer Center Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA

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Andres Roma Genomic Medicine Institute

Department of Anatomic Pathology Cleveland Clinic, Cleveland, Ohio 44195, USA

Department of Urology Stanford University School of Medicine, Stanford, California 94305, USA

Taussig Cancer Institute

Stanley Shalom Zielony Institute for Nursing Excellence Cleveland Clinic, Cleveland, Ohio 44195, USA

Department of Genetics and Genome Sciences

CASE Comprehensive Cancer Center Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA

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Rosalie Nolley Genomic Medicine Institute

Department of Anatomic Pathology Cleveland Clinic, Cleveland, Ohio 44195, USA

Department of Urology Stanford University School of Medicine, Stanford, California 94305, USA

Taussig Cancer Institute

Stanley Shalom Zielony Institute for Nursing Excellence Cleveland Clinic, Cleveland, Ohio 44195, USA

Department of Genetics and Genome Sciences

CASE Comprehensive Cancer Center Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA

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Fadi Abdul-Karim Genomic Medicine Institute

Department of Anatomic Pathology Cleveland Clinic, Cleveland, Ohio 44195, USA

Department of Urology Stanford University School of Medicine, Stanford, California 94305, USA

Taussig Cancer Institute

Stanley Shalom Zielony Institute for Nursing Excellence Cleveland Clinic, Cleveland, Ohio 44195, USA

Department of Genetics and Genome Sciences

CASE Comprehensive Cancer Center Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA

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Donna M Peehl Genomic Medicine Institute

Department of Anatomic Pathology Cleveland Clinic, Cleveland, Ohio 44195, USA

Department of Urology Stanford University School of Medicine, Stanford, California 94305, USA

Taussig Cancer Institute

Stanley Shalom Zielony Institute for Nursing Excellence Cleveland Clinic, Cleveland, Ohio 44195, USA

Department of Genetics and Genome Sciences

CASE Comprehensive Cancer Center Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA

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Charis Eng Genomic Medicine Institute

Department of Anatomic Pathology Cleveland Clinic, Cleveland, Ohio 44195, USA

Department of Urology Stanford University School of Medicine, Stanford, California 94305, USA

Taussig Cancer Institute

Stanley Shalom Zielony Institute for Nursing Excellence Cleveland Clinic, Cleveland, Ohio 44195, USA

Department of Genetics and Genome Sciences

CASE Comprehensive Cancer Center Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
Genomic Medicine Institute

Department of Anatomic Pathology Cleveland Clinic, Cleveland, Ohio 44195, USA

Department of Urology Stanford University School of Medicine, Stanford, California 94305, USA

Taussig Cancer Institute

Stanley Shalom Zielony Institute for Nursing Excellence Cleveland Clinic, Cleveland, Ohio 44195, USA

Department of Genetics and Genome Sciences

CASE Comprehensive Cancer Center Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
Genomic Medicine Institute

Department of Anatomic Pathology Cleveland Clinic, Cleveland, Ohio 44195, USA

Department of Urology Stanford University School of Medicine, Stanford, California 94305, USA

Taussig Cancer Institute

Stanley Shalom Zielony Institute for Nursing Excellence Cleveland Clinic, Cleveland, Ohio 44195, USA

Department of Genetics and Genome Sciences

CASE Comprehensive Cancer Center Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
Genomic Medicine Institute

Department of Anatomic Pathology Cleveland Clinic, Cleveland, Ohio 44195, USA

Department of Urology Stanford University School of Medicine, Stanford, California 94305, USA

Taussig Cancer Institute

Stanley Shalom Zielony Institute for Nursing Excellence Cleveland Clinic, Cleveland, Ohio 44195, USA

Department of Genetics and Genome Sciences

CASE Comprehensive Cancer Center Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
Genomic Medicine Institute

Department of Anatomic Pathology Cleveland Clinic, Cleveland, Ohio 44195, USA

Department of Urology Stanford University School of Medicine, Stanford, California 94305, USA

Taussig Cancer Institute

Stanley Shalom Zielony Institute for Nursing Excellence Cleveland Clinic, Cleveland, Ohio 44195, USA

Department of Genetics and Genome Sciences

CASE Comprehensive Cancer Center Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA

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to accurately predict oncologic outcomes for IRPC patients, especially for those with high Gleason grade lesions. Therefore, a reliable preoperative biomarker is urgently needed, which not only provides aggressive therapy for patients who will have

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Siker Kimbung Division of Oncology and Pathology, Department of Clinical Sciences, Lund, Lund University, Sweden

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Ching-yi Chang Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA

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Pär-Ola Bendahl Division of Oncology and Pathology, Department of Clinical Sciences, Lund, Lund University, Sweden

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Laura Dubois Duke Proteomics and Metabolomics Resource, Duke University School of Medicine, Durham, NC, USA

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J Will Thompson Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA
Duke Proteomics and Metabolomics Resource, Duke University School of Medicine, Durham, NC, USA

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Donald P McDonnell Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA

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Signe Borgquist Division of Oncology and Pathology, Department of Clinical Sciences, Lund, Lund University, Sweden
Clinical Trial Unit, Clinical Studies Sweden, Forum South, Skåne University Hospital, Lund, Sweden

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seen among high-grade tumors ( Nelson et al. 2013 ). In addition, the concentration of 27HC was found to be higher in ERα-positive breast tumors compared to normal breast tissue, and this was attributed to a corresponding decrease in the expression of

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Philipp Melhorn Department of Medicine I, Division of Oncology, Medical University of Vienna, Vienna, Austria

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Peter Mazal Department of Pathology, Medical University of Vienna, Vienna, Austria

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Ladislaia Wolff Department of Medicine I, Division of Oncology, Medical University of Vienna, Vienna, Austria

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Petar Popov Department of Medicine I, Division of Oncology, Medical University of Vienna, Vienna, Austria

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Elisabeth Kretschmer-Chott Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria

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Alexander Haug Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria

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Marius E Mayerhoefer Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Weill Cornell Medical College, Cornell University, New York, New York, USA

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Markus Raderer Department of Medicine I, Division of Oncology, Medical University of Vienna, Vienna, Austria

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Barbara Kiesewetter Department of Medicine I, Division of Oncology, Medical University of Vienna, Vienna, Austria

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the two predominant subgroups visually, i.e. low-grade lung NETs (two typical and five atypical carcinoids) and high-grade pancreatic NENs ( n  = 15, as 75% of pancreatic tumors were high-grade, comprising 9 patients with NET G3 and 6 with NEC). In the

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Ivan Bièche INSERM,, University of Montpellier I,, INSERM,, Laboratoire d'Anatomo-Cytopathologie,, U844, Site Saint Eloi-Bat INM, 80, rue Augustin Fliche, Montpellier F-34091, France

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Carine Chavey INSERM,, University of Montpellier I,, INSERM,, Laboratoire d'Anatomo-Cytopathologie,, U844, Site Saint Eloi-Bat INM, 80, rue Augustin Fliche, Montpellier F-34091, France
INSERM,, University of Montpellier I,, INSERM,, Laboratoire d'Anatomo-Cytopathologie,, U844, Site Saint Eloi-Bat INM, 80, rue Augustin Fliche, Montpellier F-34091, France

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Catherine Andrieu INSERM,, University of Montpellier I,, INSERM,, Laboratoire d'Anatomo-Cytopathologie,, U844, Site Saint Eloi-Bat INM, 80, rue Augustin Fliche, Montpellier F-34091, France

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Muriel Busson INSERM,, University of Montpellier I,, INSERM,, Laboratoire d'Anatomo-Cytopathologie,, U844, Site Saint Eloi-Bat INM, 80, rue Augustin Fliche, Montpellier F-34091, France
INSERM,, University of Montpellier I,, INSERM,, Laboratoire d'Anatomo-Cytopathologie,, U844, Site Saint Eloi-Bat INM, 80, rue Augustin Fliche, Montpellier F-34091, France

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Sophie Vacher INSERM,, University of Montpellier I,, INSERM,, Laboratoire d'Anatomo-Cytopathologie,, U844, Site Saint Eloi-Bat INM, 80, rue Augustin Fliche, Montpellier F-34091, France

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Ludovic Le Corre INSERM,, University of Montpellier I,, INSERM,, Laboratoire d'Anatomo-Cytopathologie,, U844, Site Saint Eloi-Bat INM, 80, rue Augustin Fliche, Montpellier F-34091, France
INSERM,, University of Montpellier I,, INSERM,, Laboratoire d'Anatomo-Cytopathologie,, U844, Site Saint Eloi-Bat INM, 80, rue Augustin Fliche, Montpellier F-34091, France

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Jean-Marc Guinebretière INSERM,, University of Montpellier I,, INSERM,, Laboratoire d'Anatomo-Cytopathologie,, U844, Site Saint Eloi-Bat INM, 80, rue Augustin Fliche, Montpellier F-34091, France

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Sandrine Burlinchon INSERM,, University of Montpellier I,, INSERM,, Laboratoire d'Anatomo-Cytopathologie,, U844, Site Saint Eloi-Bat INM, 80, rue Augustin Fliche, Montpellier F-34091, France
INSERM,, University of Montpellier I,, INSERM,, Laboratoire d'Anatomo-Cytopathologie,, U844, Site Saint Eloi-Bat INM, 80, rue Augustin Fliche, Montpellier F-34091, France

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Rosette Lidereau INSERM,, University of Montpellier I,, INSERM,, Laboratoire d'Anatomo-Cytopathologie,, U844, Site Saint Eloi-Bat INM, 80, rue Augustin Fliche, Montpellier F-34091, France

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Gwendal Lazennec INSERM,, University of Montpellier I,, INSERM,, Laboratoire d'Anatomo-Cytopathologie,, U844, Site Saint Eloi-Bat INM, 80, rue Augustin Fliche, Montpellier F-34091, France
INSERM,, University of Montpellier I,, INSERM,, Laboratoire d'Anatomo-Cytopathologie,, U844, Site Saint Eloi-Bat INM, 80, rue Augustin Fliche, Montpellier F-34091, France

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high expression of these chemokines involved gene regulation events and not gene amplification. We also observed that CXCL1, CXCL2, CXCL3, CXCL5, CXCL6 and CXCL8 chemokines were present at higher levels in metastases when compared with grade I and grade

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Mingguo Huang Department of Urology, Research Center for Biosignal, Department of Clinical Pathology, CREST, Akita University Graduate School of Medicine, 1‐1‐1 Hondo, Akita 010-8543, Japan
Department of Urology, Research Center for Biosignal, Department of Clinical Pathology, CREST, Akita University Graduate School of Medicine, 1‐1‐1 Hondo, Akita 010-8543, Japan
Department of Urology, Research Center for Biosignal, Department of Clinical Pathology, CREST, Akita University Graduate School of Medicine, 1‐1‐1 Hondo, Akita 010-8543, Japan

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Shintaro Narita Department of Urology, Research Center for Biosignal, Department of Clinical Pathology, CREST, Akita University Graduate School of Medicine, 1‐1‐1 Hondo, Akita 010-8543, Japan
Department of Urology, Research Center for Biosignal, Department of Clinical Pathology, CREST, Akita University Graduate School of Medicine, 1‐1‐1 Hondo, Akita 010-8543, Japan

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Takamitsu Inoue Department of Urology, Research Center for Biosignal, Department of Clinical Pathology, CREST, Akita University Graduate School of Medicine, 1‐1‐1 Hondo, Akita 010-8543, Japan

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Norihiko Tsuchiya Department of Urology, Research Center for Biosignal, Department of Clinical Pathology, CREST, Akita University Graduate School of Medicine, 1‐1‐1 Hondo, Akita 010-8543, Japan
Department of Urology, Research Center for Biosignal, Department of Clinical Pathology, CREST, Akita University Graduate School of Medicine, 1‐1‐1 Hondo, Akita 010-8543, Japan

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Shigeru Satoh Department of Urology, Research Center for Biosignal, Department of Clinical Pathology, CREST, Akita University Graduate School of Medicine, 1‐1‐1 Hondo, Akita 010-8543, Japan

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Hiroshi Nanjo Department of Urology, Research Center for Biosignal, Department of Clinical Pathology, CREST, Akita University Graduate School of Medicine, 1‐1‐1 Hondo, Akita 010-8543, Japan

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Takehiko Sasaki Department of Urology, Research Center for Biosignal, Department of Clinical Pathology, CREST, Akita University Graduate School of Medicine, 1‐1‐1 Hondo, Akita 010-8543, Japan
Department of Urology, Research Center for Biosignal, Department of Clinical Pathology, CREST, Akita University Graduate School of Medicine, 1‐1‐1 Hondo, Akita 010-8543, Japan

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Tomonori Habuchi Department of Urology, Research Center for Biosignal, Department of Clinical Pathology, CREST, Akita University Graduate School of Medicine, 1‐1‐1 Hondo, Akita 010-8543, Japan
Department of Urology, Research Center for Biosignal, Department of Clinical Pathology, CREST, Akita University Graduate School of Medicine, 1‐1‐1 Hondo, Akita 010-8543, Japan

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). When the PCa patients were divided into three groups according to Gleason score (GS), serum MIC1 levels were significantly higher in patients with high-grade tumors than in patients with low-grade and moderate-grade tumors (ANOVA, P =0.013; high grade

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Mairéad G McNamara Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK
Division of Cancer Sciences, University of Manchester, Manchester, UK

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Jean-Yves Scoazec Department of Pathology, Gustave Roussy Cancer Campus, Villejuif, France
Université Paris Sud, Faculté de Médecine de Bicêtre, Le Kremlin-Bicêtre, France

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Thomas Walter Department of Gastroenterology and Medical Oncology, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France

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Introduction High grade neuroendocrine carcinomas (NECs) are usually defined by the combination of a poorly differentiated tumour cell morphology and evidence of high proliferative activity, evaluated either directly through the mitotic index

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Chiara Villa Department of Neuropathology, Hôpital Universitaire Pitié-Salpêtrière, APHP, Sorbonne Université, Paris, France
Inserm U1016, CNRS UMR 8104, Institut Cochin, Université Paris Descartes-Université de Paris, Paris, France

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Bertrand Baussart Inserm U1016, CNRS UMR 8104, Institut Cochin, Université Paris Descartes-Université de Paris, Paris, France
Department of Neurosurgery, Hôpital Universitaire Pitié-Salpêtrière, APHP, Sorbonne Université, Paris, France

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Guillaume Assié Inserm U1016, CNRS UMR 8104, Institut Cochin, Université Paris Descartes-Université de Paris, Paris, France
Department of Endocrinology, Center for Rare Adrenal Diseases, Hôpital Cochin APHP, Paris, France

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Gerald Raverot Endocrinology Department, Reference Center for Rare Pituitary Diseases HYPO, "Groupement Hospitalier Est" Hospices Civils de Lyon, Bron, France
Lyon 1 University, Villeurbanne, France
Inserm U1052, CNRS UMR 5286, Cancer Research Center of Lyon, Lyon, France

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Federico Roncaroli Geoffrey Jefferson Brain Research Centre, Division of Neuroscience, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom

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Höftberger R Wolfsberger S & Knosp E 2019 Challenging Knosp high-grade pituitary adenomas . Journal of Neurosurgery 132 1739 – 1746 . ( https://doi.org/10.3171/2019.3.JNS19367 ) Micko ASG Wöhrer A Wolfsberger S & Knosp E 2015 Invasion of

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Andrew McDonald Winship Cancer Institute at Emory University, Atlanta, Georgia, USA

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Vaidehi Avadhani Grady Memorial Hospital, Atlanta, Georgia, USA

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Gabriela Oprea-Ilies Grady Memorial Hospital, Atlanta, Georgia, USA

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Katerina Zakka Winship Cancer Institute at Emory University, Atlanta, Georgia, USA

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Gregory B Lesinski Winship Cancer Institute at Emory University, Atlanta, Georgia, USA

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Olumide B Gbolahan Winship Cancer Institute at Emory University, Atlanta, Georgia, USA

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Olatunji Alese Winship Cancer Institute at Emory University, Atlanta, Georgia, USA

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in the United States has increased by 6.4-fold over the last 50 years ( Das & Dasari 2021 ). The classification of GEP-NENs can range from low-grade to high-grade (HG) disease, along with well-differentiated to poorly differentiated disease, specified

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Didier Marot
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Ivan Bieche
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Chantal Aumas
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Stéphanie Esselin
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Céline Bouquet
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Sophie Vacher
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Gwendal Lazennec
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Michel Perricaudet
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Frederique Kuttenn
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Rosette Lidereau
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Nicolas de Roux
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expression was analyzed in a series of primary breast tumors according to histological grade and ERα status. High levels of KiSS1 were detected in breast tumors but not in normal mammary tissues. KiSS1 level was high in the first stages of the disease and

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Britt B M Suelmann Department of Medical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands

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Carmen van Dooijeweert Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands

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Carsten F J Bakhuis Department of Medical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands

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Sabine Linn Department of Medical Oncology, Netherlands Cancer Institute (AVL-NKI), Amsterdam, The Netherlands

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Elsken van der Wall Department of Medical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands

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Paul J van Diest Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands

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cancer patients (≤45 years); which underlined a different, more aggressive histopathologic profile for BCdP and short-term postpartum patients with significantly higher proportion of high-grade and ER- and PR-negative tumors. In the present paper, we

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