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Department of Anatomic Pathology Cleveland Clinic, Cleveland, Ohio 44195, USA
Department of Urology Stanford University School of Medicine, Stanford, California 94305, USA
Taussig Cancer Institute
Stanley Shalom Zielony Institute for Nursing Excellence Cleveland Clinic, Cleveland, Ohio 44195, USA
Department of Genetics and Genome Sciences
CASE Comprehensive Cancer Center Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
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Department of Anatomic Pathology Cleveland Clinic, Cleveland, Ohio 44195, USA
Department of Urology Stanford University School of Medicine, Stanford, California 94305, USA
Taussig Cancer Institute
Stanley Shalom Zielony Institute for Nursing Excellence Cleveland Clinic, Cleveland, Ohio 44195, USA
Department of Genetics and Genome Sciences
CASE Comprehensive Cancer Center Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
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Department of Anatomic Pathology Cleveland Clinic, Cleveland, Ohio 44195, USA
Department of Urology Stanford University School of Medicine, Stanford, California 94305, USA
Taussig Cancer Institute
Stanley Shalom Zielony Institute for Nursing Excellence Cleveland Clinic, Cleveland, Ohio 44195, USA
Department of Genetics and Genome Sciences
CASE Comprehensive Cancer Center Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
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Department of Anatomic Pathology Cleveland Clinic, Cleveland, Ohio 44195, USA
Department of Urology Stanford University School of Medicine, Stanford, California 94305, USA
Taussig Cancer Institute
Stanley Shalom Zielony Institute for Nursing Excellence Cleveland Clinic, Cleveland, Ohio 44195, USA
Department of Genetics and Genome Sciences
CASE Comprehensive Cancer Center Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
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Department of Anatomic Pathology Cleveland Clinic, Cleveland, Ohio 44195, USA
Department of Urology Stanford University School of Medicine, Stanford, California 94305, USA
Taussig Cancer Institute
Stanley Shalom Zielony Institute for Nursing Excellence Cleveland Clinic, Cleveland, Ohio 44195, USA
Department of Genetics and Genome Sciences
CASE Comprehensive Cancer Center Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
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Department of Anatomic Pathology Cleveland Clinic, Cleveland, Ohio 44195, USA
Department of Urology Stanford University School of Medicine, Stanford, California 94305, USA
Taussig Cancer Institute
Stanley Shalom Zielony Institute for Nursing Excellence Cleveland Clinic, Cleveland, Ohio 44195, USA
Department of Genetics and Genome Sciences
CASE Comprehensive Cancer Center Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
Genomic Medicine Institute
Department of Anatomic Pathology Cleveland Clinic, Cleveland, Ohio 44195, USA
Department of Urology Stanford University School of Medicine, Stanford, California 94305, USA
Taussig Cancer Institute
Stanley Shalom Zielony Institute for Nursing Excellence Cleveland Clinic, Cleveland, Ohio 44195, USA
Department of Genetics and Genome Sciences
CASE Comprehensive Cancer Center Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
Genomic Medicine Institute
Department of Anatomic Pathology Cleveland Clinic, Cleveland, Ohio 44195, USA
Department of Urology Stanford University School of Medicine, Stanford, California 94305, USA
Taussig Cancer Institute
Stanley Shalom Zielony Institute for Nursing Excellence Cleveland Clinic, Cleveland, Ohio 44195, USA
Department of Genetics and Genome Sciences
CASE Comprehensive Cancer Center Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
Genomic Medicine Institute
Department of Anatomic Pathology Cleveland Clinic, Cleveland, Ohio 44195, USA
Department of Urology Stanford University School of Medicine, Stanford, California 94305, USA
Taussig Cancer Institute
Stanley Shalom Zielony Institute for Nursing Excellence Cleveland Clinic, Cleveland, Ohio 44195, USA
Department of Genetics and Genome Sciences
CASE Comprehensive Cancer Center Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
Genomic Medicine Institute
Department of Anatomic Pathology Cleveland Clinic, Cleveland, Ohio 44195, USA
Department of Urology Stanford University School of Medicine, Stanford, California 94305, USA
Taussig Cancer Institute
Stanley Shalom Zielony Institute for Nursing Excellence Cleveland Clinic, Cleveland, Ohio 44195, USA
Department of Genetics and Genome Sciences
CASE Comprehensive Cancer Center Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
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to accurately predict oncologic outcomes for IRPC patients, especially for those with high Gleason grade lesions. Therefore, a reliable preoperative biomarker is urgently needed, which not only provides aggressive therapy for patients who will have
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Duke Proteomics and Metabolomics Resource, Duke University School of Medicine, Durham, NC, USA
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Clinical Trial Unit, Clinical Studies Sweden, Forum South, Skåne University Hospital, Lund, Sweden
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seen among high-grade tumors ( Nelson et al. 2013 ). In addition, the concentration of 27HC was found to be higher in ERα-positive breast tumors compared to normal breast tissue, and this was attributed to a corresponding decrease in the expression of
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Weill Cornell Medical College, Cornell University, New York, New York, USA
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the two predominant subgroups visually, i.e. low-grade lung NETs (two typical and five atypical carcinoids) and high-grade pancreatic NENs ( n = 15, as 75% of pancreatic tumors were high-grade, comprising 9 patients with NET G3 and 6 with NEC). In the
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INSERM,, University of Montpellier I,, INSERM,, Laboratoire d'Anatomo-Cytopathologie,, U844, Site Saint Eloi-Bat INM, 80, rue Augustin Fliche, Montpellier F-34091, France
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INSERM,, University of Montpellier I,, INSERM,, Laboratoire d'Anatomo-Cytopathologie,, U844, Site Saint Eloi-Bat INM, 80, rue Augustin Fliche, Montpellier F-34091, France
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INSERM,, University of Montpellier I,, INSERM,, Laboratoire d'Anatomo-Cytopathologie,, U844, Site Saint Eloi-Bat INM, 80, rue Augustin Fliche, Montpellier F-34091, France
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INSERM,, University of Montpellier I,, INSERM,, Laboratoire d'Anatomo-Cytopathologie,, U844, Site Saint Eloi-Bat INM, 80, rue Augustin Fliche, Montpellier F-34091, France
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INSERM,, University of Montpellier I,, INSERM,, Laboratoire d'Anatomo-Cytopathologie,, U844, Site Saint Eloi-Bat INM, 80, rue Augustin Fliche, Montpellier F-34091, France
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high expression of these chemokines involved gene regulation events and not gene amplification. We also observed that CXCL1, CXCL2, CXCL3, CXCL5, CXCL6 and CXCL8 chemokines were present at higher levels in metastases when compared with grade I and grade
Department of Urology, Research Center for Biosignal, Department of Clinical Pathology, CREST, Akita University Graduate School of Medicine, 1‐1‐1 Hondo, Akita 010-8543, Japan
Department of Urology, Research Center for Biosignal, Department of Clinical Pathology, CREST, Akita University Graduate School of Medicine, 1‐1‐1 Hondo, Akita 010-8543, Japan
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Department of Urology, Research Center for Biosignal, Department of Clinical Pathology, CREST, Akita University Graduate School of Medicine, 1‐1‐1 Hondo, Akita 010-8543, Japan
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Department of Urology, Research Center for Biosignal, Department of Clinical Pathology, CREST, Akita University Graduate School of Medicine, 1‐1‐1 Hondo, Akita 010-8543, Japan
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Department of Urology, Research Center for Biosignal, Department of Clinical Pathology, CREST, Akita University Graduate School of Medicine, 1‐1‐1 Hondo, Akita 010-8543, Japan
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Department of Urology, Research Center for Biosignal, Department of Clinical Pathology, CREST, Akita University Graduate School of Medicine, 1‐1‐1 Hondo, Akita 010-8543, Japan
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). When the PCa patients were divided into three groups according to Gleason score (GS), serum MIC1 levels were significantly higher in patients with high-grade tumors than in patients with low-grade and moderate-grade tumors (ANOVA, P =0.013; high grade
Division of Cancer Sciences, University of Manchester, Manchester, UK
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Université Paris Sud, Faculté de Médecine de Bicêtre, Le Kremlin-Bicêtre, France
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Introduction High grade neuroendocrine carcinomas (NECs) are usually defined by the combination of a poorly differentiated tumour cell morphology and evidence of high proliferative activity, evaluated either directly through the mitotic index
Inserm U1016, CNRS UMR 8104, Institut Cochin, Université Paris Descartes-Université de Paris, Paris, France
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Department of Neurosurgery, Hôpital Universitaire Pitié-Salpêtrière, APHP, Sorbonne Université, Paris, France
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Department of Endocrinology, Center for Rare Adrenal Diseases, Hôpital Cochin APHP, Paris, France
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Lyon 1 University, Villeurbanne, France
Inserm U1052, CNRS UMR 5286, Cancer Research Center of Lyon, Lyon, France
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Höftberger R Wolfsberger S & Knosp E 2019 Challenging Knosp high-grade pituitary adenomas . Journal of Neurosurgery 132 1739 – 1746 . ( https://doi.org/10.3171/2019.3.JNS19367 ) Micko ASG Wöhrer A Wolfsberger S & Knosp E 2015 Invasion of
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in the United States has increased by 6.4-fold over the last 50 years ( Das & Dasari 2021 ). The classification of GEP-NENs can range from low-grade to high-grade (HG) disease, along with well-differentiated to poorly differentiated disease, specified
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expression was analyzed in a series of primary breast tumors according to histological grade and ERα status. High levels of KiSS1 were detected in breast tumors but not in normal mammary tissues. KiSS1 level was high in the first stages of the disease and
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cancer patients (≤45 years); which underlined a different, more aggressive histopathologic profile for BCdP and short-term postpartum patients with significantly higher proportion of high-grade and ER- and PR-negative tumors. In the present paper, we