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Paraskevi Xekouki and Constantine A Stratakis

– b Positive for PHEOs/islet cell tumor/renal adenoma Alberts et al . (1980) 36/F Pituitary adenoma (?)/PHEO/islet cell tumor (gastrinoma), Cushing's syndrome (adrenal cortical adenoma), parathyroid hyperplasia – b NA Myers & Eversman (1981) 53/F

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Tobias Hofving, Yvonne Arvidsson, Bilal Almobarak, Linda Inge, Roswitha Pfragner, Marta Persson, Göran Stenman, Erik Kristiansson, Viktor Johanson, and Ola Nilsson

the most frequently used PanNET cell lines are QGP-1 and BON-1. QGP-1 was established in 1980 from a somatostatin-producing islet cell carcinoma ( Kaku et al . 1980 , Iguchi et al . 1990 ) and it has been used to study the molecular mechanisms that

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Katarina Edfeldt, Tanveer Ahmad, Göran Åkerström, Eva Tiensuu Janson, Per Hellman, Peter Stålberg, Peyman Björklund, and Gunnar Westin

staining and positive staining of cells surrounding the islets. (E) A tumor with insular growth pattern was positively stained for Elongin A3 (left panel) and successfully blocked with an excess of immunizing peptide (right panel). Chromosome 18 aberrations

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Hermine Mohr and Natalia S Pellegata

controlled fashion. Men1 l/l ; Cre -ER mice at 12 weeks of age were treated with tamoxifen and their pancreata were analyzed 7, 14 and 30 days later. Loss of Men1 caused an increase in islet cell proliferation detectable already 7 days post

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P L Jeffery, R E Murray, A H Yeh, J F McNamara, R P Duncan, G D Francis, A C Herington, and L K Chopin

hypothalamus that functions in growth hormone release. Science 273 974 –977. Iwakura H , Hosoda K, Doi R, Komoto I, Nishimura H, Son C, Fujikura J, Tomita T, Takaya K, Ogawa Y et al. 2002 Ghrelin expression in islet cell

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M Wijnen, M M van den Heuvel-Eibrink, M Medici, R P Peeters, A J van der Lely, and S J C M M Neggers

’, ‘subsequent neoplasms’, ‘endocrine cancers’, ‘breast cancer’, ‘thyroid cancer’, ‘risk factors’, ‘radiotherapy’, ‘radiation’, ‘irradiation’, ‘chemotherapy’, ‘stem cell transplantation’, ‘total body irradiation’, ‘conformal radiotherapy’, ‘intensity

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Hiroki Ueda, Yoshimitsu Akiyama, Shu Shimada, Kaoru Mogushi, Misaki Serizawa, Satoshi Matsumura, Yusuke Mitsunori, Arihiro Aihara, Daisuke Ban, Takanori Ochiai, Atsushi Kudo, Minoru Tanabe, and Shinji Tanaka

density within mice xenograft tumors ( Ohata et al . 2017 ). All tissue sections were counterstained with hematoxylin. Immunolabeling for DAXX was defined as only nuclear staining within tumor cells ( Singhi et al . 2017 ). Stromal cells, islet of

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Andrea Weckman, Fabio Rotondo, Antonio Di Ieva, Luis V Syro, Henriett Butz, Michael D Cusimano, and Kalman Kovacs

activates autophagy in INS-1E β-cells and in isolated rat and human pancreatic islets . PLoS ONE 7 e36188 . ( doi:10.1371/journal.pone.0036188 ). Mashiter K De Marco L Van Noorden S Adams E Loizou M Joplin GF Peters TJ 1982

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Ulrich-Frank Pape, Uta Berndt, Jacqueline Müller-Nordhorn, Michael Böhmig, Stephanie Roll, Martin Koch, Stefan N Willich, and Bertram Wiedenmann

Introduction Neuroendocrine tumours (NET) are relatively infrequent and mostly slowly growing human neoplasms with an estimated annual incidence of 1–2 per 100 000 ( Modlin et al . 2003 ). These tumours are related to the endocrine cells of the

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Frank Weber and Lois M Mulligan

positional cloning of the MEN1 gene took place 63 years ago, in 1954, when the autosomal dominant inherited co-occurrence of parathyroid hyperplasia, pancreatic islet cell tumors and anterior pituitary adenoma was first proposed by the Austrian-born Paul