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blotting analysis demonstrated that WNT4 was processed and secreted as a single protein with the appropriate molecular weight of 40 kDa ( Fig. 1B ), and autocrine hGH increased the level of WNT4 produced and secreted by MCF-7 cells ( Fig. 1B ). WNT4 protein
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-wide expression profiles of 20 primary breast cancers on a cDNA microarray containing 25 344 genes, we have been attempting to identify more selective molecular targets for development of strategies for earlier diagnosis, and/or for treatment of breast cancer
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et al. 2015 , Guerrios-Rivera et al. 2017 , Perez-Cornago et al. 2017 ). Molecular mechanisms that explain the link between obesity and prostate cancer have not been elucidated. Biological mechanisms hypothesized to underlie the relationship
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.1155/2010/427401 ) Bigoni-Ordóñez GD Ortiz-Sánchez E Rosendo-Chalma P Valencia-González HA Aceves C García-Carrancá A 2018 Molecular iodine inhibits the expression of stemness markers on cancer stem-like cells of established cell lines derived from cervical
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Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France
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Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France
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Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France
Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France
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, microarray analysis of a large series of 40 NFPAs identified a molecular signature designating ‘grossly’ invasive tumors by comparison with non-invasive tumors. The product of one of these genes, MYO5A protein, may be a useful marker of invasiveness. The role
Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain
Department of Medicine, Autonomous University of Barcelona, Barcelona, Spain
Biomedical Research Networking Center in Rare Diseases (CIBERER), Institute of Health Carlos III (ISCIII), Madrid, Spain
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Department of Endocrinology, Hospital de la Princesa, Universidad Autónoma de Madrid, Instituto Princesa, Madrid, Spain
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-0565 . Influence of SRL treatment given before or after surgery in the expression of molecular markers Molecular markers expression was compared between patients who had received SRL treatment before surgery ( n = 67) and those that had not received it ( n = 33
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European Network for the Study of Adrenal tumors (ENSAT) and The Cancer Genome Atlas (TCGA) consortiums have given insight into the genetic and genomic landscape of adrenocortical cancers ( Assie et al . 2014 , Zheng et al . 2016 ). Specific molecular
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markers and grade Before examining the occurrence of phenotype changes during tumor progression, it is necessary to specify which phenotype categories will be considered here. The categories are based on: (1) a series of molecular markers related
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performed Prosigna-PAM50 assays to assess the molecular subtypes of these BCs. Patients and methods Study design and population We collected a cohort of 402 ER+/HER2− primary invasive BC patients with available follow-up ( Fig. 1 ), who underwent
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and/or specificity, alternatively the sheer number of markers (such as provided through expressional or mutational panels) makes the analyses costly and somewhat dependent on tertiary pathology centres with expertise in molecular pathology to provide