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Cécile M Vouyovitch Centre de Recherche en Cancérologie de Lyon, UMR INSERM 1052-CNRS 5286, Centre Léon Bérard, Université Claude Bernard Lyon I, Université de Lyon, Lyon, France

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Jo K Perry Liggins Institute, University of Auckland, Auckland, New Zealand

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Dong Xu Liu Liggins Institute, University of Auckland, Auckland, New Zealand

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Laurent Bezin Centre de Recherche en Neurosciences de Lyon, UMR INSERM U1028-CNRS5292, Université de Lyon, Lyon, France

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Eric Vilain Department of Human Genetics, University of California, Los Angeles, California, USA

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Jean-Jacques Diaz Centre de Recherche en Cancérologie de Lyon, UMR INSERM 1052-CNRS 5286, Centre Léon Bérard, Université Claude Bernard Lyon I, Université de Lyon, Lyon, France

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Peter E Lobie Cancer Science Institute of Singapore and Department of Pharmacology, National University of Singapore, Singapore, Republic of Singapore

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Hichem C Mertani Centre de Recherche en Cancérologie de Lyon, UMR INSERM 1052-CNRS 5286, Centre Léon Bérard, Université Claude Bernard Lyon I, Université de Lyon, Lyon, France

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blotting analysis demonstrated that WNT4 was processed and secreted as a single protein with the appropriate molecular weight of 40 kDa ( Fig. 1B ), and autocrine hGH increased the level of WNT4 produced and secreted by MCF-7 cells ( Fig. 1B ). WNT4 protein

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T Nagahata
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T Sato
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A Tomura
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M Onda
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K Nishikawa
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M Emi
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-wide expression profiles of 20 primary breast cancers on a cDNA microarray containing 25 344 genes, we have been attempting to identify more selective molecular targets for development of strategies for earlier diagnosis, and/or for treatment of breast cancer

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Cindy H Chau Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA

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Cathee Till SWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

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Douglas K Price Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA

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Phyllis J Goodman SWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

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Marian L Neuhouser Cancer Prevention Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

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Michael N Pollak Department of Oncology and Medicine, McGill University, Montreal, Canada

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Ian M Thompson CHRISTUS Santa Rosa Hospital Medical Center, San Antonio, Texas, USA

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William D Figg Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA

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et al. 2015 , Guerrios-Rivera et al. 2017 , Perez-Cornago et al. 2017 ). Molecular mechanisms that explain the link between obesity and prostate cancer have not been elucidated. Biological mechanisms hypothesized to underlie the relationship

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Irasema Mendieta Instituto de Neurobiología, UNAM-Juriquilla, Querétaro, México

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Gabriel Rodríguez-Gómez Instituto de Neurobiología, UNAM-Juriquilla, Querétaro, México

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Bertha Rueda-Zarazúa Instituto de Neurobiología, UNAM-Juriquilla, Querétaro, México

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Julia Rodríguez-Castelán Instituto de Neurobiología, UNAM-Juriquilla, Querétaro, México

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Winniberg Álvarez-León Instituto de Neurobiología, UNAM-Juriquilla, Querétaro, México

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Evangelina Delgado-González Instituto de Neurobiología, UNAM-Juriquilla, Querétaro, México

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Brenda Anguiano Instituto de Neurobiología, UNAM-Juriquilla, Querétaro, México

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Olivia Vázquez-Martínez Instituto de Neurobiología, UNAM-Juriquilla, Querétaro, México

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Mauricio Díaz-Muñoz Instituto de Neurobiología, UNAM-Juriquilla, Querétaro, México

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Carmen Aceves Instituto de Neurobiología, UNAM-Juriquilla, Querétaro, México

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.1155/2010/427401 ) Bigoni-Ordóñez GD Ortiz-Sánchez E Rosendo-Chalma P Valencia-González HA Aceves C García-Carrancá A 2018 Molecular iodine inhibits the expression of stemness markers on cancer stem-like cells of established cell lines derived from cervical

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Françoise Galland Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France
Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France

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Ludovic Lacroix Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France
Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France

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Patrick Saulnier Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France

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Philippe Dessen Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France
Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France

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Geri Meduri Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France
Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France
Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France

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Michèle Bernier Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France

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Stéphane Gaillard Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France

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Jean Guibourdenche Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France
Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France

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Thierry Fournier Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France

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Danièle Evain-Brion Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France
Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France

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Jean Michel Bidart Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France
Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France

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Philippe Chanson Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France
Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France
Assistance Publique-Hôpitaux de Paris, Institut National de la Santé et de la Recherche Médicale, Institut de Cancérologie Gustave-Roussy, Centre National de la Recherche Scientifique, Département de Génomique Fonctionnelle, Assistance Publique-Hôpitaux de Paris, Hôpital Foch, Service de Neurochirurgie, Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre F-94275, France

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, microarray analysis of a large series of 40 NFPAs identified a molecular signature designating ‘grossly’ invasive tumors by comparison with non-invasive tumors. The product of one of these genes, MYO5A protein, may be a useful marker of invasiveness. The role

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Manel Puig-Domingo Department of Endocrinology and Nutrition, Germans Trias i Pujol University Hospital, Badalona, Spain
Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain
Department of Medicine, Autonomous University of Barcelona, Barcelona, Spain
Biomedical Research Networking Center in Rare Diseases (CIBERER), Institute of Health Carlos III (ISCIII), Madrid, Spain

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Joan Gil Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain

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Miguel Sampedro-Nuñez Biomedical Research Networking Center in Rare Diseases (CIBERER), Institute of Health Carlos III (ISCIII), Madrid, Spain
Department of Endocrinology, Hospital de la Princesa, Universidad Autónoma de Madrid, Instituto Princesa, Madrid, Spain

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Mireia Jordà Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain

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Susan M Webb Department of Endocrinology/Medicine, CIBERER U747, ISCIII, Research Center for Pituitary Diseases, Hospital Sant Pau, IIB-SPau, Universitat Autònoma de Barcelona, Barcelona, Spain

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Guillermo Serra Department of Endocrinology, Son Espases University Hospital, Palma de Mallorca, Balearic Islands, Spain

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Laura Pons Department of Pathology, Germans Trias i Pujol University Hospital, Badalona, Spain

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Isabel Salinas Department of Endocrinology and Nutrition, Germans Trias i Pujol University Hospital, Badalona, Spain

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Alberto Blanco Department of Neurosurgery, Germans Trias i Pujol University Hospital, Badalona, Spain

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Montserrat Marques-Pamies Department of Endocrinology and Nutrition, Germans Trias i Pujol University Hospital, Badalona, Spain

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Elena Valassi Department of Endocrinology/Medicine, CIBERER U747, ISCIII, Research Center for Pituitary Diseases, Hospital Sant Pau, IIB-SPau, Universitat Autònoma de Barcelona, Barcelona, Spain

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Antonio Picó Biomedical Research Networking Center in Rare Diseases (CIBERER), Institute of Health Carlos III (ISCIII), Madrid, Spain
Hospital General Universitario de Alicante-Institute for Health and Biomedical Research (ISABIAL), Alicante, Spain
Department of Clinical Medicine, Miguel Hernández University, Elche, Spain

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Araceli García-Martínez Biomedical Research Networking Center in Rare Diseases (CIBERER), Institute of Health Carlos III (ISCIII), Madrid, Spain
Hospital General Universitario de Alicante-Institute for Health and Biomedical Research (ISABIAL), Alicante, Spain

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Cristina Carrato Department of Pathology, Germans Trias i Pujol University Hospital, Badalona, Spain

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Raquel Buj Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain
Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, Pennsylvania, USA

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Carlos del Pozo Department of Endocrinology, Hospital Universitari Mutua Terrassa, Terrassa, Spain

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Gabriel Obiols Department of Endocrinology, Hospital General Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain

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Carles Villabona Department of Endocrinology, Hospital Universitari de Bellvitge, Barcelona, Spain

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Rosa Cámara Endocrinology Department, Hospital Universitario y Politécnico La Fe, Valencia, Spain

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Carmen Fajardo-Montañana Endocrinology Department, Hospital Universitario de La Ribera, Alzira, Spain

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Clara V Alvarez Neoplasia & Endocrine Differentiation P0L5, Centro de Investigacion en Medicina Molecular y Enfermedades Cronicas (CIMUS), Instituto de Investigacion Sanitaria de Santiago (IDIS), Universidad de Santiago de Compostela (USC), Santiago de Compostela, Spain

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Ignacio Bernabéu Endocrinology Division, Complejo Hospitalario Universitario de Santiago de Compostela (CHUS)-SERGAS, Santiago de Compostela, Spain

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Mónica Marazuela Biomedical Research Networking Center in Rare Diseases (CIBERER), Institute of Health Carlos III (ISCIII), Madrid, Spain
Department of Endocrinology, Hospital de la Princesa, Universidad Autónoma de Madrid, Instituto Princesa, Madrid, Spain

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-0565 . Influence of SRL treatment given before or after surgery in the expression of molecular markers Molecular markers expression was compared between patients who had received SRL treatment before surgery ( n  = 67) and those that had not received it ( n  = 33

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Katja Kiseljak-Vassiliades Division of Endocrinology, Metabolism and Diabetes, University of Colorado School of Medicine, Aurora, Colorado, USA
Research Service Veterans Affairs Medical Center, Denver, Colorado, USA

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Yu Zhang Division of Endocrinology, Metabolism and Diabetes, University of Colorado School of Medicine, Aurora, Colorado, USA

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Stacey M Bagby Division of Medical Oncology, Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA

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Adwitiya Kar Division of Endocrinology, Metabolism and Diabetes, University of Colorado School of Medicine, Aurora, Colorado, USA

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Nikita Pozdeyev Division of Endocrinology, Metabolism and Diabetes, University of Colorado School of Medicine, Aurora, Colorado, USA

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Mei Xu Division of Endocrinology, Metabolism and Diabetes, University of Colorado School of Medicine, Aurora, Colorado, USA

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Katherine Gowan Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA

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Vibha Sharma Division of Endocrinology, Metabolism and Diabetes, University of Colorado School of Medicine, Aurora, Colorado, USA

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Christopher D Raeburn Department of Surgery, University of Colorado School of Medicine, Aurora, Colorado, USA

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Maria Albuja-Cruz Department of Surgery, University of Colorado School of Medicine, Aurora, Colorado, USA

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Kenneth L Jones Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA

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Lauren Fishbein Division of Endocrinology, Metabolism and Diabetes, University of Colorado School of Medicine, Aurora, Colorado, USA
Research Service Veterans Affairs Medical Center, Denver, Colorado, USA

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Rebecca E Schweppe Division of Endocrinology, Metabolism and Diabetes, University of Colorado School of Medicine, Aurora, Colorado, USA

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Hilary Somerset Department of Pathology; University of Colorado School of Medicine, Aurora, Colorado, USA

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Todd M Pitts Division of Medical Oncology, Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA

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Stephen Leong Division of Medical Oncology, Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA

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Margaret E Wierman Division of Endocrinology, Metabolism and Diabetes, University of Colorado School of Medicine, Aurora, Colorado, USA
Research Service Veterans Affairs Medical Center, Denver, Colorado, USA

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European Network for the Study of Adrenal tumors (ENSAT) and The Cancer Genome Atlas (TCGA) consortiums have given insight into the genetic and genomic landscape of adrenocortical cancers ( Assie et al . 2014 , Zheng et al . 2016 ). Specific molecular

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M Lacroix Laboratoire Jean-Claude Heuson de Cancérologie Mammaire, Institut Jules Bordet, Université Libre de Bruxelles, 127 boulevard de Waterloo, B-1000 Bruxelles, Brussels, Belgium

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R-A Toillon Laboratoire Jean-Claude Heuson de Cancérologie Mammaire, Institut Jules Bordet, Université Libre de Bruxelles, 127 boulevard de Waterloo, B-1000 Bruxelles, Brussels, Belgium

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G Leclercq Laboratoire Jean-Claude Heuson de Cancérologie Mammaire, Institut Jules Bordet, Université Libre de Bruxelles, 127 boulevard de Waterloo, B-1000 Bruxelles, Brussels, Belgium

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markers and grade Before examining the occurrence of phenotype changes during tumor progression, it is necessary to specify which phenotype categories will be considered here. The categories are based on: (1) a series of molecular markers related

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Nelson Rangel Department of Medical Sciences, University of Turin, Turin, Italy
Natural and Mathematical Sciences Faculty, Universidad del Rosario, Bogotá, Colombia

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Milena Rondon-Lagos School of Biological Sciences, Universidad Pedagógica y Tecnológica de Colombia, Tunja, Colombia

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Laura Annaratone Department of Medical Sciences, University of Turin, Turin, Italy

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Simona Osella-Abate Department of Medical Sciences, University of Turin, Turin, Italy

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Jasna Metovic Department of Medical Sciences, University of Turin, Turin, Italy

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Maria Piera Mano Department of Surgical Sciences, University of Turin, Turin, Italy

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Luca Bertero Department of Medical Sciences, University of Turin, Turin, Italy

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Paola Cassoni Department of Medical Sciences, University of Turin, Turin, Italy

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Anna Sapino Department of Medical Sciences, University of Turin, Turin, Italy
Pathology Unit, Fondazione del Piemonte per l’Oncologia (FPO) Candiolo Cancer Institute (IRCCS), Candiolo, Italy

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Isabella Castellano Department of Medical Sciences, University of Turin, Turin, Italy

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performed Prosigna-PAM50 assays to assess the molecular subtypes of these BCs. Patients and methods Study design and population We collected a cohort of 402 ER+/HER2− primary invasive BC patients with available follow-up ( Fig. 1 ), who underwent

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Johan O Paulsson Department of Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital CCK, Stockholm, Sweden

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Ninni Mu Department of Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital CCK, Stockholm, Sweden

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Ivan Shabo Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
Department of Breast, Endocrine Tumours and Sarcoma, Karolinska University Hospital, Stockholm, Sweden

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Na Wang Department of Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital CCK, Stockholm, Sweden

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Jan Zedenius Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
Department of Breast, Endocrine Tumours and Sarcoma, Karolinska University Hospital, Stockholm, Sweden

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Catharina Larsson Department of Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital CCK, Stockholm, Sweden

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C Christofer Juhlin Department of Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital CCK, Stockholm, Sweden

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and/or specificity, alternatively the sheer number of markers (such as provided through expressional or mutational panels) makes the analyses costly and somewhat dependent on tertiary pathology centres with expertise in molecular pathology to provide

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