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Julia Beck ENETS Center of Excellence for Neuroendocrine and Endocrine Tumors, University Hospital Basel, Basel, Switzerland
Department of Clinical Research, University of Basel, Basel, Switzerland

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Alexander Siebenhüner Hirslanden Zurich AG, Clinic for Hematology and Oncology, Zurich, Switzerland

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Damian Wild ENETS Center of Excellence for Neuroendocrine and Endocrine Tumors, University Hospital Basel, Basel, Switzerland
Division of Nuclear Medicine, University Hospital Basel, Basel, Switzerland

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Emanuel Christ ENETS Center of Excellence for Neuroendocrine and Endocrine Tumors, University Hospital Basel, Basel, Switzerland
Department of Clinical Research, University of Basel, Basel, Switzerland

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Julie Refardt ENETS Center of Excellence for Neuroendocrine and Endocrine Tumors, University Hospital Basel, Basel, Switzerland
Department of Clinical Research, University of Basel, Basel, Switzerland

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little information about the impact of sex differences are neuroendocrine neoplasms (NENs). NENs usually are well-differentiated tumors, mainly localized in the gastrointestinal system, pancreas, and lung ( Klöppel 2011 , Caplin et al. 2015 , Refardt

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-23-0235
Volume/Issue:
Volume 31: Issue 3
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Julie Refardt ENETS Center of Excellence, Department of Internal Medicine, Section of Endocrinology, Erasmus Medical Center and Erasmus Cancer Institute, Rotterdam, The Netherlands
ENETS Center of Excellence, Department of Endocrinology, University Hospital Basel, Basel, Switzerland

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Caroline M den Hoed Department of Gastroenterology and Hepatology, Erasmus MC Transplant Institute, Erasmus MC University Medical Center, Rotterdam, The Netherlands

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Janneke Langendonk Department of Internal Medicine, Center for Lysosomal and Metabolic Diseases, Erasmus Medical Center, Rotterdam, The Netherlands

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Wouter T Zandee Division of Endocrinology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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Ayoub Charehbili ENETS Center of Excellence, Department of Radiology & Nuclear Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

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Richard A Feelders ENETS Center of Excellence, Department of Internal Medicine, Section of Endocrinology, Erasmus Medical Center and Erasmus Cancer Institute, Rotterdam, The Netherlands

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Wouter W de Herder ENETS Center of Excellence, Department of Internal Medicine, Section of Endocrinology, Erasmus Medical Center and Erasmus Cancer Institute, Rotterdam, The Netherlands

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Tessa Brabander ENETS Center of Excellence, Department of Radiology & Nuclear Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

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Johannes Hofland ENETS Center of Excellence, Department of Internal Medicine, Section of Endocrinology, Erasmus Medical Center and Erasmus Cancer Institute, Rotterdam, The Netherlands

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overproduction or due to infections with urease-producing bacteria, for example, urinary tract or skin infections ( Stergachis et al. 2020 ). Ten cases of hyperammonemia in neuroendocrine neoplasm (NEN) patients have been described in the literature to date

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-21-0346
Volume/Issue:
Volume 29: Issue 5
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Darren Cowzer Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Ronak H Shah Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Joanne F Chou Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Ritika Kundra Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Sippy Punn Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Laura Fiedler Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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April DeMore Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Marinela Capanu Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Michael F Berger Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Department of Pathology and laboratory medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Diane Reidy-Lagunes Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Weill Medical College of Cornell University, New York, New York, USA

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Nitya Raj Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Weill Medical College of Cornell University, New York, New York, USA

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Introduction Pancreatic neuroendocrine neoplasms (panNENs) represent a heterogenous group of tumors with varying clinical behaviors and outcomes with increasing incidence and prevalence ( Dasari et al. 2017 ). Tumors are histologically

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-23-0292
Volume/Issue:
Volume 31: Issue 4
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Nicola Fazio Division of gastrointestinal medical oncology and neuroendocrine tumors, European Institute of Oncology (IEO) IRCCS, Milan, Italy

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Lorenzo Gervaso Division of gastrointestinal medical oncology and neuroendocrine tumors, European Institute of Oncology (IEO) IRCCS, Milan, Italy
Molecular Medicine Program, University of Pavia, Pavia, Italy

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Thorvardur R Halfdanarson Division of Medical Oncology Mayo Clinic, Rochester, Minnesota, USA

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Mohamad Sonbol Department of Hematology and Oncology, Mayo Clinic, Phoenix, Arizona, USA

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Rachel A Eiring Division of Medical Oncology Mayo Clinic, Rochester, Minnesota, USA

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Sara Pusceddu Division of Medical Oncology, National Cancer Institute, Milan, Italy

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Natalie Prinzi Division of Medical Oncology, National Cancer Institute, Milan, Italy

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Benedetta Lombardi Stocchetti Division of Medical Oncology, National Cancer Institute, Milan, Italy

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Simona Grozinsky-Glasberg Neuroendocrine Tumor Unit, ENETS Center of Excellence, Department of Endocrinology and Metabolism, Hadassah Medical Center and Faculty of Medicine, The Hebrew University, Jerusalem, Israel

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David J Gross Neuroendocrine Tumor Unit, ENETS Center of Excellence, Department of Endocrinology and Metabolism, Hadassah Medical Center and Faculty of Medicine, The Hebrew University, Jerusalem, Israel

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Thomas Walter Medical Oncology Department, Hopital Edourad Herriot, Hospices civils de Lyon, Lyon, France

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Patrick Robelin Medical Oncology Department, Hopital Edourad Herriot, Hospices civils de Lyon, Lyon, France

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Catherine Lombard-Bohas Medical Oncology Department, Hopital Edourad Herriot, Hospices civils de Lyon, Lyon, France

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Samuele Frassoni Department of Statistics and Quantitative Methods, University of Milan-Bicocca, Milan, Italy

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Vincenzo Bagnardi Department of Statistics and Quantitative Methods, University of Milan-Bicocca, Milan, Italy

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Lorenzo Antonuzzo Clinical Oncology Unit, Careggi University Hospital, Florence, Italy
Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy

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Clotilde Sparano Endocrinology Unit, Department of Experimental and Clinical Biomedical Sciences ’Mario Serio’, University of Florence, Florence, Italy

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Sara Massironi Division of Gastroenterology, and Center for Autoimmune Liver Diseases, European Reference Network on Hepatological Diseases (ERN RARE-LIVER), San Gerardo Hospital, University of Milano-Bicocca School of Medicine, Monza, Italy

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Fabio Gelsomino Division of Oncology. Department of Hematology and Oncology, University Hospital of Modena, Modena, Italy

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Alberto Bongiovanni Oncologia medica, IRCCS Istituto Romagnolo per lo Studio dei Tumori ’Dino Amadori’, IRST S.r.l., Meldola, Italy

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Nicoletta Ranallo Oncologia medica, IRCCS Istituto Romagnolo per lo Studio dei Tumori ’Dino Amadori’, IRST S.r.l., Meldola, Italy

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Salvatore Tafuto Oncologia Sarcomi e Tumori rari, I.R.C.C.S. Ist. Naz. Tumori di Napoli ’G. Pascale’, Napoli, Italy

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Maura Rossi Oncology Unit and Centro Documentazione Osteonecrosi, Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo, Alessandria, Italy

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Mauro Cives Department of Interdisciplinary Medicine, University of Bari ’Aldo Moro’, Bari, Italy

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Ibrahim Rasul Kakil National Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar

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Hytam Hamid Department of Surgery, Al-Moalem Medical City, Khartoum, Sudan

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Alessandra Chirco UO Oncologia Medica ASST Papa Giovanni XXIII, Bergamo, Italy

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Michela Squadroni Oncologia medica, Humanitas Gavazzeni Bergamo, Bergamo, Italy

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Anna La Salvia Medical Oncology Department, Hospital Universitario Doce de Octubre, Imas12, UCM, Madrid, Spain

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Jorge Hernando Vall Hebron University Hospital and Vall Hebron Institute of Oncology (VHIO), Barcelona, Spain

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Johannes Hofland Department of Internal Medicine, Sector Endocrinology, Rotterdam, the Netherlands

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Anna Koumarianou Hematology-Oncology Unit, Fourth Department of Internal Medicine, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece

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Sabrina Boselli Data Management-Clinical Trial Office. Scientific Direction. European Institute of Oncology (IEO) IRCCS, Milan, Italy

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Darina Tamayo Data Management-Clinical Trial Office. Scientific Direction. European Institute of Oncology (IEO) IRCCS, Milan, Italy

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Cristina Mazzon Data Management-Clinical Trial Office. Scientific Direction. European Institute of Oncology (IEO) IRCCS, Milan, Italy

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Manila Rubino Division of gastrointestinal medical oncology and neuroendocrine tumors, European Institute of Oncology (IEO) IRCCS, Milan, Italy

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Francesca Spada Division of gastrointestinal medical oncology and neuroendocrine tumors, European Institute of Oncology (IEO) IRCCS, Milan, Italy

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susceptibilities to SARS-CoV-2 infection and COVID-19 phenotypes ( Lee et al. 2020 b ). Neuroendocrine neoplasms (NENs) are a rare and heterogeneous group of malignancies, showing various clinical behavior and response to treatment. Their clinical history can

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-22-0395
Volume/Issue:
Volume 30: Issue 6
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T Vandamme Center of Oncological Research (CORE), University of Antwerp, Antwerp, Belgium
Section of Endocrinology, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

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M Beyens Center of Oncological Research (CORE), University of Antwerp, Antwerp, Belgium

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G Boons Center of Oncological Research (CORE), University of Antwerp, Antwerp, Belgium

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A Schepers Center of Medical Genetics, University of Antwerp, Antwerp, Belgium

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K Kamp Section of Endocrinology, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

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K Biermann Department of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands

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P Pauwels Department of Pathology, University of Antwerp, Antwerp, Belgium

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W W De Herder Section of Endocrinology, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

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L J Hofland Section of Endocrinology, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

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M Peeters Center of Oncological Research (CORE), University of Antwerp, Antwerp, Belgium

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G Van Camp Center of Medical Genetics, University of Antwerp, Antwerp, Belgium

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K Op de Beeck Center of Oncological Research (CORE), University of Antwerp, Antwerp, Belgium

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Introduction Neuroendocrine neoplasms of the pancreas (pNENs), originating from the islet cells, are considered rare, although incidence is increasing ( Dasari et al . 2017 ). pNENs can occur as part of genetic syndromes, such as multiple

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-18-0120
Volume/Issue:
Volume 26: Issue 1
Free access
James C Yao University of Texas MD Anderson Cancer Center, Houston, Texas, USA

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Jonathan Strosberg Department of GI Oncology, Moffitt Cancer Center, Tampa, Florida, USA

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Nicola Fazio European Institute of Oncology, IEO, IRCCS, Milan, Italy

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Marianne E Pavel Department of Medicine 1, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany

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Emily Bergsland UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California, USA

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Philippe Ruszniewski Hôpital Beaujon, University of Paris, Paris, France

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Daniel M Halperin University of Texas MD Anderson Cancer Center, Houston, Texas, USA

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Daneng Li City of Hope Comprehensive Cancer Center and Beckman Research Institute, Duarte, California, USA

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Salvatore Tafuto Sarcomas and Rare Tumours Unit, Istituto Nazionale Tumori, IRCCS Fondazione G. Pascale, Naples, Italy

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Nitya Raj Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Davide Campana Department of Clinical Medicine, Sant’Orsola-Malpighi Hospital, University of Bologna, ENETS Center of Excellence, Bologna, Italy

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Susumu Hijioka National Cancer Center Japan Tsukiji Campus, Department of Hepatobiliary and Pancreatic Oncology, Tokyo, Japan

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Markus Raderer Clinical Division of Oncology, Medical University of Vienna, Vienna, Austria

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Rosine Guimbaud CHU de Toulouse, Toulouse, France

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Pablo Gajate Hospital Universitário Ramón y Cajal, Clinical Oncology Department, Madrid, Spain

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Sara Pusceddu Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

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Albert Reising Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA

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Evgeny Degtyarev Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA

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Mark Shilkrut Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA

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Simantini Eddy Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA

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Simron Singh Sunnybrook Health Sciences Centre, Toronto, Canada

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years ( Yao et al. 2008 ). Neuroendocrine neoplasms (NENs) are comprised of well-differentiated NETs and poorly differentiated neuroendocrine carcinomas (NECs). The World Health Organization classification reported four categories, based on tumor

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Collections:
Top-cited articles of 2023
DOI:
https://doi.org/10.1530/ERC-20-0382
Volume/Issue:
Volume 28: Issue 3
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S L Asa Department of Pathology and Endocrine Oncology Site Group, Princess Margaret Cancer Centre, University Health Network, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada

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O Casar-Borota Department of Pathology, Uppsala University Hospital, Uppsala, Sweden

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P Chanson Service of Endocrinology and Reproductive Diseases, Bicêtre Hospital, Paris, France

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E Delgrange Department of Medicine, University of Louvain, Mont-sur-Meuse, Belgium

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P Earls Department of Anatomical Pathology, St Vincent’s Hospital, Sydney, Australia

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S Ezzat Department of Medicine and Endocrine Oncology Site Group, Princess Margaret Cancer Centre, University Health Network and University of Toronto, Toronto, Ontario, Canada

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A Grossman Department of Endocrinology, University of Oxford, Oxford, UK

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H Ikeda Research Institute for Pituitary Disease, Southern Tohoku General Hospital, Fukushima, Japan

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N Inoshita Department of Pathology, Toranomon Hospital, Tokyo, Japan

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N Karavitaki Department of Endocrinology, Queen Elizabeth Hospital, University of Birmingham, Birmingham, UK

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M Korbonits Division of Endocrinology, Queen Mary Hospital, Barts and the London School of Medicine, London, UK

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E R Laws Jr Department of Neurosurgery, Harvard Medical School, Brigham & Women’s Hospital, Boston, Massachusetts, USA

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M B Lopes Departments of Pathology and Neurological Surgery, University of Virginia, Charlottesville, Virginia, USA

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N Maartens Department of Neurosurgery, Royal Melbourne Hospital, The University of Melbourne, Melbourne, Australia

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I E McCutcheon Department of Neurosurgery, UT MD Anderson Cancer Center, Houston, Texas, USA

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O Mete Department of Pathology and Endocrine Oncology Site Group, Princess Margaret Cancer Centre, University Health Network, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada

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H Nishioka Department of Neurosurgery, Toranomon Hospital, Tokyo, Japan

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G Raverot Department of Endocrinology, Groupement Hospitalier EST, Hospices Civils de Lyon, University of Lyon, Lyon, France

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F Roncaroli Department of Neuropathology, Imperial College, London, UK

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W Saeger Institute of Neuropathology of the University of Hamburg, Hamburg, Germany

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L V Syro Department of Neurosurgery, Hospital Pablo Tobon Uribe, Medellin, Colombia

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A Vasiljevic Department of Pathology, Groupement Hospitalier EST, Hospices Civils de Lyon, University of Lyon, Lyon, France

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C Villa Department of Pathology, Hôpital Foch, Suresnes, France

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A Wierinckx INSERM U1052, Cancer Research Center of Lyon, University of Lyon, Lyon, France

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J Trouillas Faculty of Medicine Lyon-Est, University of Lyon, Lyon, France

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and the attendees of 14th Meeting of the International Pituitary Pathology Club, Annecy, France, November 2016
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gastrointestinal and respiratory tracts. Over the last two decades, there have been terminology shifts that reflect the potential for malignant behavior of even the most bland of those neuroendocrine neoplasms. They evolved from ‘adenoma’ to ‘tumor’ to recognize

Article Type:
Article Commentary
DOI:
https://doi.org/10.1530/ERC-17-0004
Volume/Issue:
Volume 24: Issue 4
Free access
Giulia Vocino Trucco Pathology Unit, SS. Annunziata Hospital, Savigliano, Italy

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Marco Volante Department of Oncology, University of Turin, Orbassano, Turin, Italy

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Introduction: a universal terminology and classification system The World Health Organization (WHO) has recently introduced a universal classification framework for neuroendocrine neoplasms (NENs), proposing a single model for terminology and

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-24-0004
Volume/Issue:
Volume 31: Issue 8
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Shani Avniel-Polak Neuroendocrine Tumor Laboratory, Endocrinology & Metabolism Department, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

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Gil Leibowitz Neuroendocrine Tumor Laboratory, Endocrinology & Metabolism Department, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

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Victoria Doviner Department of Pathology, Shaare Zedek Medical Center, Jerusalem, Israel

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David J Gross Neuroendocrine Tumor Laboratory, Endocrinology & Metabolism Department, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

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Simona Grozinsky-Glasberg Neuroendocrine Tumor Laboratory, Endocrinology & Metabolism Department, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

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Introduction Neuroendocrine neoplasms (NENs) constitute a heterogeneous and rare family of tumors that arise from cells of the diffuse endocrine system dispersed throughout the body, with an increasing annual incidence (~6.9/100,000 people

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-18-0121
Volume/Issue:
Volume 25: Issue 6
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Germano Gaudenzi Istituto Auxologico Italiano, IRCCS, Laboratorio Sperimentale di Ricerche di Neuroendocrinologia Geriatrica ed Oncologica, Milan, Italy

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Silvia Carra Istituto Auxologico Italiano, IRCCS, Laboratorio Sperimentale di Ricerche Endocrino-Metaboliche, Milan, Italy

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Alessandra Dicitore Department of Clinical Sciences and Community Health (DISCCO), University of Milan, Milan, Italy

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Maria Celeste Cantone Department of Clinical Sciences and Community Health (DISCCO), University of Milan, Milan, Italy

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Luca Persani Istituto Auxologico Italiano, IRCCS, Laboratorio Sperimentale di Ricerche Endocrino-Metaboliche, Milan, Italy
Department of Clinical Sciences and Community Health (DISCCO), University of Milan, Milan, Italy

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Giovanni Vitale Istituto Auxologico Italiano, IRCCS, Laboratorio Sperimentale di Ricerche di Neuroendocrinologia Geriatrica ed Oncologica, Milan, Italy
Department of Clinical Sciences and Community Health (DISCCO), University of Milan, Milan, Italy

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Introduction Neuroendocrine tumors (NETs) represent a broad class of neoplasms originating from neuroendocrine cells. NETs can cause a wide array of symptoms depending on the type of tumor, its location and the production of several factors

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-19-0437
Volume/Issue:
Volume 27: Issue 6
Free access