patients and 49 samples from clinical stage III patients. During the observation period, 43 (47.8%) patients relapsed and 22 (24.4%) patients eventually died. Using immunohistochemistry, we analysed TRPC3 expression in the epithelium of normal ovaries
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Xiang Tao, Naiqing Zhao, Hongyan Jin, Zhenbo Zhang, Yintao Liu, Jian Wu, Robert C Bast Jr, Yinhua Yu, and Youji Feng
Y Zhou, S Eppenberger-Castori, U Eppenberger, and C C Benz
good prognosis and endocrine responsiveness to others with de novo or acquired endocrine resistance and risk of early relapse ( Gruvberger et al. 2001 , Sorlie et al. 2001 , Benz 2004 a ). Additionally, a growing body of preclinical and clinical
Didier Marot, Ivan Bieche, Chantal Aumas, Stéphanie Esselin, Céline Bouquet, Sophie Vacher, Gwendal Lazennec, Michel Perricaudet, Frederique Kuttenn, Rosette Lidereau, and Nicolas de Roux
postoperative adjuvant endocrine therapy (20 mg TAM daily for 3–5 years), and no other treatment; 27 patients relapsed. The first relapse events were distributed as follows: 23 metastases, and 4 local and/or regional recurrences with metastases. To
R J Santen, R X Song, Z Zhang, R Kumar, M-H Jeng, A Masamura, J Lawrence Jr, L Berstein, and W Yue
. In this way, the beneficial effects of the aromatase inhibitor may be prolonged and relapses due to growth factor over-expression might be prevented or retarded. Figure 1 (A) Estradiol-induced cell
I Marinoni, A Wiederkeher, T Wiedmer, S Pantasis, A Di Domenico, R Frank, E Vassella, A Schmitt, and A Perren
correspondent loss of protein expression in the tumor tissue occur in 40% of PanNETs ( Jiao et al. 2011 ). DAXX and or ATRX loss correlates with chromosomal instability (CIN) and predicts for relapse in low-stage patients (Stages I to III in the absence of
J M Gee, J F Robertson, E Gutteridge, I O Ellis, S E Pinder, M Rubini, and R I Nicholson
resistance is commonly associated with retention of functional ER, such that subsequent endocrine response after tamoxifen relapse can occur. It is important that we decipher the regulatory pathways underlying the various forms of tamoxifen resistance
Régia Caroline Peixoto Lira, Paola Fernanda Fedatto, David Santos Marco Antonio, Letícia Ferro Leal, Carlos Eduardo Martinelli, Margaret de Castro, Silvio Tucci, Luciano Neder, Leandra Ramalho, Ana Luiza Seidinger, Izilda Cardinalli, Maria José Mastellaro, José Andres Yunes, Silvia Regina Brandalise, Luiz Gonzaga Tone, Sonir Roberto Rauber Antonini, and Carlos Alberto Scrideli
diagnosis ( n =7) or relapsed ( n =13). The clinical and pathological features of these patients were described previously ( Leal et al. 2011 , Lorea et al. 2012 , Gomes et al. 2014 ). Real-time PCR (qPCR) Tumor fragments were collected
Penelope D Ottewell, Ning Wang, Joshua Meek, C Anne Fowles, Peter I Croucher, Colby L Eaton, and Ingunn Holen
, this response is temporary and relapse will eventually occur with the tumour cells becoming castration resistant ( Debes & Tindall 2002 ). Up to 90% of men with metastatic castration resistant prostate cancer develop bone metastases ( Petrylak et al
Pushpa Patel, Rowan Hardy, Vaiyapuri Sumathi, Gillian Bartle, Lars-Gunnar Kindblom, Robert Grimer, Iwona Bujalska, Paul M Stewart, Elizabeth Rabbitt, Neil J L Gittoes, and Mark S Cooper
with a high probability of systemic relapse. Weaker prognostic factors include the size of the primary tumour and the level of serum alkaline phosphatase at diagnosis ( Marina et al . 2004 , Bramer et al . 2005 ). OSs arise from cells of osteoblast
Dennis H Dowhan, Matthew J Harrison, Natalie A Eriksson, Peter Bailey, Michael A Pearen, Peter J Fuller, John W Funder, Evan R Simpson, Peter J Leedman, Wayne D Tilley, Melissa A Brown, Christine L Clarke, and George E O Muscat
SurvComp package ( Haibe-Kains et al . 2008 , 2010 b ). PRMT6 signature scores were split according to their 33% and 66% quantiles. Upper and lower quantiles were used for survival analysis. We considered relapse-free survival (RFS) as the survival
