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and cell death induced by certain growth factors. We have also checked the expression of proteins known to interact with menin in our tumour samples, such as JunD, Smad3 and NFκB factors, and none of these factors showed altered transcriptional
Translational Ovarian Cancer Research Program, Department of Anatomy and Cell Biology, Department of Biochemistry, Department of Obstetrics and Gynaecology, Department of Oncology, London Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, Ontario, Canada N6A 4L6
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Translational Ovarian Cancer Research Program, Department of Anatomy and Cell Biology, Department of Biochemistry, Department of Obstetrics and Gynaecology, Department of Oncology, London Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, Ontario, Canada N6A 4L6
Translational Ovarian Cancer Research Program, Department of Anatomy and Cell Biology, Department of Biochemistry, Department of Obstetrics and Gynaecology, Department of Oncology, London Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, Ontario, Canada N6A 4L6
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Translational Ovarian Cancer Research Program, Department of Anatomy and Cell Biology, Department of Biochemistry, Department of Obstetrics and Gynaecology, Department of Oncology, London Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, Ontario, Canada N6A 4L6
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Translational Ovarian Cancer Research Program, Department of Anatomy and Cell Biology, Department of Biochemistry, Department of Obstetrics and Gynaecology, Department of Oncology, London Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, Ontario, Canada N6A 4L6
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Translational Ovarian Cancer Research Program, Department of Anatomy and Cell Biology, Department of Biochemistry, Department of Obstetrics and Gynaecology, Department of Oncology, London Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, Ontario, Canada N6A 4L6
Translational Ovarian Cancer Research Program, Department of Anatomy and Cell Biology, Department of Biochemistry, Department of Obstetrics and Gynaecology, Department of Oncology, London Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, Ontario, Canada N6A 4L6
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Translational Ovarian Cancer Research Program, Department of Anatomy and Cell Biology, Department of Biochemistry, Department of Obstetrics and Gynaecology, Department of Oncology, London Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, Ontario, Canada N6A 4L6
Translational Ovarian Cancer Research Program, Department of Anatomy and Cell Biology, Department of Biochemistry, Department of Obstetrics and Gynaecology, Department of Oncology, London Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, Ontario, Canada N6A 4L6
Translational Ovarian Cancer Research Program, Department of Anatomy and Cell Biology, Department of Biochemistry, Department of Obstetrics and Gynaecology, Department of Oncology, London Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, Ontario, Canada N6A 4L6
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Translational Ovarian Cancer Research Program, Department of Anatomy and Cell Biology, Department of Biochemistry, Department of Obstetrics and Gynaecology, Department of Oncology, London Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, Ontario, Canada N6A 4L6
Translational Ovarian Cancer Research Program, Department of Anatomy and Cell Biology, Department of Biochemistry, Department of Obstetrics and Gynaecology, Department of Oncology, London Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, Ontario, Canada N6A 4L6
Translational Ovarian Cancer Research Program, Department of Anatomy and Cell Biology, Department of Biochemistry, Department of Obstetrics and Gynaecology, Department of Oncology, London Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, Ontario, Canada N6A 4L6
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, and transforming growth factor-β3 enhance ovarian cancer metastatic potential by inducing a Smad3-dependent epithelial-to-mesenchymal transition . Molecular Cancer Research 6 695 – 705 . ( doi:10.1158/1541-7786.MCR-07-0294 ). Dunfield LD
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loci including PCNXL2 , TERC , NREP , EPB41L4A , OBFC1 , and SMAD3 ( Gudmundsson et al. 2017 , Hwangbo & Park 2018 ). Each variant is normally associated with small effect size, and individuals carrying multiple risk variants are therefore
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Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
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Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA
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Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Weill-Cornell Medical College, New York, New York, USA
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– 3462 . Costamagna E Garcia B Santisteban P 2004 The functional interaction between the paired domain transcription factor Pax8 and Smad3 is involved in transforming growth factor-beta repression of the sodium/iodide symporter gene . Journal
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promoter-proximal and enhancer elements. Menin has been reported to interact with and co-activate SMAD1, SMAD3 and SMAD5 ( Sowa et al. 2003 , 2004 ). In this fashion, menin can suppress prolactin and parathyroid hormone expression in murine cells, which
Dame Roma Mitchell Cancer Research Laboratories School of Medicine, Adelaide Prostate Cancer Research Centre
School of Medicine Freemasons Foundation Centre for Men's Health, The University of Adelaide, Adelaide, South Australia 5005, Australia
Molecular Cancer Epidemiology Laboratory Genetics and Computational Biology Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia
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Dame Roma Mitchell Cancer Research Laboratories School of Medicine, Adelaide Prostate Cancer Research Centre
School of Medicine Freemasons Foundation Centre for Men's Health, The University of Adelaide, Adelaide, South Australia 5005, Australia
Molecular Cancer Epidemiology Laboratory Genetics and Computational Biology Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia
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Dame Roma Mitchell Cancer Research Laboratories School of Medicine, Adelaide Prostate Cancer Research Centre
School of Medicine Freemasons Foundation Centre for Men's Health, The University of Adelaide, Adelaide, South Australia 5005, Australia
Molecular Cancer Epidemiology Laboratory Genetics and Computational Biology Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia
School of Biomedical Sciences Institute of Health and Biomedical Innovation, Translational Research Institute Pty Ltd, Australian Prostate Cancer Research Centre – Queensland, Queensland University of Technology, 37 Kent Street, Woolloongabba, Brisbane, Queensland 4102, Australia
Dame Roma Mitchell Cancer Research Laboratories School of Medicine, Adelaide Prostate Cancer Research Centre
School of Medicine Freemasons Foundation Centre for Men's Health, The University of Adelaide, Adelaide, South Australia 5005, Australia
Molecular Cancer Epidemiology Laboratory Genetics and Computational Biology Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia
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Dame Roma Mitchell Cancer Research Laboratories School of Medicine, Adelaide Prostate Cancer Research Centre
School of Medicine Freemasons Foundation Centre for Men's Health, The University of Adelaide, Adelaide, South Australia 5005, Australia
Molecular Cancer Epidemiology Laboratory Genetics and Computational Biology Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia
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Dame Roma Mitchell Cancer Research Laboratories School of Medicine, Adelaide Prostate Cancer Research Centre
School of Medicine Freemasons Foundation Centre for Men's Health, The University of Adelaide, Adelaide, South Australia 5005, Australia
Molecular Cancer Epidemiology Laboratory Genetics and Computational Biology Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia
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Dame Roma Mitchell Cancer Research Laboratories School of Medicine, Adelaide Prostate Cancer Research Centre
School of Medicine Freemasons Foundation Centre for Men's Health, The University of Adelaide, Adelaide, South Australia 5005, Australia
Molecular Cancer Epidemiology Laboratory Genetics and Computational Biology Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia
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-cycle regulation in prostate cancer ( Strachan et al . 2003 , Lee et al . 2013 ), the E3 ubiquitin ligase MDM2 that also harbours polymorphisms associated with the risk of prostate cancer ( Badciong & Haas 2002 , Yang et al . 2012 ) and both Smad3 and Smad4
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the role of the NADPH oxidase NOX4, an enzyme specialized in reactive oxygen species production upregulated in thyroid cancers ( Weyemi et al . 2010 ). Azouzi et al . demonstrated that NOX4 upregulation by the BRAF V600E -activated TGFβ-Smad3 pathway
Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Instituto de Salud Carlos III, Madrid, Spain
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other signaling cascades, providing points of crosstalk with the MAPK pathways. In lymphocytes and hepatocytes, TGFB (transforming growth factor B) induces the expression of DUSP4 in a SMAD3-dependent manner, impairing ERK-mediated degradation of BIM
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interacts with the TGF-β pathway ( Song et al. 2008 ) as well as with BMP ligands ( Lee et al. 2013 ). ADT increased TGF-β, TGFβRI, TGFβRII, and activation of Smads 2 and 3, resulting in apoptosis by a process where the AR interacts with Smad3. In
Cancer Epigenetics Laboratory Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, 33006 Oviedo, Spain
Department of Immunology and Oncology National Center for Biotechnology, CNB-CSIC, Cantoblanco, Madrid E-28049, Spain
Endocrinology and Nutrition Service Hospital Universitario Central de Asturias, Av. Julian Clavería s/n, 33006 Oviedo, Spain
Cancer Epigenetics Laboratory Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, 33006 Oviedo, Spain
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Cancer Epigenetics Laboratory Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, 33006 Oviedo, Spain
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Cancer Epigenetics Laboratory Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, 33006 Oviedo, Spain
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Cancer Epigenetics Laboratory Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, 33006 Oviedo, Spain
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Cancer Epigenetics Laboratory Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, 33006 Oviedo, Spain
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Cancer Epigenetics Laboratory Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, 33006 Oviedo, Spain
Department of Immunology and Oncology National Center for Biotechnology, CNB-CSIC, Cantoblanco, Madrid E-28049, Spain
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1 , termed menin, is a tumor suppressor protein ubiquitously expressed in the nucleus. It has not only been reported to interact with transcription factors such as JunD, Smad3, but also been found as a component of a multiple protein complex (through