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and cell death induced by certain growth factors. We have also checked the expression of proteins known to interact with menin in our tumour samples, such as JunD, Smad3 and NFκB factors, and none of these factors showed altered transcriptional

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Samah Rafehi Translational Ovarian Cancer Research Program, Department of Anatomy and Cell Biology, Department of Biochemistry, Department of Obstetrics and Gynaecology, Department of Oncology, London Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, Ontario, Canada N6A 4L6
Translational Ovarian Cancer Research Program, Department of Anatomy and Cell Biology, Department of Biochemistry, Department of Obstetrics and Gynaecology, Department of Oncology, London Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, Ontario, Canada N6A 4L6

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Yudith Ramos Valdes Translational Ovarian Cancer Research Program, Department of Anatomy and Cell Biology, Department of Biochemistry, Department of Obstetrics and Gynaecology, Department of Oncology, London Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, Ontario, Canada N6A 4L6

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Monique Bertrand Translational Ovarian Cancer Research Program, Department of Anatomy and Cell Biology, Department of Biochemistry, Department of Obstetrics and Gynaecology, Department of Oncology, London Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, Ontario, Canada N6A 4L6
Translational Ovarian Cancer Research Program, Department of Anatomy and Cell Biology, Department of Biochemistry, Department of Obstetrics and Gynaecology, Department of Oncology, London Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, Ontario, Canada N6A 4L6
Translational Ovarian Cancer Research Program, Department of Anatomy and Cell Biology, Department of Biochemistry, Department of Obstetrics and Gynaecology, Department of Oncology, London Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, Ontario, Canada N6A 4L6

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Jacob McGee Translational Ovarian Cancer Research Program, Department of Anatomy and Cell Biology, Department of Biochemistry, Department of Obstetrics and Gynaecology, Department of Oncology, London Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, Ontario, Canada N6A 4L6
Translational Ovarian Cancer Research Program, Department of Anatomy and Cell Biology, Department of Biochemistry, Department of Obstetrics and Gynaecology, Department of Oncology, London Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, Ontario, Canada N6A 4L6

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Michel Préfontaine Translational Ovarian Cancer Research Program, Department of Anatomy and Cell Biology, Department of Biochemistry, Department of Obstetrics and Gynaecology, Department of Oncology, London Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, Ontario, Canada N6A 4L6
Translational Ovarian Cancer Research Program, Department of Anatomy and Cell Biology, Department of Biochemistry, Department of Obstetrics and Gynaecology, Department of Oncology, London Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, Ontario, Canada N6A 4L6

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Akira Sugimoto Translational Ovarian Cancer Research Program, Department of Anatomy and Cell Biology, Department of Biochemistry, Department of Obstetrics and Gynaecology, Department of Oncology, London Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, Ontario, Canada N6A 4L6
Translational Ovarian Cancer Research Program, Department of Anatomy and Cell Biology, Department of Biochemistry, Department of Obstetrics and Gynaecology, Department of Oncology, London Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, Ontario, Canada N6A 4L6
Translational Ovarian Cancer Research Program, Department of Anatomy and Cell Biology, Department of Biochemistry, Department of Obstetrics and Gynaecology, Department of Oncology, London Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, Ontario, Canada N6A 4L6

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Gabriel E DiMattia Translational Ovarian Cancer Research Program, Department of Anatomy and Cell Biology, Department of Biochemistry, Department of Obstetrics and Gynaecology, Department of Oncology, London Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, Ontario, Canada N6A 4L6
Translational Ovarian Cancer Research Program, Department of Anatomy and Cell Biology, Department of Biochemistry, Department of Obstetrics and Gynaecology, Department of Oncology, London Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, Ontario, Canada N6A 4L6
Translational Ovarian Cancer Research Program, Department of Anatomy and Cell Biology, Department of Biochemistry, Department of Obstetrics and Gynaecology, Department of Oncology, London Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, Ontario, Canada N6A 4L6
Translational Ovarian Cancer Research Program, Department of Anatomy and Cell Biology, Department of Biochemistry, Department of Obstetrics and Gynaecology, Department of Oncology, London Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, Ontario, Canada N6A 4L6

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Trevor G Shepherd Translational Ovarian Cancer Research Program, Department of Anatomy and Cell Biology, Department of Biochemistry, Department of Obstetrics and Gynaecology, Department of Oncology, London Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, Ontario, Canada N6A 4L6
Translational Ovarian Cancer Research Program, Department of Anatomy and Cell Biology, Department of Biochemistry, Department of Obstetrics and Gynaecology, Department of Oncology, London Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, Ontario, Canada N6A 4L6
Translational Ovarian Cancer Research Program, Department of Anatomy and Cell Biology, Department of Biochemistry, Department of Obstetrics and Gynaecology, Department of Oncology, London Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, Ontario, Canada N6A 4L6
Translational Ovarian Cancer Research Program, Department of Anatomy and Cell Biology, Department of Biochemistry, Department of Obstetrics and Gynaecology, Department of Oncology, London Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, Ontario, Canada N6A 4L6

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, and transforming growth factor-β3 enhance ovarian cancer metastatic potential by inducing a Smad3-dependent epithelial-to-mesenchymal transition . Molecular Cancer Research 6 695 – 705 . ( doi:10.1158/1541-7786.MCR-07-0294 ). Dunfield LD

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Tung Hoang Department of Cancer Biomedical Science, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Gyeonggi-do, Republic of Korea

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Quy Nguyen Ngoc Department of Cancer Control and Population Health, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Gyeonggi-do, Republic of Korea

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Jeonghee Lee Department of Cancer Biomedical Science, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Gyeonggi-do, Republic of Korea

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Eun Kyung Lee Center for Thyroid Cancer, National Cancer Center, Goyang, Gyeonggi-do, Republic of Korea

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Yul Hwangbo Center for Thyroid Cancer, National Cancer Center, Goyang, Gyeonggi-do, Republic of Korea

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Jeongseon Kim Department of Cancer Biomedical Science, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Gyeonggi-do, Republic of Korea

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loci including PCNXL2 , TERC , NREP , EPB41L4A , OBFC1 , and SMAD3 ( Gudmundsson et al. 2017 , Hwangbo & Park 2018 ). Each variant is normally associated with small effect size, and individuals carrying multiple risk variants are therefore

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Kathleen A Luckett Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Jennifer R Cracchiolo Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Gnana P Krishnamoorthy Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Luis Javier Leandro-Garcia Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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James Nagarajah Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Mahesh Saqcena Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Rona Lester Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Soo Y Im Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Zhen Zhao Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Scott W Lowe Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Elisa de Stanchina Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Eric J Sherman Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Weill-Cornell Medical College, New York, New York, USA

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Alan L Ho Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Weill-Cornell Medical College, New York, New York, USA

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Steven D Leach Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Jeffrey A Knauf Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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James A Fagin Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Weill-Cornell Medical College, New York, New York, USA

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– 3462 . Costamagna E Garcia B Santisteban P 2004 The functional interaction between the paired domain transcription factor Pax8 and Smad3 is involved in transforming growth factor-beta repression of the sodium/iodide symporter gene . Journal

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Koen M A Dreijerink Department of Endocrinology VU University Medical Center, Amsterdam, The Netherlands

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H T Marc Timmers German Cancer Consortium (DKTK) partner site Freiburg German Cancer Research Center (DKFZ) and Department of Urology, Medical Center-University of Freiburg, Freiburg, Germany

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Myles Brown Department of Medical Oncology Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA

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promoter-proximal and enhancer elements. Menin has been reported to interact with and co-activate SMAD1, SMAD3 and SMAD5 ( Sowa et al. 2003 , 2004 ). In this fashion, menin can suppress prolactin and parathyroid hormone expression in murine cells, which

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Shane Stegeman School of Biomedical Sciences Institute of Health and Biomedical Innovation, Translational Research Institute Pty Ltd, Australian Prostate Cancer Research Centre – Queensland, Queensland University of Technology, 37 Kent Street, Woolloongabba, Brisbane, Queensland 4102, Australia

Dame Roma Mitchell Cancer Research Laboratories School of Medicine, Adelaide Prostate Cancer Research Centre

School of Medicine Freemasons Foundation Centre for Men's Health, The University of Adelaide, Adelaide, South Australia 5005, Australia

Molecular Cancer Epidemiology Laboratory Genetics and Computational Biology Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia

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Leire Moya School of Biomedical Sciences Institute of Health and Biomedical Innovation, Translational Research Institute Pty Ltd, Australian Prostate Cancer Research Centre – Queensland, Queensland University of Technology, 37 Kent Street, Woolloongabba, Brisbane, Queensland 4102, Australia

Dame Roma Mitchell Cancer Research Laboratories School of Medicine, Adelaide Prostate Cancer Research Centre

School of Medicine Freemasons Foundation Centre for Men's Health, The University of Adelaide, Adelaide, South Australia 5005, Australia

Molecular Cancer Epidemiology Laboratory Genetics and Computational Biology Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia

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Luke A Selth School of Biomedical Sciences Institute of Health and Biomedical Innovation, Translational Research Institute Pty Ltd, Australian Prostate Cancer Research Centre – Queensland, Queensland University of Technology, 37 Kent Street, Woolloongabba, Brisbane, Queensland 4102, Australia

Dame Roma Mitchell Cancer Research Laboratories School of Medicine, Adelaide Prostate Cancer Research Centre

School of Medicine Freemasons Foundation Centre for Men's Health, The University of Adelaide, Adelaide, South Australia 5005, Australia

Molecular Cancer Epidemiology Laboratory Genetics and Computational Biology Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia
School of Biomedical Sciences Institute of Health and Biomedical Innovation, Translational Research Institute Pty Ltd, Australian Prostate Cancer Research Centre – Queensland, Queensland University of Technology, 37 Kent Street, Woolloongabba, Brisbane, Queensland 4102, Australia

Dame Roma Mitchell Cancer Research Laboratories School of Medicine, Adelaide Prostate Cancer Research Centre

School of Medicine Freemasons Foundation Centre for Men's Health, The University of Adelaide, Adelaide, South Australia 5005, Australia

Molecular Cancer Epidemiology Laboratory Genetics and Computational Biology Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia

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Amanda B Spurdle School of Biomedical Sciences Institute of Health and Biomedical Innovation, Translational Research Institute Pty Ltd, Australian Prostate Cancer Research Centre – Queensland, Queensland University of Technology, 37 Kent Street, Woolloongabba, Brisbane, Queensland 4102, Australia

Dame Roma Mitchell Cancer Research Laboratories School of Medicine, Adelaide Prostate Cancer Research Centre

School of Medicine Freemasons Foundation Centre for Men's Health, The University of Adelaide, Adelaide, South Australia 5005, Australia

Molecular Cancer Epidemiology Laboratory Genetics and Computational Biology Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia

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Judith A Clements School of Biomedical Sciences Institute of Health and Biomedical Innovation, Translational Research Institute Pty Ltd, Australian Prostate Cancer Research Centre – Queensland, Queensland University of Technology, 37 Kent Street, Woolloongabba, Brisbane, Queensland 4102, Australia

Dame Roma Mitchell Cancer Research Laboratories School of Medicine, Adelaide Prostate Cancer Research Centre

School of Medicine Freemasons Foundation Centre for Men's Health, The University of Adelaide, Adelaide, South Australia 5005, Australia

Molecular Cancer Epidemiology Laboratory Genetics and Computational Biology Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia

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Jyotsna Batra School of Biomedical Sciences Institute of Health and Biomedical Innovation, Translational Research Institute Pty Ltd, Australian Prostate Cancer Research Centre – Queensland, Queensland University of Technology, 37 Kent Street, Woolloongabba, Brisbane, Queensland 4102, Australia

Dame Roma Mitchell Cancer Research Laboratories School of Medicine, Adelaide Prostate Cancer Research Centre

School of Medicine Freemasons Foundation Centre for Men's Health, The University of Adelaide, Adelaide, South Australia 5005, Australia

Molecular Cancer Epidemiology Laboratory Genetics and Computational Biology Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia

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-cycle regulation in prostate cancer ( Strachan et al . 2003 , Lee et al . 2013 ), the E3 ubiquitin ligase MDM2 that also harbours polymorphisms associated with the risk of prostate cancer ( Badciong & Haas 2002 , Yang et al . 2012 ) and both Smad3 and Smad4

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Camille Buffet Sorbonne Université, Unité Thyroïde-Tumeurs endocrine, Groupe de Recherche Clinique n°16 Tumeurs Thyroïdiennes, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France

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Johanna Wassermann Sorbonne Université, Service d’Oncologie, Groupe de Recherche Clinique n°16 Tumeurs Thyroïdiennes, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France

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Fabio Hecht Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, UFRJ, Rio de Janeiro, Brazil

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Laurence Leenhardt Sorbonne Université, Unité Thyroïde-Tumeurs endocrine, Groupe de Recherche Clinique n°16 Tumeurs Thyroïdiennes, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France

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Corinne Dupuy UMR 8200 CNRS, Villejuif, France
Université Paris-Saclay et Gustave Roussy, Villejuif, France

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Lionel Groussin INSERM Unité 1016, CNRS, UMR 8104, Institut Cochin, Paris, France
Université de Paris, Paris, France
Department of Endocrinology, APHP, Cochin Hospital, Paris, France

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Charlotte Lussey-Lepoutre Sorbonne Université, Service de Médecine Nucléaire, Groupe de Recherche Clinique n°16 Tumeurs Thyroïdiennes, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France
PARCC, INSERM, Equipe Labellisée par la Ligue contre le Cancer, Paris, France

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the role of the NADPH oxidase NOX4, an enzyme specialized in reactive oxygen species production upregulated in thyroid cancers ( Weyemi et al . 2010 ). Azouzi et al . demonstrated that NOX4 upregulation by the BRAF V600E -activated TGFβ-Smad3 pathway

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Miguel A Zaballos Instituto de Investigaciones Biomédicas ‘Alberto Sols’, Consejo Superior de Investigaciones Científicas (CSIC), Universidad Autónoma de Madrid (UAM), Madrid, Spain
Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Instituto de Salud Carlos III, Madrid, Spain

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Adrián Acuña-Ruiz Instituto de Investigaciones Biomédicas ‘Alberto Sols’, Consejo Superior de Investigaciones Científicas (CSIC), Universidad Autónoma de Madrid (UAM), Madrid, Spain
Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Instituto de Salud Carlos III, Madrid, Spain

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Marta Morante Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Instituto de Salud Carlos III, Madrid, Spain
Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Consejo Superior de Investigaciones Científicas (CSIC), Universidad de Cantabria, Santander, Spain

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Piero Crespo Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Instituto de Salud Carlos III, Madrid, Spain
Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Consejo Superior de Investigaciones Científicas (CSIC), Universidad de Cantabria, Santander, Spain

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Pilar Santisteban Instituto de Investigaciones Biomédicas ‘Alberto Sols’, Consejo Superior de Investigaciones Científicas (CSIC), Universidad Autónoma de Madrid (UAM), Madrid, Spain
Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Instituto de Salud Carlos III, Madrid, Spain

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other signaling cascades, providing points of crosstalk with the MAPK pathways. In lymphocytes and hepatocytes, TGFB (transforming growth factor B) induces the expression of DUSP4 in a SMAD3-dependent manner, impairing ERK-mediated degradation of BIM

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Kristina V Wells Department of Anatomy, Physiology, and Cell Biology, University of California Davis School of Veterinary Medicine, Davis, California, USA

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Margaret L Krackeler Department of Internal Medicine, University of California Davis School of Medicine, Sacramento, California, USA

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Maitreyee K Jathal Department of Medical Microbiology and Immunology, University of California Davis, Davis, California, USA
Veterans Affairs-Northern California Health System, Mather, California, USA

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Mamta Parikh Division of Hematology and Oncology, School of Medicine, University of California Davis, Sacramento, California, USA

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Paramita M Ghosh Veterans Affairs-Northern California Health System, Mather, California, USA
Department of Urologic Surgery, School of Medicine, University of California Davis, Sacramento, California, USA

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J Kent Leach Department of Orthopaedic Surgery, School of Medicine, University of California Davis, Sacramento, California, USA
Department of Biomedical Engineering, University of California Davis, Davis, California, USA

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Damian C Genetos Department of Anatomy, Physiology, and Cell Biology, University of California Davis School of Veterinary Medicine, Davis, California, USA

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interacts with the TGF-β pathway ( Song et al. 2008 ) as well as with BMP ligands ( Lee et al. 2013 ). ADT increased TGF-β, TGFβRI, TGFβRII, and activation of Smads 2 and 3, resulting in apoptosis by a process where the AR interacts with Smad3. In

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Sandra Rodríguez-Rodero Endocrinology and Nutrition Service Hospital Universitario Central de Asturias, Av. Julian Clavería s/n, 33006 Oviedo, Spain

Cancer Epigenetics Laboratory Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, 33006 Oviedo, Spain

Department of Immunology and Oncology National Center for Biotechnology, CNB-CSIC, Cantoblanco, Madrid E-28049, Spain
Endocrinology and Nutrition Service Hospital Universitario Central de Asturias, Av. Julian Clavería s/n, 33006 Oviedo, Spain

Cancer Epigenetics Laboratory Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, 33006 Oviedo, Spain

Department of Immunology and Oncology National Center for Biotechnology, CNB-CSIC, Cantoblanco, Madrid E-28049, Spain

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Elías Delgado-Álvarez Endocrinology and Nutrition Service Hospital Universitario Central de Asturias, Av. Julian Clavería s/n, 33006 Oviedo, Spain

Cancer Epigenetics Laboratory Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, 33006 Oviedo, Spain

Department of Immunology and Oncology National Center for Biotechnology, CNB-CSIC, Cantoblanco, Madrid E-28049, Spain

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Agustín F Fernández Endocrinology and Nutrition Service Hospital Universitario Central de Asturias, Av. Julian Clavería s/n, 33006 Oviedo, Spain

Cancer Epigenetics Laboratory Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, 33006 Oviedo, Spain

Department of Immunology and Oncology National Center for Biotechnology, CNB-CSIC, Cantoblanco, Madrid E-28049, Spain

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Juan L Fernández-Morera Endocrinology and Nutrition Service Hospital Universitario Central de Asturias, Av. Julian Clavería s/n, 33006 Oviedo, Spain

Cancer Epigenetics Laboratory Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, 33006 Oviedo, Spain

Department of Immunology and Oncology National Center for Biotechnology, CNB-CSIC, Cantoblanco, Madrid E-28049, Spain

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Edelmiro Menéndez-Torre Endocrinology and Nutrition Service Hospital Universitario Central de Asturias, Av. Julian Clavería s/n, 33006 Oviedo, Spain

Cancer Epigenetics Laboratory Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, 33006 Oviedo, Spain

Department of Immunology and Oncology National Center for Biotechnology, CNB-CSIC, Cantoblanco, Madrid E-28049, Spain

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Mario F Fraga Endocrinology and Nutrition Service Hospital Universitario Central de Asturias, Av. Julian Clavería s/n, 33006 Oviedo, Spain

Cancer Epigenetics Laboratory Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, 33006 Oviedo, Spain

Department of Immunology and Oncology National Center for Biotechnology, CNB-CSIC, Cantoblanco, Madrid E-28049, Spain
Endocrinology and Nutrition Service Hospital Universitario Central de Asturias, Av. Julian Clavería s/n, 33006 Oviedo, Spain

Cancer Epigenetics Laboratory Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, 33006 Oviedo, Spain

Department of Immunology and Oncology National Center for Biotechnology, CNB-CSIC, Cantoblanco, Madrid E-28049, Spain

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1 , termed menin, is a tumor suppressor protein ubiquitously expressed in the nucleus. It has not only been reported to interact with transcription factors such as JunD, Smad3, but also been found as a component of a multiple protein complex (through

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