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Gustavo Ayala Department of Pathology and Laboratory Medicine, Dan L. Duncan Cancer Center, Department of Pathology and Immunology, Department of Veterans Affairs, University of Texas Health Sciences Center Medical School, Houston, Texas, USA

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Anna Frolov Department of Pathology and Laboratory Medicine, Dan L. Duncan Cancer Center, Department of Pathology and Immunology, Department of Veterans Affairs, University of Texas Health Sciences Center Medical School, Houston, Texas, USA
Department of Pathology and Laboratory Medicine, Dan L. Duncan Cancer Center, Department of Pathology and Immunology, Department of Veterans Affairs, University of Texas Health Sciences Center Medical School, Houston, Texas, USA

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Deyali Chatterjee Department of Pathology and Laboratory Medicine, Dan L. Duncan Cancer Center, Department of Pathology and Immunology, Department of Veterans Affairs, University of Texas Health Sciences Center Medical School, Houston, Texas, USA

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Dandan He Department of Pathology and Laboratory Medicine, Dan L. Duncan Cancer Center, Department of Pathology and Immunology, Department of Veterans Affairs, University of Texas Health Sciences Center Medical School, Houston, Texas, USA

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Susan Hilsenbeck Department of Pathology and Laboratory Medicine, Dan L. Duncan Cancer Center, Department of Pathology and Immunology, Department of Veterans Affairs, University of Texas Health Sciences Center Medical School, Houston, Texas, USA

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Michael Ittmann Department of Pathology and Laboratory Medicine, Dan L. Duncan Cancer Center, Department of Pathology and Immunology, Department of Veterans Affairs, University of Texas Health Sciences Center Medical School, Houston, Texas, USA
Department of Pathology and Laboratory Medicine, Dan L. Duncan Cancer Center, Department of Pathology and Immunology, Department of Veterans Affairs, University of Texas Health Sciences Center Medical School, Houston, Texas, USA

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. Nature Medicine 19 1023 – 1029 . ( doi:10.1038/nm.3216 ). Clinckemalie L Spans L Dubois V Laurent M Helsen C Joniau S Claessens F 2013 Androgen regulation of the TMPRSS2 gene and the effect of a SNP in an androgen response element

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-14-0586
Volume/Issue:
Volume 22: Issue 3
Free access
Yichun Zheng Department of Pathology and Laboratory Medicine, Department of Urology, University of Rochester Medical Center, Rochester, New York 14642, USA
Department of Pathology and Laboratory Medicine, Department of Urology, University of Rochester Medical Center, Rochester, New York 14642, USA

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Koji Izumi Department of Pathology and Laboratory Medicine, Department of Urology, University of Rochester Medical Center, Rochester, New York 14642, USA

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Jorge L Yao Department of Pathology and Laboratory Medicine, Department of Urology, University of Rochester Medical Center, Rochester, New York 14642, USA

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Hiroshi Miyamoto Department of Pathology and Laboratory Medicine, Department of Urology, University of Rochester Medical Center, Rochester, New York 14642, USA

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of AR in another bladder cancer cell line 5637 with a full-length wild-type AR stably expressed by lentivirus. Luciferase activity was determined in the cell extracts with transfection of a plasmid (MMTV-luc) containing an androgen response element

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-11-0010
Volume/Issue:
Volume 18: Issue 4
Free access
Masaki Shiota Department of Urology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan

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Akira Yokomizo Department of Urology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan

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Seiji Naito Department of Urology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan

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quality of life in the GETUG 12 trial . European Journal of Cancer 48 209 – 217 . ( doi:10.1016/j.ejca.2011.10.015 ). Grad JM Dai JL Wu S Burnstein KL 1999 Multiple androgen response elements and a Myc consensus site in the androgen

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-12-0232
Volume/Issue:
Volume 19: Issue 6
Free access
Philipp Mayer
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Andreas Harjung
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Marco Breinig
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Lars Fischer Institute of Pathology, Department of General Surgery, Medical Clinic - Gastroenterology and Gastrointestinal Oncology, University of Heidelberg, Im Neuenheimer Feld 220, D-69120 Heidelberg, Germany

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Volker Ehemann
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Mona Malz
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Hans Scherübl Institute of Pathology, Department of General Surgery, Medical Clinic - Gastroenterology and Gastrointestinal Oncology, University of Heidelberg, Im Neuenheimer Feld 220, D-69120 Heidelberg, Germany

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Sarah Britsch
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Jens Werner Institute of Pathology, Department of General Surgery, Medical Clinic - Gastroenterology and Gastrointestinal Oncology, University of Heidelberg, Im Neuenheimer Feld 220, D-69120 Heidelberg, Germany

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Michael A Kern
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Hendrik Bläker
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Peter Schirmacher
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Frank Bergmann
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S Kimata R Nishimura T 2010 Effect of the hsp90 inhibitor geldanamycin on androgen response of prostate cancer under hypoxic conditions . International Journal of Urology 17 281 – 285 . doi:10.1111/j.1442-2042.2010.02450.x . Tannapfel

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-11-0227
Volume/Issue:
Volume 19: Issue 3
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Nicole L Moore
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Grant Buchanan
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Jonathan M Harris Dame Roma Mitchell Cancer Research Laboratories, Institute of Health and Biomedical Innovation, Discipline of Medicine, The University of Adelaide and Hanson Institute, PO Box 14, Rundle Mall, Adelaide, South Australia 5000, Australia

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Luke A Selth
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Tina Bianco-Miotto
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Adrienne R Hanson
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Stephen N Birrell
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Lisa M Butler
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Theresa E Hickey
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Wayne D Tilley
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. Steketee K Ziel-van der Made AC van der Korput HA Houtsmuller AB Trapman J 2004 A bioinformatics-based functional analysis shows that the specifically androgen-regulated gene SARG contains an active direct repeat androgen response element in

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-12-0065
Volume/Issue:
Volume 19: Issue 4
Free access
Zvi Laron Endocrinology and Diabetes Research Unit, Schneider Children’s Medical Center, Petah Tikva, Israel

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Haim Werner Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

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-glucuronosyltransferase 2B15 (UGT2B15) and UGT2B17 enzymes are major determinants of the androgen response in prostate cancer LNCaP cells . Journal of Biological Chemistry 282 33466 – 33474 . ( https://doi.org/10.1074/jbc.M703370200 ) Chutkow WA Patwari P Yoshioka

Article Type:
Review Article
Collections:
Growth Hormone in Endocrine Cancers
DOI:
https://doi.org/10.1530/ERC-22-0394
Volume/Issue:
Volume 30: Issue 9
Free access
Varinder Jeet Australian Prostate Cancer Research Centre – Queensland, Department of Urologic Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Australia

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Gregor Tevz Australian Prostate Cancer Research Centre – Queensland, Department of Urologic Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Australia

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Melanie Lehman Australian Prostate Cancer Research Centre – Queensland, Department of Urologic Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Australia
Australian Prostate Cancer Research Centre – Queensland, Department of Urologic Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Australia

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Brett Hollier Australian Prostate Cancer Research Centre – Queensland, Department of Urologic Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Australia

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Colleen Nelson Australian Prostate Cancer Research Centre – Queensland, Department of Urologic Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Australia
Australian Prostate Cancer Research Centre – Queensland, Department of Urologic Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Australia

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. 2 A). Furthermore, the androgen-induced increase in YKL40 mRNA was significantly abrogated upon treatment with 10 μM enzalutamide in LNCaP cells, whereas C4-2B cells did not show any significant reduction ( Fig. 2 A). The weak androgen response in

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-14-0267
Volume/Issue:
Volume 21: Issue 5
Open access
Yulia Koryakina Department of Microbiology, Sidney Kimmel Cancer Center, Cancer Center Member, Immunology, and Cancer Biology, University of Virginia, Jordan Hall Room 2‐16, 1300 Jefferson Park Avenue, PO Box 800734, Charlottesville, Virginia 22908, USA

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Karen E Knudsen Department of Microbiology, Sidney Kimmel Cancer Center, Cancer Center Member, Immunology, and Cancer Biology, University of Virginia, Jordan Hall Room 2‐16, 1300 Jefferson Park Avenue, PO Box 800734, Charlottesville, Virginia 22908, USA

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Daniel Gioeli Department of Microbiology, Sidney Kimmel Cancer Center, Cancer Center Member, Immunology, and Cancer Biology, University of Virginia, Jordan Hall Room 2‐16, 1300 Jefferson Park Avenue, PO Box 800734, Charlottesville, Virginia 22908, USA
Department of Microbiology, Sidney Kimmel Cancer Center, Cancer Center Member, Immunology, and Cancer Biology, University of Virginia, Jordan Hall Room 2‐16, 1300 Jefferson Park Avenue, PO Box 800734, Charlottesville, Virginia 22908, USA

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-sensitive prostate cancer cells . PNAS 103 15085 – 15090 . ( doi:10.1073/pnas.0603057103 ). Lu S Liu M Epner DE Tsai SY Tsai MJ 1999 Androgen regulation of the cyclin-dependent kinase inhibitor p21 gene through an androgen response element in the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-14-0549
Volume/Issue:
Volume 22: Issue 2
Free access
Charles E Massie Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Inmaculada Spiteri Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Helen Ross-Adams Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Hayley Luxton Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Jonathan Kay Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Hayley C Whitaker Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Mark J Dunning Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Alastair D Lamb Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK
Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK
Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Antonio Ramos-Montoya Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Daniel S Brewer Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Colin S Cooper Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK
Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Rosalind Eeles Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK
Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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UK Prostate ICGC Group
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Anne Y Warren Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Simon Tavaré Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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David E Neal Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK
Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK
Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Andy G Lynch Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Urano T Ijichi N Ouchi Y Shirahige K Aburatani H 2007 Identification of novel androgen response genes in prostate cancer cells by coupling chromatin immunoprecipitation and genomic microarray analysis . Oncogene 26 4453 – 4463

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-14-0454
Volume/Issue:
Volume 22: Issue 2
Open access
Lisa M Butler School of Medicine, University of Adelaide, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia

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Margaret M Centenera School of Medicine, University of Adelaide, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia

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Johannes V Swinnen Laboratory of Lipid Metabolism and Cancer, Department of Oncology, LKI – Leuven Cancer Institute, KU Leuven – University of Leuven, Leuven, Belgium

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synthesis supports cell survival and tumor growth . Cancer & Metabolism 1 3 . ( doi:10.1186/2049-3002-1-3 ) Heemers H Verrijdt G Organe S Claessens F Heyns W Verhoeven G Swinnen JV 2004 Identification of an androgen

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-15-0556
Volume/Issue:
Volume 23: Issue 5
Free access