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Susanne Singer Institute of Medical Biostatistics Epidemiology and Informatics (IMBEI), University Medical Center Mainz, Mainz, Germany
University Cancer Centre, Mainz, Germany

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Susan Jordan QIMR Berghofer Medical Research Institute, Herston, Australia

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Laura D Locati Head & Neck Medical Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

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Monica Pinto Rehabilitation Unit, Department of Quality of Life, Istituto Nazionale per lo Studio e la Cura dei Tumori ‘Fondazione Giovanni Pascale’ – IRCCS, Naples, Italy

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Iwona M Tomaszewska Department of Medical Education, Jagiellonian University Medical College, Krakow, Poland

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Cláudia Araújo Service of Surgical Oncology, Instituto Português do Oncologia do Porto Francisco Gentil, Porto, Portugal

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Eva Hammerlid Department of Otolaryngology and Head and Neck Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden

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E Vidhubala Department of Psycho-Oncology, Resource Centre for Tobacco Control, Cancer Institute (WIA), Chennai, Tamil Nadu, India

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Olga Husson Department of Medical Psychology, Radboud University Medical Center, Nijmegen, The Netherlands

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Naomi Kiyota Department of Medical Oncology and Hematology, Kobe University Hospital, Kobe, Japan

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Christine Brannan Mount Vernon Cancer Centre, East & North Herts NHS Trust, Northwood, London, UK

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Dina Salem Clinical Oncology, Faculty of Medicine, Ain Shams University, Cairo, Egypt

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Eva M Gamper Department of Nuclear Medicine, Medical University of Innsbruck, Innsbruck Institute of Patient-Centred Outcome Research, Innsbruck, Austria

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Juan Ignacio Arraras Oncology Departments, Complejo Hospitalario de Navarra, Pamplona, Spain

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Georgios Ioannidis Oncology Department, Nicosia General Hospital, Nicosia, Cyprus

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Guy Andry Surgery Department, Jules Bordet Institute, Brussels, Belgium

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Johanna Inhestern Clinic of Otorhinolaryngology, Jena University Hospital, Jena, Germany

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Vincent Grégoire Department of Radiation Oncology, Institut de Recherche Experimentale et Clinique, Université Catholique de Louvain, St-Luc University Hospital, Brussels, Belgium

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Lisa Licitra Head & Neck Medical Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

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on behalf of the EORTC Quality of Life Group, the EORTC Head and Neck Cancer Group, and the EORTC Endocrine Task Force
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Introduction While thyroid cancer is one of the less common malignancies with an age-standardised rate in Europe of 6.3 per 100,000 per year (3.1 in men and 9.3 in women) ( Ferlay et al . 2013 ), the incidence rates have been rising rapidly

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Lisa D Berman-Booty Department of Cancer Biology, Kimmel Cancer Center, Departments of Urology, Radiation Oncology, Thomas Jefferson University, 233 South 10th Street, BLSB 1008, Philadelphia, Pennsylvania 19107, USA
Department of Cancer Biology, Kimmel Cancer Center, Departments of Urology, Radiation Oncology, Thomas Jefferson University, 233 South 10th Street, BLSB 1008, Philadelphia, Pennsylvania 19107, USA

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Karen E Knudsen Department of Cancer Biology, Kimmel Cancer Center, Departments of Urology, Radiation Oncology, Thomas Jefferson University, 233 South 10th Street, BLSB 1008, Philadelphia, Pennsylvania 19107, USA
Department of Cancer Biology, Kimmel Cancer Center, Departments of Urology, Radiation Oncology, Thomas Jefferson University, 233 South 10th Street, BLSB 1008, Philadelphia, Pennsylvania 19107, USA
Department of Cancer Biology, Kimmel Cancer Center, Departments of Urology, Radiation Oncology, Thomas Jefferson University, 233 South 10th Street, BLSB 1008, Philadelphia, Pennsylvania 19107, USA
Department of Cancer Biology, Kimmel Cancer Center, Departments of Urology, Radiation Oncology, Thomas Jefferson University, 233 South 10th Street, BLSB 1008, Philadelphia, Pennsylvania 19107, USA

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Introduction Prostate cancer is the second most common cancer in men worldwide ( Ferlay et al . 2010 ). With >90% of prostate cancers initially diagnosed as acinar adenocarcinomas ( Fine 2012 , Humphrey 2012 ), neuroendocrine carcinomas of the

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Anja Rudolph Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Rebecca Hein Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Sara Lindström Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Lars Beckmann Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Sabine Behrens Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Jianjun Liu Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Hugues Aschard Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Manjeet K Bolla Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Jean Wang Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Thérèse Truong Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Emilie Cordina-Duverger Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Florence Menegaux Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Thomas Brüning Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Volker Harth Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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The GENICA Network Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Gianluca Severi Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Laura Baglietto Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Melissa Southey Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Stephen J Chanock Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Jolanta Lissowska Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Jonine D Figueroa Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Mikael Eriksson Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Keith Humpreys Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Hatef Darabi Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Janet E Olson Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Kristen N Stevens Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Celine M Vachon Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Julia A Knight Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Gord Glendon Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Anna Marie Mulligan Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Alan Ashworth Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Nicholas Orr Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Minouk Schoemaker Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Penny M Webb Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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kConFab Investigators Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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AOCS Management Group Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Pascal Guénel Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Hiltrud Brauch Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Graham Giles Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Montserrat García-Closas Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Kamila Czene Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Georgia Chenevix-Trench Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Fergus J Couch Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Irene L Andrulis Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Anthony Swerdlow Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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David J Hunter Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Dieter Flesch-Janys Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Douglas F Easton Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Per Hall Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Heli Nevanlinna Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Peter Kraft Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Jenny Chang-Claude Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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on behalf of the Breast Cancer Association Consortium
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Introduction Menopausal hormone therapy (MHT) is prescribed to women in order to alleviate climacteric symptoms and it is still commonly used despite evidence of associations with increased risk of cardiovascular diseases and breast cancer (BC

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Huy Q Ta Department of Microbiology, UVA Cancer Center, Immunology, and Cancer Biology

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Daniel Gioeli Department of Microbiology, UVA Cancer Center, Immunology, and Cancer Biology
Department of Microbiology, UVA Cancer Center, Immunology, and Cancer Biology

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Introduction Prostate cancer (PCa) is the second most common cancer among men worldwide, with over 1.1 million new cases of PCa reported in 2012 ( www.cancer.org ). When PCa initially presents in the clinic, the tumor is dependent on androgen for

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Jiyoung Park Department of Internal Medicine, Department of Cell Biology, Simmons Cancer Center, Touchstone Diabetes Center

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Philipp E Scherer Department of Internal Medicine, Department of Cell Biology, Simmons Cancer Center, Touchstone Diabetes Center
Department of Internal Medicine, Department of Cell Biology, Simmons Cancer Center, Touchstone Diabetes Center
Department of Internal Medicine, Department of Cell Biology, Simmons Cancer Center, Touchstone Diabetes Center

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Introduction A large number of epidemiological studies on cancer incidence link the propensity to develop certain types of cancers (e.g. colon, thyroid, esophagus, renal, endometrial, and postmenopausal breast cancer) with an individual's excess

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Abigail Read The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK
Division of Molecular Pathology, The Institute of Cancer Research, London, UK

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Rachael Natrajan The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK
Division of Molecular Pathology, The Institute of Cancer Research, London, UK

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Introduction Dysregulation of alternative splicing (AS) is widely considered a new hallmark of cancer and its products are being acknowledged as potentially useful biomarkers ( Ladomery 2013 ). Canonical RNA splicing takes place in all

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Cindy H Chau Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA

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Cathee Till SWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

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Douglas K Price Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA

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Phyllis J Goodman SWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

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Marian L Neuhouser Cancer Prevention Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

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Michael N Pollak Department of Oncology and Medicine, McGill University, Montreal, Canada

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Ian M Thompson CHRISTUS Santa Rosa Hospital Medical Center, San Antonio, Texas, USA

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William D Figg Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA

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Introduction Prostate cancer is the most common non-cutaneous malignancy and the second leading cause of cancer deaths among men in the United States (US), with approximately 248,530 new cases and about 34,130 men expected to die of the

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S Prekovic Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands

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T Van den Broeck Laboratory of Molecular Endocrinology, KU Leuven, Leuven, Belgium
Department of Urology, University Hospitals Leuven, Leuven, Belgium

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S Linder Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands

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M E van Royen Department of Pathology, Erasmus MC, Rotterdam, The Netherlands
Erasmus Optical Imaging Centre, Erasmus MC, Rotterdam, The Netherlands

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A B Houtsmuller Department of Pathology, Erasmus MC, Rotterdam, The Netherlands
Erasmus Optical Imaging Centre, Erasmus MC, Rotterdam, The Netherlands

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F Handle Laboratory of Molecular Endocrinology, KU Leuven, Leuven, Belgium

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S Joniau Department of Urology, University Hospitals Leuven, Leuven, Belgium

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W Zwart Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands
Department of Biomedical Engineering, Laboratory of Chemical Biology and Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, The Netherlands

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F Claessens Laboratory of Molecular Endocrinology, KU Leuven, Leuven, Belgium

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Introduction Metastatic prostate cancer (PCa) is an incurable disease with relative 5-year survival rate of 29% ( Sartor & de Bono 2018 ). While current therapies are effective at slowing down progression of the disease, eradication of

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Melissa Gamat University of Wisconsin Carbone Cancer Center, Madison, Wisconsin, USA

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Douglas G McNeel University of Wisconsin Carbone Cancer Center, Madison, Wisconsin, USA

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Introduction Prostate cancer is the most common cancer in men, and the second most common cause of cancer death in men in the United States ( Siegel et al. 2016 ). Androgen deprivation therapy (ADT), using surgical or chemical castration, is

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P Kauraniemi
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A Kallioniemi
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Introduction The ERBB2 ( neu / HER2 ) oncogene, located at chromosome 17q12, is one of the most intensively studied genes in cancer, especially in breast cancer. ERBB2 encodes for a 185 kDa transmembrane glycoprotein that belongs

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