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Cera M Nieto Department of Pharmacology University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA

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Leah C Rider Department of Pharmacology University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA

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Scott D Cramer Department of Pharmacology University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA

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via androgen-regulated growth factors such as TGFβ1 and insulin-like growth factor 1 (IGF1; Jiang et al . 2011 ). In Fig. 1 , a schematic of androgen-regulated signaling pathways in prostate cancer is shown. CAFs from both the peripheral and

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Sefirin Djiogue Department of Animal Biology and Physiology, Biomedical Research Center, Department of Biomedical Sciences, Laboratory of Cytometry, Department of Veterinary Anatomy, Optometry, University of Yaoundé 1, PO Box 812, Yaoundé, Cameroon

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Armel Hervé Nwabo Kamdje Department of Animal Biology and Physiology, Biomedical Research Center, Department of Biomedical Sciences, Laboratory of Cytometry, Department of Veterinary Anatomy, Optometry, University of Yaoundé 1, PO Box 812, Yaoundé, Cameroon
Department of Animal Biology and Physiology, Biomedical Research Center, Department of Biomedical Sciences, Laboratory of Cytometry, Department of Veterinary Anatomy, Optometry, University of Yaoundé 1, PO Box 812, Yaoundé, Cameroon

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Lorella Vecchio Department of Animal Biology and Physiology, Biomedical Research Center, Department of Biomedical Sciences, Laboratory of Cytometry, Department of Veterinary Anatomy, Optometry, University of Yaoundé 1, PO Box 812, Yaoundé, Cameroon

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Maulilio John Kipanyula Department of Animal Biology and Physiology, Biomedical Research Center, Department of Biomedical Sciences, Laboratory of Cytometry, Department of Veterinary Anatomy, Optometry, University of Yaoundé 1, PO Box 812, Yaoundé, Cameroon

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Mohammed Farahna Department of Animal Biology and Physiology, Biomedical Research Center, Department of Biomedical Sciences, Laboratory of Cytometry, Department of Veterinary Anatomy, Optometry, University of Yaoundé 1, PO Box 812, Yaoundé, Cameroon

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Yousef Aldebasi Department of Animal Biology and Physiology, Biomedical Research Center, Department of Biomedical Sciences, Laboratory of Cytometry, Department of Veterinary Anatomy, Optometry, University of Yaoundé 1, PO Box 812, Yaoundé, Cameroon

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Paul Faustin Seke Etet Department of Animal Biology and Physiology, Biomedical Research Center, Department of Biomedical Sciences, Laboratory of Cytometry, Department of Veterinary Anatomy, Optometry, University of Yaoundé 1, PO Box 812, Yaoundé, Cameroon

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epidermal growth factor . Cancer Research 54 5474 – 5478 . Darago A Sapota A Matych J Nasiadek M Skrzypinska-Gawrysiak M Kilanowicz A 2011 The correlation between zinc and insulin-like growth factor 1 (IGF-1), its binding protein (IGFBP

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Dawei Wu Department of Pathophysiology, College of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning, China

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Dongwei Lv Department of Sports Medicine, College of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning, China

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Ting Zhang Department of Pathophysiology, College of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning, China

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Lianying Guo Department of Pathophysiology, College of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning, China

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Fangli Ma Department of Pathophysiology, College of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning, China

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Caihua Zhang Department of Pathophysiology, College of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning, China

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Guofeng Lv Department of Sports Medicine, College of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning, China

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Lin Huang Department of Pathophysiology, College of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning, China

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integration site 1 gene ( FLI1 ). The resulting EWS-FLI1 fusion protein induces insulin-like growth factor 1 (IGF1) expression and suppresses the expression of insulin-like growth factor-binding protein 3 (IGFBP3) ( Prieur et al . 2004 , France et al . 2011

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Kathrin A Schmohl Department of Internal Medicine II, Medizinische Klinik und Poliklinik IV, Department of Biology II, Leibniz Institute for Environmental Medicine, Department of Nuclear Medicine, University Medical Center Hamburg‐Eppendorf, University Hospital of Munich, Munich, Germany

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Andrea M Müller Department of Internal Medicine II, Medizinische Klinik und Poliklinik IV, Department of Biology II, Leibniz Institute for Environmental Medicine, Department of Nuclear Medicine, University Medical Center Hamburg‐Eppendorf, University Hospital of Munich, Munich, Germany

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Alexandra Wechselberger Department of Internal Medicine II, Medizinische Klinik und Poliklinik IV, Department of Biology II, Leibniz Institute for Environmental Medicine, Department of Nuclear Medicine, University Medical Center Hamburg‐Eppendorf, University Hospital of Munich, Munich, Germany

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Svenja Rühland Department of Internal Medicine II, Medizinische Klinik und Poliklinik IV, Department of Biology II, Leibniz Institute for Environmental Medicine, Department of Nuclear Medicine, University Medical Center Hamburg‐Eppendorf, University Hospital of Munich, Munich, Germany
Department of Internal Medicine II, Medizinische Klinik und Poliklinik IV, Department of Biology II, Leibniz Institute for Environmental Medicine, Department of Nuclear Medicine, University Medical Center Hamburg‐Eppendorf, University Hospital of Munich, Munich, Germany

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Nicole Salb Department of Internal Medicine II, Medizinische Klinik und Poliklinik IV, Department of Biology II, Leibniz Institute for Environmental Medicine, Department of Nuclear Medicine, University Medical Center Hamburg‐Eppendorf, University Hospital of Munich, Munich, Germany

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Nathalie Schwenk Department of Internal Medicine II, Medizinische Klinik und Poliklinik IV, Department of Biology II, Leibniz Institute for Environmental Medicine, Department of Nuclear Medicine, University Medical Center Hamburg‐Eppendorf, University Hospital of Munich, Munich, Germany

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Heike Heuer Department of Internal Medicine II, Medizinische Klinik und Poliklinik IV, Department of Biology II, Leibniz Institute for Environmental Medicine, Department of Nuclear Medicine, University Medical Center Hamburg‐Eppendorf, University Hospital of Munich, Munich, Germany

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Janette Carlsen Department of Internal Medicine II, Medizinische Klinik und Poliklinik IV, Department of Biology II, Leibniz Institute for Environmental Medicine, Department of Nuclear Medicine, University Medical Center Hamburg‐Eppendorf, University Hospital of Munich, Munich, Germany

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Burkhard Göke Department of Internal Medicine II, Medizinische Klinik und Poliklinik IV, Department of Biology II, Leibniz Institute for Environmental Medicine, Department of Nuclear Medicine, University Medical Center Hamburg‐Eppendorf, University Hospital of Munich, Munich, Germany
Department of Internal Medicine II, Medizinische Klinik und Poliklinik IV, Department of Biology II, Leibniz Institute for Environmental Medicine, Department of Nuclear Medicine, University Medical Center Hamburg‐Eppendorf, University Hospital of Munich, Munich, Germany

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Peter J Nelson Department of Internal Medicine II, Medizinische Klinik und Poliklinik IV, Department of Biology II, Leibniz Institute for Environmental Medicine, Department of Nuclear Medicine, University Medical Center Hamburg‐Eppendorf, University Hospital of Munich, Munich, Germany

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Christine Spitzweg Department of Internal Medicine II, Medizinische Klinik und Poliklinik IV, Department of Biology II, Leibniz Institute for Environmental Medicine, Department of Nuclear Medicine, University Medical Center Hamburg‐Eppendorf, University Hospital of Munich, Munich, Germany

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growing evidence that thyroid hormones increase the motility of αvβ3-expressing immune cells, and, possibly by similar mechanisms, nerve cell migration ( De Vito et al . 2012 ). An array of growth factors, including PDGF, insulin-like growth factor 1 (IGF

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Liliya Rostomyan Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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Adrian F Daly Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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Patrick Petrossians Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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Emil Nachev Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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Anurag R Lila Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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Anne-Lise Lecoq Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium
Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium
Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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Beatriz Lecumberri Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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Giampaolo Trivellin Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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Roberto Salvatori Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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Andreas G Moraitis Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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Ian Holdaway Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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Dianne J Kranenburg - van Klaveren Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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Maria Chiara Zatelli Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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Nuria Palacios Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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Cecile Nozieres Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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Margaret Zacharin Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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Tapani Ebeling Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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Marja Ojaniemi Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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Liudmila Rozhinskaya Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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Elisa Verrua Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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Marie-Lise Jaffrain-Rea Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium
Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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Silvia Filipponi Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium
Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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Daria Gusakova Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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Vyacheslav Pronin Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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Jerome Bertherat Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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Zhanna Belaya Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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Irena Ilovayskaya Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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Mona Sahnoun-Fathallah Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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Caroline Sievers Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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Gunter K Stalla Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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Emilie Castermans Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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Jean-Hubert Caberg Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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Ekaterina Sorkina Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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Renata Simona Auriemma Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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Sachin Mittal Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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Maria Kareva Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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Philippe A Lysy Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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Philippe Emy Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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Ernesto De Menis Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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Catherine S Choong Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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Giovanna Mantovani Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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Vincent Bours Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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Wouter De Herder Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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Thierry Brue Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium
Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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Anne Barlier Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium
Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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Sebastian J C M M Neggers Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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Sabina Zacharieva Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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Philippe Chanson Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium
Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium
Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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Nalini Samir Shah Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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Constantine A Stratakis Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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Luciana A Naves Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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Albert Beckers Departments of Endocrinology and Human Genetics, Clinical Center of Endocrinology and Gerontology, Department of Endocrinology, Assistance Publique‐Hôpitaux de Paris, UMR S1185, INSERM U1185, Servicio de Endocrinología y Nutrición, Section on Endocrinology and Genetics, Division of Endocrinology, Department of Endocrinology, Section of Endocrinology, Section of Endocrinology and Internal Medicine, Servicio de Endocrinología, Service d'endocrinologie‐diabétologie, Murdoch Children's Research Institute, Departments of Internal Medicine and Pediatrics, Departments of Neuroendocrinology and Bone Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Biotechnological and Applied Clinical Sciences, Neuromed IRCCS, Andrology Department, Endocrinology Clinic, INSERM U1016, Endocrinology Department, Aix‐Marseille Université, Department of Endocrinology, Dipartimento di Medicina Clinica e Chirurgia, Department of Endocrinology, Pediatric Endocrinology Unit, Service D'endocrinologie, Endocrinology, Department of Paediatric Endocrinology, Department of Endocrinology, Laboratory of Molecular Biology, Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

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age (>97th percentile, which corresponds to >+2 s.d. ), or a final height >+2 s.d. above the mean for relevant population, associated with elevated GH/insulin-like growth factor 1 (IGF1) and imaging evidence of a pituitary lesion. Details on height

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Barbara Salani Department of Internal Medicine (DIMI), IRCCS Azienda Ospedaliera Universitaria San Martino – IST Istituto Nazionale per la Ricerca sul Cancro, Department of Experimental, CNR Institute of Organic Synthesis and Photoreactivity (ISOF), CNR Institute of Molecular Bioimaging and Physiology (IBFM), Department of Health Science (DISSAL), University of Genova, Viale Benedetto XV/6, 16132 Genova, Italy
Department of Internal Medicine (DIMI), IRCCS Azienda Ospedaliera Universitaria San Martino – IST Istituto Nazionale per la Ricerca sul Cancro, Department of Experimental, CNR Institute of Organic Synthesis and Photoreactivity (ISOF), CNR Institute of Molecular Bioimaging and Physiology (IBFM), Department of Health Science (DISSAL), University of Genova, Viale Benedetto XV/6, 16132 Genova, Italy

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Alberto Del Rio Department of Internal Medicine (DIMI), IRCCS Azienda Ospedaliera Universitaria San Martino – IST Istituto Nazionale per la Ricerca sul Cancro, Department of Experimental, CNR Institute of Organic Synthesis and Photoreactivity (ISOF), CNR Institute of Molecular Bioimaging and Physiology (IBFM), Department of Health Science (DISSAL), University of Genova, Viale Benedetto XV/6, 16132 Genova, Italy
Department of Internal Medicine (DIMI), IRCCS Azienda Ospedaliera Universitaria San Martino – IST Istituto Nazionale per la Ricerca sul Cancro, Department of Experimental, CNR Institute of Organic Synthesis and Photoreactivity (ISOF), CNR Institute of Molecular Bioimaging and Physiology (IBFM), Department of Health Science (DISSAL), University of Genova, Viale Benedetto XV/6, 16132 Genova, Italy

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Cecilia Marini Department of Internal Medicine (DIMI), IRCCS Azienda Ospedaliera Universitaria San Martino – IST Istituto Nazionale per la Ricerca sul Cancro, Department of Experimental, CNR Institute of Organic Synthesis and Photoreactivity (ISOF), CNR Institute of Molecular Bioimaging and Physiology (IBFM), Department of Health Science (DISSAL), University of Genova, Viale Benedetto XV/6, 16132 Genova, Italy

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Gianmario Sambuceti Department of Internal Medicine (DIMI), IRCCS Azienda Ospedaliera Universitaria San Martino – IST Istituto Nazionale per la Ricerca sul Cancro, Department of Experimental, CNR Institute of Organic Synthesis and Photoreactivity (ISOF), CNR Institute of Molecular Bioimaging and Physiology (IBFM), Department of Health Science (DISSAL), University of Genova, Viale Benedetto XV/6, 16132 Genova, Italy
Department of Internal Medicine (DIMI), IRCCS Azienda Ospedaliera Universitaria San Martino – IST Istituto Nazionale per la Ricerca sul Cancro, Department of Experimental, CNR Institute of Organic Synthesis and Photoreactivity (ISOF), CNR Institute of Molecular Bioimaging and Physiology (IBFM), Department of Health Science (DISSAL), University of Genova, Viale Benedetto XV/6, 16132 Genova, Italy

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Renzo Cordera Department of Internal Medicine (DIMI), IRCCS Azienda Ospedaliera Universitaria San Martino – IST Istituto Nazionale per la Ricerca sul Cancro, Department of Experimental, CNR Institute of Organic Synthesis and Photoreactivity (ISOF), CNR Institute of Molecular Bioimaging and Physiology (IBFM), Department of Health Science (DISSAL), University of Genova, Viale Benedetto XV/6, 16132 Genova, Italy
Department of Internal Medicine (DIMI), IRCCS Azienda Ospedaliera Universitaria San Martino – IST Istituto Nazionale per la Ricerca sul Cancro, Department of Experimental, CNR Institute of Organic Synthesis and Photoreactivity (ISOF), CNR Institute of Molecular Bioimaging and Physiology (IBFM), Department of Health Science (DISSAL), University of Genova, Viale Benedetto XV/6, 16132 Genova, Italy

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Davide Maggi Department of Internal Medicine (DIMI), IRCCS Azienda Ospedaliera Universitaria San Martino – IST Istituto Nazionale per la Ricerca sul Cancro, Department of Experimental, CNR Institute of Organic Synthesis and Photoreactivity (ISOF), CNR Institute of Molecular Bioimaging and Physiology (IBFM), Department of Health Science (DISSAL), University of Genova, Viale Benedetto XV/6, 16132 Genova, Italy
Department of Internal Medicine (DIMI), IRCCS Azienda Ospedaliera Universitaria San Martino – IST Istituto Nazionale per la Ricerca sul Cancro, Department of Experimental, CNR Institute of Organic Synthesis and Photoreactivity (ISOF), CNR Institute of Molecular Bioimaging and Physiology (IBFM), Department of Health Science (DISSAL), University of Genova, Viale Benedetto XV/6, 16132 Genova, Italy

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documented and associated also with decreased plasma concentrations of insulin-like growth factor 1 (IGF1) and insulin ( Pollak 2012 ). Thus, the actions of metformin are not exclusively mediated by inhibition of AMPK ( Watson 2014 ). Indeed, in recent years

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Robert X-D Song Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville, Virginia 22903, USA

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Ping Fan Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville, Virginia 22903, USA

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Wei Yue Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville, Virginia 22903, USA

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Yucai Chen Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville, Virginia 22903, USA

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Richard J Santen Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville, Virginia 22903, USA

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growth factor-1 (IGF-1)-induced uterine responses and in vivo evidence for IGF-1/estrogen receptor cross-talk. Journal of Biological Chemistry 277 8531 –8537. Knowlden JM , Hutcheson IR, Barrow D, Gee JM & Nicholson RI

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Tahmineh Tabrizian Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, USA
Institute for Aging Research, Albert Einstein College of Medicine, Bronx, New York, USA

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Donghai Wang Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, USA
Institute for Aging Research, Albert Einstein College of Medicine, Bronx, New York, USA
Division of Endocrinology, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA

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Fangxia Guan Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, USA
Institute for Aging Research, Albert Einstein College of Medicine, Bronx, New York, USA
Division of Endocrinology, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA

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Zunju Hu Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, USA
Institute for Aging Research, Albert Einstein College of Medicine, Bronx, New York, USA
Division of Endocrinology, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA

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Amanda P Beck Department of Obstetrics & Gynecology and Women’s Health, Albert Einstein College of Medicine, Bronx, New York, USA

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Fabien Delahaye Department of Genetics, Albert Einstein College of Medicine, Bronx, New York, USA
Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA

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Derek M Huffman Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, USA
Institute for Aging Research, Albert Einstein College of Medicine, Bronx, New York, USA
Division of Endocrinology, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA

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-0414 ) Huffman DM Farias Quipildor G Mao K Zhang X Wan J Apontes P Cohen P Barzilai N 2016 Central insulin-like growth factor-1 (IGF-1) restores whole-body insulin action in a model of age-related insulin resistance and IGF-1

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James F Powers Department of Pathology and Laboratory Medicine, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA

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Brent Cochran Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, Massachusetts, USA

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James D Baleja Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, Massachusetts, USA

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Hadley D Sikes Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

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Xue Zhang Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, Massachusetts, USA

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Inna Lomakin Department of Pathology and Laboratory Medicine, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA

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Troy Langford Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

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Kassi Taylor Stein Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

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Arthur S Tischler Department of Pathology and Laboratory Medicine, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA

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37°C in a water-saturated atmosphere. Growth factors and inhibitors Stem cell factor (SCF, also known as KIT ligand) was obtained from Cell Signaling Technologies. Recombinant human insulin-like growth factor 1 (IGF1) was from Abcam. ERK

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Marie-Lise Jaffrain-Rea Department of Biotechnological and Applied Clinical Sciences, Department of Neurological Sciences, Endocrinology, CNRS, AP‐HM, Endocrinology and Diabetology Unit, Endocrinology, Department of Neurology and Psychiatry, INSERM, AP‐HM, Department of Radiology, University of L'Aquila, Via Vetoio, Coppito 2, 67100 L'Aquila, Italy
Department of Biotechnological and Applied Clinical Sciences, Department of Neurological Sciences, Endocrinology, CNRS, AP‐HM, Endocrinology and Diabetology Unit, Endocrinology, Department of Neurology and Psychiatry, INSERM, AP‐HM, Department of Radiology, University of L'Aquila, Via Vetoio, Coppito 2, 67100 L'Aquila, Italy

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Sandra Rotondi Department of Biotechnological and Applied Clinical Sciences, Department of Neurological Sciences, Endocrinology, CNRS, AP‐HM, Endocrinology and Diabetology Unit, Endocrinology, Department of Neurology and Psychiatry, INSERM, AP‐HM, Department of Radiology, University of L'Aquila, Via Vetoio, Coppito 2, 67100 L'Aquila, Italy

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Annarita Turchi Department of Biotechnological and Applied Clinical Sciences, Department of Neurological Sciences, Endocrinology, CNRS, AP‐HM, Endocrinology and Diabetology Unit, Endocrinology, Department of Neurology and Psychiatry, INSERM, AP‐HM, Department of Radiology, University of L'Aquila, Via Vetoio, Coppito 2, 67100 L'Aquila, Italy

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Gianluca Occhi Department of Biotechnological and Applied Clinical Sciences, Department of Neurological Sciences, Endocrinology, CNRS, AP‐HM, Endocrinology and Diabetology Unit, Endocrinology, Department of Neurology and Psychiatry, INSERM, AP‐HM, Department of Radiology, University of L'Aquila, Via Vetoio, Coppito 2, 67100 L'Aquila, Italy

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Anne Barlier Department of Biotechnological and Applied Clinical Sciences, Department of Neurological Sciences, Endocrinology, CNRS, AP‐HM, Endocrinology and Diabetology Unit, Endocrinology, Department of Neurology and Psychiatry, INSERM, AP‐HM, Department of Radiology, University of L'Aquila, Via Vetoio, Coppito 2, 67100 L'Aquila, Italy
Department of Biotechnological and Applied Clinical Sciences, Department of Neurological Sciences, Endocrinology, CNRS, AP‐HM, Endocrinology and Diabetology Unit, Endocrinology, Department of Neurology and Psychiatry, INSERM, AP‐HM, Department of Radiology, University of L'Aquila, Via Vetoio, Coppito 2, 67100 L'Aquila, Italy

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Erika Peverelli Department of Biotechnological and Applied Clinical Sciences, Department of Neurological Sciences, Endocrinology, CNRS, AP‐HM, Endocrinology and Diabetology Unit, Endocrinology, Department of Neurology and Psychiatry, INSERM, AP‐HM, Department of Radiology, University of L'Aquila, Via Vetoio, Coppito 2, 67100 L'Aquila, Italy

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Lilya Rostomyan Department of Biotechnological and Applied Clinical Sciences, Department of Neurological Sciences, Endocrinology, CNRS, AP‐HM, Endocrinology and Diabetology Unit, Endocrinology, Department of Neurology and Psychiatry, INSERM, AP‐HM, Department of Radiology, University of L'Aquila, Via Vetoio, Coppito 2, 67100 L'Aquila, Italy

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Céline Defilles Department of Biotechnological and Applied Clinical Sciences, Department of Neurological Sciences, Endocrinology, CNRS, AP‐HM, Endocrinology and Diabetology Unit, Endocrinology, Department of Neurology and Psychiatry, INSERM, AP‐HM, Department of Radiology, University of L'Aquila, Via Vetoio, Coppito 2, 67100 L'Aquila, Italy

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Mariolina Angelini Department of Biotechnological and Applied Clinical Sciences, Department of Neurological Sciences, Endocrinology, CNRS, AP‐HM, Endocrinology and Diabetology Unit, Endocrinology, Department of Neurology and Psychiatry, INSERM, AP‐HM, Department of Radiology, University of L'Aquila, Via Vetoio, Coppito 2, 67100 L'Aquila, Italy

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Maria-Antonietta Oliva Department of Biotechnological and Applied Clinical Sciences, Department of Neurological Sciences, Endocrinology, CNRS, AP‐HM, Endocrinology and Diabetology Unit, Endocrinology, Department of Neurology and Psychiatry, INSERM, AP‐HM, Department of Radiology, University of L'Aquila, Via Vetoio, Coppito 2, 67100 L'Aquila, Italy

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Filippo Ceccato Department of Biotechnological and Applied Clinical Sciences, Department of Neurological Sciences, Endocrinology, CNRS, AP‐HM, Endocrinology and Diabetology Unit, Endocrinology, Department of Neurology and Psychiatry, INSERM, AP‐HM, Department of Radiology, University of L'Aquila, Via Vetoio, Coppito 2, 67100 L'Aquila, Italy

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Orlando Maiorani Department of Biotechnological and Applied Clinical Sciences, Department of Neurological Sciences, Endocrinology, CNRS, AP‐HM, Endocrinology and Diabetology Unit, Endocrinology, Department of Neurology and Psychiatry, INSERM, AP‐HM, Department of Radiology, University of L'Aquila, Via Vetoio, Coppito 2, 67100 L'Aquila, Italy

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Adrian F Daly Department of Biotechnological and Applied Clinical Sciences, Department of Neurological Sciences, Endocrinology, CNRS, AP‐HM, Endocrinology and Diabetology Unit, Endocrinology, Department of Neurology and Psychiatry, INSERM, AP‐HM, Department of Radiology, University of L'Aquila, Via Vetoio, Coppito 2, 67100 L'Aquila, Italy

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Vincenzo Esposito Department of Biotechnological and Applied Clinical Sciences, Department of Neurological Sciences, Endocrinology, CNRS, AP‐HM, Endocrinology and Diabetology Unit, Endocrinology, Department of Neurology and Psychiatry, INSERM, AP‐HM, Department of Radiology, University of L'Aquila, Via Vetoio, Coppito 2, 67100 L'Aquila, Italy
Department of Biotechnological and Applied Clinical Sciences, Department of Neurological Sciences, Endocrinology, CNRS, AP‐HM, Endocrinology and Diabetology Unit, Endocrinology, Department of Neurology and Psychiatry, INSERM, AP‐HM, Department of Radiology, University of L'Aquila, Via Vetoio, Coppito 2, 67100 L'Aquila, Italy

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Francesca Buttarelli Department of Biotechnological and Applied Clinical Sciences, Department of Neurological Sciences, Endocrinology, CNRS, AP‐HM, Endocrinology and Diabetology Unit, Endocrinology, Department of Neurology and Psychiatry, INSERM, AP‐HM, Department of Radiology, University of L'Aquila, Via Vetoio, Coppito 2, 67100 L'Aquila, Italy

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Dominique Figarella-Branger Department of Biotechnological and Applied Clinical Sciences, Department of Neurological Sciences, Endocrinology, CNRS, AP‐HM, Endocrinology and Diabetology Unit, Endocrinology, Department of Neurology and Psychiatry, INSERM, AP‐HM, Department of Radiology, University of L'Aquila, Via Vetoio, Coppito 2, 67100 L'Aquila, Italy
Department of Biotechnological and Applied Clinical Sciences, Department of Neurological Sciences, Endocrinology, CNRS, AP‐HM, Endocrinology and Diabetology Unit, Endocrinology, Department of Neurology and Psychiatry, INSERM, AP‐HM, Department of Radiology, University of L'Aquila, Via Vetoio, Coppito 2, 67100 L'Aquila, Italy

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Felice Giangaspero Department of Biotechnological and Applied Clinical Sciences, Department of Neurological Sciences, Endocrinology, CNRS, AP‐HM, Endocrinology and Diabetology Unit, Endocrinology, Department of Neurology and Psychiatry, INSERM, AP‐HM, Department of Radiology, University of L'Aquila, Via Vetoio, Coppito 2, 67100 L'Aquila, Italy
Department of Biotechnological and Applied Clinical Sciences, Department of Neurological Sciences, Endocrinology, CNRS, AP‐HM, Endocrinology and Diabetology Unit, Endocrinology, Department of Neurology and Psychiatry, INSERM, AP‐HM, Department of Radiology, University of L'Aquila, Via Vetoio, Coppito 2, 67100 L'Aquila, Italy

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Anna Spada Department of Biotechnological and Applied Clinical Sciences, Department of Neurological Sciences, Endocrinology, CNRS, AP‐HM, Endocrinology and Diabetology Unit, Endocrinology, Department of Neurology and Psychiatry, INSERM, AP‐HM, Department of Radiology, University of L'Aquila, Via Vetoio, Coppito 2, 67100 L'Aquila, Italy

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Carla Scaroni Department of Biotechnological and Applied Clinical Sciences, Department of Neurological Sciences, Endocrinology, CNRS, AP‐HM, Endocrinology and Diabetology Unit, Endocrinology, Department of Neurology and Psychiatry, INSERM, AP‐HM, Department of Radiology, University of L'Aquila, Via Vetoio, Coppito 2, 67100 L'Aquila, Italy

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Edoardo Alesse Department of Biotechnological and Applied Clinical Sciences, Department of Neurological Sciences, Endocrinology, CNRS, AP‐HM, Endocrinology and Diabetology Unit, Endocrinology, Department of Neurology and Psychiatry, INSERM, AP‐HM, Department of Radiology, University of L'Aquila, Via Vetoio, Coppito 2, 67100 L'Aquila, Italy

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Albert Beckers Department of Biotechnological and Applied Clinical Sciences, Department of Neurological Sciences, Endocrinology, CNRS, AP‐HM, Endocrinology and Diabetology Unit, Endocrinology, Department of Neurology and Psychiatry, INSERM, AP‐HM, Department of Radiology, University of L'Aquila, Via Vetoio, Coppito 2, 67100 L'Aquila, Italy

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, 25 were males and 37 were females, with a mean age of 44.8±12.8 years at surgery (median 44.5 years and range 18–78 years). Patients' clinical, biological and neuroradiological data were recorded. GH, prolactin (PRL) and insulin-like growth factor 1

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