Search Results
Search for other papers by Thomas Ho Lai Yau in
Google Scholar
PubMed
Search for other papers by Kwok-Leung Cheung in
Google Scholar
PubMed
phosphoinositide 3-kinase/v-akt murine thymoma viral oncogene/mammalian target of rapamycin (PI3K/AKT/mTOR) can result in continued proliferation of the cancer cells and hence develop resistance to ET ( Dixon 2014 ). Targeted therapy agents (TAs) are designed to
Laboratorio de Endocrinología Molecular y Celular, CIBER Fisiopatología de la Obesidad y Nutrición (CB06/03), Department of Endocrinology, Departamento de Medicina, Instituto de Investigaciones Sanitarias, Complejo Hospitalario Universitario de Santiago (CHUS), A Choupana, s/n., 15706 Santiago de Compostela, Spain
Search for other papers by Carlos J P Álvarez in
Google Scholar
PubMed
Laboratorio de Endocrinología Molecular y Celular, CIBER Fisiopatología de la Obesidad y Nutrición (CB06/03), Department of Endocrinology, Departamento de Medicina, Instituto de Investigaciones Sanitarias, Complejo Hospitalario Universitario de Santiago (CHUS), A Choupana, s/n., 15706 Santiago de Compostela, Spain
Search for other papers by María Lodeiro in
Google Scholar
PubMed
Laboratorio de Endocrinología Molecular y Celular, CIBER Fisiopatología de la Obesidad y Nutrición (CB06/03), Department of Endocrinology, Departamento de Medicina, Instituto de Investigaciones Sanitarias, Complejo Hospitalario Universitario de Santiago (CHUS), A Choupana, s/n., 15706 Santiago de Compostela, Spain
Search for other papers by Marily Theodoropoulou in
Google Scholar
PubMed
Laboratorio de Endocrinología Molecular y Celular, CIBER Fisiopatología de la Obesidad y Nutrición (CB06/03), Department of Endocrinology, Departamento de Medicina, Instituto de Investigaciones Sanitarias, Complejo Hospitalario Universitario de Santiago (CHUS), A Choupana, s/n., 15706 Santiago de Compostela, Spain
Search for other papers by Jesús P Camiña in
Google Scholar
PubMed
Laboratorio de Endocrinología Molecular y Celular, CIBER Fisiopatología de la Obesidad y Nutrición (CB06/03), Department of Endocrinology, Departamento de Medicina, Instituto de Investigaciones Sanitarias, Complejo Hospitalario Universitario de Santiago (CHUS), A Choupana, s/n., 15706 Santiago de Compostela, Spain
Laboratorio de Endocrinología Molecular y Celular, CIBER Fisiopatología de la Obesidad y Nutrición (CB06/03), Department of Endocrinology, Departamento de Medicina, Instituto de Investigaciones Sanitarias, Complejo Hospitalario Universitario de Santiago (CHUS), A Choupana, s/n., 15706 Santiago de Compostela, Spain
Search for other papers by Felipe F Casanueva in
Google Scholar
PubMed
Laboratorio de Endocrinología Molecular y Celular, CIBER Fisiopatología de la Obesidad y Nutrición (CB06/03), Department of Endocrinology, Departamento de Medicina, Instituto de Investigaciones Sanitarias, Complejo Hospitalario Universitario de Santiago (CHUS), A Choupana, s/n., 15706 Santiago de Compostela, Spain
Search for other papers by Yolanda Pazos in
Google Scholar
PubMed
antibodies to phospho-p44/42 mitogen-activated protein kinases (MAPK), p44/42 MAPK, phospho-Src(Y416), phospho-Akt HM(S473), phospho-Akt A-loop(T308), Akt, Rictor, phospho-mTOR (S2448), phospho-p70S6K1(T389), phospho-PDK1 (S241), Rictor siRNA and control
Search for other papers by R J Santen in
Google Scholar
PubMed
Search for other papers by R X Song in
Google Scholar
PubMed
Search for other papers by Z Zhang in
Google Scholar
PubMed
Search for other papers by R Kumar in
Google Scholar
PubMed
Search for other papers by M-H Jeng in
Google Scholar
PubMed
Search for other papers by A Masamura in
Google Scholar
PubMed
Search for other papers by J Lawrence Jr in
Google Scholar
PubMed
Search for other papers by L Berstein in
Google Scholar
PubMed
Search for other papers by W Yue in
Google Scholar
PubMed
specific proteins were scanned and relative optical densities of bands were determined using a Molecular Dynamics scanner and ImageQuant program ( Yue et al. 2002 ). Mammalian target of rapamycin (mTOR) studies The
Section of Endocrinology, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
Search for other papers by T Vandamme in
Google Scholar
PubMed
Search for other papers by M Beyens in
Google Scholar
PubMed
Search for other papers by G Boons in
Google Scholar
PubMed
Search for other papers by A Schepers in
Google Scholar
PubMed
Search for other papers by K Kamp in
Google Scholar
PubMed
Search for other papers by K Biermann in
Google Scholar
PubMed
Search for other papers by P Pauwels in
Google Scholar
PubMed
Search for other papers by W W De Herder in
Google Scholar
PubMed
Search for other papers by L J Hofland in
Google Scholar
PubMed
Search for other papers by M Peeters in
Google Scholar
PubMed
Search for other papers by G Van Camp in
Google Scholar
PubMed
Search for other papers by K Op de Beeck in
Google Scholar
PubMed
(PI3K/Akt/mTOR) pathway were found in 12–14% of tumors ( Jiao et al . 2011 , Scarpa et al . 2017 ). In the pivotal Radiant-3 trial, treatment with everolimus, an mTOR inhibitor, has demonstrated an improved progression-free survival in advanced
Department of Internal Medicine 2, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Internal Medicine 4, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Search for other papers by Elke Tatjana Aristizabal Prada in
Google Scholar
PubMed
Department of Internal Medicine 2, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Search for other papers by Vera Heinzle in
Google Scholar
PubMed
Institute of Pathology, Ludwig-Maximilians-University of Munich, Munich, Germany
Search for other papers by Thomas Knösel in
Google Scholar
PubMed
Department of Internal Medicine 2, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Internal Medicine 4, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Search for other papers by Svenja Nölting in
Google Scholar
PubMed
Department of Internal Medicine 2, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Internal Medicine 4, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Search for other papers by Gerald Spöttl in
Google Scholar
PubMed
Department of Internal Medicine 2, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Internal Medicine 4, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Search for other papers by Julian Maurer in
Google Scholar
PubMed
Department of Internal Medicine 2, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Internal Medicine 4, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Search for other papers by Christine Spitzweg in
Google Scholar
PubMed
Department of General, Visceral, Transplantation, Vascular and Thoracic Surgery, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Search for other papers by Martin Angele in
Google Scholar
PubMed
Department of Internal Medicine 2, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Internal Medicine 4, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Search for other papers by Nina Schmidt in
Google Scholar
PubMed
Klinik für Endokrinologie, Diabetologie und Klinische Ernährung, Universitätsspital Zürich, Zurich, Switzerland
Search for other papers by Felix Beuschlein in
Google Scholar
PubMed
Search for other papers by Günter K Stalla in
Google Scholar
PubMed
Search for other papers by Rainer Blaser in
Google Scholar
PubMed
Search for other papers by Klaus A Kuhn in
Google Scholar
PubMed
Department of Internal Medicine 2, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Internal Medicine 4, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Search for other papers by Christoph J Auernhammer in
Google Scholar
PubMed
-Raf-MEK-ERK, the PI3K-Akt-mTOR, the PLCγ-1 and the PKC pathway ( Huang & Reichardt 2003 , Amatu et al . 2016 ). The Trk receptor family has been demonstrated to be implicated in the growth of many different types of cancer, for example, oral squamous cell
Search for other papers by Bruno Heidi Nozima in
Google Scholar
PubMed
Search for other papers by Thais Biude Mendes in
Google Scholar
PubMed
Search for other papers by Gustavo José da Silva Pereira in
Google Scholar
PubMed
Search for other papers by Rodrigo Pinheiro Araldi in
Google Scholar
PubMed
Search for other papers by Edna Sadayo Miazato Iwamura in
Google Scholar
PubMed
Search for other papers by Soraya Soubhi Smaili in
Google Scholar
PubMed
Search for other papers by Gianna Maria Griz Carvalheira in
Google Scholar
PubMed
Search for other papers by Janete Maria Cerutti in
Google Scholar
PubMed
al. 2004 ). Others have showed that FAM129A is induced under endoplasmic reticulum (ER) stress in few cell types such as liver, kidney and cerebrum and may function to link and coordinate ER stress and mTOR/S6K1 pathway ( Sun et al. 2007
Search for other papers by Dawei Wu in
Google Scholar
PubMed
Search for other papers by Dongwei Lv in
Google Scholar
PubMed
Search for other papers by Ting Zhang in
Google Scholar
PubMed
Search for other papers by Lianying Guo in
Google Scholar
PubMed
Search for other papers by Fangli Ma in
Google Scholar
PubMed
Search for other papers by Caihua Zhang in
Google Scholar
PubMed
Search for other papers by Guofeng Lv in
Google Scholar
PubMed
Search for other papers by Lin Huang in
Google Scholar
PubMed
purchased for the detection of β-actin (AC-15; Sigma); PRAS40 (Invitrogen); cleaved PARP, p-Akt (S473), p-PDK1, p-PRAS40 (T246), p-PI3K (p85), p-S6 ribosomal protein, p-mTOR (S2448), S6 ribosomal protein, p-IGF1R (Y1135/1136)/p-IR (Y1150/1151), S6, Akt, PI3K
Search for other papers by Eyun Song in
Google Scholar
PubMed
Search for other papers by Dong Eun Song in
Google Scholar
PubMed
Search for other papers by Jonghwa Ahn in
Google Scholar
PubMed
Search for other papers by Tae Yong Kim in
Google Scholar
PubMed
Search for other papers by Won Bae Kim in
Google Scholar
PubMed
Search for other papers by Young Kee Shong in
Google Scholar
PubMed
Search for other papers by Min Ji Jeon in
Google Scholar
PubMed
Search for other papers by Won Gu Kim in
Google Scholar
PubMed
members of PI3K/AKT/mTOR pathway. The mean depth of target lesions of each sample ranged from 155.6 to 2705.4. Results Tissue samples and clinical data A total of 82 tissues were available for genetic analyses from 64 patients as follows: 63
Search for other papers by Paramita M Ghosh in
Google Scholar
PubMed
Search for other papers by Shazli N Malik in
Google Scholar
PubMed
Search for other papers by Roble G Bedolla in
Google Scholar
PubMed
Search for other papers by Yu Wang in
Google Scholar
PubMed
Search for other papers by Margarita Mikhailova in
Google Scholar
PubMed
Search for other papers by Thomas J Prihoda in
Google Scholar
PubMed
Search for other papers by Dean A Troyer in
Google Scholar
PubMed
Search for other papers by Jeffrey I Kreisberg in
Google Scholar
PubMed
phosphorylation at multiple sites ( Grewe et al. 1999 ). p70 S6 kinase is phosphorylated by a phosphoinositide kinase-related kinase, mammalian target of rapamycin (mTOR) at Thr-389. This causes re-folding of the protein resulting in exposure of the Thr-229 site
Search for other papers by Lamis Yehia in
Google Scholar
PubMed
Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA
Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
Germline High Risk Cancer Focus Group, CASE Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA
Search for other papers by Charis Eng in
Google Scholar
PubMed
mutations in the PTEN tumor suppressor gene. Regardless of clinical phenotype, such individuals with germline PTEN mutations have PTEN hamartoma tumor syndrome. Interestingly, mutations in other genes that encode components of the PI3K/AKT/mTOR