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R Nawar
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D Aron
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the use of serum molecular markers A variety of tissue molecular markers, including mutant p53, the proliferation-associated antigen ki67 protein, and loss of heterozygocity at the 17p13 and 11p15 loci, have been used to distinguish malignant

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T Jardé Université Clermont 1, Centre Jean-Perrin, Université de Regensburg, Centre Jean-Perrin, UFR Pharmacie, EA4233, CLARA, CRNH-A, 63001 Clermont-Ferrand, France

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F Caldefie-Chézet Université Clermont 1, Centre Jean-Perrin, Université de Regensburg, Centre Jean-Perrin, UFR Pharmacie, EA4233, CLARA, CRNH-A, 63001 Clermont-Ferrand, France

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N Goncalves-Mendes Université Clermont 1, Centre Jean-Perrin, Université de Regensburg, Centre Jean-Perrin, UFR Pharmacie, EA4233, CLARA, CRNH-A, 63001 Clermont-Ferrand, France

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F Mishellany Université Clermont 1, Centre Jean-Perrin, Université de Regensburg, Centre Jean-Perrin, UFR Pharmacie, EA4233, CLARA, CRNH-A, 63001 Clermont-Ferrand, France

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C Buechler Université Clermont 1, Centre Jean-Perrin, Université de Regensburg, Centre Jean-Perrin, UFR Pharmacie, EA4233, CLARA, CRNH-A, 63001 Clermont-Ferrand, France

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F Penault-Llorca Université Clermont 1, Centre Jean-Perrin, Université de Regensburg, Centre Jean-Perrin, UFR Pharmacie, EA4233, CLARA, CRNH-A, 63001 Clermont-Ferrand, France

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M P Vasson Université Clermont 1, Centre Jean-Perrin, Université de Regensburg, Centre Jean-Perrin, UFR Pharmacie, EA4233, CLARA, CRNH-A, 63001 Clermont-Ferrand, France
Université Clermont 1, Centre Jean-Perrin, Université de Regensburg, Centre Jean-Perrin, UFR Pharmacie, EA4233, CLARA, CRNH-A, 63001 Clermont-Ferrand, France

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both on breast cancer cell proliferation, on the adiponectin and leptin pathways, and on the expression of molecular markers used to diagnose and gauge prognosis of breast cancer. Materials and methods Clinical study on breast cancer biopsies Breast

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Marc Diedisheim Université de Paris, Institut Cochin, Inserm U1016, CNRS UMR8104, F-75014, Paris, France
Department of Diabetology, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France

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Solène Dermine Université de Paris, Institut Cochin, Inserm U1016, CNRS UMR8104, F-75014, Paris, France
Department of Gastroenterology and Digestive Oncology, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France

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Anne Jouinot Université de Paris, Institut Cochin, Inserm U1016, CNRS UMR8104, F-75014, Paris, France
Department of Endocrinology, Center for Rare Adrenal Diseases, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France

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Amandine Septier Université de Paris, Institut Cochin, Inserm U1016, CNRS UMR8104, F-75014, Paris, France

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Sébastien Gaujoux Université de Paris, Institut Cochin, Inserm U1016, CNRS UMR8104, F-75014, Paris, France
Department of Digestive Surgery, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France

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Bertrand Dousset Université de Paris, Institut Cochin, Inserm U1016, CNRS UMR8104, F-75014, Paris, France
Department of Digestive Surgery, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France

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Guillaume Cadiot Department of Gastroenterology, Robert-Debré Hospital, Reims, France

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Etienne Larger Université de Paris, Institut Cochin, Inserm U1016, CNRS UMR8104, F-75014, Paris, France
Department of Diabetology, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France

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Jérôme Bertherat Université de Paris, Institut Cochin, Inserm U1016, CNRS UMR8104, F-75014, Paris, France
Department of Endocrinology, Center for Rare Adrenal Diseases, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France

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Raphael Scharfmann Université de Paris, Institut Cochin, Inserm U1016, CNRS UMR8104, F-75014, Paris, France

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Benoit Terris Université de Paris, Institut Cochin, Inserm U1016, CNRS UMR8104, F-75014, Paris, France
Department of Pathology, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France

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Romain Coriat Université de Paris, Institut Cochin, Inserm U1016, CNRS UMR8104, F-75014, Paris, France
Department of Gastroenterology and Digestive Oncology, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France

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Guillaume Assié Université de Paris, Institut Cochin, Inserm U1016, CNRS UMR8104, F-75014, Paris, France
Department of Endocrinology, Center for Rare Adrenal Diseases, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France

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genomic tools ( International Cancer Genome Consortium et al. 2010 , Weinstein et al. 2013 ). This effort transformed our understanding of cancer and provided molecular markers which are now included in clinical routine. This effort is still ongoing

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H E Jones
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J M W Gee
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K M Taylor
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D Barrow
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H D Williams
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M Rubini
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R I Nicholson
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improving efficacy and duration of response in a greater number of patients but additionally, delineate other molecular markers which may predict sensitivity to EGFR inhibitors such as gefitinib. Characteristics of acquired resistance to

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Theodoros Foukakis
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Arief Gusnanto
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Amy YM Au
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Anders Höög
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Weng-Onn Lui
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Catharina Larsson
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Göran Wallin
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Jan Zedenius
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-treatment of benign lesions. In the current study, 26 potential molecular markers were evaluated by qRT-PCR in a panel of 75 follicular tumors that covered the entire clinical spectrum, from innocent FTAs, borderline AFTAs and MI-FTCs, to pernicious WI

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Maria Rosaria Sapio
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Anna Guerra
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Daniela Posca
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Paolo Piero Limone Department of Endocrinologia ed Oncologia Molecolare e Clinica, ASO Ordine Mauriziano di Torino,, Biologia e Patologia Cellulare e Molecolare,, Institute of Endocrinologia ed Oncologia Sperimentale ‘G Salvatore’,, Università Federico II, Via S. Panini, 5, Naples 80131 Italy

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Maurilio Deandrea Department of Endocrinologia ed Oncologia Molecolare e Clinica, ASO Ordine Mauriziano di Torino,, Biologia e Patologia Cellulare e Molecolare,, Institute of Endocrinologia ed Oncologia Sperimentale ‘G Salvatore’,, Università Federico II, Via S. Panini, 5, Naples 80131 Italy

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Manuela Motta Department of Endocrinologia ed Oncologia Molecolare e Clinica, ASO Ordine Mauriziano di Torino,, Biologia e Patologia Cellulare e Molecolare,, Institute of Endocrinologia ed Oncologia Sperimentale ‘G Salvatore’,, Università Federico II, Via S. Panini, 5, Naples 80131 Italy

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Giancarlo Troncone Department of Endocrinologia ed Oncologia Molecolare e Clinica, ASO Ordine Mauriziano di Torino,, Biologia e Patologia Cellulare e Molecolare,, Institute of Endocrinologia ed Oncologia Sperimentale ‘G Salvatore’,, Università Federico II, Via S. Panini, 5, Naples 80131 Italy

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Alessia Caleo Department of Endocrinologia ed Oncologia Molecolare e Clinica, ASO Ordine Mauriziano di Torino,, Biologia e Patologia Cellulare e Molecolare,, Institute of Endocrinologia ed Oncologia Sperimentale ‘G Salvatore’,, Università Federico II, Via S. Panini, 5, Naples 80131 Italy

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Pasquale Vallefuoco
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Guido Rossi Department of Endocrinologia ed Oncologia Molecolare e Clinica, ASO Ordine Mauriziano di Torino,, Biologia e Patologia Cellulare e Molecolare,, Institute of Endocrinologia ed Oncologia Sperimentale ‘G Salvatore’,, Università Federico II, Via S. Panini, 5, Naples 80131 Italy
Department of Endocrinologia ed Oncologia Molecolare e Clinica, ASO Ordine Mauriziano di Torino,, Biologia e Patologia Cellulare e Molecolare,, Institute of Endocrinologia ed Oncologia Sperimentale ‘G Salvatore’,, Università Federico II, Via S. Panini, 5, Naples 80131 Italy

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Gianfranco Fenzi
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Mario Vitale
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, Barroeta et al . 2006 , Nakamura et al . 2006 , Rossi et al . 2006 ). More recently, the identification of oncogenes with pathogenetic role in the mechanism of thyroid cell transformation has provided new molecular markers of PTC. The thymine

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Teresa M Seccia
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Ambrogio Fassina
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Gastone G Nussdorfer
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Achille C Pessina
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Gian Paolo Rossi
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even on morphological grounds. Although several criteria have been claimed to allow discrimination between benign and malignant tumors ( Lack 1997 ), including some molecular markers such as the DNA index ( Suzuki et al. 1992 b , Gicquel & Le Bouc

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William R Doerfler Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, Pennysylvania, USA

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Alyaksandr V Nikitski Department of Pathology, University of Pittsburgh, Pittsburgh, Pennysylvania, USA

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Elena M Morariu Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, Pennysylvania, USA

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N Paul Ohori Department of Pathology, University of Pittsburgh, Pittsburgh, Pennysylvania, USA

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Simion I Chiosea Department of Pathology, University of Pittsburgh, Pittsburgh, Pennysylvania, USA

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Michael S Landau Department of Pathology, University of Pittsburgh, Pittsburgh, Pennysylvania, USA

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Marina N Nikiforova Department of Pathology, University of Pittsburgh, Pittsburgh, Pennysylvania, USA

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Yuri E Nikiforov Department of Pathology, University of Pittsburgh, Pittsburgh, Pennysylvania, USA

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Linwah Yip Division of Endocrine Surgery, University of Pittsburgh, Pittsburgh, Pennysylvania, USA

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Pooja Manroa Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, Pennysylvania, USA
Division of Endocrinology, University of Texas Medical Branch, Galveston, Texas, USA

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testing is being increasingly used in thyroid nodules with indeterminate cytology, including Hürthle cell nodules, to assist in the management of these patients ( Patel et al. 2018 , Steward et al. 2019 ). However, how the molecular markers of Hürthle

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Patricia de Cremoux Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France

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Dan Rosenberg Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France

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Jacques Goussard Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France

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Catherine Brémont-Weil Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France

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Frédérique Tissier Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France

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Carine Tran-Perennou Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France

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Lionnel Groussin Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France

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Xavier Bertagna Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France

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Jérôme Bertherat Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France

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Marie-Laure Raffin-Sanson Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France
Unité de Pharmacologie, Ecole Nationale Vétérinaire d'Alfort, Laboratoire d'Oncobiologie, Department of Pathology, Department of Endocrinology, Department of Endocrinology, Faculté de Médecine Paris-Ile de France Ouest, INSERM, Département d'Endocrinologie Métabolisme and Cancer, CNRS, Faculté de Médecine René Descartes, Institut Curie, 26 rue d'Ulm, 75005 Paris, France

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classification, Weiss criteria, and molecular markers ( Macfarlane 1958 , Weiss et al . 1989 , Gicquel et al . 2001 ). Three normal adrenal samples, consisting of tissue adjacent to an adrenal cyst or another non-secreting benign tumor, were also studied

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Kwon Joong Na Department of Community Health, Korea Health Promotion Institute, Seoul, Republic of Korea
Department of Clinical Medical Sciences, Seoul National University, College of Medicine, Seoul, Republic of Korea

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Hongyoon Choi Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Republic of Korea
Cheonan Public Health Center, Chungnam, Republic of Korea

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’s multiple testing corrections. Expression of immunosuppressive molecular markers, CTLA-4, PD-L1 and HLA-G, was statistically compared according to TDS and the BRAF V600E mutation status. The correlation between TDS and immunosuppressive markers was

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