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Vassiliki Kotoula
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Elias Sozopoulos Department of Pathology, Department of Pathology, Laboratory of Environmental Mutagenesis and Carcinogenesis, Department of Medical Oncology, Department of Medicine, Institute of Pathology, Memorial Sloan-Kettering Cancer Center, School of Medicine, Aristotle University of Thessaloniki, University Campus, Thessaloniki 54006, Greece

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Helen Litsiou Department of Pathology, Department of Pathology, Laboratory of Environmental Mutagenesis and Carcinogenesis, Department of Medical Oncology, Department of Medicine, Institute of Pathology, Memorial Sloan-Kettering Cancer Center, School of Medicine, Aristotle University of Thessaloniki, University Campus, Thessaloniki 54006, Greece

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Galinos Fanourakis Department of Pathology, Department of Pathology, Laboratory of Environmental Mutagenesis and Carcinogenesis, Department of Medical Oncology, Department of Medicine, Institute of Pathology, Memorial Sloan-Kettering Cancer Center, School of Medicine, Aristotle University of Thessaloniki, University Campus, Thessaloniki 54006, Greece

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Triantafyllia Koletsa
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Gerassimos Voutsinas Department of Pathology, Department of Pathology, Laboratory of Environmental Mutagenesis and Carcinogenesis, Department of Medical Oncology, Department of Medicine, Institute of Pathology, Memorial Sloan-Kettering Cancer Center, School of Medicine, Aristotle University of Thessaloniki, University Campus, Thessaloniki 54006, Greece

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Sophia Tseleni-Balafouta Department of Pathology, Department of Pathology, Laboratory of Environmental Mutagenesis and Carcinogenesis, Department of Medical Oncology, Department of Medicine, Institute of Pathology, Memorial Sloan-Kettering Cancer Center, School of Medicine, Aristotle University of Thessaloniki, University Campus, Thessaloniki 54006, Greece

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Constantine S Mitsiades Department of Pathology, Department of Pathology, Laboratory of Environmental Mutagenesis and Carcinogenesis, Department of Medical Oncology, Department of Medicine, Institute of Pathology, Memorial Sloan-Kettering Cancer Center, School of Medicine, Aristotle University of Thessaloniki, University Campus, Thessaloniki 54006, Greece
Department of Pathology, Department of Pathology, Laboratory of Environmental Mutagenesis and Carcinogenesis, Department of Medical Oncology, Department of Medicine, Institute of Pathology, Memorial Sloan-Kettering Cancer Center, School of Medicine, Aristotle University of Thessaloniki, University Campus, Thessaloniki 54006, Greece

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Axel Wellmann Department of Pathology, Department of Pathology, Laboratory of Environmental Mutagenesis and Carcinogenesis, Department of Medical Oncology, Department of Medicine, Institute of Pathology, Memorial Sloan-Kettering Cancer Center, School of Medicine, Aristotle University of Thessaloniki, University Campus, Thessaloniki 54006, Greece

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Nicholas Mitsiades Department of Pathology, Department of Pathology, Laboratory of Environmental Mutagenesis and Carcinogenesis, Department of Medical Oncology, Department of Medicine, Institute of Pathology, Memorial Sloan-Kettering Cancer Center, School of Medicine, Aristotle University of Thessaloniki, University Campus, Thessaloniki 54006, Greece
Department of Pathology, Department of Pathology, Laboratory of Environmental Mutagenesis and Carcinogenesis, Department of Medical Oncology, Department of Medicine, Institute of Pathology, Memorial Sloan-Kettering Cancer Center, School of Medicine, Aristotle University of Thessaloniki, University Campus, Thessaloniki 54006, Greece
Department of Pathology, Department of Pathology, Laboratory of Environmental Mutagenesis and Carcinogenesis, Department of Medical Oncology, Department of Medicine, Institute of Pathology, Memorial Sloan-Kettering Cancer Center, School of Medicine, Aristotle University of Thessaloniki, University Campus, Thessaloniki 54006, Greece

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slides were counterstained with hematoxylin. Immunostaining was evaluated with a 20× lens by two expert pathologists (V K and T K) who were blinded to the mutational status of the tumors. A scoring system of negative (<10% positive cells per tumor), faint

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-08-0101
Volume/Issue:
Volume 16: Issue 2
Free access
Lamis Yehia Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA

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Charis Eng Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA
Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
Germline High Risk Cancer Focus Group, CASE Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA

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associated point probabilities of <1, 3 and 10%, respectively. Adapted minimally from American Journal of Human Genetics , vol 88 , Tan MH, Mester J, Peterson C et al ., A clinical scoring system for selection of patients for PTEN mutation testing is

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-18-0162
Volume/Issue:
Volume 25: Issue 8
Free access
Chiara Villa Department of Neuropathology, Hôpital Universitaire Pitié-Salpêtrière, APHP, Sorbonne Université, Paris, France
Inserm U1016, CNRS UMR 8104, Institut Cochin, Université Paris Descartes-Université de Paris, Paris, France

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Bertrand Baussart Inserm U1016, CNRS UMR 8104, Institut Cochin, Université Paris Descartes-Université de Paris, Paris, France
Department of Neurosurgery, Hôpital Universitaire Pitié-Salpêtrière, APHP, Sorbonne Université, Paris, France

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Guillaume Assié Inserm U1016, CNRS UMR 8104, Institut Cochin, Université Paris Descartes-Université de Paris, Paris, France
Department of Endocrinology, Center for Rare Adrenal Diseases, Hôpital Cochin APHP, Paris, France

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Gerald Raverot Endocrinology Department, Reference Center for Rare Pituitary Diseases HYPO, "Groupement Hospitalier Est" Hospices Civils de Lyon, Bron, France
Lyon 1 University, Villeurbanne, France
Inserm U1052, CNRS UMR 5286, Cancer Research Center of Lyon, Lyon, France

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Federico Roncaroli Geoffrey Jefferson Brain Research Centre, Division of Neuroscience, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom

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microscopic features. ENDO5 recognises the need for the multidisciplinary staging of PitNETs and of a prognostically relevant and predictive scoring system. CNS5 emphasises that the involvement of parasellar structures affects the extent of surgical

Article Type:
Review Article
Collections:
Mini Reviews in Endocrine Related Cancer
DOI:
https://doi.org/10.1530/ERC-23-0021
Volume/Issue:
Volume 30: Issue 8
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Meggie M C M Drissen Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands

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Janet R Vos Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands

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Romana T Netea-Maier Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Nijmegen, The Netherlands

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Martin Gotthardt Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

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Nicoline Hoogerbrugge Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands

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C Yang Y Chen JL Rybicki LA Milas K Pederson H Remzi B Orloff MS , 2011 A clinical scoring system for selection of patients for PTEN mutation testing is proposed on the basis of a prospective study of 3042 probands . American Journal

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-23-0009
Volume/Issue:
Volume 30: Issue 10
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Marie Mc Ilroy
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Fergal J Fleming
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Yvonne Buggy
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Arnold D K Hill
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Leonie S Young
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controls were performed using matched IgG controls (DAKO). Immunostained slides were scored using the Allred scoring system ( Harvey et al. 1999 ). Two independent observers without knowledge of prognostic factors scored the slides

Article Type:
Research Article
DOI:
https://doi.org/10.1677/erc.1.01222
Volume/Issue:
Volume 13: Issue 4
Free access
Christian F Singer
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Gernot Hudelist
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Wolfgang Lamm
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Ruth Mueller
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Klaus Czerwenka
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Ernst Kubista
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-quantitative scoring system (immunoreactive score) was used to allow for a reproducible evaluation of PDGF-R, EGF-R, IGF-1R, c-Abl and c-Kit in immunohistochemically stained tissue sections ( Remmele & Stegner 1987 ). The immunoreactive score (staining intensity

Article Type:
Research Article
DOI:
https://doi.org/10.1677/erc.1.00801
Volume/Issue:
Volume 11: Issue 4
Free access
Peter M van Koetsveld Division of Endocrinology, Department of Pathology, Dipartimento di Scienze Mediche, IRCCS Istituto Auxologico Italiano, Department of Pathology, Department of Internal Medicine, Erasmus Medical Center, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands

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Giovanni Vitale Division of Endocrinology, Department of Pathology, Dipartimento di Scienze Mediche, IRCCS Istituto Auxologico Italiano, Department of Pathology, Department of Internal Medicine, Erasmus Medical Center, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
Division of Endocrinology, Department of Pathology, Dipartimento di Scienze Mediche, IRCCS Istituto Auxologico Italiano, Department of Pathology, Department of Internal Medicine, Erasmus Medical Center, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
Division of Endocrinology, Department of Pathology, Dipartimento di Scienze Mediche, IRCCS Istituto Auxologico Italiano, Department of Pathology, Department of Internal Medicine, Erasmus Medical Center, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands

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Richard A Feelders Division of Endocrinology, Department of Pathology, Dipartimento di Scienze Mediche, IRCCS Istituto Auxologico Italiano, Department of Pathology, Department of Internal Medicine, Erasmus Medical Center, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands

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Marlijn Waaijers Division of Endocrinology, Department of Pathology, Dipartimento di Scienze Mediche, IRCCS Istituto Auxologico Italiano, Department of Pathology, Department of Internal Medicine, Erasmus Medical Center, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands

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Diana M Sprij-Mooij Division of Endocrinology, Department of Pathology, Dipartimento di Scienze Mediche, IRCCS Istituto Auxologico Italiano, Department of Pathology, Department of Internal Medicine, Erasmus Medical Center, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands

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Ronald R de Krijger Division of Endocrinology, Department of Pathology, Dipartimento di Scienze Mediche, IRCCS Istituto Auxologico Italiano, Department of Pathology, Department of Internal Medicine, Erasmus Medical Center, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands

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Ernst-Jan M Speel Division of Endocrinology, Department of Pathology, Dipartimento di Scienze Mediche, IRCCS Istituto Auxologico Italiano, Department of Pathology, Department of Internal Medicine, Erasmus Medical Center, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands

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Johannes Hofland Division of Endocrinology, Department of Pathology, Dipartimento di Scienze Mediche, IRCCS Istituto Auxologico Italiano, Department of Pathology, Department of Internal Medicine, Erasmus Medical Center, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands

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Steven W J Lamberts Division of Endocrinology, Department of Pathology, Dipartimento di Scienze Mediche, IRCCS Istituto Auxologico Italiano, Department of Pathology, Department of Internal Medicine, Erasmus Medical Center, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands

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Wouter W de Herder Division of Endocrinology, Department of Pathology, Dipartimento di Scienze Mediche, IRCCS Istituto Auxologico Italiano, Department of Pathology, Department of Internal Medicine, Erasmus Medical Center, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands

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Leo J Hofland Division of Endocrinology, Department of Pathology, Dipartimento di Scienze Mediche, IRCCS Istituto Auxologico Italiano, Department of Pathology, Department of Internal Medicine, Erasmus Medical Center, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands

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scoring systems for adrenocortical carcinomas . Histopathology 51 239 – 245 . ( doi:10.1111/j.1365-2559.2007.02747.x ). Schmittgen TD Livak KJ 2008 Analyzing real-time PCR data by the comparative C (T) method . Nature Protocols 3 1101

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-12-0217
Volume/Issue:
Volume 20: Issue 3
Free access
Cecile N Chougnet Departments of Nuclear Medicine and Endocrine Tumors, Medical Imaging, Biostatistics and Epidemiology, Pathology, Oncologic Surgery, Department of Endocrinology, Departments of Medical Oncology, Digestive Oncology

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Sophie Leboulleux Departments of Nuclear Medicine and Endocrine Tumors, Medical Imaging, Biostatistics and Epidemiology, Pathology, Oncologic Surgery, Department of Endocrinology, Departments of Medical Oncology, Digestive Oncology

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Caroline Caramella Departments of Nuclear Medicine and Endocrine Tumors, Medical Imaging, Biostatistics and Epidemiology, Pathology, Oncologic Surgery, Department of Endocrinology, Departments of Medical Oncology, Digestive Oncology

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Jean Lumbroso Departments of Nuclear Medicine and Endocrine Tumors, Medical Imaging, Biostatistics and Epidemiology, Pathology, Oncologic Surgery, Department of Endocrinology, Departments of Medical Oncology, Digestive Oncology

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Isabelle Borget Departments of Nuclear Medicine and Endocrine Tumors, Medical Imaging, Biostatistics and Epidemiology, Pathology, Oncologic Surgery, Department of Endocrinology, Departments of Medical Oncology, Digestive Oncology

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Désirée Déandreis Departments of Nuclear Medicine and Endocrine Tumors, Medical Imaging, Biostatistics and Epidemiology, Pathology, Oncologic Surgery, Department of Endocrinology, Departments of Medical Oncology, Digestive Oncology

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Pierre Duvillard Departments of Nuclear Medicine and Endocrine Tumors, Medical Imaging, Biostatistics and Epidemiology, Pathology, Oncologic Surgery, Department of Endocrinology, Departments of Medical Oncology, Digestive Oncology

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Dominique Elias Departments of Nuclear Medicine and Endocrine Tumors, Medical Imaging, Biostatistics and Epidemiology, Pathology, Oncologic Surgery, Department of Endocrinology, Departments of Medical Oncology, Digestive Oncology

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Thierry de Baere Departments of Nuclear Medicine and Endocrine Tumors, Medical Imaging, Biostatistics and Epidemiology, Pathology, Oncologic Surgery, Department of Endocrinology, Departments of Medical Oncology, Digestive Oncology

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Fritz-Line Vélayoudom-Céphise Departments of Nuclear Medicine and Endocrine Tumors, Medical Imaging, Biostatistics and Epidemiology, Pathology, Oncologic Surgery, Department of Endocrinology, Departments of Medical Oncology, Digestive Oncology

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Joël Guigay Departments of Nuclear Medicine and Endocrine Tumors, Medical Imaging, Biostatistics and Epidemiology, Pathology, Oncologic Surgery, Department of Endocrinology, Departments of Medical Oncology, Digestive Oncology

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Michel Ducreux Departments of Nuclear Medicine and Endocrine Tumors, Medical Imaging, Biostatistics and Epidemiology, Pathology, Oncologic Surgery, Department of Endocrinology, Departments of Medical Oncology, Digestive Oncology

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Martin Schlumberger Departments of Nuclear Medicine and Endocrine Tumors, Medical Imaging, Biostatistics and Epidemiology, Pathology, Oncologic Surgery, Department of Endocrinology, Departments of Medical Oncology, Digestive Oncology

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Eric Baudin Departments of Nuclear Medicine and Endocrine Tumors, Medical Imaging, Biostatistics and Epidemiology, Pathology, Oncologic Surgery, Department of Endocrinology, Departments of Medical Oncology, Digestive Oncology

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.1038/sj.bjc.6605618 ). Volante M Brizzi MP Faggiano A La Rosa S Rapa I Ferrero A Mansueto G Righi L Garancini S Capella C 2007 Somatostatin receptor type 2A immunohistochemistry in neuroendocrine tumors: a proposal of scoring

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-12-0169
Volume/Issue:
Volume 20: Issue 2
Free access
Satya Das Vanderbilt University Medical Center, Division of Hematology and Oncology, Department of Medicine, Nashville, Tennessee, USA

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Liping Du Vanderbilt University of Medical Center, Department of Biostatistics, Nashville, Tennessee, USA

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Aimee Schad Rush Medical Center, Department of Medicine, Chicago, Illinois, USA

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Shikha Jain Department of Medicine, University of Illinois Chicago, Chicago, Illinois, USA

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Aaron Jessop Department of Radiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA

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Chirayu Shah Department of Radiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA

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David Eisner Vanderbilt University Medical Center, Division of Hematology and Oncology, Department of Medicine, Nashville, Tennessee, USA

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Dana Cardin Vanderbilt University Medical Center, Division of Hematology and Oncology, Department of Medicine, Nashville, Tennessee, USA

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Kristen Ciombor Vanderbilt University Medical Center, Division of Hematology and Oncology, Department of Medicine, Nashville, Tennessee, USA

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Laura Goff Vanderbilt University Medical Center, Division of Hematology and Oncology, Department of Medicine, Nashville, Tennessee, USA

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Marques Bradshaw Department of Radiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA

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Dominique Delbeke Department of Radiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA

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Martin Sandler Department of Radiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA

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Jordan Berlin Vanderbilt University Medical Center, Division of Hematology and Oncology, Department of Medicine, Nashville, Tennessee, USA

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characterized as well-differentiated. Data analysis A single investigator from VICC generated a CS for each patient based on the scoring system detailed below. Independent radiologists at VICC measured post-treatment response (complete response, partial

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-20-0482
Volume/Issue:
Volume 28: Issue 3
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S G Creemers Division of Endocrinology, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

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R A Feelders Division of Endocrinology, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

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N Valdes Servicio de Endocrinología y Nutrición, Hospital Universitario de Asturias, Oviedo, Spain

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C L Ronchi Comprehensive Cancer Center Mainfranken, University of Würzburg, Würzburg, Germany
Institute of Metabolism and System Research, University of Birmingham, Birmingham, UK

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M Volante Department of Oncology, University of Turin, Orbassano, Turin, Italy

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B M van Hemel Department of Pathology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

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M Luconi Endocrinology Unit, Department of Experimental and Clinical Biomedical Sciences ‘Mario Serio’, University of Florence, Florence, Italy

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M H T Ettaieb Departments of Internal Medicine and Endocrinology, Máxima Medical Center, Eindhoven, The Netherlands

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M Mannelli Endocrinology Unit, Department of Experimental and Clinical Biomedical Sciences ‘Mario Serio’, University of Florence, Florence, Italy

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M D Chiara Instituto Universitario de Oncologia del Principado de Asturias, Universidad de Oviedo, Oviedo, Spain

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M Fassnacht Division of Endocrinology and Diabetes, Department of Internal Medicine, University Hospital, University of Würzburg, Würzburg, Germany

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M Papotti Department of Oncology, University of Turin, Orbassano, Turin, Italy

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M N Kerstens Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

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G Nesi Division of Pathological Anatomy, University of Florence, Florence, Italy

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H R Haak Departments of Internal Medicine and Endocrinology, Máxima Medical Center, Eindhoven, The Netherlands

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F J van Kemenade Department of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands

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L J Hofland Division of Endocrinology, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

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), consisting of nine histopathological criteria, is the most frequently used scoring system to differentiate between benign and malignant adrenocortical tumors ( Weiss et al. 1989 , Aubert et al. 2002 ) and is also recommended in the European clinical

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-19-0378
Volume/Issue:
Volume 27: Issue 10
Restricted access