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Maria Chiara Zatelli
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Daniela Piccin
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Federico Tagliati
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Maria Rosaria Ambrosio
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Marta Bondanelli
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Antonio Bianchi
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Herbert A Schmid
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Massimo Scanarini
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Alfredo Pontecorvi
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Laura De Marinis
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Giulio Maira
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Ettore C degli Uberti
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vascularization. Previous evidence has shown that somatostatin (SRIF) and its analogs might exert antiproliferative effects on pituitary adenomas, by interacting with one or more of its five transmembrane G-protein-coupled receptors (SSTR1–5; Zatelli et

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V Craig Jordan Dallas/Ft. Worth Living Legend Chair of Cancer Research, Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA

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provide their raw data for inclusion in the overview analysis that would be updated every 5 years. The publication in 1998 ( Early Breast Cancer Trialists’ Collaborative Group 1998 ) not only focused specifically on the worth of tamoxifen as a targeted

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Katrin-Janine Heiliger
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Julia Hess
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Donata Vitagliano Research Unit of Radiation Cytogenetics, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, Division of Pathology, Institute of Radiation Biology, Institute of Endocrinology and Metabolism, Department of Surgery and Cancer, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany

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Paolo Salerno Research Unit of Radiation Cytogenetics, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, Division of Pathology, Institute of Radiation Biology, Institute of Endocrinology and Metabolism, Department of Surgery and Cancer, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany

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Herbert Braselmann
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Giuliana Salvatore Research Unit of Radiation Cytogenetics, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, Division of Pathology, Institute of Radiation Biology, Institute of Endocrinology and Metabolism, Department of Surgery and Cancer, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany

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Clara Ugolini Research Unit of Radiation Cytogenetics, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, Division of Pathology, Institute of Radiation Biology, Institute of Endocrinology and Metabolism, Department of Surgery and Cancer, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany

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Isolde Summerer Research Unit of Radiation Cytogenetics, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, Division of Pathology, Institute of Radiation Biology, Institute of Endocrinology and Metabolism, Department of Surgery and Cancer, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany

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Tatjana Bogdanova Research Unit of Radiation Cytogenetics, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, Division of Pathology, Institute of Radiation Biology, Institute of Endocrinology and Metabolism, Department of Surgery and Cancer, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany

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Kristian Unger Research Unit of Radiation Cytogenetics, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, Division of Pathology, Institute of Radiation Biology, Institute of Endocrinology and Metabolism, Department of Surgery and Cancer, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany

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Gerry Thomas Research Unit of Radiation Cytogenetics, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, Division of Pathology, Institute of Radiation Biology, Institute of Endocrinology and Metabolism, Department of Surgery and Cancer, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany

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Massimo Santoro Research Unit of Radiation Cytogenetics, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, Division of Pathology, Institute of Radiation Biology, Institute of Endocrinology and Metabolism, Department of Surgery and Cancer, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany

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Horst Zitzelsberger
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-Trk-T1 mice were euthanised and thyroids were immediately fixed in buffered formalin for 4 h at room temperature. Tissues underwent automated processing and paraffin embedding; 5 μm sections were cut and haematoxylin and eosin stained (H&E) for

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Piotr T Wysocki Laboratory of Experimental Medicine, Medical University of Warsaw, Warsaw, Poland
Department of Oncology, Medical University of Warsaw, Warsaw, Poland

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Karol Czubak Laboratory of Experimental Medicine, Medical University of Warsaw, Warsaw, Poland

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Anna A Marusiak Laboratory of Molecular OncoSignalling, IMol Polish Academy of Sciences, Warsaw, Poland

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Monika Kolanowska Warsaw Genomics INC, Warsaw, Poland

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Dominika Nowis Laboratory of Experimental Medicine, Medical University of Warsaw, Warsaw, Poland
Department of Immunology, Medical University of Warsaw, Warsaw, Poland

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(47 cases of conventional variant of PTC (cPTC), 9 follicular variant PTCs (fvPTC), 5 FTCs, 1 FTC + fvPTC, 3 HTCs, 2 DTCs with incomplete histological data). All patients provided written informed consent. Histological material was evaluated by

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Mylène Honorat Université de Lyon, Inserm, Centre Léon Bérard, Laboratoire de Toxicologie, Laboratoire de Ciblage Thérapeutique en Cancérologie, Centre René Huguenin, Inserm, University of Illinois at Chicago Cancer Center, Lyon1, ISPB, Lyon F-69008, France
Université de Lyon, Inserm, Centre Léon Bérard, Laboratoire de Toxicologie, Laboratoire de Ciblage Thérapeutique en Cancérologie, Centre René Huguenin, Inserm, University of Illinois at Chicago Cancer Center, Lyon1, ISPB, Lyon F-69008, France
Université de Lyon, Inserm, Centre Léon Bérard, Laboratoire de Toxicologie, Laboratoire de Ciblage Thérapeutique en Cancérologie, Centre René Huguenin, Inserm, University of Illinois at Chicago Cancer Center, Lyon1, ISPB, Lyon F-69008, France

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Aurelia Mesnier Université de Lyon, Inserm, Centre Léon Bérard, Laboratoire de Toxicologie, Laboratoire de Ciblage Thérapeutique en Cancérologie, Centre René Huguenin, Inserm, University of Illinois at Chicago Cancer Center, Lyon1, ISPB, Lyon F-69008, France
Université de Lyon, Inserm, Centre Léon Bérard, Laboratoire de Toxicologie, Laboratoire de Ciblage Thérapeutique en Cancérologie, Centre René Huguenin, Inserm, University of Illinois at Chicago Cancer Center, Lyon1, ISPB, Lyon F-69008, France
Université de Lyon, Inserm, Centre Léon Bérard, Laboratoire de Toxicologie, Laboratoire de Ciblage Thérapeutique en Cancérologie, Centre René Huguenin, Inserm, University of Illinois at Chicago Cancer Center, Lyon1, ISPB, Lyon F-69008, France

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Julie Vendrell Université de Lyon, Inserm, Centre Léon Bérard, Laboratoire de Toxicologie, Laboratoire de Ciblage Thérapeutique en Cancérologie, Centre René Huguenin, Inserm, University of Illinois at Chicago Cancer Center, Lyon1, ISPB, Lyon F-69008, France
Université de Lyon, Inserm, Centre Léon Bérard, Laboratoire de Toxicologie, Laboratoire de Ciblage Thérapeutique en Cancérologie, Centre René Huguenin, Inserm, University of Illinois at Chicago Cancer Center, Lyon1, ISPB, Lyon F-69008, France
Université de Lyon, Inserm, Centre Léon Bérard, Laboratoire de Toxicologie, Laboratoire de Ciblage Thérapeutique en Cancérologie, Centre René Huguenin, Inserm, University of Illinois at Chicago Cancer Center, Lyon1, ISPB, Lyon F-69008, France

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Jérôme Guitton Université de Lyon, Inserm, Centre Léon Bérard, Laboratoire de Toxicologie, Laboratoire de Ciblage Thérapeutique en Cancérologie, Centre René Huguenin, Inserm, University of Illinois at Chicago Cancer Center, Lyon1, ISPB, Lyon F-69008, France
Université de Lyon, Inserm, Centre Léon Bérard, Laboratoire de Toxicologie, Laboratoire de Ciblage Thérapeutique en Cancérologie, Centre René Huguenin, Inserm, University of Illinois at Chicago Cancer Center, Lyon1, ISPB, Lyon F-69008, France
Université de Lyon, Inserm, Centre Léon Bérard, Laboratoire de Toxicologie, Laboratoire de Ciblage Thérapeutique en Cancérologie, Centre René Huguenin, Inserm, University of Illinois at Chicago Cancer Center, Lyon1, ISPB, Lyon F-69008, France

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Ivan Bieche Université de Lyon, Inserm, Centre Léon Bérard, Laboratoire de Toxicologie, Laboratoire de Ciblage Thérapeutique en Cancérologie, Centre René Huguenin, Inserm, University of Illinois at Chicago Cancer Center, Lyon1, ISPB, Lyon F-69008, France
Université de Lyon, Inserm, Centre Léon Bérard, Laboratoire de Toxicologie, Laboratoire de Ciblage Thérapeutique en Cancérologie, Centre René Huguenin, Inserm, University of Illinois at Chicago Cancer Center, Lyon1, ISPB, Lyon F-69008, France

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Rosette Lidereau Université de Lyon, Inserm, Centre Léon Bérard, Laboratoire de Toxicologie, Laboratoire de Ciblage Thérapeutique en Cancérologie, Centre René Huguenin, Inserm, University of Illinois at Chicago Cancer Center, Lyon1, ISPB, Lyon F-69008, France
Université de Lyon, Inserm, Centre Léon Bérard, Laboratoire de Toxicologie, Laboratoire de Ciblage Thérapeutique en Cancérologie, Centre René Huguenin, Inserm, University of Illinois at Chicago Cancer Center, Lyon1, ISPB, Lyon F-69008, France

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Gary D Kruh Université de Lyon, Inserm, Centre Léon Bérard, Laboratoire de Toxicologie, Laboratoire de Ciblage Thérapeutique en Cancérologie, Centre René Huguenin, Inserm, University of Illinois at Chicago Cancer Center, Lyon1, ISPB, Lyon F-69008, France

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Charles Dumontet Université de Lyon, Inserm, Centre Léon Bérard, Laboratoire de Toxicologie, Laboratoire de Ciblage Thérapeutique en Cancérologie, Centre René Huguenin, Inserm, University of Illinois at Chicago Cancer Center, Lyon1, ISPB, Lyon F-69008, France
Université de Lyon, Inserm, Centre Léon Bérard, Laboratoire de Toxicologie, Laboratoire de Ciblage Thérapeutique en Cancérologie, Centre René Huguenin, Inserm, University of Illinois at Chicago Cancer Center, Lyon1, ISPB, Lyon F-69008, France
Université de Lyon, Inserm, Centre Léon Bérard, Laboratoire de Toxicologie, Laboratoire de Ciblage Thérapeutique en Cancérologie, Centre René Huguenin, Inserm, University of Illinois at Chicago Cancer Center, Lyon1, ISPB, Lyon F-69008, France

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Pascale Cohen Université de Lyon, Inserm, Centre Léon Bérard, Laboratoire de Toxicologie, Laboratoire de Ciblage Thérapeutique en Cancérologie, Centre René Huguenin, Inserm, University of Illinois at Chicago Cancer Center, Lyon1, ISPB, Lyon F-69008, France
Université de Lyon, Inserm, Centre Léon Bérard, Laboratoire de Toxicologie, Laboratoire de Ciblage Thérapeutique en Cancérologie, Centre René Huguenin, Inserm, University of Illinois at Chicago Cancer Center, Lyon1, ISPB, Lyon F-69008, France
Université de Lyon, Inserm, Centre Léon Bérard, Laboratoire de Toxicologie, Laboratoire de Ciblage Thérapeutique en Cancérologie, Centre René Huguenin, Inserm, University of Illinois at Chicago Cancer Center, Lyon1, ISPB, Lyon F-69008, France

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Lea Payen Université de Lyon, Inserm, Centre Léon Bérard, Laboratoire de Toxicologie, Laboratoire de Ciblage Thérapeutique en Cancérologie, Centre René Huguenin, Inserm, University of Illinois at Chicago Cancer Center, Lyon1, ISPB, Lyon F-69008, France
Université de Lyon, Inserm, Centre Léon Bérard, Laboratoire de Toxicologie, Laboratoire de Ciblage Thérapeutique en Cancérologie, Centre René Huguenin, Inserm, University of Illinois at Chicago Cancer Center, Lyon1, ISPB, Lyon F-69008, France
Université de Lyon, Inserm, Centre Léon Bérard, Laboratoire de Toxicologie, Laboratoire de Ciblage Thérapeutique en Cancérologie, Centre René Huguenin, Inserm, University of Illinois at Chicago Cancer Center, Lyon1, ISPB, Lyon F-69008, France
Université de Lyon, Inserm, Centre Léon Bérard, Laboratoire de Toxicologie, Laboratoire de Ciblage Thérapeutique en Cancérologie, Centre René Huguenin, Inserm, University of Illinois at Chicago Cancer Center, Lyon1, ISPB, Lyon F-69008, France

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with ER-negative and ER-positive hormone-refractory breast cancers. Standard agents include cyclophosphamide, methotrexate, vinca alkaloids anthracyclines, taxanes, and 5-fluorouracil (5-FU), with the latter agent recently assuming a larger role as a

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V Craig Jordan Departments of Oncology and Pharmacology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, District of Columbia 20057, USA

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Walpole again 5 years later in 1972, but this time he was the examiner of my PhD thesis entitled ‘A study of the structure function relationship of substituted triphenylethylenes and triphenylethanes’. Figure 3 The principal players in the discovery of ICI

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Kreepa G Kooblall OCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK

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Victoria J Stokes OCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK

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Omair A Shariq OCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK

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Katherine A English OCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK

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Mark Stevenson OCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK

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John Broxholme Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, UK

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Benjamin Wright Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, UK

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Helen E Lockstone Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, UK

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David Buck Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, UK

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Simona Grozinsky-Glasberg Neuroendocrine Tumor Unit, ENETS Center of Excellence, Endocrinology & Metabolism Department, Hadassah Medical Center and Faculty of Medicine, The Hebrew University of Jerusalem, Israel

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Christopher J Yates OCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK

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Rajesh V Thakker OCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK
Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK

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Kate E Lines OCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK

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screening for tumours, from as young as 5 years of age. Current clinical guidelines recommend annual surveillance for tumours by biochemical analyses (e.g. calcium, fasting glucose and hormones such as insulin, gastrin and prolactin) and radiological

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Manisha Taya Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA

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Maria de la Luz Garcia-Hernandez Division of Allergy/Immunology and Rheumatology, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA

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Javier Rangel-Moreno Division of Allergy/Immunology and Rheumatology, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA

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Briaunna Minor Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA

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Erin Gibbons Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA

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Stephen R Hammes Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA

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Subjects Review Board. Tissues were paraffin embedded and processed into 5 μm sections. Sections were deparaffinized and rehydrated for immunofluorescence and hematoxylin and eosin (H&E) staining. Cell cultures and reagents Human TSC2 -null 621

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Xiaoli Liu Division of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Changchun, Jilin, China

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Chunhai Zhang Division of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Changchun, Jilin, China

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Xiaomiao Wang Division of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Changchun, Jilin, China

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Can Cui Division of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Changchun, Jilin, China

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Hanwen Cui Division of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Changchun, Jilin, China

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Baishu Zhu Division of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Changchun, Jilin, China

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Anqi Chen Division of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Changchun, Jilin, China

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Lu Zhang Division of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Changchun, Jilin, China

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Jingwei Xin Division of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Changchun, Jilin, China

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Qingfeng Fu Division of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Changchun, Jilin, China

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Gianlorenzo Dionigi Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
Division of Surgery, Istituto Auxologico Italiano, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Milan, Italy

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Hui Sun Division of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Changchun, Jilin, China

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He S Yang Q Guo W Lai Y Du H Peng X 2019 Copy number gain of ZEB1 mediates a double-negative feedback loop with miR-33a-5p that regulates EMT and bone metastasis of prostate cancer dependent on TGF-beta signaling . Theranostics 9 6063

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De-tao Yin Department of Thyroid Surgery, Key Discipline Laboratory of Clinical Medicine Henan, Department of Endocrinology, Division of Radiobiology, Division of Endocrinology and Metabolism, The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, People's Republic of China
Department of Thyroid Surgery, Key Discipline Laboratory of Clinical Medicine Henan, Department of Endocrinology, Division of Radiobiology, Division of Endocrinology and Metabolism, The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, People's Republic of China

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Wenxun Wu Department of Thyroid Surgery, Key Discipline Laboratory of Clinical Medicine Henan, Department of Endocrinology, Division of Radiobiology, Division of Endocrinology and Metabolism, The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, People's Republic of China

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Mingchuang Li Department of Thyroid Surgery, Key Discipline Laboratory of Clinical Medicine Henan, Department of Endocrinology, Division of Radiobiology, Division of Endocrinology and Metabolism, The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, People's Republic of China
Department of Thyroid Surgery, Key Discipline Laboratory of Clinical Medicine Henan, Department of Endocrinology, Division of Radiobiology, Division of Endocrinology and Metabolism, The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, People's Republic of China

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Qi-en Wang Department of Thyroid Surgery, Key Discipline Laboratory of Clinical Medicine Henan, Department of Endocrinology, Division of Radiobiology, Division of Endocrinology and Metabolism, The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, People's Republic of China

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Hongqiang Li Department of Thyroid Surgery, Key Discipline Laboratory of Clinical Medicine Henan, Department of Endocrinology, Division of Radiobiology, Division of Endocrinology and Metabolism, The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, People's Republic of China
Department of Thyroid Surgery, Key Discipline Laboratory of Clinical Medicine Henan, Department of Endocrinology, Division of Radiobiology, Division of Endocrinology and Metabolism, The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, People's Republic of China

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Yongfei Wang Department of Thyroid Surgery, Key Discipline Laboratory of Clinical Medicine Henan, Department of Endocrinology, Division of Radiobiology, Division of Endocrinology and Metabolism, The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, People's Republic of China
Department of Thyroid Surgery, Key Discipline Laboratory of Clinical Medicine Henan, Department of Endocrinology, Division of Radiobiology, Division of Endocrinology and Metabolism, The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, People's Republic of China

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Yifeng Tang Department of Thyroid Surgery, Key Discipline Laboratory of Clinical Medicine Henan, Department of Endocrinology, Division of Radiobiology, Division of Endocrinology and Metabolism, The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, People's Republic of China
Department of Thyroid Surgery, Key Discipline Laboratory of Clinical Medicine Henan, Department of Endocrinology, Division of Radiobiology, Division of Endocrinology and Metabolism, The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, People's Republic of China

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Mingzhao Xing Department of Thyroid Surgery, Key Discipline Laboratory of Clinical Medicine Henan, Department of Endocrinology, Division of Radiobiology, Division of Endocrinology and Metabolism, The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, People's Republic of China

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Q Shen RL Gao JX He G 2010a Homozygous deletion but not mutation of exons 5 and 8 of the fragile histidine triad (FHIT) gene is associated with features of differentiated thyroid carcinoma . Annals of Clinical Laboratory Science 40 267

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