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Neuroendocrinology Group, Neurosurgical Clinic, Department of Neurosurgery, Neurosurgical Clinic, Neurosurgical Clinic, Department of Internal Medicine 1 and Clinical Chemistry, Laboratorio de Fisiología y Biología Molecular, IFIBYNE-CONICET, Max Planck Institute of Psychiatry, Kraepelinstrasse 10, D-80804 Munich, Germany
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Neuroendocrinology Group, Neurosurgical Clinic, Department of Neurosurgery, Neurosurgical Clinic, Neurosurgical Clinic, Department of Internal Medicine 1 and Clinical Chemistry, Laboratorio de Fisiología y Biología Molecular, IFIBYNE-CONICET, Max Planck Institute of Psychiatry, Kraepelinstrasse 10, D-80804 Munich, Germany
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), affected cyclin and cyclin-dependent kinases (CDKs), modulated phosphatidylinositol 3 kinase (PI3K)/Akt and MAP kinase signal pathways, affected apoptotic proteins (Bcl-2 and Bax), reduced secretion of angiogenic factors and modified the expression of
Translational Ovarian Cancer Research Program, Department of Anatomy and Cell Biology, Department of Biochemistry, Department of Obstetrics and Gynaecology, Department of Oncology, London Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, Ontario, Canada N6A 4L6
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Translational Ovarian Cancer Research Program, Department of Anatomy and Cell Biology, Department of Biochemistry, Department of Obstetrics and Gynaecology, Department of Oncology, London Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, Ontario, Canada N6A 4L6
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Translational Ovarian Cancer Research Program, Department of Anatomy and Cell Biology, Department of Biochemistry, Department of Obstetrics and Gynaecology, Department of Oncology, London Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, Ontario, Canada N6A 4L6
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Translational Ovarian Cancer Research Program, Department of Anatomy and Cell Biology, Department of Biochemistry, Department of Obstetrics and Gynaecology, Department of Oncology, London Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, Ontario, Canada N6A 4L6
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Translational Ovarian Cancer Research Program, Department of Anatomy and Cell Biology, Department of Biochemistry, Department of Obstetrics and Gynaecology, Department of Oncology, London Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, Ontario, Canada N6A 4L6
Translational Ovarian Cancer Research Program, Department of Anatomy and Cell Biology, Department of Biochemistry, Department of Obstetrics and Gynaecology, Department of Oncology, London Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, Ontario, Canada N6A 4L6
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Translational Ovarian Cancer Research Program, Department of Anatomy and Cell Biology, Department of Biochemistry, Department of Obstetrics and Gynaecology, Department of Oncology, London Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, Ontario, Canada N6A 4L6
Translational Ovarian Cancer Research Program, Department of Anatomy and Cell Biology, Department of Biochemistry, Department of Obstetrics and Gynaecology, Department of Oncology, London Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, Ontario, Canada N6A 4L6
Translational Ovarian Cancer Research Program, Department of Anatomy and Cell Biology, Department of Biochemistry, Department of Obstetrics and Gynaecology, Department of Oncology, London Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, Ontario, Canada N6A 4L6
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Translational Ovarian Cancer Research Program, Department of Anatomy and Cell Biology, Department of Biochemistry, Department of Obstetrics and Gynaecology, Department of Oncology, London Regional Cancer Program, 790 Commissioners Road East, Room A4-836, London, Ontario, Canada N6A 4L6
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, and transforming growth factor-β3 enhance ovarian cancer metastatic potential by inducing a Smad3-dependent epithelial-to-mesenchymal transition . Molecular Cancer Research 6 695 – 705 . ( doi:10.1158/1541-7786.MCR-07-0294 ). Dunfield LD
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. Post-operatively, the patient was rendered normocalcemic and has remained so for 3 years of follow-up. At age 18 and again at age 25, the patient had JTs removed by an oral surgeon with no operative or pathological reports available. Figure 1 Kindred
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Smad4 degradation. EMBO Reports 3 171 –176. Wei N , Tsuge T, Serino G, Dohmae N, Takio K, Matsui M & Deng XW 1998 The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory
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Department of Pathology, AP-HP, Hôpital Pitié-Salpétrière, Pierre et Marie Curie Université, Paris, France
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Department of Endocrinology, Center for Rare Adrenal Diseases, AP-HP, Hôpital Cochin, Paris, France
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-β pathway, via SMAD2/SMAD3 inactivation. Interestingly SMAD3 expression is higher in ARMC5 PMAH (Supplementary Table 4). The third large molecular group is associated with alterations of the Wnt/β-catenin signaling pathway. This group, composed mainly
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al. 1999 ). The DIO3 gene is also transcriptionally induced by transforming growth factor beta (TGFB) via a Smad and MAPK-dependent pathway, by hypoxia-inducible factor 1 alpha (HIF1A) and by Wnt/beta-catenin pathway ( Huang et al. 2005
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members, such as ZEB1 (δEF1 or AREB6) and ZEB2 (Smad-interacting protein 1 (SIP1)) ( Gregory et al . 2011 ). The role of the androgen axis in PCa pathogenesis has been described previously ( Nieto et al . 2007 ). However, data available on the role of
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The vitamin D system Vitamin D belongs to a group of steroids with a broken ring known as secosteroids. The most important forms of vitamin D are vitamin D 3 (cholecalciferol), produced in the human skin; and vitamin D 2 (ergocalciferol), derived
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change ( Supplementary Table 2 , see section on supplementary data given at the end of this article). STAT3 pY705, SMAD3, RPTOR, PRAS40, pT246, and Annexin VII (ANXA7) were moderately inversely correlated with % tumor size change, and four biomarkers
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.0794 MAP3K1 1,2,3,4 123 4.9 11.5 0.0241 10.7 0.0480 9.1 0.1181 8.3 0.1925 8.5 0.3423 SMAD4 1,2,3 105 4.8 1.2 0.0022 1.0 0.0038 NA NA NA NA NA NA CIC 2,3 89 4.5 NA NA 0.8 0