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Suman Rice Division of Basic Medical Sciences, St George’s University of London, Cranmer Terrace, London SW17 0RE, UK

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Saffron A Whitehead Division of Basic Medical Sciences, St George’s University of London, Cranmer Terrace, London SW17 0RE, UK

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Introduction Breast cancer is not a disease of the modern world and its oldest recorded description was found in an Egyptian seven papyri written between 3000 and 1500 BC. Although the term ‘cancer’ did not exist at that time (the

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Steven M Hill Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA

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Victoria P Belancio Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA

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Robert T Dauchy Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA

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Shulin Xiang Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA

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Samantha Brimer Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA

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Lulu Mao Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA

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Adam Hauch Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA

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Peter W Lundberg Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA

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Whitney Summers Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA

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Lin Yuan Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA

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Tripp Frasch Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA

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David E Blask Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA
Department of Structural and Cellular Biology, Department of Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium, Circadian Cancer Biology Group, Tulane Center for Circadian Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL-49, New Orleans, Louisiana 70112, USA

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exposure to light at night has been described as playing an important role in the development, promotion, and progression of breast cancer ( Reiter 1991 , Claustrat et al . 2005 , Jasser et al . 2006 , Reiter et al 2007 , Stevens et al . 2007

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V Craig Jordan Dallas/Ft. Worth Living Legend Chair of Cancer Research, Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA

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one has lived through the evolving applications of ICI 46,474 (tamoxifen)’. Tamoxifen, used as a long-term adjuvant therapy, burst onto the international scene in the 1990s ( Early Breast Cancer Trialists’ Collaborative Group 1998 ). The Oxford

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Larry J Suva Departments of Orthopaedic Surgery, Physiology and Biophysics, Radiation Oncology, Breast Cancer Research Program, Hematology and Oncology, Barton Research Institute, Center for Orthopaedic Research
Departments of Orthopaedic Surgery, Physiology and Biophysics, Radiation Oncology, Breast Cancer Research Program, Hematology and Oncology, Barton Research Institute, Center for Orthopaedic Research
Departments of Orthopaedic Surgery, Physiology and Biophysics, Radiation Oncology, Breast Cancer Research Program, Hematology and Oncology, Barton Research Institute, Center for Orthopaedic Research

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Robert J Griffin Departments of Orthopaedic Surgery, Physiology and Biophysics, Radiation Oncology, Breast Cancer Research Program, Hematology and Oncology, Barton Research Institute, Center for Orthopaedic Research
Departments of Orthopaedic Surgery, Physiology and Biophysics, Radiation Oncology, Breast Cancer Research Program, Hematology and Oncology, Barton Research Institute, Center for Orthopaedic Research

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Issam Makhoul Departments of Orthopaedic Surgery, Physiology and Biophysics, Radiation Oncology, Breast Cancer Research Program, Hematology and Oncology, Barton Research Institute, Center for Orthopaedic Research
Departments of Orthopaedic Surgery, Physiology and Biophysics, Radiation Oncology, Breast Cancer Research Program, Hematology and Oncology, Barton Research Institute, Center for Orthopaedic Research

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complex process ( Coussens & Werb 2002 , de Visser et al . 2005 ). Despite recent widespread patient screening advances as well as heightened health awareness, a significant proportion of women still present with advanced breast cancer. The diagnosis of

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Gerard A Tarulli Dame Roma Mitchell Cancer Research Laboratories (DRMCRL) Faculty of Health Sciences, School of Medicine, The University of Adelaide, Adelaide, South Australia 5005, Australia

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Lisa M Butler Dame Roma Mitchell Cancer Research Laboratories (DRMCRL) Faculty of Health Sciences, School of Medicine, The University of Adelaide, Adelaide, South Australia 5005, Australia

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Wayne D Tilley Dame Roma Mitchell Cancer Research Laboratories (DRMCRL) Faculty of Health Sciences, School of Medicine, The University of Adelaide, Adelaide, South Australia 5005, Australia

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Theresa E Hickey Dame Roma Mitchell Cancer Research Laboratories (DRMCRL) Faculty of Health Sciences, School of Medicine, The University of Adelaide, Adelaide, South Australia 5005, Australia

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preparation for milk production during lactation. ERa expression is a hallmark of the majority (>70%) of early-stage breast cancers and therefore ERa is the main target of adjuvant hormone therapy in women with this disease. Aberrant ERa signalling can also

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Thérèse Truong Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif, France

Université Paris-Sud UMRS 1018, Villejuif, France

Biostatistical Unit MRC, Cambridge, UK

School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia

Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France

Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France

Département d'informatique médicale Center Georges-François Leclerc, Dijon, France

Center Eugène Marquis Rennes, France
Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif, France

Université Paris-Sud UMRS 1018, Villejuif, France

Biostatistical Unit MRC, Cambridge, UK

School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia

Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France

Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France

Département d'informatique médicale Center Georges-François Leclerc, Dijon, France

Center Eugène Marquis Rennes, France

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Benoît Liquet Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif, France

Université Paris-Sud UMRS 1018, Villejuif, France

Biostatistical Unit MRC, Cambridge, UK

School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia

Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France

Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France

Département d'informatique médicale Center Georges-François Leclerc, Dijon, France

Center Eugène Marquis Rennes, France
Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif, France

Université Paris-Sud UMRS 1018, Villejuif, France

Biostatistical Unit MRC, Cambridge, UK

School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia

Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France

Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France

Département d'informatique médicale Center Georges-François Leclerc, Dijon, France

Center Eugène Marquis Rennes, France

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Florence Menegaux Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif, France

Université Paris-Sud UMRS 1018, Villejuif, France

Biostatistical Unit MRC, Cambridge, UK

School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia

Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France

Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France

Département d'informatique médicale Center Georges-François Leclerc, Dijon, France

Center Eugène Marquis Rennes, France
Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif, France

Université Paris-Sud UMRS 1018, Villejuif, France

Biostatistical Unit MRC, Cambridge, UK

School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia

Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France

Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France

Département d'informatique médicale Center Georges-François Leclerc, Dijon, France

Center Eugène Marquis Rennes, France

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Sabine Plancoulaine Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif, France

Université Paris-Sud UMRS 1018, Villejuif, France

Biostatistical Unit MRC, Cambridge, UK

School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia

Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France

Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France

Département d'informatique médicale Center Georges-François Leclerc, Dijon, France

Center Eugène Marquis Rennes, France
Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif, France

Université Paris-Sud UMRS 1018, Villejuif, France

Biostatistical Unit MRC, Cambridge, UK

School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia

Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France

Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France

Département d'informatique médicale Center Georges-François Leclerc, Dijon, France

Center Eugène Marquis Rennes, France

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Pierre Laurent-Puig Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif, France

Université Paris-Sud UMRS 1018, Villejuif, France

Biostatistical Unit MRC, Cambridge, UK

School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia

Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France

Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France

Département d'informatique médicale Center Georges-François Leclerc, Dijon, France

Center Eugène Marquis Rennes, France

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Claire Mulot Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif, France

Université Paris-Sud UMRS 1018, Villejuif, France

Biostatistical Unit MRC, Cambridge, UK

School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia

Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France

Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France

Département d'informatique médicale Center Georges-François Leclerc, Dijon, France

Center Eugène Marquis Rennes, France

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Emilie Cordina-Duverger Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif, France

Université Paris-Sud UMRS 1018, Villejuif, France

Biostatistical Unit MRC, Cambridge, UK

School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia

Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France

Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France

Département d'informatique médicale Center Georges-François Leclerc, Dijon, France

Center Eugène Marquis Rennes, France
Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif, France

Université Paris-Sud UMRS 1018, Villejuif, France

Biostatistical Unit MRC, Cambridge, UK

School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia

Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France

Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France

Département d'informatique médicale Center Georges-François Leclerc, Dijon, France

Center Eugène Marquis Rennes, France

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Marie Sanchez Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif, France

Université Paris-Sud UMRS 1018, Villejuif, France

Biostatistical Unit MRC, Cambridge, UK

School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia

Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France

Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France

Département d'informatique médicale Center Georges-François Leclerc, Dijon, France

Center Eugène Marquis Rennes, France
Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif, France

Université Paris-Sud UMRS 1018, Villejuif, France

Biostatistical Unit MRC, Cambridge, UK

School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia

Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France

Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France

Département d'informatique médicale Center Georges-François Leclerc, Dijon, France

Center Eugène Marquis Rennes, France

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Patrick Arveux Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif, France

Université Paris-Sud UMRS 1018, Villejuif, France

Biostatistical Unit MRC, Cambridge, UK

School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia

Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France

Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France

Département d'informatique médicale Center Georges-François Leclerc, Dijon, France

Center Eugène Marquis Rennes, France

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Pierre Kerbrat Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif, France

Université Paris-Sud UMRS 1018, Villejuif, France

Biostatistical Unit MRC, Cambridge, UK

School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia

Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France

Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France

Département d'informatique médicale Center Georges-François Leclerc, Dijon, France

Center Eugène Marquis Rennes, France

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Sylvia Richardson Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif, France

Université Paris-Sud UMRS 1018, Villejuif, France

Biostatistical Unit MRC, Cambridge, UK

School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia

Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France

Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France

Département d'informatique médicale Center Georges-François Leclerc, Dijon, France

Center Eugène Marquis Rennes, France

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Pascal Guénel Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif, France

Université Paris-Sud UMRS 1018, Villejuif, France

Biostatistical Unit MRC, Cambridge, UK

School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia

Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France

Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France

Département d'informatique médicale Center Georges-François Leclerc, Dijon, France

Center Eugène Marquis Rennes, France
Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif, France

Université Paris-Sud UMRS 1018, Villejuif, France

Biostatistical Unit MRC, Cambridge, UK

School of Mathematics and Physics The University of Queensland, St Lucia, Queensland, Australia

Inserm CESP Center for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over Lifecourse, Villejuif, France

Université Paris Descartes INSERM UMR-S775 EPIGENETEC, Paris, France

Département d'informatique médicale Center Georges-François Leclerc, Dijon, France

Center Eugène Marquis Rennes, France

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natural circadian rhythm due to exposure to light at night has long been suspected to have an effect on breast cancer risk ( Stevens et al . 2014 ). In 2007, results from experimental and epidemiological studies led the International Agency for Research

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Yu-Feng Tian
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Chi-Hong Chu
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Mei-Hsuan Wu
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Chia-Lin Chang
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Tsan Yang
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Yu-Ching Chou
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Giu-Cheng Hsu
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Cheng-Ping Yu
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Jyh-Cherng Yu
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Chien-An Sun
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Introduction Evidence is accumulating that obesity and insulin resistance are implicated in the etiology of breast cancer ( Rose et al. 2004 ). Adipose tissue is the site of peripheral aromatization of adrenal androgens to

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M Bullock Hormones and Cancer Group, Cancer Genetics Laboratory, Kolling Institute of Medical Research, Royal North Shore Hospital, Pacific Highway Saint Leonards, Sydney, New South Wales 2065, Australia

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Introduction Breast cancer is a leading cause of female death worldwide. Each year, almost 1.4 million women are diagnosed with breast cancer, and the disease will be responsible for 450 000 deaths ( Siegel et al . 2011 ). This review will

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L Hilakivi-Clarke Lombardi Comprehensive Cancer Center, Department of Oncology, 3970 Reservoir Road NW, Box 571468, Washington DC 20057-1468, USA

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C Wang Lombardi Comprehensive Cancer Center, Department of Oncology, 3970 Reservoir Road NW, Box 571468, Washington DC 20057-1468, USA

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M Kalil Lombardi Comprehensive Cancer Center, Department of Oncology, 3970 Reservoir Road NW, Box 571468, Washington DC 20057-1468, USA

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R Riggins Lombardi Comprehensive Cancer Center, Department of Oncology, 3970 Reservoir Road NW, Box 571468, Washington DC 20057-1468, USA

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R G Pestell Lombardi Comprehensive Cancer Center, Department of Oncology, 3970 Reservoir Road NW, Box 571468, Washington DC 20057-1468, USA

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Introduction Breast cancer accounts for approximately 30% of all cancers diagnosed in women in the USA. As the second leading cause of cancer death in women, breast cancer accounts for approximately 15% of all female cancer deaths

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Fahmida Rasha Department of Nutritional Sciences, Texas Tech University, Lubbock, Texas, USA
Obesity Research Institute, Texas Tech University, Lubbock, Texas, USA

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Latha Ramalingam Department of Nutritional Sciences, Texas Tech University, Lubbock, Texas, USA
Obesity Research Institute, Texas Tech University, Lubbock, Texas, USA

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Lauren Gollahon Department of Nutritional Sciences, Texas Tech University, Lubbock, Texas, USA
Obesity Research Institute, Texas Tech University, Lubbock, Texas, USA
Department of Biological Sciences, Texas Tech University, Lubbock, Texas, USA

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Rakshanda Layeequr Rahman Obesity Research Institute, Texas Tech University, Lubbock, Texas, USA
Department of Surgery, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas, USA

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Shaikh Mizanoor Rahman Department of Nutritional Sciences, Texas Tech University, Lubbock, Texas, USA
Obesity Research Institute, Texas Tech University, Lubbock, Texas, USA

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Kalhara Menikdiwela Department of Nutritional Sciences, Texas Tech University, Lubbock, Texas, USA
Obesity Research Institute, Texas Tech University, Lubbock, Texas, USA

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Naima Moustaid-Moussa Department of Nutritional Sciences, Texas Tech University, Lubbock, Texas, USA
Obesity Research Institute, Texas Tech University, Lubbock, Texas, USA

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Introduction Breast cancer (BC) is the most common type of cancer among women worldwide ( George et al. 2013 ) and the second leading cause of cancer deaths in US women ( Suganuma et al. 2005 ). Additionally, one in eight US women have a

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