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Eduardo Vilar
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Ramón Salazar
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Jose Pérez-García
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Javier Cortes
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Josep Tabernero
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Introduction Neuroendocrine tumors (NETs) of the digestive tract include different subsets of malignancies, such as pancreatic endocrine tumors (PETs), carcinoid tumors (CTs), and other poorly differentiated gastroentero-pancreatic

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Monica Ter-Minassian Department of Medical Oncology, Departments of Environmental Health, Biostatistics, Dana-Farber Cancer Institute, Dana 1250, 450 Brookline Avenue, Boston, Massachusetts 02215, USA
Department of Medical Oncology, Departments of Environmental Health, Biostatistics, Dana-Farber Cancer Institute, Dana 1250, 450 Brookline Avenue, Boston, Massachusetts 02215, USA

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Jennifer A Chan Department of Medical Oncology, Departments of Environmental Health, Biostatistics, Dana-Farber Cancer Institute, Dana 1250, 450 Brookline Avenue, Boston, Massachusetts 02215, USA

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Susanne M Hooshmand Department of Medical Oncology, Departments of Environmental Health, Biostatistics, Dana-Farber Cancer Institute, Dana 1250, 450 Brookline Avenue, Boston, Massachusetts 02215, USA

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Lauren K Brais Department of Medical Oncology, Departments of Environmental Health, Biostatistics, Dana-Farber Cancer Institute, Dana 1250, 450 Brookline Avenue, Boston, Massachusetts 02215, USA

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Anastassia Daskalova Department of Medical Oncology, Departments of Environmental Health, Biostatistics, Dana-Farber Cancer Institute, Dana 1250, 450 Brookline Avenue, Boston, Massachusetts 02215, USA

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Rachel Heafield Department of Medical Oncology, Departments of Environmental Health, Biostatistics, Dana-Farber Cancer Institute, Dana 1250, 450 Brookline Avenue, Boston, Massachusetts 02215, USA

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Laurie Buchanan Department of Medical Oncology, Departments of Environmental Health, Biostatistics, Dana-Farber Cancer Institute, Dana 1250, 450 Brookline Avenue, Boston, Massachusetts 02215, USA

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Zhi Rong Qian Department of Medical Oncology, Departments of Environmental Health, Biostatistics, Dana-Farber Cancer Institute, Dana 1250, 450 Brookline Avenue, Boston, Massachusetts 02215, USA

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Charles S Fuchs Department of Medical Oncology, Departments of Environmental Health, Biostatistics, Dana-Farber Cancer Institute, Dana 1250, 450 Brookline Avenue, Boston, Massachusetts 02215, USA

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Xihong Lin Department of Medical Oncology, Departments of Environmental Health, Biostatistics, Dana-Farber Cancer Institute, Dana 1250, 450 Brookline Avenue, Boston, Massachusetts 02215, USA

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David C Christiani Department of Medical Oncology, Departments of Environmental Health, Biostatistics, Dana-Farber Cancer Institute, Dana 1250, 450 Brookline Avenue, Boston, Massachusetts 02215, USA

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Matthew H Kulke Department of Medical Oncology, Departments of Environmental Health, Biostatistics, Dana-Farber Cancer Institute, Dana 1250, 450 Brookline Avenue, Boston, Massachusetts 02215, USA

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gastroenteropancreatic NET; we focused our analyses on two major subgroups: small bowel NET and panNET. We found that delays in diagnosis from initial symptoms were shorter than previously reported. We also noted that median disease-free and OS times were shorter than

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Thomas Yang Sun Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA

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Lan Zhao Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA

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Paul Van Hummelen Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA

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Brock Martin Department of Pathology, Stanford University School of Medicine, Stanford, California, USA

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Kathleen Hornbacker Clinical Trials Office, Stanford University, Stanford, California, USA

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HoJoon Lee Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA

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Li C Xia Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
Division of Biostatistics, Department of Epidemiology and Public Health, Albert Einstein College of Medicine, Bronx, New York, USA

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Sukhmani K Padda Cedars-Sinai Medical Center, Department of Medical Oncology, Los Angeles, California, USA

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Hanlee P Ji Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
Stanford Genome Technology Center, Stanford, California, USA

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Pamela Kunz Yale School of Medicine, Smilow Cancer Hospital, Yale Cancer Center, New Haven, Connecticut, USA

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Introduction Neuroendocrine neoplasms (NENs) commonly originate from the gastroenteropancreatic (GEP) organs and the lungs but can also arise from most other organs in the body, including the genitourinary tract, head and neck, the gynecologic

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Kimberly Kamp Sector of Endocrinology, Department of Nuclear Medicine, Centro de Oncologia, Department of Pathophysiology, Department of Internal Medicine

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Brenda Gumz Sector of Endocrinology, Department of Nuclear Medicine, Centro de Oncologia, Department of Pathophysiology, Department of Internal Medicine

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Richard A Feelders Sector of Endocrinology, Department of Nuclear Medicine, Centro de Oncologia, Department of Pathophysiology, Department of Internal Medicine

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Dik J Kwekkeboom Sector of Endocrinology, Department of Nuclear Medicine, Centro de Oncologia, Department of Pathophysiology, Department of Internal Medicine

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Gregory Kaltsas Sector of Endocrinology, Department of Nuclear Medicine, Centro de Oncologia, Department of Pathophysiology, Department of Internal Medicine

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Frederico P Costa Sector of Endocrinology, Department of Nuclear Medicine, Centro de Oncologia, Department of Pathophysiology, Department of Internal Medicine

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Wouter W de Herder Sector of Endocrinology, Department of Nuclear Medicine, Centro de Oncologia, Department of Pathophysiology, Department of Internal Medicine

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Introduction Neuroendocrine tumors (NETs) form a heterogeneous group of relatively rare neoplasms that originate from different types of neuroendocrine cells ( Modlin et al . 2008 ). The incidence and prevalence of gastroenteropancreatic NETs (GEP

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Andrea Frilling
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Goran Åkerström Department of Surgery and Cancer, Department of Surgery, Department of Surgery University of Verona, Department of Gastroenterology and Hepatology, Department of Surgery, Department of Gastroenterological Surgery, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0HS, UK

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Massimo Falconi Department of Surgery and Cancer, Department of Surgery, Department of Surgery University of Verona, Department of Gastroenterology and Hepatology, Department of Surgery, Department of Gastroenterological Surgery, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0HS, UK

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Marianne Pavel Department of Surgery and Cancer, Department of Surgery, Department of Surgery University of Verona, Department of Gastroenterology and Hepatology, Department of Surgery, Department of Gastroenterological Surgery, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0HS, UK

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Jose Ramos Department of Surgery and Cancer, Department of Surgery, Department of Surgery University of Verona, Department of Gastroenterology and Hepatology, Department of Surgery, Department of Gastroenterological Surgery, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0HS, UK

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Mark Kidd Department of Surgery and Cancer, Department of Surgery, Department of Surgery University of Verona, Department of Gastroenterology and Hepatology, Department of Surgery, Department of Gastroenterological Surgery, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0HS, UK

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Irvin Mark Modlin Department of Surgery and Cancer, Department of Surgery, Department of Surgery University of Verona, Department of Gastroenterology and Hepatology, Department of Surgery, Department of Gastroenterological Surgery, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0HS, UK

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Introduction Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are also referred to as neuroendocrine tumors (NETs) or ‘carcinoids’, although this term is archaic and should be discarded in favor of a nomenclature reflective of specific

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Maria Chiara Zatelli
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Mirella Torta
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Antonette Leon
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Maria Rosaria Ambrosio
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Massimo Gion
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Paola Tomassetti
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Filippo De Braud
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Gianfranco Delle Fave
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Luigi Dogliotti
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Ettore C degli Uberti
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, an Italian multicenter observational study has been performed in a large series of gastroenteropancreatic (GEP) NET patients and healthy controls to assess the usefulness of CgA determination for the diagnosis of sporadic GEP NETs and to establish the

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Lisa Bodei Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
LuGenIum Consortium for Independent Research, Milan, Rotterdam, Bad Berka, London

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Irvin M Modlin LuGenIum Consortium for Independent Research, Milan, Rotterdam, Bad Berka, London
Emeritus Professor Gastroenterological Surgery, Yale University, School of Medicine, New Haven, Connecticut, USA

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Markus Luster Department of Nuclear Medicine, University Hospital Marburg, Marburg, Germany

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Flavio Forrer Nuclear Medicine, Cantonal Hospital, St. Gallen, Switzerland

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Marta Cremonesi Division of Health Physics, European Institute of Oncology, Milan, Italy

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Rodney J Hicks Centre for Cancer Imaging, The Peter MacCallum Cancer Centre, St Andrew’s Place, East Melbourne, Australia

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Samer Ezziddin Department of Nuclear Medicine, Saarland University Hospital, Homburg, Saarland, Germany

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Mark Kidd Wren Laboratories, Branford, Connecticut, USA

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Arturo Chiti Humanitas University, Milan, Italy

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Introduction It is now widely accepted that peptide receptor radionuclide therapy (PRRT) is an effective treatment for inoperable or metastatic neuroendocrine tumors (NETs), particularly well-differentiated gastroenteropancreatic (GEP) or

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Amira Mohamed Aix-Marseille Université, Molecular Biology Laboratory, Aix-Marseille Université, Department of Internal Medicine and Center of Excellence for Biomedical Research, Endocrinology Department, Oncology Department, Surgery Department, Biopathology Department, Pathology Laboratory, Surgery Department, Department of Integrative Biology and Pharmacology, CNRS, CRN2M‐UMR 7286, Faculté de Médecine, Secteur Nord – CS80011, 51, Bd Pierre Dramard, 13344 Marseille Cedex 15, France
Aix-Marseille Université, Molecular Biology Laboratory, Aix-Marseille Université, Department of Internal Medicine and Center of Excellence for Biomedical Research, Endocrinology Department, Oncology Department, Surgery Department, Biopathology Department, Pathology Laboratory, Surgery Department, Department of Integrative Biology and Pharmacology, CNRS, CRN2M‐UMR 7286, Faculté de Médecine, Secteur Nord – CS80011, 51, Bd Pierre Dramard, 13344 Marseille Cedex 15, France

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Marie-Pierre Blanchard Aix-Marseille Université, Molecular Biology Laboratory, Aix-Marseille Université, Department of Internal Medicine and Center of Excellence for Biomedical Research, Endocrinology Department, Oncology Department, Surgery Department, Biopathology Department, Pathology Laboratory, Surgery Department, Department of Integrative Biology and Pharmacology, CNRS, CRN2M‐UMR 7286, Faculté de Médecine, Secteur Nord – CS80011, 51, Bd Pierre Dramard, 13344 Marseille Cedex 15, France

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Manuela Albertelli Aix-Marseille Université, Molecular Biology Laboratory, Aix-Marseille Université, Department of Internal Medicine and Center of Excellence for Biomedical Research, Endocrinology Department, Oncology Department, Surgery Department, Biopathology Department, Pathology Laboratory, Surgery Department, Department of Integrative Biology and Pharmacology, CNRS, CRN2M‐UMR 7286, Faculté de Médecine, Secteur Nord – CS80011, 51, Bd Pierre Dramard, 13344 Marseille Cedex 15, France

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Federica Barbieri Aix-Marseille Université, Molecular Biology Laboratory, Aix-Marseille Université, Department of Internal Medicine and Center of Excellence for Biomedical Research, Endocrinology Department, Oncology Department, Surgery Department, Biopathology Department, Pathology Laboratory, Surgery Department, Department of Integrative Biology and Pharmacology, CNRS, CRN2M‐UMR 7286, Faculté de Médecine, Secteur Nord – CS80011, 51, Bd Pierre Dramard, 13344 Marseille Cedex 15, France

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Thierry Brue Aix-Marseille Université, Molecular Biology Laboratory, Aix-Marseille Université, Department of Internal Medicine and Center of Excellence for Biomedical Research, Endocrinology Department, Oncology Department, Surgery Department, Biopathology Department, Pathology Laboratory, Surgery Department, Department of Integrative Biology and Pharmacology, CNRS, CRN2M‐UMR 7286, Faculté de Médecine, Secteur Nord – CS80011, 51, Bd Pierre Dramard, 13344 Marseille Cedex 15, France
Aix-Marseille Université, Molecular Biology Laboratory, Aix-Marseille Université, Department of Internal Medicine and Center of Excellence for Biomedical Research, Endocrinology Department, Oncology Department, Surgery Department, Biopathology Department, Pathology Laboratory, Surgery Department, Department of Integrative Biology and Pharmacology, CNRS, CRN2M‐UMR 7286, Faculté de Médecine, Secteur Nord – CS80011, 51, Bd Pierre Dramard, 13344 Marseille Cedex 15, France

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Patricia Niccoli Aix-Marseille Université, Molecular Biology Laboratory, Aix-Marseille Université, Department of Internal Medicine and Center of Excellence for Biomedical Research, Endocrinology Department, Oncology Department, Surgery Department, Biopathology Department, Pathology Laboratory, Surgery Department, Department of Integrative Biology and Pharmacology, CNRS, CRN2M‐UMR 7286, Faculté de Médecine, Secteur Nord – CS80011, 51, Bd Pierre Dramard, 13344 Marseille Cedex 15, France

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Jean-Robert Delpero Aix-Marseille Université, Molecular Biology Laboratory, Aix-Marseille Université, Department of Internal Medicine and Center of Excellence for Biomedical Research, Endocrinology Department, Oncology Department, Surgery Department, Biopathology Department, Pathology Laboratory, Surgery Department, Department of Integrative Biology and Pharmacology, CNRS, CRN2M‐UMR 7286, Faculté de Médecine, Secteur Nord – CS80011, 51, Bd Pierre Dramard, 13344 Marseille Cedex 15, France

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Genevieve Monges Aix-Marseille Université, Molecular Biology Laboratory, Aix-Marseille Université, Department of Internal Medicine and Center of Excellence for Biomedical Research, Endocrinology Department, Oncology Department, Surgery Department, Biopathology Department, Pathology Laboratory, Surgery Department, Department of Integrative Biology and Pharmacology, CNRS, CRN2M‐UMR 7286, Faculté de Médecine, Secteur Nord – CS80011, 51, Bd Pierre Dramard, 13344 Marseille Cedex 15, France

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Stephane Garcia Aix-Marseille Université, Molecular Biology Laboratory, Aix-Marseille Université, Department of Internal Medicine and Center of Excellence for Biomedical Research, Endocrinology Department, Oncology Department, Surgery Department, Biopathology Department, Pathology Laboratory, Surgery Department, Department of Integrative Biology and Pharmacology, CNRS, CRN2M‐UMR 7286, Faculté de Médecine, Secteur Nord – CS80011, 51, Bd Pierre Dramard, 13344 Marseille Cedex 15, France

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Diego Ferone Aix-Marseille Université, Molecular Biology Laboratory, Aix-Marseille Université, Department of Internal Medicine and Center of Excellence for Biomedical Research, Endocrinology Department, Oncology Department, Surgery Department, Biopathology Department, Pathology Laboratory, Surgery Department, Department of Integrative Biology and Pharmacology, CNRS, CRN2M‐UMR 7286, Faculté de Médecine, Secteur Nord – CS80011, 51, Bd Pierre Dramard, 13344 Marseille Cedex 15, France

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Tullio Florio Aix-Marseille Université, Molecular Biology Laboratory, Aix-Marseille Université, Department of Internal Medicine and Center of Excellence for Biomedical Research, Endocrinology Department, Oncology Department, Surgery Department, Biopathology Department, Pathology Laboratory, Surgery Department, Department of Integrative Biology and Pharmacology, CNRS, CRN2M‐UMR 7286, Faculté de Médecine, Secteur Nord – CS80011, 51, Bd Pierre Dramard, 13344 Marseille Cedex 15, France

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Alain Enjalbert Aix-Marseille Université, Molecular Biology Laboratory, Aix-Marseille Université, Department of Internal Medicine and Center of Excellence for Biomedical Research, Endocrinology Department, Oncology Department, Surgery Department, Biopathology Department, Pathology Laboratory, Surgery Department, Department of Integrative Biology and Pharmacology, CNRS, CRN2M‐UMR 7286, Faculté de Médecine, Secteur Nord – CS80011, 51, Bd Pierre Dramard, 13344 Marseille Cedex 15, France
Aix-Marseille Université, Molecular Biology Laboratory, Aix-Marseille Université, Department of Internal Medicine and Center of Excellence for Biomedical Research, Endocrinology Department, Oncology Department, Surgery Department, Biopathology Department, Pathology Laboratory, Surgery Department, Department of Integrative Biology and Pharmacology, CNRS, CRN2M‐UMR 7286, Faculté de Médecine, Secteur Nord – CS80011, 51, Bd Pierre Dramard, 13344 Marseille Cedex 15, France

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Vincent Moutardier Aix-Marseille Université, Molecular Biology Laboratory, Aix-Marseille Université, Department of Internal Medicine and Center of Excellence for Biomedical Research, Endocrinology Department, Oncology Department, Surgery Department, Biopathology Department, Pathology Laboratory, Surgery Department, Department of Integrative Biology and Pharmacology, CNRS, CRN2M‐UMR 7286, Faculté de Médecine, Secteur Nord – CS80011, 51, Bd Pierre Dramard, 13344 Marseille Cedex 15, France

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Agnes Schonbrunn Aix-Marseille Université, Molecular Biology Laboratory, Aix-Marseille Université, Department of Internal Medicine and Center of Excellence for Biomedical Research, Endocrinology Department, Oncology Department, Surgery Department, Biopathology Department, Pathology Laboratory, Surgery Department, Department of Integrative Biology and Pharmacology, CNRS, CRN2M‐UMR 7286, Faculté de Médecine, Secteur Nord – CS80011, 51, Bd Pierre Dramard, 13344 Marseille Cedex 15, France

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Corinne Gerard Aix-Marseille Université, Molecular Biology Laboratory, Aix-Marseille Université, Department of Internal Medicine and Center of Excellence for Biomedical Research, Endocrinology Department, Oncology Department, Surgery Department, Biopathology Department, Pathology Laboratory, Surgery Department, Department of Integrative Biology and Pharmacology, CNRS, CRN2M‐UMR 7286, Faculté de Médecine, Secteur Nord – CS80011, 51, Bd Pierre Dramard, 13344 Marseille Cedex 15, France

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Anne Barlier Aix-Marseille Université, Molecular Biology Laboratory, Aix-Marseille Université, Department of Internal Medicine and Center of Excellence for Biomedical Research, Endocrinology Department, Oncology Department, Surgery Department, Biopathology Department, Pathology Laboratory, Surgery Department, Department of Integrative Biology and Pharmacology, CNRS, CRN2M‐UMR 7286, Faculté de Médecine, Secteur Nord – CS80011, 51, Bd Pierre Dramard, 13344 Marseille Cedex 15, France
Aix-Marseille Université, Molecular Biology Laboratory, Aix-Marseille Université, Department of Internal Medicine and Center of Excellence for Biomedical Research, Endocrinology Department, Oncology Department, Surgery Department, Biopathology Department, Pathology Laboratory, Surgery Department, Department of Integrative Biology and Pharmacology, CNRS, CRN2M‐UMR 7286, Faculté de Médecine, Secteur Nord – CS80011, 51, Bd Pierre Dramard, 13344 Marseille Cedex 15, France

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Alexandru Saveanu Aix-Marseille Université, Molecular Biology Laboratory, Aix-Marseille Université, Department of Internal Medicine and Center of Excellence for Biomedical Research, Endocrinology Department, Oncology Department, Surgery Department, Biopathology Department, Pathology Laboratory, Surgery Department, Department of Integrative Biology and Pharmacology, CNRS, CRN2M‐UMR 7286, Faculté de Médecine, Secteur Nord – CS80011, 51, Bd Pierre Dramard, 13344 Marseille Cedex 15, France
Aix-Marseille Université, Molecular Biology Laboratory, Aix-Marseille Université, Department of Internal Medicine and Center of Excellence for Biomedical Research, Endocrinology Department, Oncology Department, Surgery Department, Biopathology Department, Pathology Laboratory, Surgery Department, Department of Integrative Biology and Pharmacology, CNRS, CRN2M‐UMR 7286, Faculté de Médecine, Secteur Nord – CS80011, 51, Bd Pierre Dramard, 13344 Marseille Cedex 15, France

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Introduction Gastroenteropancreatic neuroendocrine tumors (GEP–NETs) constitute a rare group of tumors, with a significant increase in incidence and prevalence in the past few decades ( Oberg 2011 ). GEP–NETs still raise difficult therapeutic

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Tessa Brabander Department of Radiology & Nuclear Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

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Wouter A van der Zwan Department of Radiology & Nuclear Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

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Jaap J M Teunissen Department of Radiology & Nuclear Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

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Boen L R Kam Department of Radiology & Nuclear Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

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Wouter W de Herder Department of Internal Medicine, ENETS Center of Excellence, Erasmus Medical Center, Rotterdam, The Netherlands

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Richard A Feelders Department of Internal Medicine, ENETS Center of Excellence, Erasmus Medical Center, Rotterdam, The Netherlands

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Eric P Krenning Department of Radiology & Nuclear Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

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Dik J Kwekkeboom Department of Radiology & Nuclear Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

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for PRRT are Yttrium-90 and Lutetium-177, linked to [DOTA 0 ,Tyr 3 ]octreotide ( 90 Y-DOTATOC) or [DOTA 0 ,Tyr 3 ]octreotate ( 177 Lu-DOTATATE), respectively. The objective response rate in patients with gastroenteropancreatic neuroendocrine tumours

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Wouter T Zandee Department of Internal Medicine, Sector Endocrinology, ENETS Centre of Excellence, Erasmus MC, Rotterdam, the Netherlands

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Kimberly Kamp Department of Internal Medicine, Sector Endocrinology, ENETS Centre of Excellence, Erasmus MC, Rotterdam, the Netherlands

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Roxanne C van Adrichem Department of Internal Medicine, Sector Endocrinology, ENETS Centre of Excellence, Erasmus MC, Rotterdam, the Netherlands

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Richard A Feelders Department of Internal Medicine, Sector Endocrinology, ENETS Centre of Excellence, Erasmus MC, Rotterdam, the Netherlands

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Wouter W de Herder Department of Internal Medicine, Sector Endocrinology, ENETS Centre of Excellence, Erasmus MC, Rotterdam, the Netherlands

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chromogranin A as marker for survival in patients with metastatic endocrine gastroenteropancreatic tumors . Clinical Gastroenterology and Hepatology 6 820 – 827 . ( doi:10.1016/j.cgh.2008.02.052 ) Barclay TH Schapira DV 1983 Malignant tumors

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