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Maria Rosaria Rusciano Department of Biologia e Patologia Cellulare e Molecolare, Department of Endocrinologia ed Oncologia Molecolare e Clinica, Department of Scienze Farmaceutiche, Department of Biochimica e Biotecnologie Mediche, CEINGE-Biotecnologie Avanzate, CISI, Facoltà di Medicina, Università Federico II, Naples, Italy

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Marcella Salzano Department of Biologia e Patologia Cellulare e Molecolare, Department of Endocrinologia ed Oncologia Molecolare e Clinica, Department of Scienze Farmaceutiche, Department of Biochimica e Biotecnologie Mediche, CEINGE-Biotecnologie Avanzate, CISI, Facoltà di Medicina, Università Federico II, Naples, Italy

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Sara Monaco Department of Biologia e Patologia Cellulare e Molecolare, Department of Endocrinologia ed Oncologia Molecolare e Clinica, Department of Scienze Farmaceutiche, Department of Biochimica e Biotecnologie Mediche, CEINGE-Biotecnologie Avanzate, CISI, Facoltà di Medicina, Università Federico II, Naples, Italy

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Maria Rosaria Sapio Department of Biologia e Patologia Cellulare e Molecolare, Department of Endocrinologia ed Oncologia Molecolare e Clinica, Department of Scienze Farmaceutiche, Department of Biochimica e Biotecnologie Mediche, CEINGE-Biotecnologie Avanzate, CISI, Facoltà di Medicina, Università Federico II, Naples, Italy

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Maddalena Illario Department of Biologia e Patologia Cellulare e Molecolare, Department of Endocrinologia ed Oncologia Molecolare e Clinica, Department of Scienze Farmaceutiche, Department of Biochimica e Biotecnologie Mediche, CEINGE-Biotecnologie Avanzate, CISI, Facoltà di Medicina, Università Federico II, Naples, Italy

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Valentina De Falco Department of Biologia e Patologia Cellulare e Molecolare, Department of Endocrinologia ed Oncologia Molecolare e Clinica, Department of Scienze Farmaceutiche, Department of Biochimica e Biotecnologie Mediche, CEINGE-Biotecnologie Avanzate, CISI, Facoltà di Medicina, Università Federico II, Naples, Italy

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Massimo Santoro Department of Biologia e Patologia Cellulare e Molecolare, Department of Endocrinologia ed Oncologia Molecolare e Clinica, Department of Scienze Farmaceutiche, Department of Biochimica e Biotecnologie Mediche, CEINGE-Biotecnologie Avanzate, CISI, Facoltà di Medicina, Università Federico II, Naples, Italy

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Pietro Campiglia Department of Biologia e Patologia Cellulare e Molecolare, Department of Endocrinologia ed Oncologia Molecolare e Clinica, Department of Scienze Farmaceutiche, Department of Biochimica e Biotecnologie Mediche, CEINGE-Biotecnologie Avanzate, CISI, Facoltà di Medicina, Università Federico II, Naples, Italy

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Lucio Pastore Department of Biologia e Patologia Cellulare e Molecolare, Department of Endocrinologia ed Oncologia Molecolare e Clinica, Department of Scienze Farmaceutiche, Department of Biochimica e Biotecnologie Mediche, CEINGE-Biotecnologie Avanzate, CISI, Facoltà di Medicina, Università Federico II, Naples, Italy
Department of Biologia e Patologia Cellulare e Molecolare, Department of Endocrinologia ed Oncologia Molecolare e Clinica, Department of Scienze Farmaceutiche, Department of Biochimica e Biotecnologie Mediche, CEINGE-Biotecnologie Avanzate, CISI, Facoltà di Medicina, Università Federico II, Naples, Italy

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Gianfranco Fenzi Department of Biologia e Patologia Cellulare e Molecolare, Department of Endocrinologia ed Oncologia Molecolare e Clinica, Department of Scienze Farmaceutiche, Department of Biochimica e Biotecnologie Mediche, CEINGE-Biotecnologie Avanzate, CISI, Facoltà di Medicina, Università Federico II, Naples, Italy

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Guido Rossi Department of Biologia e Patologia Cellulare e Molecolare, Department of Endocrinologia ed Oncologia Molecolare e Clinica, Department of Scienze Farmaceutiche, Department of Biochimica e Biotecnologie Mediche, CEINGE-Biotecnologie Avanzate, CISI, Facoltà di Medicina, Università Federico II, Naples, Italy
Department of Biologia e Patologia Cellulare e Molecolare, Department of Endocrinologia ed Oncologia Molecolare e Clinica, Department of Scienze Farmaceutiche, Department of Biochimica e Biotecnologie Mediche, CEINGE-Biotecnologie Avanzate, CISI, Facoltà di Medicina, Università Federico II, Naples, Italy

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Mario Vitale Department of Biologia e Patologia Cellulare e Molecolare, Department of Endocrinologia ed Oncologia Molecolare e Clinica, Department of Scienze Farmaceutiche, Department of Biochimica e Biotecnologie Mediche, CEINGE-Biotecnologie Avanzate, CISI, Facoltà di Medicina, Università Federico II, Naples, Italy
Department of Biologia e Patologia Cellulare e Molecolare, Department of Endocrinologia ed Oncologia Molecolare e Clinica, Department of Scienze Farmaceutiche, Department of Biochimica e Biotecnologie Mediche, CEINGE-Biotecnologie Avanzate, CISI, Facoltà di Medicina, Università Federico II, Naples, Italy

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Introduction Papillary thyroid carcinoma (PTC) is the most common thyroid cancer, accounting for more than 80% of thyroid malignancies ( Sherman 2003 ). It frequently carries genetic alterations, all resulting in the inappropriate activation

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-09-0214
Volume/Issue:
Volume 17: Issue 1
Free access
Charles E Massie Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Inmaculada Spiteri Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Helen Ross-Adams Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Hayley Luxton Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Jonathan Kay Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Hayley C Whitaker Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Mark J Dunning Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Alastair D Lamb Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK
Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK
Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Antonio Ramos-Montoya Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Daniel S Brewer Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Colin S Cooper Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK
Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Rosalind Eeles Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK
Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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UK Prostate ICGC Group
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Anne Y Warren Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Simon Tavaré Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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David E Neal Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK
Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK
Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Andy G Lynch Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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, Caini et al . 2014 ), metabolic stress ( Freedland 2005 , Kalaany & Sabatini 2009 ) and epigenetic alterations ( Lee et al . 1994 , Kanwal et al . 2014 ). It is likely that non-genetic and genetic alterations interact during tumourigenesis and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-14-0454
Volume/Issue:
Volume 22: Issue 2
Open access
Johan O Paulsson Department of Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital CCK, Stockholm, Sweden

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Ninni Mu Department of Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital CCK, Stockholm, Sweden

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Ivan Shabo Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
Department of Breast, Endocrine Tumours and Sarcoma, Karolinska University Hospital, Stockholm, Sweden

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Na Wang Department of Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital CCK, Stockholm, Sweden

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Jan Zedenius Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
Department of Breast, Endocrine Tumours and Sarcoma, Karolinska University Hospital, Stockholm, Sweden

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Catharina Larsson Department of Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital CCK, Stockholm, Sweden

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C Christofer Juhlin Department of Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital CCK, Stockholm, Sweden

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for 6 months, and then discharged to the primary healthcare system for follow-up with a general practitioner ( Hennings et al . 2012 ). There is currently a lack of knowledge of molecular alterations of the TERT gene locus that can have a possible

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-18-0050
Volume/Issue:
Volume 25: Issue 7
Free access
F Cetani
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E Pardi
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E Ambrogini
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P Viacava
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S Borsari
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M Lemmi
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L Cianferotti
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P Miccoli
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A Pinchera
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A Arnold
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C Marcocci
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parafibromin staining in a small rim of normal tissue surrounding the LI adenoma. Only one study has investigated genetic alterations in multiple tumors occurring in the same patient with sporadic PHPT (five cases of double adenomas; Dwight et al

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-06-0092
Volume/Issue:
Volume 14: Issue 2
Free access
Kathryn E Ware Departments of Molecular Genetics and Medicine Duke University, 213 Research Dr, 0045 CARL Building, Durham, North Carolina 27710, USA

Department of Medicine Duke Cancer Institute, Duke University, Durham, North Carolina, USA

Masonic Cancer Center University of Minnesota Masonic Cancer Center, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, Minnesota 55455, USA

Department of Laboratory Medicine and Pathology University of Minnesota, Minneapolis, Minnesota, USA

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Mariano A Garcia-Blanco Departments of Molecular Genetics and Medicine Duke University, 213 Research Dr, 0045 CARL Building, Durham, North Carolina 27710, USA

Department of Medicine Duke Cancer Institute, Duke University, Durham, North Carolina, USA

Masonic Cancer Center University of Minnesota Masonic Cancer Center, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, Minnesota 55455, USA

Department of Laboratory Medicine and Pathology University of Minnesota, Minneapolis, Minnesota, USA
Departments of Molecular Genetics and Medicine Duke University, 213 Research Dr, 0045 CARL Building, Durham, North Carolina 27710, USA

Department of Medicine Duke Cancer Institute, Duke University, Durham, North Carolina, USA

Masonic Cancer Center University of Minnesota Masonic Cancer Center, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, Minnesota 55455, USA

Department of Laboratory Medicine and Pathology University of Minnesota, Minneapolis, Minnesota, USA

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Andrew J Armstrong Departments of Molecular Genetics and Medicine Duke University, 213 Research Dr, 0045 CARL Building, Durham, North Carolina 27710, USA

Department of Medicine Duke Cancer Institute, Duke University, Durham, North Carolina, USA

Masonic Cancer Center University of Minnesota Masonic Cancer Center, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, Minnesota 55455, USA

Department of Laboratory Medicine and Pathology University of Minnesota, Minneapolis, Minnesota, USA
Departments of Molecular Genetics and Medicine Duke University, 213 Research Dr, 0045 CARL Building, Durham, North Carolina 27710, USA

Department of Medicine Duke Cancer Institute, Duke University, Durham, North Carolina, USA

Masonic Cancer Center University of Minnesota Masonic Cancer Center, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, Minnesota 55455, USA

Department of Laboratory Medicine and Pathology University of Minnesota, Minneapolis, Minnesota, USA

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Scott M Dehm Departments of Molecular Genetics and Medicine Duke University, 213 Research Dr, 0045 CARL Building, Durham, North Carolina 27710, USA

Department of Medicine Duke Cancer Institute, Duke University, Durham, North Carolina, USA

Masonic Cancer Center University of Minnesota Masonic Cancer Center, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, Minnesota 55455, USA

Department of Laboratory Medicine and Pathology University of Minnesota, Minneapolis, Minnesota, USA
Departments of Molecular Genetics and Medicine Duke University, 213 Research Dr, 0045 CARL Building, Durham, North Carolina 27710, USA

Department of Medicine Duke Cancer Institute, Duke University, Durham, North Carolina, USA

Masonic Cancer Center University of Minnesota Masonic Cancer Center, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, Minnesota 55455, USA

Department of Laboratory Medicine and Pathology University of Minnesota, Minneapolis, Minnesota, USA

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variant protein. This suggests that expression of AR variants in CWR22Pc cells is limited to those cells harboring the genetic duplication and that these genomic alterations cause variations in AR splicing. Indeed, AR intragenic rearrangements have also

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-13-0470
Volume/Issue:
Volume 21: Issue 4
Free access
Rossella Libè
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Amato Fratticci
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Jérôme Bertherat
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monoclonal populations of cells, whereas benign tumors might be monoclonal as well as polyclonal ( Beuschlein et al. 1994 , Gicquel et al. 1994 ). Monoclonal tumors result from genetic alterations conferring a growth advantage to the cell

Article Type:
Review Article
DOI:
https://doi.org/10.1677/erc.1.01130
Volume/Issue:
Volume 14: Issue 1
Free access
Johanna Sandgren Department of Surgical Sciences, Rudbeck Laboratory, Department of Cell and Molecular Biology, Department of Biology and Pharmaceutical Botany, Department of Molecular Medicine and Surgery, Department of General, Southern Research Institute, Uppsala University Hospital
Department of Surgical Sciences, Rudbeck Laboratory, Department of Cell and Molecular Biology, Department of Biology and Pharmaceutical Botany, Department of Molecular Medicine and Surgery, Department of General, Southern Research Institute, Uppsala University Hospital

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Teresita Diaz de Ståhl Department of Surgical Sciences, Rudbeck Laboratory, Department of Cell and Molecular Biology, Department of Biology and Pharmaceutical Botany, Department of Molecular Medicine and Surgery, Department of General, Southern Research Institute, Uppsala University Hospital

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Robin Andersson Department of Surgical Sciences, Rudbeck Laboratory, Department of Cell and Molecular Biology, Department of Biology and Pharmaceutical Botany, Department of Molecular Medicine and Surgery, Department of General, Southern Research Institute, Uppsala University Hospital

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Uwe Menzel Department of Surgical Sciences, Rudbeck Laboratory, Department of Cell and Molecular Biology, Department of Biology and Pharmaceutical Botany, Department of Molecular Medicine and Surgery, Department of General, Southern Research Institute, Uppsala University Hospital

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Arkadiusz Piotrowski Department of Surgical Sciences, Rudbeck Laboratory, Department of Cell and Molecular Biology, Department of Biology and Pharmaceutical Botany, Department of Molecular Medicine and Surgery, Department of General, Southern Research Institute, Uppsala University Hospital

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Helena Nord Department of Surgical Sciences, Rudbeck Laboratory, Department of Cell and Molecular Biology, Department of Biology and Pharmaceutical Botany, Department of Molecular Medicine and Surgery, Department of General, Southern Research Institute, Uppsala University Hospital

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Martin Bäckdahl Department of Surgical Sciences, Rudbeck Laboratory, Department of Cell and Molecular Biology, Department of Biology and Pharmaceutical Botany, Department of Molecular Medicine and Surgery, Department of General, Southern Research Institute, Uppsala University Hospital

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Nimrod B Kiss Department of Surgical Sciences, Rudbeck Laboratory, Department of Cell and Molecular Biology, Department of Biology and Pharmaceutical Botany, Department of Molecular Medicine and Surgery, Department of General, Southern Research Institute, Uppsala University Hospital

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Michael Brauckhoff Department of Surgical Sciences, Rudbeck Laboratory, Department of Cell and Molecular Biology, Department of Biology and Pharmaceutical Botany, Department of Molecular Medicine and Surgery, Department of General, Southern Research Institute, Uppsala University Hospital

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Jan Komorowski Department of Surgical Sciences, Rudbeck Laboratory, Department of Cell and Molecular Biology, Department of Biology and Pharmaceutical Botany, Department of Molecular Medicine and Surgery, Department of General, Southern Research Institute, Uppsala University Hospital

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Henning Dralle Department of Surgical Sciences, Rudbeck Laboratory, Department of Cell and Molecular Biology, Department of Biology and Pharmaceutical Botany, Department of Molecular Medicine and Surgery, Department of General, Southern Research Institute, Uppsala University Hospital

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Ola Hessman Department of Surgical Sciences, Rudbeck Laboratory, Department of Cell and Molecular Biology, Department of Biology and Pharmaceutical Botany, Department of Molecular Medicine and Surgery, Department of General, Southern Research Institute, Uppsala University Hospital

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Catharina Larsson Department of Surgical Sciences, Rudbeck Laboratory, Department of Cell and Molecular Biology, Department of Biology and Pharmaceutical Botany, Department of Molecular Medicine and Surgery, Department of General, Southern Research Institute, Uppsala University Hospital

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Göran Åkerström Department of Surgical Sciences, Rudbeck Laboratory, Department of Cell and Molecular Biology, Department of Biology and Pharmaceutical Botany, Department of Molecular Medicine and Surgery, Department of General, Southern Research Institute, Uppsala University Hospital

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Carl Bruder Department of Surgical Sciences, Rudbeck Laboratory, Department of Cell and Molecular Biology, Department of Biology and Pharmaceutical Botany, Department of Molecular Medicine and Surgery, Department of General, Southern Research Institute, Uppsala University Hospital

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Jan P Dumanski Department of Surgical Sciences, Rudbeck Laboratory, Department of Cell and Molecular Biology, Department of Biology and Pharmaceutical Botany, Department of Molecular Medicine and Surgery, Department of General, Southern Research Institute, Uppsala University Hospital

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Gunnar Westin Department of Surgical Sciences, Rudbeck Laboratory, Department of Cell and Molecular Biology, Department of Biology and Pharmaceutical Botany, Department of Molecular Medicine and Surgery, Department of General, Southern Research Institute, Uppsala University Hospital

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gene, in hereditary paraganglioma . Science 287 848 – 851 . Bender BU Gutsche M Glasker S Muller B Kirste G Eng C Neumann HP 2000 Differential genetic alterations in von Hippel–Lindau syndrome-associated and sporadic

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-09-0310
Volume/Issue:
Volume 17: Issue 3
Free access
Tobias Åkerström Department of Surgical Sciences, Department of Endocrinology and Metabolism, General, University of Sydney, Department of Medicine I, Department of General, Department of Molecular Medicine and Surgery, Department of Immunology, Klinik für Chirurgie und Zentrum für Minimal Invasive Chirurgie, Uppsala University, Uppsala, Sweden

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Holger Sven Willenberg Department of Surgical Sciences, Department of Endocrinology and Metabolism, General, University of Sydney, Department of Medicine I, Department of General, Department of Molecular Medicine and Surgery, Department of Immunology, Klinik für Chirurgie und Zentrum für Minimal Invasive Chirurgie, Uppsala University, Uppsala, Sweden

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Kenko Cupisti Department of Surgical Sciences, Department of Endocrinology and Metabolism, General, University of Sydney, Department of Medicine I, Department of General, Department of Molecular Medicine and Surgery, Department of Immunology, Klinik für Chirurgie und Zentrum für Minimal Invasive Chirurgie, Uppsala University, Uppsala, Sweden

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Julian Ip Department of Surgical Sciences, Department of Endocrinology and Metabolism, General, University of Sydney, Department of Medicine I, Department of General, Department of Molecular Medicine and Surgery, Department of Immunology, Klinik für Chirurgie und Zentrum für Minimal Invasive Chirurgie, Uppsala University, Uppsala, Sweden

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Samuel Backman Department of Surgical Sciences, Department of Endocrinology and Metabolism, General, University of Sydney, Department of Medicine I, Department of General, Department of Molecular Medicine and Surgery, Department of Immunology, Klinik für Chirurgie und Zentrum für Minimal Invasive Chirurgie, Uppsala University, Uppsala, Sweden

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Ana Moser Department of Surgical Sciences, Department of Endocrinology and Metabolism, General, University of Sydney, Department of Medicine I, Department of General, Department of Molecular Medicine and Surgery, Department of Immunology, Klinik für Chirurgie und Zentrum für Minimal Invasive Chirurgie, Uppsala University, Uppsala, Sweden

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Rajani Maharjan Department of Surgical Sciences, Department of Endocrinology and Metabolism, General, University of Sydney, Department of Medicine I, Department of General, Department of Molecular Medicine and Surgery, Department of Immunology, Klinik für Chirurgie und Zentrum für Minimal Invasive Chirurgie, Uppsala University, Uppsala, Sweden

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Bruce Robinson Department of Surgical Sciences, Department of Endocrinology and Metabolism, General, University of Sydney, Department of Medicine I, Department of General, Department of Molecular Medicine and Surgery, Department of Immunology, Klinik für Chirurgie und Zentrum für Minimal Invasive Chirurgie, Uppsala University, Uppsala, Sweden

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K Alexander Iwen Department of Surgical Sciences, Department of Endocrinology and Metabolism, General, University of Sydney, Department of Medicine I, Department of General, Department of Molecular Medicine and Surgery, Department of Immunology, Klinik für Chirurgie und Zentrum für Minimal Invasive Chirurgie, Uppsala University, Uppsala, Sweden

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Henning Dralle Department of Surgical Sciences, Department of Endocrinology and Metabolism, General, University of Sydney, Department of Medicine I, Department of General, Department of Molecular Medicine and Surgery, Department of Immunology, Klinik für Chirurgie und Zentrum für Minimal Invasive Chirurgie, Uppsala University, Uppsala, Sweden

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Cristina D Volpe Department of Surgical Sciences, Department of Endocrinology and Metabolism, General, University of Sydney, Department of Medicine I, Department of General, Department of Molecular Medicine and Surgery, Department of Immunology, Klinik für Chirurgie und Zentrum für Minimal Invasive Chirurgie, Uppsala University, Uppsala, Sweden

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Martin Bäckdahl Department of Surgical Sciences, Department of Endocrinology and Metabolism, General, University of Sydney, Department of Medicine I, Department of General, Department of Molecular Medicine and Surgery, Department of Immunology, Klinik für Chirurgie und Zentrum für Minimal Invasive Chirurgie, Uppsala University, Uppsala, Sweden

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Johan Botling Department of Surgical Sciences, Department of Endocrinology and Metabolism, General, University of Sydney, Department of Medicine I, Department of General, Department of Molecular Medicine and Surgery, Department of Immunology, Klinik für Chirurgie und Zentrum für Minimal Invasive Chirurgie, Uppsala University, Uppsala, Sweden

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Peter Stålberg Department of Surgical Sciences, Department of Endocrinology and Metabolism, General, University of Sydney, Department of Medicine I, Department of General, Department of Molecular Medicine and Surgery, Department of Immunology, Klinik für Chirurgie und Zentrum für Minimal Invasive Chirurgie, Uppsala University, Uppsala, Sweden

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Gunnar Westin Department of Surgical Sciences, Department of Endocrinology and Metabolism, General, University of Sydney, Department of Medicine I, Department of General, Department of Molecular Medicine and Surgery, Department of Immunology, Klinik für Chirurgie und Zentrum für Minimal Invasive Chirurgie, Uppsala University, Uppsala, Sweden

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Martin K Walz Department of Surgical Sciences, Department of Endocrinology and Metabolism, General, University of Sydney, Department of Medicine I, Department of General, Department of Molecular Medicine and Surgery, Department of Immunology, Klinik für Chirurgie und Zentrum für Minimal Invasive Chirurgie, Uppsala University, Uppsala, Sweden

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Hendrik Lehnert Department of Surgical Sciences, Department of Endocrinology and Metabolism, General, University of Sydney, Department of Medicine I, Department of General, Department of Molecular Medicine and Surgery, Department of Immunology, Klinik für Chirurgie und Zentrum für Minimal Invasive Chirurgie, Uppsala University, Uppsala, Sweden

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Stan Sidhu Department of Surgical Sciences, Department of Endocrinology and Metabolism, General, University of Sydney, Department of Medicine I, Department of General, Department of Molecular Medicine and Surgery, Department of Immunology, Klinik für Chirurgie und Zentrum für Minimal Invasive Chirurgie, Uppsala University, Uppsala, Sweden

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Jan Zedenius Department of Surgical Sciences, Department of Endocrinology and Metabolism, General, University of Sydney, Department of Medicine I, Department of General, Department of Molecular Medicine and Surgery, Department of Immunology, Klinik für Chirurgie und Zentrum für Minimal Invasive Chirurgie, Uppsala University, Uppsala, Sweden

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Peyman Björklund Department of Surgical Sciences, Department of Endocrinology and Metabolism, General, University of Sydney, Department of Medicine I, Department of General, Department of Molecular Medicine and Surgery, Department of Immunology, Klinik für Chirurgie und Zentrum für Minimal Invasive Chirurgie, Uppsala University, Uppsala, Sweden

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Per Hellman Department of Surgical Sciences, Department of Endocrinology and Metabolism, General, University of Sydney, Department of Medicine I, Department of General, Department of Molecular Medicine and Surgery, Department of Immunology, Klinik für Chirurgie und Zentrum für Minimal Invasive Chirurgie, Uppsala University, Uppsala, Sweden

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abdominal CT scan. These were deemed functionally silent after negative hormone analyses and were removed on suspicion of malignancy (size or other radiological signs). Molecular genetic analyses DNA/RNA was extracted using Allprep DNA/RNA mini kit, (Qiagen

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-15-0321
Volume/Issue:
Volume 22: Issue 5
Free access
Lucieli Ceolin Thyroid Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brasil

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Marta Amaro da Silveira Duval Thyroid Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brasil

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Antônio Felippe Benini Thyroid Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brasil

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Carla Vaz Ferreira Thyroid Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brasil

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Ana Luiza Maia Thyroid Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brasil

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mutation into the mouse endogenous Ret gene caused CCH but not MTC, suggesting that, in the background of a normally expressed Ret -mutant allele, the accumulation of secondary genetic alterations is required for the development of MTC ( Smith-Hicks et

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-18-0574
Volume/Issue:
Volume 26: Issue 9
Free access
Maria A Tichomirowa Departments of, Endocrinology, Molecular Genetics, Institute of Pathology, Laboratory of Biochemistry and Molecular Biology, CRN2M, Department of Experimental Medicine, Neuromed, Division of Endocrinology, Department of Endocrinology, Group for Advanced Molecular Investigation, Service d'Endocrinologie, Department of Endocrinology, Unit of Endocrinology, Department of Endocrinology, Department of Endocrinology, Clinical Center of Endocrinology and Gerontology, Faculty of Medicine, Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Internal Medicine and Endocrinology, Department of Endocrinology, Service d'Endocrinologie, Centre Hospitalier Universitaire de Liège, Domaine Universitaire du Sart‐Tilman, University of Liège, 4000 Liège, Belgium

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Misu Lee Departments of, Endocrinology, Molecular Genetics, Institute of Pathology, Laboratory of Biochemistry and Molecular Biology, CRN2M, Department of Experimental Medicine, Neuromed, Division of Endocrinology, Department of Endocrinology, Group for Advanced Molecular Investigation, Service d'Endocrinologie, Department of Endocrinology, Unit of Endocrinology, Department of Endocrinology, Department of Endocrinology, Clinical Center of Endocrinology and Gerontology, Faculty of Medicine, Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Internal Medicine and Endocrinology, Department of Endocrinology, Service d'Endocrinologie, Centre Hospitalier Universitaire de Liège, Domaine Universitaire du Sart‐Tilman, University of Liège, 4000 Liège, Belgium

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Anne Barlier Departments of, Endocrinology, Molecular Genetics, Institute of Pathology, Laboratory of Biochemistry and Molecular Biology, CRN2M, Department of Experimental Medicine, Neuromed, Division of Endocrinology, Department of Endocrinology, Group for Advanced Molecular Investigation, Service d'Endocrinologie, Department of Endocrinology, Unit of Endocrinology, Department of Endocrinology, Department of Endocrinology, Clinical Center of Endocrinology and Gerontology, Faculty of Medicine, Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Internal Medicine and Endocrinology, Department of Endocrinology, Service d'Endocrinologie, Centre Hospitalier Universitaire de Liège, Domaine Universitaire du Sart‐Tilman, University of Liège, 4000 Liège, Belgium
Departments of, Endocrinology, Molecular Genetics, Institute of Pathology, Laboratory of Biochemistry and Molecular Biology, CRN2M, Department of Experimental Medicine, Neuromed, Division of Endocrinology, Department of Endocrinology, Group for Advanced Molecular Investigation, Service d'Endocrinologie, Department of Endocrinology, Unit of Endocrinology, Department of Endocrinology, Department of Endocrinology, Clinical Center of Endocrinology and Gerontology, Faculty of Medicine, Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Internal Medicine and Endocrinology, Department of Endocrinology, Service d'Endocrinologie, Centre Hospitalier Universitaire de Liège, Domaine Universitaire du Sart‐Tilman, University of Liège, 4000 Liège, Belgium

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Adrian F Daly Departments of, Endocrinology, Molecular Genetics, Institute of Pathology, Laboratory of Biochemistry and Molecular Biology, CRN2M, Department of Experimental Medicine, Neuromed, Division of Endocrinology, Department of Endocrinology, Group for Advanced Molecular Investigation, Service d'Endocrinologie, Department of Endocrinology, Unit of Endocrinology, Department of Endocrinology, Department of Endocrinology, Clinical Center of Endocrinology and Gerontology, Faculty of Medicine, Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Internal Medicine and Endocrinology, Department of Endocrinology, Service d'Endocrinologie, Centre Hospitalier Universitaire de Liège, Domaine Universitaire du Sart‐Tilman, University of Liège, 4000 Liège, Belgium

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Ilaria Marinoni Departments of, Endocrinology, Molecular Genetics, Institute of Pathology, Laboratory of Biochemistry and Molecular Biology, CRN2M, Department of Experimental Medicine, Neuromed, Division of Endocrinology, Department of Endocrinology, Group for Advanced Molecular Investigation, Service d'Endocrinologie, Department of Endocrinology, Unit of Endocrinology, Department of Endocrinology, Department of Endocrinology, Clinical Center of Endocrinology and Gerontology, Faculty of Medicine, Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Internal Medicine and Endocrinology, Department of Endocrinology, Service d'Endocrinologie, Centre Hospitalier Universitaire de Liège, Domaine Universitaire du Sart‐Tilman, University of Liège, 4000 Liège, Belgium

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Marie-Lise Jaffrain-Rea Departments of, Endocrinology, Molecular Genetics, Institute of Pathology, Laboratory of Biochemistry and Molecular Biology, CRN2M, Department of Experimental Medicine, Neuromed, Division of Endocrinology, Department of Endocrinology, Group for Advanced Molecular Investigation, Service d'Endocrinologie, Department of Endocrinology, Unit of Endocrinology, Department of Endocrinology, Department of Endocrinology, Clinical Center of Endocrinology and Gerontology, Faculty of Medicine, Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Internal Medicine and Endocrinology, Department of Endocrinology, Service d'Endocrinologie, Centre Hospitalier Universitaire de Liège, Domaine Universitaire du Sart‐Tilman, University of Liège, 4000 Liège, Belgium
Departments of, Endocrinology, Molecular Genetics, Institute of Pathology, Laboratory of Biochemistry and Molecular Biology, CRN2M, Department of Experimental Medicine, Neuromed, Division of Endocrinology, Department of Endocrinology, Group for Advanced Molecular Investigation, Service d'Endocrinologie, Department of Endocrinology, Unit of Endocrinology, Department of Endocrinology, Department of Endocrinology, Clinical Center of Endocrinology and Gerontology, Faculty of Medicine, Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Internal Medicine and Endocrinology, Department of Endocrinology, Service d'Endocrinologie, Centre Hospitalier Universitaire de Liège, Domaine Universitaire du Sart‐Tilman, University of Liège, 4000 Liège, Belgium

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Luciana A Naves Departments of, Endocrinology, Molecular Genetics, Institute of Pathology, Laboratory of Biochemistry and Molecular Biology, CRN2M, Department of Experimental Medicine, Neuromed, Division of Endocrinology, Department of Endocrinology, Group for Advanced Molecular Investigation, Service d'Endocrinologie, Department of Endocrinology, Unit of Endocrinology, Department of Endocrinology, Department of Endocrinology, Clinical Center of Endocrinology and Gerontology, Faculty of Medicine, Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Internal Medicine and Endocrinology, Department of Endocrinology, Service d'Endocrinologie, Centre Hospitalier Universitaire de Liège, Domaine Universitaire du Sart‐Tilman, University of Liège, 4000 Liège, Belgium

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Patrice Rodien Departments of, Endocrinology, Molecular Genetics, Institute of Pathology, Laboratory of Biochemistry and Molecular Biology, CRN2M, Department of Experimental Medicine, Neuromed, Division of Endocrinology, Department of Endocrinology, Group for Advanced Molecular Investigation, Service d'Endocrinologie, Department of Endocrinology, Unit of Endocrinology, Department of Endocrinology, Department of Endocrinology, Clinical Center of Endocrinology and Gerontology, Faculty of Medicine, Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Internal Medicine and Endocrinology, Department of Endocrinology, Service d'Endocrinologie, Centre Hospitalier Universitaire de Liège, Domaine Universitaire du Sart‐Tilman, University of Liège, 4000 Liège, Belgium

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Vincent Rohmer Departments of, Endocrinology, Molecular Genetics, Institute of Pathology, Laboratory of Biochemistry and Molecular Biology, CRN2M, Department of Experimental Medicine, Neuromed, Division of Endocrinology, Department of Endocrinology, Group for Advanced Molecular Investigation, Service d'Endocrinologie, Department of Endocrinology, Unit of Endocrinology, Department of Endocrinology, Department of Endocrinology, Clinical Center of Endocrinology and Gerontology, Faculty of Medicine, Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Internal Medicine and Endocrinology, Department of Endocrinology, Service d'Endocrinologie, Centre Hospitalier Universitaire de Liège, Domaine Universitaire du Sart‐Tilman, University of Liège, 4000 Liège, Belgium

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Fabio Rueda Faucz Departments of, Endocrinology, Molecular Genetics, Institute of Pathology, Laboratory of Biochemistry and Molecular Biology, CRN2M, Department of Experimental Medicine, Neuromed, Division of Endocrinology, Department of Endocrinology, Group for Advanced Molecular Investigation, Service d'Endocrinologie, Department of Endocrinology, Unit of Endocrinology, Department of Endocrinology, Department of Endocrinology, Clinical Center of Endocrinology and Gerontology, Faculty of Medicine, Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Internal Medicine and Endocrinology, Department of Endocrinology, Service d'Endocrinologie, Centre Hospitalier Universitaire de Liège, Domaine Universitaire du Sart‐Tilman, University of Liège, 4000 Liège, Belgium

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Philippe Caron Departments of, Endocrinology, Molecular Genetics, Institute of Pathology, Laboratory of Biochemistry and Molecular Biology, CRN2M, Department of Experimental Medicine, Neuromed, Division of Endocrinology, Department of Endocrinology, Group for Advanced Molecular Investigation, Service d'Endocrinologie, Department of Endocrinology, Unit of Endocrinology, Department of Endocrinology, Department of Endocrinology, Clinical Center of Endocrinology and Gerontology, Faculty of Medicine, Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Internal Medicine and Endocrinology, Department of Endocrinology, Service d'Endocrinologie, Centre Hospitalier Universitaire de Liège, Domaine Universitaire du Sart‐Tilman, University of Liège, 4000 Liège, Belgium

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Bruno Estour Departments of, Endocrinology, Molecular Genetics, Institute of Pathology, Laboratory of Biochemistry and Molecular Biology, CRN2M, Department of Experimental Medicine, Neuromed, Division of Endocrinology, Department of Endocrinology, Group for Advanced Molecular Investigation, Service d'Endocrinologie, Department of Endocrinology, Unit of Endocrinology, Department of Endocrinology, Department of Endocrinology, Clinical Center of Endocrinology and Gerontology, Faculty of Medicine, Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Internal Medicine and Endocrinology, Department of Endocrinology, Service d'Endocrinologie, Centre Hospitalier Universitaire de Liège, Domaine Universitaire du Sart‐Tilman, University of Liège, 4000 Liège, Belgium

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Pierre Lecomte Departments of, Endocrinology, Molecular Genetics, Institute of Pathology, Laboratory of Biochemistry and Molecular Biology, CRN2M, Department of Experimental Medicine, Neuromed, Division of Endocrinology, Department of Endocrinology, Group for Advanced Molecular Investigation, Service d'Endocrinologie, Department of Endocrinology, Unit of Endocrinology, Department of Endocrinology, Department of Endocrinology, Clinical Center of Endocrinology and Gerontology, Faculty of Medicine, Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Internal Medicine and Endocrinology, Department of Endocrinology, Service d'Endocrinologie, Centre Hospitalier Universitaire de Liège, Domaine Universitaire du Sart‐Tilman, University of Liège, 4000 Liège, Belgium

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Françoise Borson-Chazot Departments of, Endocrinology, Molecular Genetics, Institute of Pathology, Laboratory of Biochemistry and Molecular Biology, CRN2M, Department of Experimental Medicine, Neuromed, Division of Endocrinology, Department of Endocrinology, Group for Advanced Molecular Investigation, Service d'Endocrinologie, Department of Endocrinology, Unit of Endocrinology, Department of Endocrinology, Department of Endocrinology, Clinical Center of Endocrinology and Gerontology, Faculty of Medicine, Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Internal Medicine and Endocrinology, Department of Endocrinology, Service d'Endocrinologie, Centre Hospitalier Universitaire de Liège, Domaine Universitaire du Sart‐Tilman, University of Liège, 4000 Liège, Belgium

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Alfred Penfornis Departments of, Endocrinology, Molecular Genetics, Institute of Pathology, Laboratory of Biochemistry and Molecular Biology, CRN2M, Department of Experimental Medicine, Neuromed, Division of Endocrinology, Department of Endocrinology, Group for Advanced Molecular Investigation, Service d'Endocrinologie, Department of Endocrinology, Unit of Endocrinology, Department of Endocrinology, Department of Endocrinology, Clinical Center of Endocrinology and Gerontology, Faculty of Medicine, Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Internal Medicine and Endocrinology, Department of Endocrinology, Service d'Endocrinologie, Centre Hospitalier Universitaire de Liège, Domaine Universitaire du Sart‐Tilman, University of Liège, 4000 Liège, Belgium

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Maria Yaneva Departments of, Endocrinology, Molecular Genetics, Institute of Pathology, Laboratory of Biochemistry and Molecular Biology, CRN2M, Department of Experimental Medicine, Neuromed, Division of Endocrinology, Department of Endocrinology, Group for Advanced Molecular Investigation, Service d'Endocrinologie, Department of Endocrinology, Unit of Endocrinology, Department of Endocrinology, Department of Endocrinology, Clinical Center of Endocrinology and Gerontology, Faculty of Medicine, Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Internal Medicine and Endocrinology, Department of Endocrinology, Service d'Endocrinologie, Centre Hospitalier Universitaire de Liège, Domaine Universitaire du Sart‐Tilman, University of Liège, 4000 Liège, Belgium

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Mirtha Guitelman Departments of, Endocrinology, Molecular Genetics, Institute of Pathology, Laboratory of Biochemistry and Molecular Biology, CRN2M, Department of Experimental Medicine, Neuromed, Division of Endocrinology, Department of Endocrinology, Group for Advanced Molecular Investigation, Service d'Endocrinologie, Department of Endocrinology, Unit of Endocrinology, Department of Endocrinology, Department of Endocrinology, Clinical Center of Endocrinology and Gerontology, Faculty of Medicine, Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Internal Medicine and Endocrinology, Department of Endocrinology, Service d'Endocrinologie, Centre Hospitalier Universitaire de Liège, Domaine Universitaire du Sart‐Tilman, University of Liège, 4000 Liège, Belgium

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Emily Castermans Departments of, Endocrinology, Molecular Genetics, Institute of Pathology, Laboratory of Biochemistry and Molecular Biology, CRN2M, Department of Experimental Medicine, Neuromed, Division of Endocrinology, Department of Endocrinology, Group for Advanced Molecular Investigation, Service d'Endocrinologie, Department of Endocrinology, Unit of Endocrinology, Department of Endocrinology, Department of Endocrinology, Clinical Center of Endocrinology and Gerontology, Faculty of Medicine, Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Internal Medicine and Endocrinology, Department of Endocrinology, Service d'Endocrinologie, Centre Hospitalier Universitaire de Liège, Domaine Universitaire du Sart‐Tilman, University of Liège, 4000 Liège, Belgium

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Catherine Verhaege Departments of, Endocrinology, Molecular Genetics, Institute of Pathology, Laboratory of Biochemistry and Molecular Biology, CRN2M, Department of Experimental Medicine, Neuromed, Division of Endocrinology, Department of Endocrinology, Group for Advanced Molecular Investigation, Service d'Endocrinologie, Department of Endocrinology, Unit of Endocrinology, Department of Endocrinology, Department of Endocrinology, Clinical Center of Endocrinology and Gerontology, Faculty of Medicine, Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Internal Medicine and Endocrinology, Department of Endocrinology, Service d'Endocrinologie, Centre Hospitalier Universitaire de Liège, Domaine Universitaire du Sart‐Tilman, University of Liège, 4000 Liège, Belgium

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Jean-Louis Wémeau Departments of, Endocrinology, Molecular Genetics, Institute of Pathology, Laboratory of Biochemistry and Molecular Biology, CRN2M, Department of Experimental Medicine, Neuromed, Division of Endocrinology, Department of Endocrinology, Group for Advanced Molecular Investigation, Service d'Endocrinologie, Department of Endocrinology, Unit of Endocrinology, Department of Endocrinology, Department of Endocrinology, Clinical Center of Endocrinology and Gerontology, Faculty of Medicine, Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Internal Medicine and Endocrinology, Department of Endocrinology, Service d'Endocrinologie, Centre Hospitalier Universitaire de Liège, Domaine Universitaire du Sart‐Tilman, University of Liège, 4000 Liège, Belgium

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Antoine Tabarin Departments of, Endocrinology, Molecular Genetics, Institute of Pathology, Laboratory of Biochemistry and Molecular Biology, CRN2M, Department of Experimental Medicine, Neuromed, Division of Endocrinology, Department of Endocrinology, Group for Advanced Molecular Investigation, Service d'Endocrinologie, Department of Endocrinology, Unit of Endocrinology, Department of Endocrinology, Department of Endocrinology, Clinical Center of Endocrinology and Gerontology, Faculty of Medicine, Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Internal Medicine and Endocrinology, Department of Endocrinology, Service d'Endocrinologie, Centre Hospitalier Universitaire de Liège, Domaine Universitaire du Sart‐Tilman, University of Liège, 4000 Liège, Belgium

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Carmen Fajardo Montañana Departments of, Endocrinology, Molecular Genetics, Institute of Pathology, Laboratory of Biochemistry and Molecular Biology, CRN2M, Department of Experimental Medicine, Neuromed, Division of Endocrinology, Department of Endocrinology, Group for Advanced Molecular Investigation, Service d'Endocrinologie, Department of Endocrinology, Unit of Endocrinology, Department of Endocrinology, Department of Endocrinology, Clinical Center of Endocrinology and Gerontology, Faculty of Medicine, Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Internal Medicine and Endocrinology, Department of Endocrinology, Service d'Endocrinologie, Centre Hospitalier Universitaire de Liège, Domaine Universitaire du Sart‐Tilman, University of Liège, 4000 Liège, Belgium

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Brigitte Delemer Departments of, Endocrinology, Molecular Genetics, Institute of Pathology, Laboratory of Biochemistry and Molecular Biology, CRN2M, Department of Experimental Medicine, Neuromed, Division of Endocrinology, Department of Endocrinology, Group for Advanced Molecular Investigation, Service d'Endocrinologie, Department of Endocrinology, Unit of Endocrinology, Department of Endocrinology, Department of Endocrinology, Clinical Center of Endocrinology and Gerontology, Faculty of Medicine, Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Internal Medicine and Endocrinology, Department of Endocrinology, Service d'Endocrinologie, Centre Hospitalier Universitaire de Liège, Domaine Universitaire du Sart‐Tilman, University of Liège, 4000 Liège, Belgium

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Veronique Kerlan Departments of, Endocrinology, Molecular Genetics, Institute of Pathology, Laboratory of Biochemistry and Molecular Biology, CRN2M, Department of Experimental Medicine, Neuromed, Division of Endocrinology, Department of Endocrinology, Group for Advanced Molecular Investigation, Service d'Endocrinologie, Department of Endocrinology, Unit of Endocrinology, Department of Endocrinology, Department of Endocrinology, Clinical Center of Endocrinology and Gerontology, Faculty of Medicine, Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Internal Medicine and Endocrinology, Department of Endocrinology, Service d'Endocrinologie, Centre Hospitalier Universitaire de Liège, Domaine Universitaire du Sart‐Tilman, University of Liège, 4000 Liège, Belgium

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Jean-Louis Sadoul Departments of, Endocrinology, Molecular Genetics, Institute of Pathology, Laboratory of Biochemistry and Molecular Biology, CRN2M, Department of Experimental Medicine, Neuromed, Division of Endocrinology, Department of Endocrinology, Group for Advanced Molecular Investigation, Service d'Endocrinologie, Department of Endocrinology, Unit of Endocrinology, Department of Endocrinology, Department of Endocrinology, Clinical Center of Endocrinology and Gerontology, Faculty of Medicine, Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Internal Medicine and Endocrinology, Department of Endocrinology, Service d'Endocrinologie, Centre Hospitalier Universitaire de Liège, Domaine Universitaire du Sart‐Tilman, University of Liège, 4000 Liège, Belgium

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Christine Cortet Rudelli Departments of, Endocrinology, Molecular Genetics, Institute of Pathology, Laboratory of Biochemistry and Molecular Biology, CRN2M, Department of Experimental Medicine, Neuromed, Division of Endocrinology, Department of Endocrinology, Group for Advanced Molecular Investigation, Service d'Endocrinologie, Department of Endocrinology, Unit of Endocrinology, Department of Endocrinology, Department of Endocrinology, Clinical Center of Endocrinology and Gerontology, Faculty of Medicine, Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Internal Medicine and Endocrinology, Department of Endocrinology, Service d'Endocrinologie, Centre Hospitalier Universitaire de Liège, Domaine Universitaire du Sart‐Tilman, University of Liège, 4000 Liège, Belgium

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Françoise Archambeaud Departments of, Endocrinology, Molecular Genetics, Institute of Pathology, Laboratory of Biochemistry and Molecular Biology, CRN2M, Department of Experimental Medicine, Neuromed, Division of Endocrinology, Department of Endocrinology, Group for Advanced Molecular Investigation, Service d'Endocrinologie, Department of Endocrinology, Unit of Endocrinology, Department of Endocrinology, Department of Endocrinology, Clinical Center of Endocrinology and Gerontology, Faculty of Medicine, Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Internal Medicine and Endocrinology, Department of Endocrinology, Service d'Endocrinologie, Centre Hospitalier Universitaire de Liège, Domaine Universitaire du Sart‐Tilman, University of Liège, 4000 Liège, Belgium

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Sabine Zacharieva Departments of, Endocrinology, Molecular Genetics, Institute of Pathology, Laboratory of Biochemistry and Molecular Biology, CRN2M, Department of Experimental Medicine, Neuromed, Division of Endocrinology, Department of Endocrinology, Group for Advanced Molecular Investigation, Service d'Endocrinologie, Department of Endocrinology, Unit of Endocrinology, Department of Endocrinology, Department of Endocrinology, Clinical Center of Endocrinology and Gerontology, Faculty of Medicine, Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Internal Medicine and Endocrinology, Department of Endocrinology, Service d'Endocrinologie, Centre Hospitalier Universitaire de Liège, Domaine Universitaire du Sart‐Tilman, University of Liège, 4000 Liège, Belgium

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Marily Theodoropoulou Departments of, Endocrinology, Molecular Genetics, Institute of Pathology, Laboratory of Biochemistry and Molecular Biology, CRN2M, Department of Experimental Medicine, Neuromed, Division of Endocrinology, Department of Endocrinology, Group for Advanced Molecular Investigation, Service d'Endocrinologie, Department of Endocrinology, Unit of Endocrinology, Department of Endocrinology, Department of Endocrinology, Clinical Center of Endocrinology and Gerontology, Faculty of Medicine, Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Internal Medicine and Endocrinology, Department of Endocrinology, Service d'Endocrinologie, Centre Hospitalier Universitaire de Liège, Domaine Universitaire du Sart‐Tilman, University of Liège, 4000 Liège, Belgium

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Thierry Brue Departments of, Endocrinology, Molecular Genetics, Institute of Pathology, Laboratory of Biochemistry and Molecular Biology, CRN2M, Department of Experimental Medicine, Neuromed, Division of Endocrinology, Department of Endocrinology, Group for Advanced Molecular Investigation, Service d'Endocrinologie, Department of Endocrinology, Unit of Endocrinology, Department of Endocrinology, Department of Endocrinology, Clinical Center of Endocrinology and Gerontology, Faculty of Medicine, Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Internal Medicine and Endocrinology, Department of Endocrinology, Service d'Endocrinologie, Centre Hospitalier Universitaire de Liège, Domaine Universitaire du Sart‐Tilman, University of Liège, 4000 Liège, Belgium

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Alain Enjalbert Departments of, Endocrinology, Molecular Genetics, Institute of Pathology, Laboratory of Biochemistry and Molecular Biology, CRN2M, Department of Experimental Medicine, Neuromed, Division of Endocrinology, Department of Endocrinology, Group for Advanced Molecular Investigation, Service d'Endocrinologie, Department of Endocrinology, Unit of Endocrinology, Department of Endocrinology, Department of Endocrinology, Clinical Center of Endocrinology and Gerontology, Faculty of Medicine, Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Internal Medicine and Endocrinology, Department of Endocrinology, Service d'Endocrinologie, Centre Hospitalier Universitaire de Liège, Domaine Universitaire du Sart‐Tilman, University of Liège, 4000 Liège, Belgium
Departments of, Endocrinology, Molecular Genetics, Institute of Pathology, Laboratory of Biochemistry and Molecular Biology, CRN2M, Department of Experimental Medicine, Neuromed, Division of Endocrinology, Department of Endocrinology, Group for Advanced Molecular Investigation, Service d'Endocrinologie, Department of Endocrinology, Unit of Endocrinology, Department of Endocrinology, Department of Endocrinology, Clinical Center of Endocrinology and Gerontology, Faculty of Medicine, Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Internal Medicine and Endocrinology, Department of Endocrinology, Service d'Endocrinologie, Centre Hospitalier Universitaire de Liège, Domaine Universitaire du Sart‐Tilman, University of Liège, 4000 Liège, Belgium

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Vincent Bours Departments of, Endocrinology, Molecular Genetics, Institute of Pathology, Laboratory of Biochemistry and Molecular Biology, CRN2M, Department of Experimental Medicine, Neuromed, Division of Endocrinology, Department of Endocrinology, Group for Advanced Molecular Investigation, Service d'Endocrinologie, Department of Endocrinology, Unit of Endocrinology, Department of Endocrinology, Department of Endocrinology, Clinical Center of Endocrinology and Gerontology, Faculty of Medicine, Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Internal Medicine and Endocrinology, Department of Endocrinology, Service d'Endocrinologie, Centre Hospitalier Universitaire de Liège, Domaine Universitaire du Sart‐Tilman, University of Liège, 4000 Liège, Belgium

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Natalia S Pellegata Departments of, Endocrinology, Molecular Genetics, Institute of Pathology, Laboratory of Biochemistry and Molecular Biology, CRN2M, Department of Experimental Medicine, Neuromed, Division of Endocrinology, Department of Endocrinology, Group for Advanced Molecular Investigation, Service d'Endocrinologie, Department of Endocrinology, Unit of Endocrinology, Department of Endocrinology, Department of Endocrinology, Clinical Center of Endocrinology and Gerontology, Faculty of Medicine, Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Internal Medicine and Endocrinology, Department of Endocrinology, Service d'Endocrinologie, Centre Hospitalier Universitaire de Liège, Domaine Universitaire du Sart‐Tilman, University of Liège, 4000 Liège, Belgium

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Albert Beckers Departments of, Endocrinology, Molecular Genetics, Institute of Pathology, Laboratory of Biochemistry and Molecular Biology, CRN2M, Department of Experimental Medicine, Neuromed, Division of Endocrinology, Department of Endocrinology, Group for Advanced Molecular Investigation, Service d'Endocrinologie, Department of Endocrinology, Unit of Endocrinology, Department of Endocrinology, Department of Endocrinology, Clinical Center of Endocrinology and Gerontology, Faculty of Medicine, Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Endocrinology, Department of Internal Medicine and Endocrinology, Department of Endocrinology, Service d'Endocrinologie, Centre Hospitalier Universitaire de Liège, Domaine Universitaire du Sart‐Tilman, University of Liège, 4000 Liège, Belgium

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tumors: clinical, genetic and functional characterization . Human Mutation 31 E1825 – E1835 . doi:10.1002/humu.21354 . Morosétti R Kawamata N Gombart AF Miller CW Hatta Y Hirama T Said JW Tomonaga M Koeffler HP 1995 Alterations

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-11-0362
Volume/Issue:
Volume 19: Issue 3
Free access