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Vincenzo Corbo, Irene Dalai, Maria Scardoni, Stefano Barbi, Stefania Beghelli, Samantha Bersani, Luca Albarello, Claudio Doglioni, Christina Schott, Paola Capelli, Marco Chilosi, Letizia Boninsegna, Karl-Friedrich Becker, Massimo Falconi, and Aldo Scarpa

analysis of MEN1 was executed on 100 primary neoplasms and 3 human PET cell lines. Immunohistochemical staining for menin was performed on 140 PETs, 71 of which coincided with those analyzed for mutations. MEN1 gene mutational analysis in 100 PETs Twenty

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Vaishali I Parekh, Sita D Modali, James Welch, William F Simonds, Lee S Weinstein, Electron Kebebew, and Sunita K Agarwal

Dear Editor, Pancreatic neuroendocrine tumors (PNETs/pNETs/p-NETs/PanNETs) are rare endocrine neoplasms that can be either functioning tumors that secrete hormones characteristic of their endocrine cell of origin or nonfunctioning tumors. The

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Wenzel M Hackeng, Lodewijk A A Brosens, and Koen M A Dreijerink

.3390/cancers12061461 ) Bosco D Meda P Morel P Matthey-Doret D Caille D Toso C Buhler LH Berney T 2005 Expression and secretion of alpha1-proteinase inhibitor are regulated by proinflammatory cytokines in human pancreatic islet cells

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M Fuertes, M Sapochnik, L Tedesco, S Senin, A Attorresi, P Ajler, G Carrizo, A Cervio, G Sevlever, J J Bonfiglio, G K Stalla, and E Arzt

, Farrell 2014 ). Despite their high prevalence in the general population ( Beckers 2010 , Fernandez et al . 2010 ), these tumors are invariably benign and exhibit features of differentiated pituitary cell function as well as premature proliferative arrest

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Maria Chiara Zatelli, Mariella Minoia, Chiara Martini, Federico Tagliati, Maria Rosaria Ambrosio, Marco Schiavon, Mattia Buratto, Fiorella Calabrese, Erica Gentilin, Giorgio Cavallesco, Lisa Berdondini, Federico Rea, and Ettore C degli Uberti

and islet-cell carcinoma . Best Practice & Research. Clinical Endocrinology & Metabolism 21 163 – 172 . Yao JC Phan AT Chang DZ Wolff RA Hess K Gupta S Jacobs C Mares JE Landgraf AN Rashid A 2008 Efficacy of RAD001

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Bristi Basu, Bhawna Sirohi, and Pippa Corrie

pancreatic endocrine tumours (islet cell tumours). Other tumours in this diverse group are NETs of unknown primary, adrenal gland tumours, poorly differentiated anaplastic small cell tumours and NETs that comprise the multiple endocrine neoplasia type I and

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Aura D Herrera-Martínez, Rosanna van den Dungen, Fadime Dogan-Oruc, Peter M van Koetsveld, Michael D Culler, Wouter W de Herder, Raúl M Luque, Richard A Feelders, and Leo J Hofland

metastasis of a human non-functional PNET. The QGP-1 cell line was established from a somatostatin-secreting pancreatic islet cell carcinoma and purchased from the Japanese Collection of Research Bioresources Cell Bank (JRCB, Osaka, Japan) ( Kaku et al

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Christodoulos P Pipinikas, Alison M Berner, Teresa Sposito, and Christina Thirlwell

Introduction Neuroendocrine neoplasms (NENs) develop from cells of neuroendocrine differentiation distributed throughout the body, most commonly in the small intestine, lung and pancreas (PanNENs) ( Dasari et al. 2017 ). PanNENs were

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Michael Solarski, Fabio Rotondo, William D Foulkes, John R Priest, Luis V Syro, Henriett Butz, Michael D Cusimano, and Kalman Kovacs

Harfe BD German MS 2007 MicroRNA expression is required for pancreatic islet cell genesis in the mouse . Diabetes 56 2938 – 2945 . ( ) 17804764 10.2337/db07-0175 Mandelbaum AD Melkman-Zehavi T Oren R Kredo

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Aura D Herrera-Martínez, Leo J Hofland, María A Gálvez Moreno, Justo P Castaño, Wouter W de Herder, and Richard A Feelders

Introduction Neuroendocrine neoplasms (NENs) represent a heterogeneous group of rare neoplasms, which originate from enterochromaffin cells that are located throughout the whole body. NENs located in the gastrointestinal tract and pancreas are