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C J Fabian
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B F Kimler
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M S Mayo
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S A Khan
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and/or RPFNA, there is a great deal of interest in supplementing morphologic interpretations with molecular markers ( Fabian et al. 2002 , Ljung et al. 2004 , Gornstein et al. 2004 , Sneige 2004 ). Simple assessment of ploidy has been

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M Xing Division of Endocrinology and Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, 1830 E. Monument St/Suite 333 Baltimore, MD 21287, USA

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mutation with additional sensitive and specific molecular markers will likely be the next step in increasing the FNAB diagnostic sensitivity. This approach was tested recently by combined use of BRAF mutation with RET/PTC ( Salvatore et al. 2004 ), a

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Maria Denaro Department of Surgical Pathology Medical, Molecular and Critical Area, University of Pisa, Pisa, Italy

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Clara Ugolini Department of Laboratory Medicine Section of Pathology Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy

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Anello Marcello Poma Department of Surgical Pathology Medical, Molecular and Critical Area, University of Pisa, Pisa, Italy

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Nicla Borrelli Department of Surgical Pathology Medical, Molecular and Critical Area, University of Pisa, Pisa, Italy

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Gabriele Materazzi Department of Surgical Pathology Medical, Molecular and Critical Area, University of Pisa, Pisa, Italy

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Paolo Piaggi National Institute of Diabetes and Digestive and Kidney Diseases Phoenix, Arizona, USA

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Massimo Chiarugi Department of Surgical Pathology Medical, Molecular and Critical Area, University of Pisa, Pisa, Italy

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Paolo Miccoli Department of Surgical Pathology Medical, Molecular and Critical Area, University of Pisa, Pisa, Italy

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Paolo Vitti Department of Clinical and Experimental Medicine University of Pisa, Pisa, Italy

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Fulvio Basolo Department of Surgical Pathology Medical, Molecular and Critical Area, University of Pisa, Pisa, Italy

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Introduction miRNA expression in thyroid cancer is an important and promising diagnostic marker since alterations have been identified not only between cancerous and either normal thyroid tissue or benign proliferative multinodular goiters

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Luming Wu Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China

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Jing Xie Department of Pathology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China

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Yan Qi Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China

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Tingwei Su Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China

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Lei Jiang Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China

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Weiwei Zhou Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China

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Yiran Jiang Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China

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Cui Zhang Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China

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Xu Zhong Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China

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Yanan Cao Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China

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Weiqing Wang Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China

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secretion ( Boulkroun et al. 2012 , Lenzini et al. 2015 ). However, studies on molecular characterization of non-functional ACAs (NFACAs) are scarce. Some studies have identified CTNNB1 mutations lead to ACAs, and are mostly involved in the

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Matthias S Dettmer Institute of Pathology, Division of Nuclear Medicine, Department of Neuropathology, Institute of Surgical Pathology, Institute of Surgical Pathology, University of Bern, Murtenstrasse 31, 3010 Bern, Switzerland

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Anja Schmitt Institute of Pathology, Division of Nuclear Medicine, Department of Neuropathology, Institute of Surgical Pathology, Institute of Surgical Pathology, University of Bern, Murtenstrasse 31, 3010 Bern, Switzerland

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Hans Steinert Institute of Pathology, Division of Nuclear Medicine, Department of Neuropathology, Institute of Surgical Pathology, Institute of Surgical Pathology, University of Bern, Murtenstrasse 31, 3010 Bern, Switzerland

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David Capper Institute of Pathology, Division of Nuclear Medicine, Department of Neuropathology, Institute of Surgical Pathology, Institute of Surgical Pathology, University of Bern, Murtenstrasse 31, 3010 Bern, Switzerland

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Holger Moch Institute of Pathology, Division of Nuclear Medicine, Department of Neuropathology, Institute of Surgical Pathology, Institute of Surgical Pathology, University of Bern, Murtenstrasse 31, 3010 Bern, Switzerland

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Paul Komminoth Institute of Pathology, Division of Nuclear Medicine, Department of Neuropathology, Institute of Surgical Pathology, Institute of Surgical Pathology, University of Bern, Murtenstrasse 31, 3010 Bern, Switzerland

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Aurel Perren Institute of Pathology, Division of Nuclear Medicine, Department of Neuropathology, Institute of Surgical Pathology, Institute of Surgical Pathology, University of Bern, Murtenstrasse 31, 3010 Bern, Switzerland

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Molecular prognostic markers in papillary and follicular thyroid cancer: current status and future directions . Molecular and Cellular Endocrinology 322 8 – 28 . ( doi:10.1016/j.mce.2010.01.007 ). Huang FW Hodis E Xu MJ Kryukov GV Chin L

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Krystallenia I Alexandraki Second Department of Surgery, Aretaieion Hospital, National and Kapodistrian University of Athens, Athens, Greece

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Ariadni Spyroglou Second Department of Surgery, Aretaieion Hospital, National and Kapodistrian University of Athens, Athens, Greece
Clinic for Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich, Zurich, Switzerland

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Stylianos Kykalos Second Department of Propaedeutic Surgery, Laiko Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece

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Kosmas Daskalakis Department of Surgery, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
Endocrine Unit, First Department of Propaedeutic Medicine, Laiko University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece

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Georgios Kyriakopoulos Department of Pathology, Evaggelismos Hospital, Athens, Greece

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Georgios C Sotiropoulos Clinic for Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich, Zurich, Switzerland

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Gregory A Kaltsas Endocrine Unit, First Department of Propaedeutic Medicine, Laiko University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece

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Ashley B Grossman Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, University of Oxford, Oxford, UK
NET Unit, Royal Free Hospital, London, UK
Barts and the London School of Medicine, London, UK

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dedifferentiation at a molecular or pathological level is lacking. Diagnostic tools for progression Circulating markers NENs can secrete a wide range of amines and polypeptide hormones into the circulation. Classic biomarkers include CgA, NSE and

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Elke Tatjana Aristizabal Prada Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Campus Grosshadern, Munich, Germany
Department of Internal Medicine 2, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Internal Medicine 4, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany

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Vera Heinzle Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Campus Grosshadern, Munich, Germany
Department of Internal Medicine 2, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany

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Thomas Knösel Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Campus Grosshadern, Munich, Germany
Institute of Pathology, Ludwig-Maximilians-University of Munich, Munich, Germany

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Svenja Nölting Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Campus Grosshadern, Munich, Germany
Department of Internal Medicine 2, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Internal Medicine 4, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany

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Gerald Spöttl Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Campus Grosshadern, Munich, Germany
Department of Internal Medicine 2, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Internal Medicine 4, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany

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Julian Maurer Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Campus Grosshadern, Munich, Germany
Department of Internal Medicine 2, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Internal Medicine 4, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany

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Christine Spitzweg Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Campus Grosshadern, Munich, Germany
Department of Internal Medicine 2, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Internal Medicine 4, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany

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Martin Angele Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Campus Grosshadern, Munich, Germany
Department of General, Visceral, Transplantation, Vascular and Thoracic Surgery, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany

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Nina Schmidt Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Campus Grosshadern, Munich, Germany
Department of Internal Medicine 2, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Internal Medicine 4, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany

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Felix Beuschlein Department of Internal Medicine 4, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Klinik für Endokrinologie, Diabetologie und Klinische Ernährung, Universitätsspital Zürich, Zurich, Switzerland

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Günter K Stalla Clinical Neuroendocrinology, Max Planck Institute of Psychiatry, Munich, Germany

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Rainer Blaser Institute of Medical Statistics and Epidemiology, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany

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Klaus A Kuhn Institute of Medical Statistics and Epidemiology, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany

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Christoph J Auernhammer Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Campus Grosshadern, Munich, Germany
Department of Internal Medicine 2, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Internal Medicine 4, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany

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well as cell cycle components. Furthermore, we evaluated the prevalence of Trks immunohistochemically in a large patient cohort and could assess possible predictive markers for personalized molecular targeted therapy with Trk inhibitors. In the first

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Teresa M Seccia
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Ambrogio Fassina
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Gastone G Nussdorfer
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Achille C Pessina
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Gian Paolo Rossi
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even on morphological grounds. Although several criteria have been claimed to allow discrimination between benign and malignant tumors ( Lack 1997 ), including some molecular markers such as the DNA index ( Suzuki et al. 1992 b , Gicquel & Le Bouc

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Xuan Chen Department of Breast Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Sixuan Liu Department of Breast Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Xue Peng Department of Breast Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Xiangyun Zong Department of Breast Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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forecast ovarian function recovery. All these studies have obtained valuable results, but AMH as a marker of ovarian reserve still has some limitations, one of which is that it varies widely among individuals and it is difficult to set a reference value

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Kirk Jensen Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA

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Athanasios Bikas Department of Internal Medicine, Georgetown University Hospital MedStar, Washington Hospital Center Internal Medicine Residency Program, Washington, District of Columbia, USA

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Aneeta Patel Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA

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Yevgeniya Kushchayeva National Institutes of Health, NIDDK, Bethesda, Maryland, USA

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John Costello Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA

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Dennis McDaniel Uniformed Services University of the Health Sciences, Biomedical Instrumentation Center, Bethesda, Maryland, USA

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Kenneth Burman MedStar Washington Hospital Center, Endocrinology, Washington, District of Columbia, USA

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Vasyl Vasko Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA

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-inducible signaling pathways. The effect of NFV on expression of thyroid-specific genes and markers of epithelial-to-mesenchymal transition To determine if NFV influences thyroid cancer cell differentiation, we examined the expression of thyroid-specific genes

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