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and/or RPFNA, there is a great deal of interest in supplementing morphologic interpretations with molecular markers ( Fabian et al. 2002 , Ljung et al. 2004 , Gornstein et al. 2004 , Sneige 2004 ). Simple assessment of ploidy has been
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mutation with additional sensitive and specific molecular markers will likely be the next step in increasing the FNAB diagnostic sensitivity. This approach was tested recently by combined use of BRAF mutation with RET/PTC ( Salvatore et al. 2004 ), a
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Introduction miRNA expression in thyroid cancer is an important and promising diagnostic marker since alterations have been identified not only between cancerous and either normal thyroid tissue or benign proliferative multinodular goiters
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China
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secretion ( Boulkroun et al. 2012 , Lenzini et al. 2015 ). However, studies on molecular characterization of non-functional ACAs (NFACAs) are scarce. Some studies have identified CTNNB1 mutations lead to ACAs, and are mostly involved in the
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Molecular prognostic markers in papillary and follicular thyroid cancer: current status and future directions . Molecular and Cellular Endocrinology 322 8 – 28 . ( doi:10.1016/j.mce.2010.01.007 ). Huang FW Hodis E Xu MJ Kryukov GV Chin L
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Clinic for Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich, Zurich, Switzerland
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Endocrine Unit, First Department of Propaedeutic Medicine, Laiko University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece
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NET Unit, Royal Free Hospital, London, UK
Barts and the London School of Medicine, London, UK
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dedifferentiation at a molecular or pathological level is lacking. Diagnostic tools for progression Circulating markers NENs can secrete a wide range of amines and polypeptide hormones into the circulation. Classic biomarkers include CgA, NSE and
Department of Internal Medicine 2, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Internal Medicine 4, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
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Department of Internal Medicine 2, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
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Institute of Pathology, Ludwig-Maximilians-University of Munich, Munich, Germany
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Department of Internal Medicine 2, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Internal Medicine 4, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
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Department of Internal Medicine 2, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Internal Medicine 4, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
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Department of Internal Medicine 2, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Internal Medicine 4, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
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Department of Internal Medicine 2, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Internal Medicine 4, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
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Department of General, Visceral, Transplantation, Vascular and Thoracic Surgery, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
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Department of Internal Medicine 2, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Internal Medicine 4, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
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Klinik für Endokrinologie, Diabetologie und Klinische Ernährung, Universitätsspital Zürich, Zurich, Switzerland
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Department of Internal Medicine 2, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Internal Medicine 4, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
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well as cell cycle components. Furthermore, we evaluated the prevalence of Trks immunohistochemically in a large patient cohort and could assess possible predictive markers for personalized molecular targeted therapy with Trk inhibitors. In the first
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even on morphological grounds. Although several criteria have been claimed to allow discrimination between benign and malignant tumors ( Lack 1997 ), including some molecular markers such as the DNA index ( Suzuki et al. 1992 b , Gicquel & Le Bouc
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forecast ovarian function recovery. All these studies have obtained valuable results, but AMH as a marker of ovarian reserve still has some limitations, one of which is that it varies widely among individuals and it is difficult to set a reference value
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-inducible signaling pathways. The effect of NFV on expression of thyroid-specific genes and markers of epithelial-to-mesenchymal transition To determine if NFV influences thyroid cancer cell differentiation, we examined the expression of thyroid-specific genes