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Ajay-Mohan Mohan Department of Nuclear Medicine, Charité – Universitätsmedizin Berlin, Berlin, Germany
Berlin Experimental Radionuclide Imaging Center (BERIC), Charité - Universitätsmedizin Berlin, Berlin, Germany

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Sonal Prasad Department of Nuclear Medicine, Charité – Universitätsmedizin Berlin, Berlin, Germany
Berlin Experimental Radionuclide Imaging Center (BERIC), Charité - Universitätsmedizin Berlin, Berlin, Germany

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Fabian Schmitz-Peiffer Department of Nuclear Medicine, Charité – Universitätsmedizin Berlin, Berlin, Germany
Berlin Experimental Radionuclide Imaging Center (BERIC), Charité - Universitätsmedizin Berlin, Berlin, Germany

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Catharina Lange Department of Nuclear Medicine, Charité – Universitätsmedizin Berlin, Berlin, Germany

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Mathias Lukas Department of Nuclear Medicine, Charité – Universitätsmedizin Berlin, Berlin, Germany

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Eva J Koziolek Department of Nuclear Medicine, Charité – Universitätsmedizin Berlin, Berlin, Germany
German Cancer Consortium (DKTK), partner site Berlin, Berlin, Germany

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Jakob Albrecht Department of Nuclear Medicine, Charité – Universitätsmedizin Berlin, Berlin, Germany
Berlin Experimental Radionuclide Imaging Center (BERIC), Charité - Universitätsmedizin Berlin, Berlin, Germany
German Cancer Consortium (DKTK), partner site Berlin, Berlin, Germany

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Daniel Messroghli Department of Internal Medicine - Cardiology, Deutsches Herzzentrum Berlin, Berlin, Germany
Preclinical MRI Center, Charité - Universitätsmedizin Berlin, Berlin, Germany

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Ulrike Stein German Cancer Consortium (DKTK), partner site Berlin, Berlin, Germany
Experimental and Clinical Research Center, Charité-Universitätsmedizin Berlin, and Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Translational Oncology of Solid Tumours, Berlin, Germany

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Matthias Ilmer German Cancer Consortium (DKTK), partner site Berlin, Berlin, Germany
Department of General, Visceral, and Transplantation Surgery, University Hospital, LMU Munich, Munich, Germany
German Cancer Research Center (DKFZ), Heidelberg, Germany

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Katharina Wang Department of Medicine IV, University Hospital, LMU Munich, Munich, Germany

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Laura Schober Department of Medicine IV, University Hospital, LMU Munich, Munich, Germany

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Astrid Reul Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital, University of Zurich (USZ) and University of Zurich (UZH), Zurich, Switzerland

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Julian Maurer Department of Medicine IV, University Hospital, LMU Munich, Munich, Germany

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Juliane Friemel Department of Pathology and Molecular Pathology, University Zurich and University Hospital Zürich, Zurich, Switzerland

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Achim Weber Department of Pathology and Molecular Pathology, University Zurich and University Hospital Zürich, Zurich, Switzerland

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Richard A Zuellig Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital, University of Zurich (USZ) and University of Zurich (UZH), Zurich, Switzerland

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Constanze Hantel Department of Medicine IV, University Hospital, LMU Munich, Munich, Germany
Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital, University of Zurich (USZ) and University of Zurich (UZH), Zurich, Switzerland

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Ralph Fritsch Department of Medical Oncology and Hematology, University Zurich and University Hospital Zürich, Zurich, Switzerland

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Martin Reincke Department of Medicine IV, University Hospital, LMU Munich, Munich, Germany

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Karel Pacak Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institute of Health (NIH), Bethesda, Maryland, USA

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Ashley B Grossman Green Templeton College, University of Oxford, London, United Kingdom
Centre for Endocrinology, Barts and the London School of Medicine, Queen Mary University of London, United Kingdom
ENETS Centre of Excellence, Royal Free Hospital, London, United Kingdom

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Christoph J Auernhammer Department of Medicine IV, University Hospital, LMU Munich, Munich, Germany
ENETS Centre of Excellence, Interdisciplinary Center of Neuroendocrine Tumours of the GastroEnteroPancreatic System at the University Hospital of Munich, Munich, Germany

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Felix Beuschlein Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital, University of Zurich (USZ) and University of Zurich (UZH), Zurich, Switzerland

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Winfried Brenner Department of Nuclear Medicine, Charité – Universitätsmedizin Berlin, Berlin, Germany
Berlin Experimental Radionuclide Imaging Center (BERIC), Charité - Universitätsmedizin Berlin, Berlin, Germany
German Cancer Consortium (DKTK), partner site Berlin, Berlin, Germany

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Nicola Beindorff Berlin Experimental Radionuclide Imaging Center (BERIC), Charité - Universitätsmedizin Berlin, Berlin, Germany

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Svenja Nölting Department of Medicine IV, University Hospital, LMU Munich, Munich, Germany
Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital, University of Zurich (USZ) and University of Zurich (UZH), Zurich, Switzerland

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and metastatic panNETs ( Yao et al. 2011 , 2016 ), while in neuroendocrine carcinomas (NECs) small studies have reported only modest activity of everolimus ( Panzuto et al. 2017 , Okuyama et al. 2020 ). According to the latest World Health

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Hongbing Chen Department of Urology, Department of Pathology and Laboratory Medicine, Broad Center for Regenerative Medicine and Stem Cell Biology, Transplant Immunology Laboratory, Department of Pathology, Department of Pathology, Department of Pathology, Department of Pathology, The Geriatrics Research Institute, First Affiliated Hospital of Anhui Medical University, Anhui, China
Department of Urology, Department of Pathology and Laboratory Medicine, Broad Center for Regenerative Medicine and Stem Cell Biology, Transplant Immunology Laboratory, Department of Pathology, Department of Pathology, Department of Pathology, Department of Pathology, The Geriatrics Research Institute, First Affiliated Hospital of Anhui Medical University, Anhui, China

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Yin Sun Department of Urology, Department of Pathology and Laboratory Medicine, Broad Center for Regenerative Medicine and Stem Cell Biology, Transplant Immunology Laboratory, Department of Pathology, Department of Pathology, Department of Pathology, Department of Pathology, The Geriatrics Research Institute, First Affiliated Hospital of Anhui Medical University, Anhui, China

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Chengyu Wu Department of Urology, Department of Pathology and Laboratory Medicine, Broad Center for Regenerative Medicine and Stem Cell Biology, Transplant Immunology Laboratory, Department of Pathology, Department of Pathology, Department of Pathology, Department of Pathology, The Geriatrics Research Institute, First Affiliated Hospital of Anhui Medical University, Anhui, China

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Clara E Magyar Department of Urology, Department of Pathology and Laboratory Medicine, Broad Center for Regenerative Medicine and Stem Cell Biology, Transplant Immunology Laboratory, Department of Pathology, Department of Pathology, Department of Pathology, Department of Pathology, The Geriatrics Research Institute, First Affiliated Hospital of Anhui Medical University, Anhui, China

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Xinmin Li Department of Urology, Department of Pathology and Laboratory Medicine, Broad Center for Regenerative Medicine and Stem Cell Biology, Transplant Immunology Laboratory, Department of Pathology, Department of Pathology, Department of Pathology, Department of Pathology, The Geriatrics Research Institute, First Affiliated Hospital of Anhui Medical University, Anhui, China
Department of Urology, Department of Pathology and Laboratory Medicine, Broad Center for Regenerative Medicine and Stem Cell Biology, Transplant Immunology Laboratory, Department of Pathology, Department of Pathology, Department of Pathology, Department of Pathology, The Geriatrics Research Institute, First Affiliated Hospital of Anhui Medical University, Anhui, China

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Liang Cheng Department of Urology, Department of Pathology and Laboratory Medicine, Broad Center for Regenerative Medicine and Stem Cell Biology, Transplant Immunology Laboratory, Department of Pathology, Department of Pathology, Department of Pathology, Department of Pathology, The Geriatrics Research Institute, First Affiliated Hospital of Anhui Medical University, Anhui, China

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Jorge L Yao Department of Urology, Department of Pathology and Laboratory Medicine, Broad Center for Regenerative Medicine and Stem Cell Biology, Transplant Immunology Laboratory, Department of Pathology, Department of Pathology, Department of Pathology, Department of Pathology, The Geriatrics Research Institute, First Affiliated Hospital of Anhui Medical University, Anhui, China

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Steven Shen Department of Urology, Department of Pathology and Laboratory Medicine, Broad Center for Regenerative Medicine and Stem Cell Biology, Transplant Immunology Laboratory, Department of Pathology, Department of Pathology, Department of Pathology, Department of Pathology, The Geriatrics Research Institute, First Affiliated Hospital of Anhui Medical University, Anhui, China

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Adeboye O Osunkoya Department of Urology, Department of Pathology and Laboratory Medicine, Broad Center for Regenerative Medicine and Stem Cell Biology, Transplant Immunology Laboratory, Department of Pathology, Department of Pathology, Department of Pathology, Department of Pathology, The Geriatrics Research Institute, First Affiliated Hospital of Anhui Medical University, Anhui, China

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Chaozhao Liang Department of Urology, Department of Pathology and Laboratory Medicine, Broad Center for Regenerative Medicine and Stem Cell Biology, Transplant Immunology Laboratory, Department of Pathology, Department of Pathology, Department of Pathology, Department of Pathology, The Geriatrics Research Institute, First Affiliated Hospital of Anhui Medical University, Anhui, China

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Jiaoti Huang Department of Urology, Department of Pathology and Laboratory Medicine, Broad Center for Regenerative Medicine and Stem Cell Biology, Transplant Immunology Laboratory, Department of Pathology, Department of Pathology, Department of Pathology, Department of Pathology, The Geriatrics Research Institute, First Affiliated Hospital of Anhui Medical University, Anhui, China
Department of Urology, Department of Pathology and Laboratory Medicine, Broad Center for Regenerative Medicine and Stem Cell Biology, Transplant Immunology Laboratory, Department of Pathology, Department of Pathology, Department of Pathology, Department of Pathology, The Geriatrics Research Institute, First Affiliated Hospital of Anhui Medical University, Anhui, China
Department of Urology, Department of Pathology and Laboratory Medicine, Broad Center for Regenerative Medicine and Stem Cell Biology, Transplant Immunology Laboratory, Department of Pathology, Department of Pathology, Department of Pathology, Department of Pathology, The Geriatrics Research Institute, First Affiliated Hospital of Anhui Medical University, Anhui, China

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normally quiescent ( Bonkhoff 2001 , Huang et al . 2006 ). While adenocarcinomas comprise the majority of PC, there are variant forms among which small cell neuroendocrine carcinoma (SCNC) is an important histological subtype that is often seen in

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Ta-Chun Yuan
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Suresh Veeramani
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Ming-Fong Lin
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MJ, Tsokos M, Sheahan MD, Nguyen P et al. 1994 Terminal neuroendocrine differentiation of human prostate carcinoma cells in response to increased intracellular cyclic AMP. PNAS 91 5330 –5334. Bjorge JD , Pang A

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Elizabeth Grubbs Departments of Surgical Oncology, GI Medical Oncology, and Endocrine Neoplasia and Hormonal Disorders, University of Texas MD Anderson Cancer Center, Houston, Texas

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Daniel Halperin Departments of Surgical Oncology, GI Medical Oncology, and Endocrine Neoplasia and Hormonal Disorders, University of Texas MD Anderson Cancer Center, Houston, Texas

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Steven G Waguespack Departments of Surgical Oncology, GI Medical Oncology, and Endocrine Neoplasia and Hormonal Disorders, University of Texas MD Anderson Cancer Center, Houston, Texas

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Robert F Gagel Departments of Surgical Oncology, GI Medical Oncology, and Endocrine Neoplasia and Hormonal Disorders, University of Texas MD Anderson Cancer Center, Houston, Texas

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carcinoma, pancreatic neuroendocrine tumours, metastatic pheochromocytoma/paraganglioma and parathyroid cancer. To re-energize the workshop concept – greater than 25% of the meeting time was spent in smaller working groups that focused on the important

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James C Yao University of Texas MD Anderson Cancer Center, Houston, Texas, USA

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Jonathan Strosberg Department of GI Oncology, Moffitt Cancer Center, Tampa, Florida, USA

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Nicola Fazio European Institute of Oncology, IEO, IRCCS, Milan, Italy

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Marianne E Pavel Department of Medicine 1, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany

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Emily Bergsland UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California, USA

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Philippe Ruszniewski Hôpital Beaujon, University of Paris, Paris, France

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Daniel M Halperin University of Texas MD Anderson Cancer Center, Houston, Texas, USA

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Daneng Li City of Hope Comprehensive Cancer Center and Beckman Research Institute, Duarte, California, USA

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Salvatore Tafuto Sarcomas and Rare Tumours Unit, Istituto Nazionale Tumori, IRCCS Fondazione G. Pascale, Naples, Italy

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Nitya Raj Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Davide Campana Department of Clinical Medicine, Sant’Orsola-Malpighi Hospital, University of Bologna, ENETS Center of Excellence, Bologna, Italy

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Susumu Hijioka National Cancer Center Japan Tsukiji Campus, Department of Hepatobiliary and Pancreatic Oncology, Tokyo, Japan

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Markus Raderer Clinical Division of Oncology, Medical University of Vienna, Vienna, Austria

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Rosine Guimbaud CHU de Toulouse, Toulouse, France

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Pablo Gajate Hospital Universitário Ramón y Cajal, Clinical Oncology Department, Madrid, Spain

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Sara Pusceddu Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

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Albert Reising Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA

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Evgeny Degtyarev Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA

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Mark Shilkrut Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA

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Simantini Eddy Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA

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Simron Singh Sunnybrook Health Sciences Centre, Toronto, Canada

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years ( Yao et al. 2008 ). Neuroendocrine neoplasms (NENs) are comprised of well-differentiated NETs and poorly differentiated neuroendocrine carcinomas (NECs). The World Health Organization classification reported four categories, based on tumor

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Yulong Li Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases

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William F Simonds National Institutes of Health, Bethesda, Maryland, USA

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with malignant potential found in familial syndromes of hyperparathyroidism, including 1) HPT-JT-associated parathyroid carcinoma; 2) MEN1-associated nonfunctioning pancreatic neuroendocrine tumors (pNETs), gastrinoma and insulinoma, and thymic and

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Nele Garbrecht
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Martin Anlauf
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Anja Schmitt Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany

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Tobias Henopp
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Bence Sipos
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Andreas Raffel Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany

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Claus F Eisenberger Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany

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Wolfram T Knoefel Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany

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Marianne Pavel Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany

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Christian Fottner Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany

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Thomas J Musholt Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany

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Anja Rinke Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany

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Rudolf Arnold Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany

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Uta Berndt Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany

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Ursula Plöckinger Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany

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Bertram Wiedenmann Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany

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Holger Moch Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany

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Philipp U Heitz Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany

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Paul Komminoth Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany
Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany

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Aurel Perren Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany
Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany

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Günter Klöppel
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of uncertain biological behavior (wdNETubs), well-differentiated neuroendocrine carcinomas (wdNECs), or poorly differentiated neuroendocrine carcinomas (pdNECs; Klöppel et al . 2004 ). Proliferative activity was determined by counting Ki-67/MIB-1

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David J Gross
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Gabriel Munter
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Menachem Bitan
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Tali Siegal
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Alberto Gabizon
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Ronny Weitzen
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Ofer Merimsky
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Aliza Ackerstein
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Asher Salmon
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Avishai Sella
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Shimon Slavin
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patients with endocrine malignancies, we did not discern a beneficial effect on the course of the disease. Our findings are in keeping with recent reports on the effect of IM in patients with small cell lung carcinoma, a cancer with a related neuroendocrine

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Viktor Johanson
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Introduction Medullary thyroid carcinoma (MTC) accounts for 5–10% of all thyroid cancer. Most cases are sporadic but about 25% occur in patients with the multiple endocrine neoplasia type 2 (MEN2) syndrome ( Brauckhoff et al

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James F H Pittaway Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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Constantinos Lipsos Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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Katia Mariniello Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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Leonardo Guasti Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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Paper Expression Frequency Cases Prognostic relevance of DLK1 Endocrine and neuroendocrine  Adrenocortical carcinoma (Hadjidemetriou et al. 2019) Protein IHC 100% 9 (Hadjidemetriou et al. 2019

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