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Introduction The growth of the normal and abnormal prostate requires a source of androgens. This is evident in advanced prostate cancer as the early studies of Huggins and Hodges showed that surgical castration plus adrenalectomy leads to a
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Introduction Prostate cancer represents the most common cancer among men in the Western world. It is expected that 1 in 8 men in Europe and North America will be diagnosed with prostate cancer at some point during their lives; incidence
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Cancer Biology, Medicina Sperimentale e Patologia, Biological Sciences, Pharmacy and Experimental Therapeutics, Institute for Pathology, Pathology, Urology, Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
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Cancer Biology, Medicina Sperimentale e Patologia, Biological Sciences, Pharmacy and Experimental Therapeutics, Institute for Pathology, Pathology, Urology, Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
Cancer Biology, Medicina Sperimentale e Patologia, Biological Sciences, Pharmacy and Experimental Therapeutics, Institute for Pathology, Pathology, Urology, Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
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Introduction The complex molecular mechanisms underlying the progression of prostate cancer from organ-confined tumor to metastatic disease are largely unknown. Identification of the molecular changes associated with the metastasis process of
INSERM, University of Montpellier I, U844, Site Saint Eloi, Bâtiment INM, 80 rue Augustin Fliche, Montpellier F-34091, France
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INSERM, University of Montpellier I, U844, Site Saint Eloi, Bâtiment INM, 80 rue Augustin Fliche, Montpellier F-34091, France
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INSERM, University of Montpellier I, U844, Site Saint Eloi, Bâtiment INM, 80 rue Augustin Fliche, Montpellier F-34091, France
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Introduction Prostate cancer and chemokines Prostate cancer (PCa) is the most commonly diagnosed cancer in males and the second leading cause of death from cancer in men. Its incidence has increased dramatically since the advent of prostate
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Introduction Despite significant effort made in the fight against cancers, prostate cancer (PCa) is still the most frequent non-cutaneous male malignancy, and it is the second most common cause of cancer death in the United States with an estimated
Urology Department of Development and Regeneration, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
Laboratory for Structural Bioinformatics Center for Life Science Technologies, RIKEN, Yokohama, Japan
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Urology Department of Development and Regeneration, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
Laboratory for Structural Bioinformatics Center for Life Science Technologies, RIKEN, Yokohama, Japan
Laboratory of Molecular Endocrinology Department of Cellular and Molecular Medicine, Katholieke Universiteit Leuven, Herestraat 49, B-3000 Leuven, Belgium
Urology Department of Development and Regeneration, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
Laboratory for Structural Bioinformatics Center for Life Science Technologies, RIKEN, Yokohama, Japan
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Urology Department of Development and Regeneration, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
Laboratory for Structural Bioinformatics Center for Life Science Technologies, RIKEN, Yokohama, Japan
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Urology Department of Development and Regeneration, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
Laboratory for Structural Bioinformatics Center for Life Science Technologies, RIKEN, Yokohama, Japan
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Urology Department of Development and Regeneration, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
Laboratory for Structural Bioinformatics Center for Life Science Technologies, RIKEN, Yokohama, Japan
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Urology Department of Development and Regeneration, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
Laboratory for Structural Bioinformatics Center for Life Science Technologies, RIKEN, Yokohama, Japan
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Urology Department of Development and Regeneration, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
Laboratory for Structural Bioinformatics Center for Life Science Technologies, RIKEN, Yokohama, Japan
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Introduction Prostate cancer (PCa) remains a major healthcare problem and it is expected that the prevalence will only increase due to aging of the population. In 2013, it is estimated that PCa will account for 28% of all cancers in the USA with 29
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Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA
Department of Urology, University of Minnesota, Minneapolis, MN, USA
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Introduction Prostate cancer is the most frequently diagnosed cancer in men and accounts for an estimated 142,000 deaths in eveloped countries each year ( Torre et al . 2015 ). Five-year survival rates for localized diseases are high (>90
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Introduction Prostate cancer is the second leading cause of cancer-related deaths and the most frequently diagnosed cancer in men in Western countries ( Weir et al. 2003 , Jemal et al. 2004 ). Initially, prostate cancer is
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Introduction Prostate cancer is the most common visceral malignancy in men in the USA and the second leading cause of cancer deaths in this population. There is a large body of literature linking alterations of the fibroblast growth
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Centre for Endocrinology, Diabetes and Metabolism, Birmingham Healthcare Partners, Birmingham, UK
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Introduction In the UK, prostate cancer is the number one male malignancy accounting for 25% of all new cancer diagnoses in men ( Siegel et al . 2012 ). In 2011, there were almost 42,000 new cases with an age-standardised incidence rate of