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Trevor M Penning Perelman School of Medicine Center of Excellence in Environmental Toxicology, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6084, USA

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Introduction The growth of the normal and abnormal prostate requires a source of androgens. This is evident in advanced prostate cancer as the early studies of Huggins and Hodges showed that surgical castration plus adrenalectomy leads to a

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-14-0109
Volume/Issue:
Volume 21: Issue 4
Free access
Nely Díaz-Mejía Vall d’Hebron Institute of Oncology (VHIO) and Vall d’Hebron University Hospital, Barcelona, Spain

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David García-Illescas Vall d’Hebron Institute of Oncology (VHIO) and Vall d’Hebron University Hospital, Barcelona, Spain

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Rafael Morales-Barrera Vall d’Hebron Institute of Oncology (VHIO) and Vall d’Hebron University Hospital, Barcelona, Spain

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Cristina Suarez Vall d’Hebron Institute of Oncology (VHIO) and Vall d’Hebron University Hospital, Barcelona, Spain

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Jacques Planas Vall d’Hebron Institute of Oncology (VHIO) and Vall d’Hebron University Hospital, Barcelona, Spain

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Xavier Maldonado Vall d’Hebron Institute of Oncology (VHIO) and Vall d’Hebron University Hospital, Barcelona, Spain

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Joan Carles Vall d’Hebron Institute of Oncology (VHIO) and Vall d’Hebron University Hospital, Barcelona, Spain

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Joaquin Mateo Vall d’Hebron Institute of Oncology (VHIO) and Vall d’Hebron University Hospital, Barcelona, Spain

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Introduction Prostate cancer represents the most common cancer among men in the Western world. It is expected that 1 in 8 men in Europe and North America will be diagnosed with prostate cancer at some point during their lives; incidence

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-21-0133
Volume/Issue:
Volume 28: Issue 8
Free access
David Vindrieux INSERM, University of Montpellier I, U844, Site Saint Eloi, Bâtiment INM, 80 rue Augustin Fliche, Montpellier F-34091, France
INSERM, University of Montpellier I, U844, Site Saint Eloi, Bâtiment INM, 80 rue Augustin Fliche, Montpellier F-34091, France

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Pauline Escobar INSERM, University of Montpellier I, U844, Site Saint Eloi, Bâtiment INM, 80 rue Augustin Fliche, Montpellier F-34091, France
INSERM, University of Montpellier I, U844, Site Saint Eloi, Bâtiment INM, 80 rue Augustin Fliche, Montpellier F-34091, France

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Gwendal Lazennec INSERM, University of Montpellier I, U844, Site Saint Eloi, Bâtiment INM, 80 rue Augustin Fliche, Montpellier F-34091, France
INSERM, University of Montpellier I, U844, Site Saint Eloi, Bâtiment INM, 80 rue Augustin Fliche, Montpellier F-34091, France

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Introduction Prostate cancer and chemokines Prostate cancer (PCa) is the most commonly diagnosed cancer in males and the second leading cause of death from cancer in men. Its incidence has increased dramatically since the advent of prostate

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-09-0109
Volume/Issue:
Volume 16: Issue 3
Free access
Lei Gu Cancer Biology, Medicina Sperimentale e Patologia, Biological Sciences, Pharmacy and Experimental Therapeutics, Institute for Pathology, Pathology, Urology, Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA

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Paraskevi Vogiatzi Cancer Biology, Medicina Sperimentale e Patologia, Biological Sciences, Pharmacy and Experimental Therapeutics, Institute for Pathology, Pathology, Urology, Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA

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Martin Puhr Cancer Biology, Medicina Sperimentale e Patologia, Biological Sciences, Pharmacy and Experimental Therapeutics, Institute for Pathology, Pathology, Urology, Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA

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Ayush Dagvadorj Cancer Biology, Medicina Sperimentale e Patologia, Biological Sciences, Pharmacy and Experimental Therapeutics, Institute for Pathology, Pathology, Urology, Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA

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Jacqueline Lutz Cancer Biology, Medicina Sperimentale e Patologia, Biological Sciences, Pharmacy and Experimental Therapeutics, Institute for Pathology, Pathology, Urology, Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA

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Amy Ryder Cancer Biology, Medicina Sperimentale e Patologia, Biological Sciences, Pharmacy and Experimental Therapeutics, Institute for Pathology, Pathology, Urology, Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA

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Sankar Addya Cancer Biology, Medicina Sperimentale e Patologia, Biological Sciences, Pharmacy and Experimental Therapeutics, Institute for Pathology, Pathology, Urology, Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA

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Paolo Fortina Cancer Biology, Medicina Sperimentale e Patologia, Biological Sciences, Pharmacy and Experimental Therapeutics, Institute for Pathology, Pathology, Urology, Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
Cancer Biology, Medicina Sperimentale e Patologia, Biological Sciences, Pharmacy and Experimental Therapeutics, Institute for Pathology, Pathology, Urology, Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA

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Carlton Cooper Cancer Biology, Medicina Sperimentale e Patologia, Biological Sciences, Pharmacy and Experimental Therapeutics, Institute for Pathology, Pathology, Urology, Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA

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Benjamin Leiby Cancer Biology, Medicina Sperimentale e Patologia, Biological Sciences, Pharmacy and Experimental Therapeutics, Institute for Pathology, Pathology, Urology, Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA

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Abhijit Dasgupta Cancer Biology, Medicina Sperimentale e Patologia, Biological Sciences, Pharmacy and Experimental Therapeutics, Institute for Pathology, Pathology, Urology, Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA

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Terry Hyslop Cancer Biology, Medicina Sperimentale e Patologia, Biological Sciences, Pharmacy and Experimental Therapeutics, Institute for Pathology, Pathology, Urology, Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA

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Lukas Bubendorf Cancer Biology, Medicina Sperimentale e Patologia, Biological Sciences, Pharmacy and Experimental Therapeutics, Institute for Pathology, Pathology, Urology, Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA

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Kalle Alanen Cancer Biology, Medicina Sperimentale e Patologia, Biological Sciences, Pharmacy and Experimental Therapeutics, Institute for Pathology, Pathology, Urology, Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA

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Tuomas Mirtti Cancer Biology, Medicina Sperimentale e Patologia, Biological Sciences, Pharmacy and Experimental Therapeutics, Institute for Pathology, Pathology, Urology, Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA

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Marja T Nevalainen Cancer Biology, Medicina Sperimentale e Patologia, Biological Sciences, Pharmacy and Experimental Therapeutics, Institute for Pathology, Pathology, Urology, Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
Cancer Biology, Medicina Sperimentale e Patologia, Biological Sciences, Pharmacy and Experimental Therapeutics, Institute for Pathology, Pathology, Urology, Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
Cancer Biology, Medicina Sperimentale e Patologia, Biological Sciences, Pharmacy and Experimental Therapeutics, Institute for Pathology, Pathology, Urology, Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA

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Introduction The complex molecular mechanisms underlying the progression of prostate cancer from organ-confined tumor to metastatic disease are largely unknown. Identification of the molecular changes associated with the metastasis process of

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-09-0328
Volume/Issue:
Volume 17: Issue 2
Free access
Fazlul H Sarkar Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, 740 HWCRC, 4100 John R Street, Detroit, Michigan 48201, USA

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Yiwei Li Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, 740 HWCRC, 4100 John R Street, Detroit, Michigan 48201, USA

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Zhiwei Wang Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, 740 HWCRC, 4100 John R Street, Detroit, Michigan 48201, USA

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Dejuan Kong Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, 740 HWCRC, 4100 John R Street, Detroit, Michigan 48201, USA

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Introduction Despite significant effort made in the fight against cancers, prostate cancer (PCa) is still the most frequent non-cutaneous male malignancy, and it is the second most common cause of cancer death in the United States with an estimated

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-10-0074
Volume/Issue:
Volume 17: Issue 3
Free access
Christine Helsen Laboratory of Molecular Endocrinology Department of Cellular and Molecular Medicine, Katholieke Universiteit Leuven, Herestraat 49, B-3000 Leuven, Belgium

Urology Department of Development and Regeneration, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium

Laboratory for Structural Bioinformatics Center for Life Science Technologies, RIKEN, Yokohama, Japan

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Thomas Van den Broeck Laboratory of Molecular Endocrinology Department of Cellular and Molecular Medicine, Katholieke Universiteit Leuven, Herestraat 49, B-3000 Leuven, Belgium

Urology Department of Development and Regeneration, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium

Laboratory for Structural Bioinformatics Center for Life Science Technologies, RIKEN, Yokohama, Japan
Laboratory of Molecular Endocrinology Department of Cellular and Molecular Medicine, Katholieke Universiteit Leuven, Herestraat 49, B-3000 Leuven, Belgium

Urology Department of Development and Regeneration, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium

Laboratory for Structural Bioinformatics Center for Life Science Technologies, RIKEN, Yokohama, Japan

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Arnout Voet Laboratory of Molecular Endocrinology Department of Cellular and Molecular Medicine, Katholieke Universiteit Leuven, Herestraat 49, B-3000 Leuven, Belgium

Urology Department of Development and Regeneration, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium

Laboratory for Structural Bioinformatics Center for Life Science Technologies, RIKEN, Yokohama, Japan

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Stefan Prekovic Laboratory of Molecular Endocrinology Department of Cellular and Molecular Medicine, Katholieke Universiteit Leuven, Herestraat 49, B-3000 Leuven, Belgium

Urology Department of Development and Regeneration, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium

Laboratory for Structural Bioinformatics Center for Life Science Technologies, RIKEN, Yokohama, Japan

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Hendrik Van Poppel Laboratory of Molecular Endocrinology Department of Cellular and Molecular Medicine, Katholieke Universiteit Leuven, Herestraat 49, B-3000 Leuven, Belgium

Urology Department of Development and Regeneration, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium

Laboratory for Structural Bioinformatics Center for Life Science Technologies, RIKEN, Yokohama, Japan

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Steven Joniau Laboratory of Molecular Endocrinology Department of Cellular and Molecular Medicine, Katholieke Universiteit Leuven, Herestraat 49, B-3000 Leuven, Belgium

Urology Department of Development and Regeneration, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium

Laboratory for Structural Bioinformatics Center for Life Science Technologies, RIKEN, Yokohama, Japan

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Frank Claessens Laboratory of Molecular Endocrinology Department of Cellular and Molecular Medicine, Katholieke Universiteit Leuven, Herestraat 49, B-3000 Leuven, Belgium

Urology Department of Development and Regeneration, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium

Laboratory for Structural Bioinformatics Center for Life Science Technologies, RIKEN, Yokohama, Japan

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Introduction Prostate cancer (PCa) remains a major healthcare problem and it is expected that the prevalence will only increase due to aging of the population. In 2013, it is estimated that PCa will account for 28% of all cancers in the USA with 29

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-13-0545
Volume/Issue:
Volume 21: Issue 4
Free access
Jamie L Van Etten Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA

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Scott M Dehm Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA
Department of Urology, University of Minnesota, Minneapolis, MN, USA

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Introduction Prostate cancer is the most frequently diagnosed cancer in men and accounts for an estimated 142,000 deaths in eveloped countries each year ( Torre et al . 2015 ). Five-year survival rates for localized diseases are high (>90

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-16-0049
Volume/Issue:
Volume 23: Issue 4
Free access
Glenn T G Chang
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Mila Jhamai
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Wytske M van Weerden
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Guido Jenster
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Albert O Brinkmann
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Introduction Prostate cancer is the second leading cause of cancer-related deaths and the most frequently diagnosed cancer in men in Western countries ( Weir et al. 2003 , Jemal et al. 2004 ). Initially, prostate cancer is

Article Type:
Research Article
DOI:
https://doi.org/10.1677/erc.1.00853
Volume/Issue:
Volume 11: Issue 4
Free access
B Kwabi-Addo Department of Pathology, Baylor College of Medicine and Michael E DeBakey Department of Veterans Affairs Medical Center, Houston, Texas 77030, USA

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M Ozen Department of Pathology, Baylor College of Medicine and Michael E DeBakey Department of Veterans Affairs Medical Center, Houston, Texas 77030, USA

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M Ittmann Department of Pathology, Baylor College of Medicine and Michael E DeBakey Department of Veterans Affairs Medical Center, Houston, Texas 77030, USA

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Introduction Prostate cancer is the most common visceral malignancy in men in the USA and the second leading cause of cancer deaths in this population. There is a large body of literature linking alterations of the fibroblast growth

Article Type:
Review Article
DOI:
https://doi.org/10.1677/erc.1.00535
Volume/Issue:
Volume 11: Issue 4
Free access
Himisha Beltran Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA

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Francesca Demichelis Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Trento, Italy

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Introduction The treatment landscape of advanced prostate cancer continues to evolve. Drugs with varied mechanisms of action now being used in earlier disease settings, and patients are living longer with longer exposure to systemic therapies

Article Type:
Review Article
Collections:
Top-cited articles of 2023
DOI:
https://doi.org/10.1530/ERC-21-0140
Volume/Issue:
Volume 28: Issue 8
Free access