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. Statistical analysis Descriptive characteristics were summarized by case vs control status and compared using the chi-square test or Wilcoxon rank sum test. First, the univariate association of continuous levels of pro-NT with colon cancer was assessed using
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Clinic for Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Medical Faculty of Heinrich Heine, University Düsseldorf, Düsseldorf, Germany
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) analyses were performed to establish ideal cutoff values to discriminate between surviving and non-surviving patients. Survival was compared using log-rank (Mantel–Cox) test displayed with hazard ratio (HR) and 95% confidence interval (CI). All reported P
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collection from the bigger list of differentially expressed genes. This method applies a Kolmogorov–Smirnov (KS) test, assessing the distribution of a pre-defined gene set (‘IGF family’ or ‘IGF signaling pathway’) expression, within a large ranked gene list
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available, were abstracted to complete them. Statistical analysis The nonparametric Spearman’s rank correlation coefficient ( r s ) or Pearson correlation coefficient (rp) were used to evaluate the correlations between potential surrogate markers and
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Department of Urology, Institute for Pathology, Institute of Pathology, Department of Urology, St Claraspital, Basel, Switzerland
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., Cary, NC, USA). Differences between two groups were analyzed with the Wilcoxon Rank Sum test; differences between more than two groups were analyzed using the Kruskal–Wallis Rank Sum test. Survival curves were plotted using the Kaplan–Meier method and
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Department of Research, Veterans Administration Greater Los Angeles, Los Angeles, California, USA
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biochemical recurrence in those with a prostate-specific antigen (PSA) level ≤10. Univariate associations between the level of sCD105 and other variables were examined with Kruskal–Wallis test, Wilcoxon rank-sum test, or Spearman rank correlation, where
ENETS Center of Excellence, Department of Endocrinology, University Hospital Basel, Basel, Switzerland
Department of Clinical Research, University of Basel, Basel, Switzerland
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Department of Clinical Research, University of Basel, Basel, Switzerland
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parts. First, data of all eligible patients were evaluated according to their SSTR status. Survival rates (= survival from date of diagnosis to last date of follow-up or death) were calculated with the Kaplan–Meier method, the log-rank test was used to
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Spearman rank correlation. Cloning and stable transfection of tumor cell lines were reported in Supplementary information , see section on supplementary data given at the end of this article. Statistical analysis All analyses were performed with Stata (v
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/100–1/10; score=3, 1/10–1/2; score=4, >1/2. Statistical analysis The Mann–Whitney U test was used to compare the IHC scores of molecular markers with clinicopathological characteristics. Spearman's rank correlation test was used to study relationships among
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that higher levels of CD8 in the tumour stroma had a statistically significant negative effect on survival duration ( P = 0.016, log rank; Fig. 3A ). In addition to using CD68 to detect CLS, in these same sections, we also examined the impact of CD68