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Yong Lin
Yong Lin
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Xiaofei Jiang
Xiaofei Jiang
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Ye Shen
Ye Shen
Department of Laboratory Medicine, Institute of Endocrinology and Diabetologia, Division of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Central Urumqi Road, Shanghai 200040, People's Republic of China
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Min Li
Min Li
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Huili Ma
Huili Ma
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Mingzhao Xing
Mingzhao Xing
Department of Laboratory Medicine, Institute of Endocrinology and Diabetologia, Division of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Central Urumqi Road, Shanghai 200040, People's Republic of China
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Yuan Lu
Yuan Lu
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PMD18-T-β-actin constructs with 10 2 –10 8 copies/μl DNA. Immunohistochemistry Immunohistochemical staining was performed on tissue sections to examine molecular markers of pituitary adenomas and protein expression of PIK3CA and Ki-67. Five
M Xing
M Xing
Division of Endocrinology and Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, 1830 E. Monument St/Suite 333 Baltimore, MD 21287, USA
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mutation with additional sensitive and specific molecular markers will likely be the next step in increasing the FNAB diagnostic sensitivity. This approach was tested recently by combined use of BRAF mutation with RET/PTC ( Salvatore et al. 2004 ), a
V Häyry
V Häyry
Institute of Biomedicine, Departments of Pathology, Otorhinolaryngology, Developmental Biology, University of Helsinki, Biomedicum, Haartmaninkatu 8, PL 63, Helsinki 00014 HY, Finland
Institute of Biomedicine, Departments of Pathology, Otorhinolaryngology, Developmental Biology, University of Helsinki, Biomedicum, Haartmaninkatu 8, PL 63, Helsinki 00014 HY, Finland
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Institute of Biomedicine, Departments of Pathology, Otorhinolaryngology, Developmental Biology, University of Helsinki, Biomedicum, Haartmaninkatu 8, PL 63, Helsinki 00014 HY, Finland
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K Salmenkivi
K Salmenkivi
Institute of Biomedicine, Departments of Pathology, Otorhinolaryngology, Developmental Biology, University of Helsinki, Biomedicum, Haartmaninkatu 8, PL 63, Helsinki 00014 HY, Finland
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J Arola
J Arola
Institute of Biomedicine, Departments of Pathology, Otorhinolaryngology, Developmental Biology, University of Helsinki, Biomedicum, Haartmaninkatu 8, PL 63, Helsinki 00014 HY, Finland
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P Heikkilä
P Heikkilä
Institute of Biomedicine, Departments of Pathology, Otorhinolaryngology, Developmental Biology, University of Helsinki, Biomedicum, Haartmaninkatu 8, PL 63, Helsinki 00014 HY, Finland
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C Haglund
C Haglund
Institute of Biomedicine, Departments of Pathology, Otorhinolaryngology, Developmental Biology, University of Helsinki, Biomedicum, Haartmaninkatu 8, PL 63, Helsinki 00014 HY, Finland
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H Sariola
H Sariola
Institute of Biomedicine, Departments of Pathology, Otorhinolaryngology, Developmental Biology, University of Helsinki, Biomedicum, Haartmaninkatu 8, PL 63, Helsinki 00014 HY, Finland
Institute of Biomedicine, Departments of Pathology, Otorhinolaryngology, Developmental Biology, University of Helsinki, Biomedicum, Haartmaninkatu 8, PL 63, Helsinki 00014 HY, Finland
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Institute of Biomedicine, Departments of Pathology, Otorhinolaryngology, Developmental Biology, University of Helsinki, Biomedicum, Haartmaninkatu 8, PL 63, Helsinki 00014 HY, Finland
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histopathological material (Fisher's exact test P =0.006). Discussion Several histochemical and molecular markers (MIB-1, Cd34, VEGF, hTERT; p53, bcl-2 and c-erbB-2) have been investigated to identify the metastatic subgroup of phaeochromocytoma ( de Krijger et al
S G Creemers
S G Creemers
Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
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Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
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L J Hofland
L J Hofland
Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
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Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
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E Korpershoek
E Korpershoek
Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
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Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
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G J H Franssen
G J H Franssen
Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
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Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
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F J van Kemenade
F J van Kemenade
Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
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Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
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W W de Herder
W W de Herder
Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
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Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
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R A Feelders
R A Feelders
Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
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Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
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analyzed the discriminative value of the molecular markers were included in this overview. Total sensitivity and specificity represents a weighted mean Study ACC ( n ) ACA ( n ) Sens (%) Spec (%) Cutoff Reference diagnosis Comments IGF2 Gicquel et al
Athanasios Bikas
Athanasios Bikas
Division of Endocrinology, Department of Pediatrics, Biomedical Instrumental Center, Center for Endocrine Surgery, Department of Surgery, Department of Medicine, Medstar Washington Hospital Center, 110 Irving Street Northwest, Washington, District of Columbia 20010, USA
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Kirk Jensen
Kirk Jensen
Division of Endocrinology, Department of Pediatrics, Biomedical Instrumental Center, Center for Endocrine Surgery, Department of Surgery, Department of Medicine, Medstar Washington Hospital Center, 110 Irving Street Northwest, Washington, District of Columbia 20010, USA
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Aneeta Patel
Aneeta Patel
Division of Endocrinology, Department of Pediatrics, Biomedical Instrumental Center, Center for Endocrine Surgery, Department of Surgery, Department of Medicine, Medstar Washington Hospital Center, 110 Irving Street Northwest, Washington, District of Columbia 20010, USA
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John Costello Jr
John Costello Jr
Division of Endocrinology, Department of Pediatrics, Biomedical Instrumental Center, Center for Endocrine Surgery, Department of Surgery, Department of Medicine, Medstar Washington Hospital Center, 110 Irving Street Northwest, Washington, District of Columbia 20010, USA
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Dennis McDaniel
Dennis McDaniel
Division of Endocrinology, Department of Pediatrics, Biomedical Instrumental Center, Center for Endocrine Surgery, Department of Surgery, Department of Medicine, Medstar Washington Hospital Center, 110 Irving Street Northwest, Washington, District of Columbia 20010, USA
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Joanna Klubo-Gwiezdzinska
Joanna Klubo-Gwiezdzinska
Division of Endocrinology, Department of Pediatrics, Biomedical Instrumental Center, Center for Endocrine Surgery, Department of Surgery, Department of Medicine, Medstar Washington Hospital Center, 110 Irving Street Northwest, Washington, District of Columbia 20010, USA
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Olexander Larin
Olexander Larin
Division of Endocrinology, Department of Pediatrics, Biomedical Instrumental Center, Center for Endocrine Surgery, Department of Surgery, Department of Medicine, Medstar Washington Hospital Center, 110 Irving Street Northwest, Washington, District of Columbia 20010, USA
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Victoria Hoperia
Victoria Hoperia
Division of Endocrinology, Department of Pediatrics, Biomedical Instrumental Center, Center for Endocrine Surgery, Department of Surgery, Department of Medicine, Medstar Washington Hospital Center, 110 Irving Street Northwest, Washington, District of Columbia 20010, USA
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Kenneth D Burman
Kenneth D Burman
Division of Endocrinology, Department of Pediatrics, Biomedical Instrumental Center, Center for Endocrine Surgery, Department of Surgery, Department of Medicine, Medstar Washington Hospital Center, 110 Irving Street Northwest, Washington, District of Columbia 20010, USA
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Lisa Boyle
Lisa Boyle
Division of Endocrinology, Department of Pediatrics, Biomedical Instrumental Center, Center for Endocrine Surgery, Department of Surgery, Department of Medicine, Medstar Washington Hospital Center, 110 Irving Street Northwest, Washington, District of Columbia 20010, USA
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Leonard Wartofsky
Leonard Wartofsky
Division of Endocrinology, Department of Pediatrics, Biomedical Instrumental Center, Center for Endocrine Surgery, Department of Surgery, Department of Medicine, Medstar Washington Hospital Center, 110 Irving Street Northwest, Washington, District of Columbia 20010, USA
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Vasyl Vasko
Vasyl Vasko
Division of Endocrinology, Department of Pediatrics, Biomedical Instrumental Center, Center for Endocrine Surgery, Department of Surgery, Department of Medicine, Medstar Washington Hospital Center, 110 Irving Street Northwest, Washington, District of Columbia 20010, USA
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was associated with overexpression of BiP in cells cultured in low-, but not in high-glucose medium ( Fig. 2 C). Expression of a molecular marker of oncosis (perforin) was also induced in thyroid cancer cells treated by metformin ( Fig. 2 C). Confocal
G Galli
G Galli
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R Zonefrati
R Zonefrati
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A Gozzini
A Gozzini
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C Mavilia
C Mavilia
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V Martineti
V Martineti
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I Tognarini
I Tognarini
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G Nesi
G Nesi
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T Marcucci
T Marcucci
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F Tonelli
F Tonelli
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M Tommasi
M Tommasi
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C Casini Raggi
C Casini Raggi
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P Pinzani
P Pinzani
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M L Brandi
M L Brandi
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in culture. The rarity of somatostatinoma cell cultures makes the SS-C cell line a unique model for evaluation of both molecular marker expression and in vitro effects of molecules active on expressed targets. Here we provide evidence for control of
G Bidaux
G Bidaux
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M Roudbaraki
M Roudbaraki
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C Merle
C Merle
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A Crépin
A Crépin
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P Delcourt
P Delcourt
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C Slomianny
C Slomianny
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S Thebault
S Thebault
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J-L Bonnal
J-L Bonnal
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M Benahmed
M Benahmed
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F Cabon
F Cabon
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B Mauroy
B Mauroy
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N Prevarskaya
N Prevarskaya
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prostate cancer. It is therefore essential to understand what drives the progression to androgen-independence and identify the molecular markers for both the early androgen-dependent and the advanced androgen-independent prostate cancer stages. It
Stefano Caramuta
Stefano Caramuta
Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
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Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
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Linkiat Lee
Linkiat Lee
Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
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Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
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Deniz M Özata
Deniz M Özata
Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
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Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
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Pinar Akçakaya
Pinar Akçakaya
Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
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Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
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Hong Xie
Hong Xie
Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
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Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
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Anders Höög
Anders Höög
Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
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Jan Zedenius
Jan Zedenius
Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
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Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
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Martin Bäckdahl
Martin Bäckdahl
Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
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Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
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Catharina Larsson
Catharina Larsson
Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
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Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
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Weng-Onn Lui
Weng-Onn Lui
Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
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Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
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adrenocortical tumor diagnostics, the identification of additional molecular markers with diagnostic and prognostic potential for clinical management of ACC is needed. Previous reports identified over-expression of IGF2, loss-of-heterozygosity at 11p15 and 17p13
Brian Hung-Hin Lang
Brian Hung-Hin Lang
Department of Surgery, Department of Surgery, School of Public Health, Department of Pathology, Cancer Research Institute, The University of Hong Kong, Hong Kong SAR, China
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Young Jun Chai
Young Jun Chai
Department of Surgery, Department of Surgery, School of Public Health, Department of Pathology, Cancer Research Institute, The University of Hong Kong, Hong Kong SAR, China
Department of Surgery, Department of Surgery, School of Public Health, Department of Pathology, Cancer Research Institute, The University of Hong Kong, Hong Kong SAR, China
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Department of Surgery, Department of Surgery, School of Public Health, Department of Pathology, Cancer Research Institute, The University of Hong Kong, Hong Kong SAR, China
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Benjamin J Cowling
Benjamin J Cowling
Department of Surgery, Department of Surgery, School of Public Health, Department of Pathology, Cancer Research Institute, The University of Hong Kong, Hong Kong SAR, China
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Hye Sook Min
Hye Sook Min
Department of Surgery, Department of Surgery, School of Public Health, Department of Pathology, Cancer Research Institute, The University of Hong Kong, Hong Kong SAR, China
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Kyu Eun Lee
Kyu Eun Lee
Department of Surgery, Department of Surgery, School of Public Health, Department of Pathology, Cancer Research Institute, The University of Hong Kong, Hong Kong SAR, China
Department of Surgery, Department of Surgery, School of Public Health, Department of Pathology, Cancer Research Institute, The University of Hong Kong, Hong Kong SAR, China
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Department of Surgery, Department of Surgery, School of Public Health, Department of Pathology, Cancer Research Institute, The University of Hong Kong, Hong Kong SAR, China
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Yeo-Kyu Youn
Yeo-Kyu Youn
Department of Surgery, Department of Surgery, School of Public Health, Department of Pathology, Cancer Research Institute, The University of Hong Kong, Hong Kong SAR, China
Department of Surgery, Department of Surgery, School of Public Health, Department of Pathology, Cancer Research Institute, The University of Hong Kong, Hong Kong SAR, China
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Department of Surgery, Department of Surgery, School of Public Health, Department of Pathology, Cancer Research Institute, The University of Hong Kong, Hong Kong SAR, China
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, Zhao et al . 2013 ). In recent years, a T1799A point mutation in the v-raf murine sarcoma viral oncogene homolog B1 ( BRAF ) resulting in a valine-to-glutamic acid switch at codon 600 ( BRAF V600E ) has emerged as a molecular marker for aggressive
Karel Pacak
Karel Pacak
Section of Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
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Mark Kidd
Mark Kidd
WREN Laboratories, Branford, Connecticut, USA
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Leah Meuter
Leah Meuter
Section of Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
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Irvin M Modlin
Irvin M Modlin
Gastroenterological and Endoscopic Surgery, Yale University School of Medicine, New Haven, Connecticut, USA
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therapies including surgery on the management of PPGLs. This study also indicates that PHEOs/PGLs may effectively secrete molecular markers that can be detected in the blood. There have been only a few other studies that have evaluated circulating levels
