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Viktoria Evdokimova
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Manoj Gandhi
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Jayanagendra Rayapureddi Department of Pathology, Molecular Genetics, University of Pittsburgh, 200 Lothrop Street, PUH, Room C-606, Pittsburgh, Pennsylvania 15213, USA Departments of

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James R Stringer Department of Pathology, Molecular Genetics, University of Pittsburgh, 200 Lothrop Street, PUH, Room C-606, Pittsburgh, Pennsylvania 15213, USA Departments of

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Yuri E Nikiforov
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Pierotti MA Della Porta G Fusco A Vecchio G 1990 PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas . Cell 60 557 – 563 . doi:10

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Urbain Weyemi CNRS, University Paris-Sud 11, Institut Gustave Roussy, UBRM, Sanquin Research, FRE2939, Villejuif F-94805, France
CNRS, University Paris-Sud 11, Institut Gustave Roussy, UBRM, Sanquin Research, FRE2939, Villejuif F-94805, France
CNRS, University Paris-Sud 11, Institut Gustave Roussy, UBRM, Sanquin Research, FRE2939, Villejuif F-94805, France

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Bernard Caillou CNRS, University Paris-Sud 11, Institut Gustave Roussy, UBRM, Sanquin Research, FRE2939, Villejuif F-94805, France

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Monique Talbot CNRS, University Paris-Sud 11, Institut Gustave Roussy, UBRM, Sanquin Research, FRE2939, Villejuif F-94805, France
CNRS, University Paris-Sud 11, Institut Gustave Roussy, UBRM, Sanquin Research, FRE2939, Villejuif F-94805, France

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Rabii Ameziane-El-Hassani CNRS, University Paris-Sud 11, Institut Gustave Roussy, UBRM, Sanquin Research, FRE2939, Villejuif F-94805, France
CNRS, University Paris-Sud 11, Institut Gustave Roussy, UBRM, Sanquin Research, FRE2939, Villejuif F-94805, France

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Ludovic Lacroix CNRS, University Paris-Sud 11, Institut Gustave Roussy, UBRM, Sanquin Research, FRE2939, Villejuif F-94805, France

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Odile Lagent-Chevallier CNRS, University Paris-Sud 11, Institut Gustave Roussy, UBRM, Sanquin Research, FRE2939, Villejuif F-94805, France
CNRS, University Paris-Sud 11, Institut Gustave Roussy, UBRM, Sanquin Research, FRE2939, Villejuif F-94805, France
CNRS, University Paris-Sud 11, Institut Gustave Roussy, UBRM, Sanquin Research, FRE2939, Villejuif F-94805, France

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Abir Al Ghuzlan CNRS, University Paris-Sud 11, Institut Gustave Roussy, UBRM, Sanquin Research, FRE2939, Villejuif F-94805, France

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Dirk Roos CNRS, University Paris-Sud 11, Institut Gustave Roussy, UBRM, Sanquin Research, FRE2939, Villejuif F-94805, France

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Jean-Michel Bidart CNRS, University Paris-Sud 11, Institut Gustave Roussy, UBRM, Sanquin Research, FRE2939, Villejuif F-94805, France
CNRS, University Paris-Sud 11, Institut Gustave Roussy, UBRM, Sanquin Research, FRE2939, Villejuif F-94805, France

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Alain Virion CNRS, University Paris-Sud 11, Institut Gustave Roussy, UBRM, Sanquin Research, FRE2939, Villejuif F-94805, France
CNRS, University Paris-Sud 11, Institut Gustave Roussy, UBRM, Sanquin Research, FRE2939, Villejuif F-94805, France
CNRS, University Paris-Sud 11, Institut Gustave Roussy, UBRM, Sanquin Research, FRE2939, Villejuif F-94805, France

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Martin Schlumberger CNRS, University Paris-Sud 11, Institut Gustave Roussy, UBRM, Sanquin Research, FRE2939, Villejuif F-94805, France
CNRS, University Paris-Sud 11, Institut Gustave Roussy, UBRM, Sanquin Research, FRE2939, Villejuif F-94805, France

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Corinne Dupuy CNRS, University Paris-Sud 11, Institut Gustave Roussy, UBRM, Sanquin Research, FRE2939, Villejuif F-94805, France
CNRS, University Paris-Sud 11, Institut Gustave Roussy, UBRM, Sanquin Research, FRE2939, Villejuif F-94805, France
CNRS, University Paris-Sud 11, Institut Gustave Roussy, UBRM, Sanquin Research, FRE2939, Villejuif F-94805, France

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surgery at Institut Gustave Roussy. Informed consent was obtained from all patients. These samples included normal thyroid tissue ( n =8); nodular and/or diffuse hyperplasia ( n =11); follicular adenoma ( n =4); papillary carcinoma ( n =11); follicular

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A Raitila
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M Georgitsi
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A Karhu
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K Tuppurainen
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M J Mäkinen
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K Birkenkamp-Demtröder
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K Salmenkivi
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T F Ørntoft
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J Arola
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V Launonen
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P Vahteristo
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L A Aaltonen
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and 87 years (mean age 51 years ±15.5). Information on sex was available for 59 cases, of which 37 were females and 22 were males. One male individual had two tumors of the thyroid gland: one follicular adenoma and one papillary carcinoma

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Sandra Lassalle INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Véronique Hofman INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Marius Ilie INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Christelle Bonnetaud INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Marie-Pierre Puisségur INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Patrick Brest INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Céline Loubatier INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Nicolas Guevara INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Olivier Bordone INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Bruno Cardinaud INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Kévin Lebrigand INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Géraldine Rios INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Joseph Santini INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Brigitte Franc INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Bernard Mari INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Abir Al Ghuzlan INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Philippe Vielh INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Pascal Barbry INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Paul Hofman INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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invasive pT1N0M0 Female 28 None FTA, follicular thyroid adenoma; C-PTC, classical papillary thyroid carcinoma; FV-PTC, follicular variant of papillary carcinoma; WDT-UMP, well-differentiated tumor of uncertain malignant potential; FT-UMP, follicular tumor

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Lucas Leite Cunha Laboratory of Cancer Molecular Genetics, Laboratory of Cell Signaling, Department of Radiology, Adolfo Lutz Institute, Department of Pathology, Laboratory of Investigative and Molecular Pathology (Ciped), Faculty of Medical Sciences, University of Campinas (Unicamp), PO Box 6111, 126 Tessalia Vieira de Camargo Street, Campinas, São Paulo, Brazil

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Elaine Cristina Morari Laboratory of Cancer Molecular Genetics, Laboratory of Cell Signaling, Department of Radiology, Adolfo Lutz Institute, Department of Pathology, Laboratory of Investigative and Molecular Pathology (Ciped), Faculty of Medical Sciences, University of Campinas (Unicamp), PO Box 6111, 126 Tessalia Vieira de Camargo Street, Campinas, São Paulo, Brazil

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Ana Carolina Trindade Guihen Laboratory of Cancer Molecular Genetics, Laboratory of Cell Signaling, Department of Radiology, Adolfo Lutz Institute, Department of Pathology, Laboratory of Investigative and Molecular Pathology (Ciped), Faculty of Medical Sciences, University of Campinas (Unicamp), PO Box 6111, 126 Tessalia Vieira de Camargo Street, Campinas, São Paulo, Brazil

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Daniela Razolli Laboratory of Cancer Molecular Genetics, Laboratory of Cell Signaling, Department of Radiology, Adolfo Lutz Institute, Department of Pathology, Laboratory of Investigative and Molecular Pathology (Ciped), Faculty of Medical Sciences, University of Campinas (Unicamp), PO Box 6111, 126 Tessalia Vieira de Camargo Street, Campinas, São Paulo, Brazil

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Renê Gerhard Laboratory of Cancer Molecular Genetics, Laboratory of Cell Signaling, Department of Radiology, Adolfo Lutz Institute, Department of Pathology, Laboratory of Investigative and Molecular Pathology (Ciped), Faculty of Medical Sciences, University of Campinas (Unicamp), PO Box 6111, 126 Tessalia Vieira de Camargo Street, Campinas, São Paulo, Brazil

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Suely Nonogaki Laboratory of Cancer Molecular Genetics, Laboratory of Cell Signaling, Department of Radiology, Adolfo Lutz Institute, Department of Pathology, Laboratory of Investigative and Molecular Pathology (Ciped), Faculty of Medical Sciences, University of Campinas (Unicamp), PO Box 6111, 126 Tessalia Vieira de Camargo Street, Campinas, São Paulo, Brazil

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Fernando Augusto Soares Laboratory of Cancer Molecular Genetics, Laboratory of Cell Signaling, Department of Radiology, Adolfo Lutz Institute, Department of Pathology, Laboratory of Investigative and Molecular Pathology (Ciped), Faculty of Medical Sciences, University of Campinas (Unicamp), PO Box 6111, 126 Tessalia Vieira de Camargo Street, Campinas, São Paulo, Brazil

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José Vassallo Laboratory of Cancer Molecular Genetics, Laboratory of Cell Signaling, Department of Radiology, Adolfo Lutz Institute, Department of Pathology, Laboratory of Investigative and Molecular Pathology (Ciped), Faculty of Medical Sciences, University of Campinas (Unicamp), PO Box 6111, 126 Tessalia Vieira de Camargo Street, Campinas, São Paulo, Brazil

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Laura Sterian Ward Laboratory of Cancer Molecular Genetics, Laboratory of Cell Signaling, Department of Radiology, Adolfo Lutz Institute, Department of Pathology, Laboratory of Investigative and Molecular Pathology (Ciped), Faculty of Medical Sciences, University of Campinas (Unicamp), PO Box 6111, 126 Tessalia Vieira de Camargo Street, Campinas, São Paulo, Brazil

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. doi:10.1056/NEJM198612253152606 . El Demellawy D Nasr A Alowami S 2008 Application of CD56, P63 and CK19 immunohistochemistry in the diagnosis of papillary carcinoma of the thyroid . Diagnostic Pathology 3 5 doi:10

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Pierlorenzo Pallante Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Biotecnologie Avanzate-Napoli, Department of Molecular Virology, Facoltà di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli ‘Federico II’, Via Pansini 5, 80131 Napoli, Italy
Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Biotecnologie Avanzate-Napoli, Department of Molecular Virology, Facoltà di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli ‘Federico II’, Via Pansini 5, 80131 Napoli, Italy

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Rosa Visone Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Biotecnologie Avanzate-Napoli, Department of Molecular Virology, Facoltà di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli ‘Federico II’, Via Pansini 5, 80131 Napoli, Italy

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Carlo Maria Croce Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Biotecnologie Avanzate-Napoli, Department of Molecular Virology, Facoltà di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli ‘Federico II’, Via Pansini 5, 80131 Napoli, Italy

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Alfredo Fusco Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Biotecnologie Avanzate-Napoli, Department of Molecular Virology, Facoltà di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli ‘Federico II’, Via Pansini 5, 80131 Napoli, Italy
Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Biotecnologie Avanzate-Napoli, Department of Molecular Virology, Facoltà di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli ‘Federico II’, Via Pansini 5, 80131 Napoli, Italy

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papillary carcinomas . Cell 60 557 – 563 . Griffiths-Jones S Grocock RJ van Dongen S Bateman A Enright AJ 2006 miRBase: microRNA sequences, targets and gene nomenclature . Nucleic Acids Research 34

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Susan J Hsiao Division of Molecular and Genomic Pathology, Department of Pathology, University of Pittsburgh School of Medicine, 3477 Euler Way, Room 8031, Pittsburgh, Pennsylvania 15213, USA

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Yuri E Nikiforov Division of Molecular and Genomic Pathology, Department of Pathology, University of Pittsburgh School of Medicine, 3477 Euler Way, Room 8031, Pittsburgh, Pennsylvania 15213, USA

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be seen in up to 50% of patients older than 60 years of age ( Mazzaferri 1992 , 1993 , Guth et al . 2009 ). Only 5% of thyroid nodules are malignant ( Brito et al . 2013 ). Most thyroid cancers are well-differentiated papillary carcinomas or

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E Fiore
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T Rago
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M A Provenzale
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M Scutari
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C Ugolini Department of Endocrinology, Section of Pathology, Department of Surgery, Section of Cytopathology

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F Basolo Department of Endocrinology, Section of Pathology, Department of Surgery, Section of Cytopathology

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G Di Coscio Department of Endocrinology, Section of Pathology, Department of Surgery, Section of Cytopathology

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P Berti Department of Endocrinology, Section of Pathology, Department of Surgery, Section of Cytopathology

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L Grasso
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carcinomas are point mutations of the BRAF gene and RET/PTC rearrangement. These genetic alterations are found in more than 70% of papillary carcinomas and they rarely overlap in the same tumor ( Ciampi & Nikiforov 2007 , Nikiforova & Nikiforov 2008 ). It

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Fei Li Department of Endocrinology Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Middle Road, Shanghai 200072, China

First Clinical Medical College Nanjing Medical University, Nanjing 210029, China

Jiangsu Institute of Nuclear Medicine Wuxi 214063, China

Department of Cardiology Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China

Department of Neurology and Neuroscience Weill Cornell Medical College, New York, New York 10065, USA

Departments of Nuclear Medicine

Ultrasound Medicine Shanghai Tenth People's Hospital, Shanghai 200072, China

Thyroid Institute Tongji University, Shanghai 200072, China

Division of Endocrinology Diabetes and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Department of Endocrinology Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Middle Road, Shanghai 200072, China

First Clinical Medical College Nanjing Medical University, Nanjing 210029, China

Jiangsu Institute of Nuclear Medicine Wuxi 214063, China

Department of Cardiology Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China

Department of Neurology and Neuroscience Weill Cornell Medical College, New York, New York 10065, USA

Departments of Nuclear Medicine

Ultrasound Medicine Shanghai Tenth People's Hospital, Shanghai 200072, China

Thyroid Institute Tongji University, Shanghai 200072, China

Division of Endocrinology Diabetes and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Department of Endocrinology Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Middle Road, Shanghai 200072, China

First Clinical Medical College Nanjing Medical University, Nanjing 210029, China

Jiangsu Institute of Nuclear Medicine Wuxi 214063, China

Department of Cardiology Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China

Department of Neurology and Neuroscience Weill Cornell Medical College, New York, New York 10065, USA

Departments of Nuclear Medicine

Ultrasound Medicine Shanghai Tenth People's Hospital, Shanghai 200072, China

Thyroid Institute Tongji University, Shanghai 200072, China

Division of Endocrinology Diabetes and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA

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Guangqi Chen Department of Endocrinology Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Middle Road, Shanghai 200072, China

First Clinical Medical College Nanjing Medical University, Nanjing 210029, China

Jiangsu Institute of Nuclear Medicine Wuxi 214063, China

Department of Cardiology Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China

Department of Neurology and Neuroscience Weill Cornell Medical College, New York, New York 10065, USA

Departments of Nuclear Medicine

Ultrasound Medicine Shanghai Tenth People's Hospital, Shanghai 200072, China

Thyroid Institute Tongji University, Shanghai 200072, China

Division of Endocrinology Diabetes and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA

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Chunjun Sheng Department of Endocrinology Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Middle Road, Shanghai 200072, China

First Clinical Medical College Nanjing Medical University, Nanjing 210029, China

Jiangsu Institute of Nuclear Medicine Wuxi 214063, China

Department of Cardiology Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China

Department of Neurology and Neuroscience Weill Cornell Medical College, New York, New York 10065, USA

Departments of Nuclear Medicine

Ultrasound Medicine Shanghai Tenth People's Hospital, Shanghai 200072, China

Thyroid Institute Tongji University, Shanghai 200072, China

Division of Endocrinology Diabetes and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA

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Aaron M Gusdon Department of Endocrinology Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Middle Road, Shanghai 200072, China

First Clinical Medical College Nanjing Medical University, Nanjing 210029, China

Jiangsu Institute of Nuclear Medicine Wuxi 214063, China

Department of Cardiology Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China

Department of Neurology and Neuroscience Weill Cornell Medical College, New York, New York 10065, USA

Departments of Nuclear Medicine

Ultrasound Medicine Shanghai Tenth People's Hospital, Shanghai 200072, China

Thyroid Institute Tongji University, Shanghai 200072, China

Division of Endocrinology Diabetes and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA

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Yueye Huang Department of Endocrinology Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Middle Road, Shanghai 200072, China

First Clinical Medical College Nanjing Medical University, Nanjing 210029, China

Jiangsu Institute of Nuclear Medicine Wuxi 214063, China

Department of Cardiology Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China

Department of Neurology and Neuroscience Weill Cornell Medical College, New York, New York 10065, USA

Departments of Nuclear Medicine

Ultrasound Medicine Shanghai Tenth People's Hospital, Shanghai 200072, China

Thyroid Institute Tongji University, Shanghai 200072, China

Division of Endocrinology Diabetes and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA

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Zhongwei Lv Department of Endocrinology Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Middle Road, Shanghai 200072, China

First Clinical Medical College Nanjing Medical University, Nanjing 210029, China

Jiangsu Institute of Nuclear Medicine Wuxi 214063, China

Department of Cardiology Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China

Department of Neurology and Neuroscience Weill Cornell Medical College, New York, New York 10065, USA

Departments of Nuclear Medicine

Ultrasound Medicine Shanghai Tenth People's Hospital, Shanghai 200072, China

Thyroid Institute Tongji University, Shanghai 200072, China

Division of Endocrinology Diabetes and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Department of Endocrinology Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Middle Road, Shanghai 200072, China

First Clinical Medical College Nanjing Medical University, Nanjing 210029, China

Jiangsu Institute of Nuclear Medicine Wuxi 214063, China

Department of Cardiology Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China

Department of Neurology and Neuroscience Weill Cornell Medical College, New York, New York 10065, USA

Departments of Nuclear Medicine

Ultrasound Medicine Shanghai Tenth People's Hospital, Shanghai 200072, China

Thyroid Institute Tongji University, Shanghai 200072, China

Division of Endocrinology Diabetes and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA

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Huixiong Xu Department of Endocrinology Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Middle Road, Shanghai 200072, China

First Clinical Medical College Nanjing Medical University, Nanjing 210029, China

Jiangsu Institute of Nuclear Medicine Wuxi 214063, China

Department of Cardiology Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China

Department of Neurology and Neuroscience Weill Cornell Medical College, New York, New York 10065, USA

Departments of Nuclear Medicine

Ultrasound Medicine Shanghai Tenth People's Hospital, Shanghai 200072, China

Thyroid Institute Tongji University, Shanghai 200072, China

Division of Endocrinology Diabetes and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Department of Endocrinology Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Middle Road, Shanghai 200072, China

First Clinical Medical College Nanjing Medical University, Nanjing 210029, China

Jiangsu Institute of Nuclear Medicine Wuxi 214063, China

Department of Cardiology Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China

Department of Neurology and Neuroscience Weill Cornell Medical College, New York, New York 10065, USA

Departments of Nuclear Medicine

Ultrasound Medicine Shanghai Tenth People's Hospital, Shanghai 200072, China

Thyroid Institute Tongji University, Shanghai 200072, China

Division of Endocrinology Diabetes and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA

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Mingzhao Xing Department of Endocrinology Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Middle Road, Shanghai 200072, China

First Clinical Medical College Nanjing Medical University, Nanjing 210029, China

Jiangsu Institute of Nuclear Medicine Wuxi 214063, China

Department of Cardiology Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China

Department of Neurology and Neuroscience Weill Cornell Medical College, New York, New York 10065, USA

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Thyroid Institute Tongji University, Shanghai 200072, China

Division of Endocrinology Diabetes and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Department of Endocrinology Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Middle Road, Shanghai 200072, China

First Clinical Medical College Nanjing Medical University, Nanjing 210029, China

Jiangsu Institute of Nuclear Medicine Wuxi 214063, China

Department of Cardiology Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China

Department of Neurology and Neuroscience Weill Cornell Medical College, New York, New York 10065, USA

Departments of Nuclear Medicine

Ultrasound Medicine Shanghai Tenth People's Hospital, Shanghai 200072, China

Thyroid Institute Tongji University, Shanghai 200072, China

Division of Endocrinology Diabetes and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA

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Shen Qu Department of Endocrinology Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Middle Road, Shanghai 200072, China

First Clinical Medical College Nanjing Medical University, Nanjing 210029, China

Jiangsu Institute of Nuclear Medicine Wuxi 214063, China

Department of Cardiology Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China

Department of Neurology and Neuroscience Weill Cornell Medical College, New York, New York 10065, USA

Departments of Nuclear Medicine

Ultrasound Medicine Shanghai Tenth People's Hospital, Shanghai 200072, China

Thyroid Institute Tongji University, Shanghai 200072, China

Division of Endocrinology Diabetes and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Department of Endocrinology Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Middle Road, Shanghai 200072, China

First Clinical Medical College Nanjing Medical University, Nanjing 210029, China

Jiangsu Institute of Nuclear Medicine Wuxi 214063, China

Department of Cardiology Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China

Department of Neurology and Neuroscience Weill Cornell Medical College, New York, New York 10065, USA

Departments of Nuclear Medicine

Ultrasound Medicine Shanghai Tenth People's Hospital, Shanghai 200072, China

Thyroid Institute Tongji University, Shanghai 200072, China

Division of Endocrinology Diabetes and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Department of Endocrinology Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Middle Road, Shanghai 200072, China

First Clinical Medical College Nanjing Medical University, Nanjing 210029, China

Jiangsu Institute of Nuclear Medicine Wuxi 214063, China

Department of Cardiology Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China

Department of Neurology and Neuroscience Weill Cornell Medical College, New York, New York 10065, USA

Departments of Nuclear Medicine

Ultrasound Medicine Shanghai Tenth People's Hospital, Shanghai 200072, China

Thyroid Institute Tongji University, Shanghai 200072, China

Division of Endocrinology Diabetes and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA

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, Tufano et al . 2012 ). However, the value of the BRAFV600E mutation as a prognostic marker in PTMC is not entirely clear, although PTMC also belongs to the well-differentiated papillary carcinoma group. Results from some individual studies indicated that

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Dominique D Liddy Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA

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Zhongyue Zhang University of Florida Health Cancer Center, Gainesville, Florida, USA

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Kalyanee Shirlekar University of Florida Health Cancer Center, Gainesville, Florida, USA

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Zhongping He University of Florida Health Cancer Center, Gainesville, Florida, USA
Department of Biostatistics, University of Florida College of Medicine, Gainesville, Florida, USA

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Kelly M Herremans Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA

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Song Han Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA

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Jason O Brant University of Florida Health Cancer Center, Gainesville, Florida, USA
Department of Biostatistics, University of Florida College of Medicine, Gainesville, Florida, USA

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Francis D Moore Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA

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Steven J Hughes Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA

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Aditya S Shirali Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA

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conventional PTC (identified as papillary adenocarcinoma, NOS in TCGA-THCA), follicular-variant PTC (FV-PTC, identified as papillary carcinoma, follicular variant in TCGA-THCA), and tall cell variant PTC (TCV-PTC, identified as papillary carcinoma, columnar

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