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Urbain Weyemi CNRS, University Paris-Sud 11, Institut Gustave Roussy, UBRM, Sanquin Research, FRE2939, Villejuif F-94805, France
CNRS, University Paris-Sud 11, Institut Gustave Roussy, UBRM, Sanquin Research, FRE2939, Villejuif F-94805, France
CNRS, University Paris-Sud 11, Institut Gustave Roussy, UBRM, Sanquin Research, FRE2939, Villejuif F-94805, France

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Bernard Caillou CNRS, University Paris-Sud 11, Institut Gustave Roussy, UBRM, Sanquin Research, FRE2939, Villejuif F-94805, France

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Monique Talbot CNRS, University Paris-Sud 11, Institut Gustave Roussy, UBRM, Sanquin Research, FRE2939, Villejuif F-94805, France
CNRS, University Paris-Sud 11, Institut Gustave Roussy, UBRM, Sanquin Research, FRE2939, Villejuif F-94805, France

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Rabii Ameziane-El-Hassani CNRS, University Paris-Sud 11, Institut Gustave Roussy, UBRM, Sanquin Research, FRE2939, Villejuif F-94805, France
CNRS, University Paris-Sud 11, Institut Gustave Roussy, UBRM, Sanquin Research, FRE2939, Villejuif F-94805, France

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Ludovic Lacroix CNRS, University Paris-Sud 11, Institut Gustave Roussy, UBRM, Sanquin Research, FRE2939, Villejuif F-94805, France

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Odile Lagent-Chevallier CNRS, University Paris-Sud 11, Institut Gustave Roussy, UBRM, Sanquin Research, FRE2939, Villejuif F-94805, France
CNRS, University Paris-Sud 11, Institut Gustave Roussy, UBRM, Sanquin Research, FRE2939, Villejuif F-94805, France
CNRS, University Paris-Sud 11, Institut Gustave Roussy, UBRM, Sanquin Research, FRE2939, Villejuif F-94805, France

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Abir Al Ghuzlan CNRS, University Paris-Sud 11, Institut Gustave Roussy, UBRM, Sanquin Research, FRE2939, Villejuif F-94805, France

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Dirk Roos CNRS, University Paris-Sud 11, Institut Gustave Roussy, UBRM, Sanquin Research, FRE2939, Villejuif F-94805, France

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Jean-Michel Bidart CNRS, University Paris-Sud 11, Institut Gustave Roussy, UBRM, Sanquin Research, FRE2939, Villejuif F-94805, France
CNRS, University Paris-Sud 11, Institut Gustave Roussy, UBRM, Sanquin Research, FRE2939, Villejuif F-94805, France

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Alain Virion CNRS, University Paris-Sud 11, Institut Gustave Roussy, UBRM, Sanquin Research, FRE2939, Villejuif F-94805, France
CNRS, University Paris-Sud 11, Institut Gustave Roussy, UBRM, Sanquin Research, FRE2939, Villejuif F-94805, France
CNRS, University Paris-Sud 11, Institut Gustave Roussy, UBRM, Sanquin Research, FRE2939, Villejuif F-94805, France

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Martin Schlumberger CNRS, University Paris-Sud 11, Institut Gustave Roussy, UBRM, Sanquin Research, FRE2939, Villejuif F-94805, France
CNRS, University Paris-Sud 11, Institut Gustave Roussy, UBRM, Sanquin Research, FRE2939, Villejuif F-94805, France

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Corinne Dupuy CNRS, University Paris-Sud 11, Institut Gustave Roussy, UBRM, Sanquin Research, FRE2939, Villejuif F-94805, France
CNRS, University Paris-Sud 11, Institut Gustave Roussy, UBRM, Sanquin Research, FRE2939, Villejuif F-94805, France
CNRS, University Paris-Sud 11, Institut Gustave Roussy, UBRM, Sanquin Research, FRE2939, Villejuif F-94805, France

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surgery at Institut Gustave Roussy. Informed consent was obtained from all patients. These samples included normal thyroid tissue ( n =8); nodular and/or diffuse hyperplasia ( n =11); follicular adenoma ( n =4); papillary carcinoma ( n =11); follicular

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-09-0175
Volume/Issue:
Volume 17: Issue 1
Free access
A Raitila
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M Georgitsi
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A Karhu
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K Tuppurainen
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M J Mäkinen
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K Birkenkamp-Demtröder
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K Salmenkivi
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T F Ørntoft
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J Arola
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V Launonen
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P Vahteristo
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L A Aaltonen
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and 87 years (mean age 51 years ±15.5). Information on sex was available for 59 cases, of which 37 were females and 22 were males. One male individual had two tumors of the thyroid gland: one follicular adenoma and one papillary carcinoma

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-07-0025
Volume/Issue:
Volume 14: Issue 3
Free access
Sandra Lassalle INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Véronique Hofman INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Marius Ilie INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Christelle Bonnetaud INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Marie-Pierre Puisségur INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Patrick Brest INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Céline Loubatier INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Nicolas Guevara INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Olivier Bordone INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Bruno Cardinaud INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Kévin Lebrigand INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Géraldine Rios INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Joseph Santini INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Brigitte Franc INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Bernard Mari INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Abir Al Ghuzlan INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Philippe Vielh INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Pascal Barbry INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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Paul Hofman INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France
INSERM ERI-21/EA4319, CHU Nice, Human Tissue Biobank Unit, University of Nice Sophia Antipolis, CNRS and University of Nice Sophia Antipolis, Department of Otorhinolaryngology, Department of Pathology, Department of Biopathology, University of Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice, France

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invasive pT1N0M0 Female 28 None FTA, follicular thyroid adenoma; C-PTC, classical papillary thyroid carcinoma; FV-PTC, follicular variant of papillary carcinoma; WDT-UMP, well-differentiated tumor of uncertain malignant potential; FT-UMP, follicular tumor

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-10-0283
Volume/Issue:
Volume 18: Issue 5
Free access
Lucas Leite Cunha Laboratory of Cancer Molecular Genetics, Laboratory of Cell Signaling, Department of Radiology, Adolfo Lutz Institute, Department of Pathology, Laboratory of Investigative and Molecular Pathology (Ciped), Faculty of Medical Sciences, University of Campinas (Unicamp), PO Box 6111, 126 Tessalia Vieira de Camargo Street, Campinas, São Paulo, Brazil

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Elaine Cristina Morari Laboratory of Cancer Molecular Genetics, Laboratory of Cell Signaling, Department of Radiology, Adolfo Lutz Institute, Department of Pathology, Laboratory of Investigative and Molecular Pathology (Ciped), Faculty of Medical Sciences, University of Campinas (Unicamp), PO Box 6111, 126 Tessalia Vieira de Camargo Street, Campinas, São Paulo, Brazil

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Ana Carolina Trindade Guihen Laboratory of Cancer Molecular Genetics, Laboratory of Cell Signaling, Department of Radiology, Adolfo Lutz Institute, Department of Pathology, Laboratory of Investigative and Molecular Pathology (Ciped), Faculty of Medical Sciences, University of Campinas (Unicamp), PO Box 6111, 126 Tessalia Vieira de Camargo Street, Campinas, São Paulo, Brazil

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Daniela Razolli Laboratory of Cancer Molecular Genetics, Laboratory of Cell Signaling, Department of Radiology, Adolfo Lutz Institute, Department of Pathology, Laboratory of Investigative and Molecular Pathology (Ciped), Faculty of Medical Sciences, University of Campinas (Unicamp), PO Box 6111, 126 Tessalia Vieira de Camargo Street, Campinas, São Paulo, Brazil

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Renê Gerhard Laboratory of Cancer Molecular Genetics, Laboratory of Cell Signaling, Department of Radiology, Adolfo Lutz Institute, Department of Pathology, Laboratory of Investigative and Molecular Pathology (Ciped), Faculty of Medical Sciences, University of Campinas (Unicamp), PO Box 6111, 126 Tessalia Vieira de Camargo Street, Campinas, São Paulo, Brazil

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Suely Nonogaki Laboratory of Cancer Molecular Genetics, Laboratory of Cell Signaling, Department of Radiology, Adolfo Lutz Institute, Department of Pathology, Laboratory of Investigative and Molecular Pathology (Ciped), Faculty of Medical Sciences, University of Campinas (Unicamp), PO Box 6111, 126 Tessalia Vieira de Camargo Street, Campinas, São Paulo, Brazil

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Fernando Augusto Soares Laboratory of Cancer Molecular Genetics, Laboratory of Cell Signaling, Department of Radiology, Adolfo Lutz Institute, Department of Pathology, Laboratory of Investigative and Molecular Pathology (Ciped), Faculty of Medical Sciences, University of Campinas (Unicamp), PO Box 6111, 126 Tessalia Vieira de Camargo Street, Campinas, São Paulo, Brazil

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José Vassallo Laboratory of Cancer Molecular Genetics, Laboratory of Cell Signaling, Department of Radiology, Adolfo Lutz Institute, Department of Pathology, Laboratory of Investigative and Molecular Pathology (Ciped), Faculty of Medical Sciences, University of Campinas (Unicamp), PO Box 6111, 126 Tessalia Vieira de Camargo Street, Campinas, São Paulo, Brazil

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Laura Sterian Ward Laboratory of Cancer Molecular Genetics, Laboratory of Cell Signaling, Department of Radiology, Adolfo Lutz Institute, Department of Pathology, Laboratory of Investigative and Molecular Pathology (Ciped), Faculty of Medical Sciences, University of Campinas (Unicamp), PO Box 6111, 126 Tessalia Vieira de Camargo Street, Campinas, São Paulo, Brazil

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. doi:10.1056/NEJM198612253152606 . El Demellawy D Nasr A Alowami S 2008 Application of CD56, P63 and CK19 immunohistochemistry in the diagnosis of papillary carcinoma of the thyroid . Diagnostic Pathology 3 5 doi:10

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-11-0285
Volume/Issue:
Volume 19: Issue 3
Free access
Pierlorenzo Pallante Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Biotecnologie Avanzate-Napoli, Department of Molecular Virology, Facoltà di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli ‘Federico II’, Via Pansini 5, 80131 Napoli, Italy
Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Biotecnologie Avanzate-Napoli, Department of Molecular Virology, Facoltà di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli ‘Federico II’, Via Pansini 5, 80131 Napoli, Italy

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Rosa Visone Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Biotecnologie Avanzate-Napoli, Department of Molecular Virology, Facoltà di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli ‘Federico II’, Via Pansini 5, 80131 Napoli, Italy

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Carlo Maria Croce Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Biotecnologie Avanzate-Napoli, Department of Molecular Virology, Facoltà di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli ‘Federico II’, Via Pansini 5, 80131 Napoli, Italy

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Alfredo Fusco Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Biotecnologie Avanzate-Napoli, Department of Molecular Virology, Facoltà di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli ‘Federico II’, Via Pansini 5, 80131 Napoli, Italy
Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Biotecnologie Avanzate-Napoli, Department of Molecular Virology, Facoltà di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli ‘Federico II’, Via Pansini 5, 80131 Napoli, Italy

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papillary carcinomas . Cell 60 557 – 563 . Griffiths-Jones S Grocock RJ van Dongen S Bateman A Enright AJ 2006 miRBase: microRNA sequences, targets and gene nomenclature . Nucleic Acids Research 34

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-09-0217
Volume/Issue:
Volume 17: Issue 1
Free access
Susan J Hsiao Division of Molecular and Genomic Pathology, Department of Pathology, University of Pittsburgh School of Medicine, 3477 Euler Way, Room 8031, Pittsburgh, Pennsylvania 15213, USA

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Yuri E Nikiforov Division of Molecular and Genomic Pathology, Department of Pathology, University of Pittsburgh School of Medicine, 3477 Euler Way, Room 8031, Pittsburgh, Pennsylvania 15213, USA

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be seen in up to 50% of patients older than 60 years of age ( Mazzaferri 1992 , 1993 , Guth et al . 2009 ). Only 5% of thyroid nodules are malignant ( Brito et al . 2013 ). Most thyroid cancers are well-differentiated papillary carcinomas or

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-14-0166
Volume/Issue:
Volume 21: Issue 5
Free access
Fei Li Department of Endocrinology, First Clinical Medical College, Jiangsu Institute of Nuclear Medicine, Department of Cardiology, Department of Neurology and Neuroscience, Departments of Nuclear Medicine, Ultrasound Medicine, Thyroid Institute, Division of Endocrinology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Middle Road, Shanghai 200072, China
Department of Endocrinology, First Clinical Medical College, Jiangsu Institute of Nuclear Medicine, Department of Cardiology, Department of Neurology and Neuroscience, Departments of Nuclear Medicine, Ultrasound Medicine, Thyroid Institute, Division of Endocrinology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Middle Road, Shanghai 200072, China
Department of Endocrinology, First Clinical Medical College, Jiangsu Institute of Nuclear Medicine, Department of Cardiology, Department of Neurology and Neuroscience, Departments of Nuclear Medicine, Ultrasound Medicine, Thyroid Institute, Division of Endocrinology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Middle Road, Shanghai 200072, China

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Guangqi Chen Department of Endocrinology, First Clinical Medical College, Jiangsu Institute of Nuclear Medicine, Department of Cardiology, Department of Neurology and Neuroscience, Departments of Nuclear Medicine, Ultrasound Medicine, Thyroid Institute, Division of Endocrinology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Middle Road, Shanghai 200072, China

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Chunjun Sheng Department of Endocrinology, First Clinical Medical College, Jiangsu Institute of Nuclear Medicine, Department of Cardiology, Department of Neurology and Neuroscience, Departments of Nuclear Medicine, Ultrasound Medicine, Thyroid Institute, Division of Endocrinology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Middle Road, Shanghai 200072, China

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Aaron M Gusdon Department of Endocrinology, First Clinical Medical College, Jiangsu Institute of Nuclear Medicine, Department of Cardiology, Department of Neurology and Neuroscience, Departments of Nuclear Medicine, Ultrasound Medicine, Thyroid Institute, Division of Endocrinology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Middle Road, Shanghai 200072, China

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Yueye Huang Department of Endocrinology, First Clinical Medical College, Jiangsu Institute of Nuclear Medicine, Department of Cardiology, Department of Neurology and Neuroscience, Departments of Nuclear Medicine, Ultrasound Medicine, Thyroid Institute, Division of Endocrinology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Middle Road, Shanghai 200072, China

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Zhongwei Lv Department of Endocrinology, First Clinical Medical College, Jiangsu Institute of Nuclear Medicine, Department of Cardiology, Department of Neurology and Neuroscience, Departments of Nuclear Medicine, Ultrasound Medicine, Thyroid Institute, Division of Endocrinology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Middle Road, Shanghai 200072, China
Department of Endocrinology, First Clinical Medical College, Jiangsu Institute of Nuclear Medicine, Department of Cardiology, Department of Neurology and Neuroscience, Departments of Nuclear Medicine, Ultrasound Medicine, Thyroid Institute, Division of Endocrinology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Middle Road, Shanghai 200072, China

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Huixiong Xu Department of Endocrinology, First Clinical Medical College, Jiangsu Institute of Nuclear Medicine, Department of Cardiology, Department of Neurology and Neuroscience, Departments of Nuclear Medicine, Ultrasound Medicine, Thyroid Institute, Division of Endocrinology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Middle Road, Shanghai 200072, China
Department of Endocrinology, First Clinical Medical College, Jiangsu Institute of Nuclear Medicine, Department of Cardiology, Department of Neurology and Neuroscience, Departments of Nuclear Medicine, Ultrasound Medicine, Thyroid Institute, Division of Endocrinology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Middle Road, Shanghai 200072, China

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Mingzhao Xing Department of Endocrinology, First Clinical Medical College, Jiangsu Institute of Nuclear Medicine, Department of Cardiology, Department of Neurology and Neuroscience, Departments of Nuclear Medicine, Ultrasound Medicine, Thyroid Institute, Division of Endocrinology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Middle Road, Shanghai 200072, China
Department of Endocrinology, First Clinical Medical College, Jiangsu Institute of Nuclear Medicine, Department of Cardiology, Department of Neurology and Neuroscience, Departments of Nuclear Medicine, Ultrasound Medicine, Thyroid Institute, Division of Endocrinology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Middle Road, Shanghai 200072, China

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Shen Qu Department of Endocrinology, First Clinical Medical College, Jiangsu Institute of Nuclear Medicine, Department of Cardiology, Department of Neurology and Neuroscience, Departments of Nuclear Medicine, Ultrasound Medicine, Thyroid Institute, Division of Endocrinology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Middle Road, Shanghai 200072, China
Department of Endocrinology, First Clinical Medical College, Jiangsu Institute of Nuclear Medicine, Department of Cardiology, Department of Neurology and Neuroscience, Departments of Nuclear Medicine, Ultrasound Medicine, Thyroid Institute, Division of Endocrinology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Middle Road, Shanghai 200072, China
Department of Endocrinology, First Clinical Medical College, Jiangsu Institute of Nuclear Medicine, Department of Cardiology, Department of Neurology and Neuroscience, Departments of Nuclear Medicine, Ultrasound Medicine, Thyroid Institute, Division of Endocrinology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Middle Road, Shanghai 200072, China

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, Tufano et al . 2012 ). However, the value of the BRAFV600E mutation as a prognostic marker in PTMC is not entirely clear, although PTMC also belongs to the well-differentiated papillary carcinoma group. Results from some individual studies indicated that

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DOI:
https://doi.org/10.1530/ERC-14-0531
Volume/Issue:
Volume 22: Issue 2
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E Fiore
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T Rago
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M A Provenzale
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M Scutari
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C Ugolini Department of Endocrinology, Section of Pathology, Department of Surgery, Section of Cytopathology

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F Basolo Department of Endocrinology, Section of Pathology, Department of Surgery, Section of Cytopathology

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G Di Coscio Department of Endocrinology, Section of Pathology, Department of Surgery, Section of Cytopathology

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P Berti Department of Endocrinology, Section of Pathology, Department of Surgery, Section of Cytopathology

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carcinomas are point mutations of the BRAF gene and RET/PTC rearrangement. These genetic alterations are found in more than 70% of papillary carcinomas and they rarely overlap in the same tumor ( Ciampi & Nikiforov 2007 , Nikiforova & Nikiforov 2008 ). It

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https://doi.org/10.1677/ERC-09-0036
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Volume 16: Issue 4
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Greta Gandolfi
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Dario de Biase Laboratory of Translational Research, Arcispedale S. Maria Nuova – IRCCS, Department of Pharmacology and Biotechnology (FaBiT), University of Bologna, 40139, Pathology Unit, Department of Oncology, Arcispedale S. Maria Nuova – IRCCS, Department of Medicine (DIMES) – Anatomic Pathology Unit, Bellaria Hospital, University of Bologna, Viale Risorgimento 80, Reggio Emilia, 42123, Italy
Laboratory of Translational Research, Arcispedale S. Maria Nuova – IRCCS, Department of Pharmacology and Biotechnology (FaBiT), University of Bologna, 40139, Pathology Unit, Department of Oncology, Arcispedale S. Maria Nuova – IRCCS, Department of Medicine (DIMES) – Anatomic Pathology Unit, Bellaria Hospital, University of Bologna, Viale Risorgimento 80, Reggio Emilia, 42123, Italy

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Valentina Sancisi
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Moira Ragazzi Laboratory of Translational Research, Arcispedale S. Maria Nuova – IRCCS, Department of Pharmacology and Biotechnology (FaBiT), University of Bologna, 40139, Pathology Unit, Department of Oncology, Arcispedale S. Maria Nuova – IRCCS, Department of Medicine (DIMES) – Anatomic Pathology Unit, Bellaria Hospital, University of Bologna, Viale Risorgimento 80, Reggio Emilia, 42123, Italy

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Giorgia Acquaviva Laboratory of Translational Research, Arcispedale S. Maria Nuova – IRCCS, Department of Pharmacology and Biotechnology (FaBiT), University of Bologna, 40139, Pathology Unit, Department of Oncology, Arcispedale S. Maria Nuova – IRCCS, Department of Medicine (DIMES) – Anatomic Pathology Unit, Bellaria Hospital, University of Bologna, Viale Risorgimento 80, Reggio Emilia, 42123, Italy

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Annalisa Pession Laboratory of Translational Research, Arcispedale S. Maria Nuova – IRCCS, Department of Pharmacology and Biotechnology (FaBiT), University of Bologna, 40139, Pathology Unit, Department of Oncology, Arcispedale S. Maria Nuova – IRCCS, Department of Medicine (DIMES) – Anatomic Pathology Unit, Bellaria Hospital, University of Bologna, Viale Risorgimento 80, Reggio Emilia, 42123, Italy

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Simonetta Piana Laboratory of Translational Research, Arcispedale S. Maria Nuova – IRCCS, Department of Pharmacology and Biotechnology (FaBiT), University of Bologna, 40139, Pathology Unit, Department of Oncology, Arcispedale S. Maria Nuova – IRCCS, Department of Medicine (DIMES) – Anatomic Pathology Unit, Bellaria Hospital, University of Bologna, Viale Risorgimento 80, Reggio Emilia, 42123, Italy

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Giovanni Tallini Laboratory of Translational Research, Arcispedale S. Maria Nuova – IRCCS, Department of Pharmacology and Biotechnology (FaBiT), University of Bologna, 40139, Pathology Unit, Department of Oncology, Arcispedale S. Maria Nuova – IRCCS, Department of Medicine (DIMES) – Anatomic Pathology Unit, Bellaria Hospital, University of Bologna, Viale Risorgimento 80, Reggio Emilia, 42123, Italy

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Alessia Ciarrocchi
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.1155/2013/965212 ). Sancisi V Nicoli D Ragazzi M Piana S Ciarrocchi A 2012 BRAFV600E mutation does not mean distant metastasis in thyroid papillary carcinomas . Journal of Clinical Endocrinology and Metabolism 97 E1745 – E1749 . ( doi:10.1210/jc.2012

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https://doi.org/10.1530/ERC-14-0361
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Volume 21: Issue 5
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Michael Derwahl Department of Medicine, St Hedwig Hospital and Charite, University Medicine Berlin, Grosse Hamburger Straße 5‐11, 10115 Berlin, Germany

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Diana Nicula Department of Medicine, St Hedwig Hospital and Charite, University Medicine Berlin, Grosse Hamburger Straße 5‐11, 10115 Berlin, Germany

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, Tavangar et al . 2007 ), no ER immunoreactivity was observed in other studies ( Jaklic et al . 1995 , Arain et al . 2003 ). These widely varying results were described for both papillary carcinoma and follicular thyroid carcinoma (FTC) samples. The

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DOI:
https://doi.org/10.1530/ERC-14-0053
Volume/Issue:
Volume 21: Issue 5
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