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Pierotti MA Della Porta G Fusco A Vecchio G 1990 PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas . Cell 60 557 – 563 . doi:10
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surgery at Institut Gustave Roussy. Informed consent was obtained from all patients. These samples included normal thyroid tissue ( n =8); nodular and/or diffuse hyperplasia ( n =11); follicular adenoma ( n =4); papillary carcinoma ( n =11); follicular
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and 87 years (mean age 51 years ±15.5). Information on sex was available for 59 cases, of which 37 were females and 22 were males. One male individual had two tumors of the thyroid gland: one follicular adenoma and one papillary carcinoma
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invasive pT1N0M0 Female 28 None FTA, follicular thyroid adenoma; C-PTC, classical papillary thyroid carcinoma; FV-PTC, follicular variant of papillary carcinoma; WDT-UMP, well-differentiated tumor of uncertain malignant potential; FT-UMP, follicular tumor
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. doi:10.1056/NEJM198612253152606 . El Demellawy D Nasr A Alowami S 2008 Application of CD56, P63 and CK19 immunohistochemistry in the diagnosis of papillary carcinoma of the thyroid . Diagnostic Pathology 3 5 doi:10
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papillary carcinomas . Cell 60 557 – 563 . Griffiths-Jones S Grocock RJ van Dongen S Bateman A Enright AJ 2006 miRBase: microRNA sequences, targets and gene nomenclature . Nucleic Acids Research 34
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be seen in up to 50% of patients older than 60 years of age ( Mazzaferri 1992 , 1993 , Guth et al . 2009 ). Only 5% of thyroid nodules are malignant ( Brito et al . 2013 ). Most thyroid cancers are well-differentiated papillary carcinomas or
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carcinomas are point mutations of the BRAF gene and RET/PTC rearrangement. These genetic alterations are found in more than 70% of papillary carcinomas and they rarely overlap in the same tumor ( Ciampi & Nikiforov 2007 , Nikiforova & Nikiforov 2008 ). It
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, Tufano et al . 2012 ). However, the value of the BRAFV600E mutation as a prognostic marker in PTMC is not entirely clear, although PTMC also belongs to the well-differentiated papillary carcinoma group. Results from some individual studies indicated that
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conventional PTC (identified as papillary adenocarcinoma, NOS in TCGA-THCA), follicular-variant PTC (FV-PTC, identified as papillary carcinoma, follicular variant in TCGA-THCA), and tall cell variant PTC (TCV-PTC, identified as papillary carcinoma, columnar