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Nidal Muhanna Guided Therapeutic (GTx) Program, TECHNA Institute, Princess Margaret Cancer Center and University Health Network, Toronto, Ontario, Canada
Department of Otolaryngology-Head and Neck Surgery-Surgical Oncology, Princess Margaret Cancer Centre/University Health Network, University of Toronto, Toronto, Ontario, Canada
Department of Otolaryngology-Head and Neck Surgery, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel

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Harley H L Chan Guided Therapeutic (GTx) Program, TECHNA Institute, Princess Margaret Cancer Center and University Health Network, Toronto, Ontario, Canada
Department of Otolaryngology-Head and Neck Surgery-Surgical Oncology, Princess Margaret Cancer Centre/University Health Network, University of Toronto, Toronto, Ontario, Canada

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Jason L Townson Guided Therapeutic (GTx) Program, TECHNA Institute, Princess Margaret Cancer Center and University Health Network, Toronto, Ontario, Canada
Department of Otolaryngology-Head and Neck Surgery-Surgical Oncology, Princess Margaret Cancer Centre/University Health Network, University of Toronto, Toronto, Ontario, Canada

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Cheng S Jin Guided Therapeutic (GTx) Program, TECHNA Institute, Princess Margaret Cancer Center and University Health Network, Toronto, Ontario, Canada
Department of Otolaryngology-Head and Neck Surgery-Surgical Oncology, Princess Margaret Cancer Centre/University Health Network, University of Toronto, Toronto, Ontario, Canada

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Lili Ding Guided Therapeutic (GTx) Program, TECHNA Institute, Princess Margaret Cancer Center and University Health Network, Toronto, Ontario, Canada

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Michael S Valic Guided Therapeutic (GTx) Program, TECHNA Institute, Princess Margaret Cancer Center and University Health Network, Toronto, Ontario, Canada

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Catriona M Douglas Guided Therapeutic (GTx) Program, TECHNA Institute, Princess Margaret Cancer Center and University Health Network, Toronto, Ontario, Canada
Department of Otolaryngology-Head and Neck Surgery-Surgical Oncology, Princess Margaret Cancer Centre/University Health Network, University of Toronto, Toronto, Ontario, Canada

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Christina M MacLaughlin Guided Therapeutic (GTx) Program, TECHNA Institute, Princess Margaret Cancer Center and University Health Network, Toronto, Ontario, Canada

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Juan Chen Guided Therapeutic (GTx) Program, TECHNA Institute, Princess Margaret Cancer Center and University Health Network, Toronto, Ontario, Canada

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Gang Zheng Guided Therapeutic (GTx) Program, TECHNA Institute, Princess Margaret Cancer Center and University Health Network, Toronto, Ontario, Canada
Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada

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Jonathan C Irish Guided Therapeutic (GTx) Program, TECHNA Institute, Princess Margaret Cancer Center and University Health Network, Toronto, Ontario, Canada
Department of Otolaryngology-Head and Neck Surgery-Surgical Oncology, Princess Margaret Cancer Centre/University Health Network, University of Toronto, Toronto, Ontario, Canada

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to the minimal amount of tumor cell damage that was observed in the laser control group by both H&E staining and TUNEL assay (8.23% positive, n  = 3) ( Fig. 5Ci and Di ), PLP-PDT caused significant tumor tissue damage and apoptosis (TUNEL 66.39 ± 0

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Lauren N Pontius Duke University Medical Center, Durham, North Carolina, USA

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Linda M Youngwirth Duke University Medical Center, Durham, North Carolina, USA

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Samantha M Thomas Duke University Medical Center, Durham, North Carolina, USA

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Randall P Scheri Duke University Medical Center, Durham, North Carolina, USA

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Sanziana A Roman Duke University Medical Center, Durham, North Carolina, USA

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Julie A Sosa Duke University Medical Center, Durham, North Carolina, USA

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. 2013 ). One single institution study by Kim et al ., including 662 PTC patients, of whom 33 (5%) had LVI, found that there was a significant association between LVI and both lateral cervical lymph node metastases and an increased risk of disease

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Dheeraj Karamchandani Department of Endocrine Surgery, Biostatistics Unit, Department of Endocrinology, King's College Hospital NHS Foundation Trust, King's College London, Denmark Hill, London SE5 9RS, UK

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Ramiro Arias-Amaya Department of Endocrine Surgery, Biostatistics Unit, Department of Endocrinology, King's College Hospital NHS Foundation Trust, King's College London, Denmark Hill, London SE5 9RS, UK

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Nora Donaldson Department of Endocrine Surgery, Biostatistics Unit, Department of Endocrinology, King's College Hospital NHS Foundation Trust, King's College London, Denmark Hill, London SE5 9RS, UK

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Jackie Gilbert Department of Endocrine Surgery, Biostatistics Unit, Department of Endocrinology, King's College Hospital NHS Foundation Trust, King's College London, Denmark Hill, London SE5 9RS, UK

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Klaus-Martin Schulte Department of Endocrine Surgery, Biostatistics Unit, Department of Endocrinology, King's College Hospital NHS Foundation Trust, King's College London, Denmark Hill, London SE5 9RS, UK
Department of Endocrine Surgery, Biostatistics Unit, Department of Endocrinology, King's College Hospital NHS Foundation Trust, King's College London, Denmark Hill, London SE5 9RS, UK

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Villeneuve et al . 2007 11 391 0 0 0 0 0 11 391 Total ( n ) 50 861 394 236 117 26 154 51 788 Percentage of total 98.2 0.8 0.5 0.2 0.1 0.3 100.1 The number of renal transplants indicates the number of

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Maria Denaro Department of Surgical Pathology Medical, Molecular and Critical Area, University of Pisa, Pisa, Italy

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Clara Ugolini Department of Laboratory Medicine Section of Pathology Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy

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Anello Marcello Poma Department of Surgical Pathology Medical, Molecular and Critical Area, University of Pisa, Pisa, Italy

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Nicla Borrelli Department of Surgical Pathology Medical, Molecular and Critical Area, University of Pisa, Pisa, Italy

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Gabriele Materazzi Department of Surgical Pathology Medical, Molecular and Critical Area, University of Pisa, Pisa, Italy

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Paolo Piaggi National Institute of Diabetes and Digestive and Kidney Diseases Phoenix, Arizona, USA

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Massimo Chiarugi Department of Surgical Pathology Medical, Molecular and Critical Area, University of Pisa, Pisa, Italy

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Paolo Miccoli Department of Surgical Pathology Medical, Molecular and Critical Area, University of Pisa, Pisa, Italy

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Paolo Vitti Department of Clinical and Experimental Medicine University of Pisa, Pisa, Italy

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Fulvio Basolo Department of Surgical Pathology Medical, Molecular and Critical Area, University of Pisa, Pisa, Italy

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2014 Blocks to thyroid cancer cell apoptosis can be overcome by inhibition of the MAPK and PI3K/AKT pathways . Cell Death and Disease 5 e1104 . ( doi:10.1038/cddis.2014.78 ) He H Jazdzewski K Li W Liyanarachchi S Nagy R

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Samuel M O’Toole Department of Endocrinology, St Bartholomew’s Hospital, London, UK

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Anju Sahdev Department of Radiology, St Bartholomew’s Hospital, London, UK

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Satya Bhattacharya Department of Surgery, The Royal London Hospital, London, UK

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Roger Feakins Department of Histopathology, The Royal London Hospital, London, UK

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Evelien F Gevers Department of Paediatric Endocrinology, The Royal London Hospital, London, UK

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William M Drake Department of Endocrinology, St Bartholomew’s Hospital, London, UK

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excised 22 mm grade 2 pNET with evidence of vascular and perineural invasion. The Ki67 index was 5%. Post-operatively, he required pancreatic enzyme supplementation for exocrine pancreatic insufficiency. Follow-up 12 months post-operatively demonstrated

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Feng Wu Department of Endocrinology, The Third Xiang-Ya Hospital, Central South University, Changsha, Hunan, People’s Republic of China
Department of Pathology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People’s Republic of China

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Fuxingzi Li Department of Endocrinology and Metabolism, National Clinical Research Center for Metabolic Diseases, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People’s Republic of China

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Xiao Lin Department of Endocrinology and Metabolism, National Clinical Research Center for Metabolic Diseases, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People’s Republic of China
Department of Geriatrics, Institute of Aging and Geriatrics, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People’s Republic of China

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Feng Xu Department of Endocrinology and Metabolism, National Clinical Research Center for Metabolic Diseases, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People’s Republic of China

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Rong-Rong Cui Department of Endocrinology and Metabolism, National Clinical Research Center for Metabolic Diseases, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People’s Republic of China

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Jia-Yu Zhong Department of Endocrinology and Metabolism, National Clinical Research Center for Metabolic Diseases, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People’s Republic of China
Department of Geriatrics, Institute of Aging and Geriatrics, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People’s Republic of China

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Ting Zhu Department of Endocrinology and Metabolism, National Clinical Research Center for Metabolic Diseases, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People’s Republic of China

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Su-Kang Shan Department of Endocrinology and Metabolism, National Clinical Research Center for Metabolic Diseases, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People’s Republic of China

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Xiao-Bo Liao Department of Cardiovascular Surgery, the Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People’s Republic of China

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Ling-Qing Yuan Department of Endocrinology and Metabolism, National Clinical Research Center for Metabolic Diseases, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People’s Republic of China

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Zhao-Hui Mo Department of Endocrinology, The Third Xiang-Ya Hospital, Central South University, Changsha, Hunan, People’s Republic of China

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. 2014 ). miR-21-5p is one of the most well-studied miRNAs and is implicated in promoting cancer growth and development that is often overexpressed in a wide variety of solid tumour tissues ( Yao et al. 2009 , Au Yeung et al. 2016 ). miR-21’s pro

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Federica Panebianco Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

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Alyaksandr V Nikitski Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

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Marina N Nikiforova Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

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Cihan Kaya Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

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Linwah Yip Division of Endocrine Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

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Vincenzo Condello Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

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Abigail I Wald Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

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Yuri E Nikiforov Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

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Simion I Chiosea Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

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well circumscribed and lobulated. The center of the mass showed complex fibrous septae, perhaps outlining the initial primary capsule of the smaller nodule. H&E, 40×. (B) About 5% of the mass showed branching papillae covered by follicular cells with

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Yu Wang Genomic Medicine Institute

Department of Anatomic Pathology Cleveland Clinic, Cleveland, Ohio 44195, USA

Department of Urology Stanford University School of Medicine, Stanford, California 94305, USA

Taussig Cancer Institute

Stanley Shalom Zielony Institute for Nursing Excellence Cleveland Clinic, Cleveland, Ohio 44195, USA

Department of Genetics and Genome Sciences

CASE Comprehensive Cancer Center Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA

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Andres Roma Genomic Medicine Institute

Department of Anatomic Pathology Cleveland Clinic, Cleveland, Ohio 44195, USA

Department of Urology Stanford University School of Medicine, Stanford, California 94305, USA

Taussig Cancer Institute

Stanley Shalom Zielony Institute for Nursing Excellence Cleveland Clinic, Cleveland, Ohio 44195, USA

Department of Genetics and Genome Sciences

CASE Comprehensive Cancer Center Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA

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Rosalie Nolley Genomic Medicine Institute

Department of Anatomic Pathology Cleveland Clinic, Cleveland, Ohio 44195, USA

Department of Urology Stanford University School of Medicine, Stanford, California 94305, USA

Taussig Cancer Institute

Stanley Shalom Zielony Institute for Nursing Excellence Cleveland Clinic, Cleveland, Ohio 44195, USA

Department of Genetics and Genome Sciences

CASE Comprehensive Cancer Center Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA

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Fadi Abdul-Karim Genomic Medicine Institute

Department of Anatomic Pathology Cleveland Clinic, Cleveland, Ohio 44195, USA

Department of Urology Stanford University School of Medicine, Stanford, California 94305, USA

Taussig Cancer Institute

Stanley Shalom Zielony Institute for Nursing Excellence Cleveland Clinic, Cleveland, Ohio 44195, USA

Department of Genetics and Genome Sciences

CASE Comprehensive Cancer Center Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA

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Donna M Peehl Genomic Medicine Institute

Department of Anatomic Pathology Cleveland Clinic, Cleveland, Ohio 44195, USA

Department of Urology Stanford University School of Medicine, Stanford, California 94305, USA

Taussig Cancer Institute

Stanley Shalom Zielony Institute for Nursing Excellence Cleveland Clinic, Cleveland, Ohio 44195, USA

Department of Genetics and Genome Sciences

CASE Comprehensive Cancer Center Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA

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Charis Eng Genomic Medicine Institute

Department of Anatomic Pathology Cleveland Clinic, Cleveland, Ohio 44195, USA

Department of Urology Stanford University School of Medicine, Stanford, California 94305, USA

Taussig Cancer Institute

Stanley Shalom Zielony Institute for Nursing Excellence Cleveland Clinic, Cleveland, Ohio 44195, USA

Department of Genetics and Genome Sciences

CASE Comprehensive Cancer Center Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
Genomic Medicine Institute

Department of Anatomic Pathology Cleveland Clinic, Cleveland, Ohio 44195, USA

Department of Urology Stanford University School of Medicine, Stanford, California 94305, USA

Taussig Cancer Institute

Stanley Shalom Zielony Institute for Nursing Excellence Cleveland Clinic, Cleveland, Ohio 44195, USA

Department of Genetics and Genome Sciences

CASE Comprehensive Cancer Center Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
Genomic Medicine Institute

Department of Anatomic Pathology Cleveland Clinic, Cleveland, Ohio 44195, USA

Department of Urology Stanford University School of Medicine, Stanford, California 94305, USA

Taussig Cancer Institute

Stanley Shalom Zielony Institute for Nursing Excellence Cleveland Clinic, Cleveland, Ohio 44195, USA

Department of Genetics and Genome Sciences

CASE Comprehensive Cancer Center Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
Genomic Medicine Institute

Department of Anatomic Pathology Cleveland Clinic, Cleveland, Ohio 44195, USA

Department of Urology Stanford University School of Medicine, Stanford, California 94305, USA

Taussig Cancer Institute

Stanley Shalom Zielony Institute for Nursing Excellence Cleveland Clinic, Cleveland, Ohio 44195, USA

Department of Genetics and Genome Sciences

CASE Comprehensive Cancer Center Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
Genomic Medicine Institute

Department of Anatomic Pathology Cleveland Clinic, Cleveland, Ohio 44195, USA

Department of Urology Stanford University School of Medicine, Stanford, California 94305, USA

Taussig Cancer Institute

Stanley Shalom Zielony Institute for Nursing Excellence Cleveland Clinic, Cleveland, Ohio 44195, USA

Department of Genetics and Genome Sciences

CASE Comprehensive Cancer Center Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA

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stage T2b–T2c tumors, PSA between 10 and 20 ng/ml, or Gleason score 7 ( D'Amico et al . 1998 b ). After radical prostatectomy (RP), 65–80% of patients with IRPC had 5-year relapse-free survival (RFS) ( D'Amico et al . 1998 b , c , d , Meng et al

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Yael Laitman The Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, Tel-Hashomer, Israel

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Anat Jaffe Endocrinology and Diabetes Unit, Hillel Yaffe Medical Center, Hadera, Israel

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Hagit Schayek The Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, Tel-Hashomer, Israel

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Eitan Friedman The Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, Tel-Hashomer, Israel
The Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel

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with mild autistic disorder at age 5 years and is treated since with Clotiapine 2.5 mg/day. At age 24, he was diagnosed with pituitary micro-adenoma based on elevated prolactin (PRL) levels (2200 IU/L (45–375)), and MRI showing 7 mm pituitary micro

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P Pallante
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R Visone
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M Ferracin
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A Ferraro
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M T Berlingieri
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G Troncone
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G Chiappetta
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C G Liu
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M Santoro
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M Negrini
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C M Croce
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A Fusco
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degradation ( Rhoades et al. 2002 , Tang et al. 2003 , Ambros 2004 , Bartel 2004 ). They are also functional when positioned in a coding region or even in 5′-UTR ( Pillai 2005 ). The miRNA expression pattern is regulated during development and is

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