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Claudia Lanari
Claudia Lanari
Instituto de Biología y Medicina Experimental (IBYME‐CONICET), Oral and Pharyngeal Cancer Branch, Buenos Aires, Argentina
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Victoria Wargon
Victoria Wargon
Instituto de Biología y Medicina Experimental (IBYME‐CONICET), Oral and Pharyngeal Cancer Branch, Buenos Aires, Argentina
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Paola Rojas
Paola Rojas
Instituto de Biología y Medicina Experimental (IBYME‐CONICET), Oral and Pharyngeal Cancer Branch, Buenos Aires, Argentina
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Alfredo A Molinolo
Alfredo A Molinolo
Instituto de Biología y Medicina Experimental (IBYME‐CONICET), Oral and Pharyngeal Cancer Branch, Buenos Aires, Argentina
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Introduction Breast cancer is the most frequently diagnosed malignant neoplasia and is a leading cause of cancer death in females worldwide. Breast cancer ranks second overall in cancer mortality (10.9%) and accounts for 23% (1.38 million) of new
Takashi Suzuki
Takashi Suzuki
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Yasuhiro Miki
Yasuhiro Miki
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Yasuhiro Nakamura
Yasuhiro Nakamura
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Takuya Moriya
Takuya Moriya
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Kiyoshi Ito
Kiyoshi Ito
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Noriaki Ohuchi
Noriaki Ohuchi
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Hironobu Sasano
Hironobu Sasano
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tissues including reproductive organs. A majority of breast carcinoma tissues express estrogen (ER) and androgen (AR) receptors, and estrogens greatly contribute to the growth of breast cancers. Breast carcinoma tissues have been demonstrated to process
Xuan Chen
Xuan Chen
Department of Breast Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Sixuan Liu
Sixuan Liu
Department of Breast Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Xue Peng
Xue Peng
Department of Breast Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Xiangyun Zong
Xiangyun Zong
Department of Breast Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
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only functions in the ovary. In addition, studies found that anti-Müllerian hormone receptor II (AMHRII) is expressed in the breast during the occurrence of breast cancer, which is a hormone-dependent tumor. This implies that AMH may be closely
Daniel Medina
Daniel Medina
Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
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Introduction Breast cancer is a major cancer of women in the United States and Western Europe with approximately 211 000 new cases predicted in the United States in 2005 ( American Cancer Society 2005 ). Breast cancer accounted for
Jianguang Ji
Jianguang Ji
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Asta Fôrsti
Asta Fôrsti
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Jan Sundquist
Jan Sundquist
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Kari Hemminki
Kari Hemminki
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-binding globulin after twin pregnancy ( Thomas et al. 1998 , Hall 2003 ). These changes may influence the occurrence of hormone responsive cancers, such as breast, endometrial, and ovarian cancers ( Neale et al. 2004 , 2005 a , Neale et al. b ). A slightly
Patsy S H Soon
Patsy S H Soon
Hormones and Cancer Group, Northern Clinical School, South Western Sydney Clinical School, Department of Surgery, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales, Australia
Hormones and Cancer Group, Northern Clinical School, South Western Sydney Clinical School, Department of Surgery, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales, Australia
Hormones and Cancer Group, Northern Clinical School, South Western Sydney Clinical School, Department of Surgery, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales, Australia
Hormones and Cancer Group, Northern Clinical School, South Western Sydney Clinical School, Department of Surgery, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales, Australia
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Hormones and Cancer Group, Northern Clinical School, South Western Sydney Clinical School, Department of Surgery, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales, Australia
Hormones and Cancer Group, Northern Clinical School, South Western Sydney Clinical School, Department of Surgery, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales, Australia
Hormones and Cancer Group, Northern Clinical School, South Western Sydney Clinical School, Department of Surgery, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales, Australia
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Edward Kim
Edward Kim
Hormones and Cancer Group, Northern Clinical School, South Western Sydney Clinical School, Department of Surgery, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales, Australia
Hormones and Cancer Group, Northern Clinical School, South Western Sydney Clinical School, Department of Surgery, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales, Australia
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Hormones and Cancer Group, Northern Clinical School, South Western Sydney Clinical School, Department of Surgery, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales, Australia
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Cindy K Pon
Cindy K Pon
Hormones and Cancer Group, Northern Clinical School, South Western Sydney Clinical School, Department of Surgery, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales, Australia
Hormones and Cancer Group, Northern Clinical School, South Western Sydney Clinical School, Department of Surgery, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales, Australia
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Hormones and Cancer Group, Northern Clinical School, South Western Sydney Clinical School, Department of Surgery, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales, Australia
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Anthony J Gill
Anthony J Gill
Hormones and Cancer Group, Northern Clinical School, South Western Sydney Clinical School, Department of Surgery, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales, Australia
Hormones and Cancer Group, Northern Clinical School, South Western Sydney Clinical School, Department of Surgery, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales, Australia
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Hormones and Cancer Group, Northern Clinical School, South Western Sydney Clinical School, Department of Surgery, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales, Australia
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Katrina Moore
Katrina Moore
Hormones and Cancer Group, Northern Clinical School, South Western Sydney Clinical School, Department of Surgery, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales, Australia
Hormones and Cancer Group, Northern Clinical School, South Western Sydney Clinical School, Department of Surgery, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales, Australia
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Hormones and Cancer Group, Northern Clinical School, South Western Sydney Clinical School, Department of Surgery, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales, Australia
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Andrew J Spillane
Andrew J Spillane
Hormones and Cancer Group, Northern Clinical School, South Western Sydney Clinical School, Department of Surgery, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales, Australia
Hormones and Cancer Group, Northern Clinical School, South Western Sydney Clinical School, Department of Surgery, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales, Australia
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Hormones and Cancer Group, Northern Clinical School, South Western Sydney Clinical School, Department of Surgery, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales, Australia
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Diana E Benn
Diana E Benn
Hormones and Cancer Group, Northern Clinical School, South Western Sydney Clinical School, Department of Surgery, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales, Australia
Hormones and Cancer Group, Northern Clinical School, South Western Sydney Clinical School, Department of Surgery, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales, Australia
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Hormones and Cancer Group, Northern Clinical School, South Western Sydney Clinical School, Department of Surgery, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales, Australia
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Robert C Baxter
Robert C Baxter
Hormones and Cancer Group, Northern Clinical School, South Western Sydney Clinical School, Department of Surgery, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales, Australia
Hormones and Cancer Group, Northern Clinical School, South Western Sydney Clinical School, Department of Surgery, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales, Australia
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Hormones and Cancer Group, Northern Clinical School, South Western Sydney Clinical School, Department of Surgery, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales, Australia
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signature to accurately predict disease outcome in breast cancer ( Wald et al . 2011 ). In patients with breast cancer, as in patients with other solid tumours, metastatic disease rather than the primary tumour is the main cause of death ( Sporn 1996 ). EMT
Kevin C Knower
Kevin C Knower
Cancer Drug Discovery, Department of Molecular Biology and Biochemistry, Department of Environmental Health, MIMR-PHI Institute of Medical Research, PO BOX 5152, Clayton, Victoria 3168, Australia
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Sarah Q To
Sarah Q To
Cancer Drug Discovery, Department of Molecular Biology and Biochemistry, Department of Environmental Health, MIMR-PHI Institute of Medical Research, PO BOX 5152, Clayton, Victoria 3168, Australia
Cancer Drug Discovery, Department of Molecular Biology and Biochemistry, Department of Environmental Health, MIMR-PHI Institute of Medical Research, PO BOX 5152, Clayton, Victoria 3168, Australia
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Cancer Drug Discovery, Department of Molecular Biology and Biochemistry, Department of Environmental Health, MIMR-PHI Institute of Medical Research, PO BOX 5152, Clayton, Victoria 3168, Australia
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Yuet-Kin Leung
Yuet-Kin Leung
Cancer Drug Discovery, Department of Molecular Biology and Biochemistry, Department of Environmental Health, MIMR-PHI Institute of Medical Research, PO BOX 5152, Clayton, Victoria 3168, Australia
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Shuk-Mei Ho
Shuk-Mei Ho
Cancer Drug Discovery, Department of Molecular Biology and Biochemistry, Department of Environmental Health, MIMR-PHI Institute of Medical Research, PO BOX 5152, Clayton, Victoria 3168, Australia
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Colin D Clyne
Colin D Clyne
Cancer Drug Discovery, Department of Molecular Biology and Biochemistry, Department of Environmental Health, MIMR-PHI Institute of Medical Research, PO BOX 5152, Clayton, Victoria 3168, Australia
Cancer Drug Discovery, Department of Molecular Biology and Biochemistry, Department of Environmental Health, MIMR-PHI Institute of Medical Research, PO BOX 5152, Clayton, Victoria 3168, Australia
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Cancer Drug Discovery, Department of Molecular Biology and Biochemistry, Department of Environmental Health, MIMR-PHI Institute of Medical Research, PO BOX 5152, Clayton, Victoria 3168, Australia
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Introduction Normal growth and function of the mammary glands are dependent on the body's endocrine system. Many factors that influence breast cancer risk are therefore endocrine-associated processes, such as age at menopause, age at menarche
Ana B Crujeiras
Ana B Crujeiras
Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain
Laboratory of Molecular and Cellular Endocrinology, Instituto de Investigación Sanitaria (IDIS), Complejo Hospitalario Universitario de Santiago (CHUS/SERGAS), Santiago de Compostela University (USC), Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Madrid, Spain
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Laboratory of Molecular and Cellular Endocrinology, Instituto de Investigación Sanitaria (IDIS), Complejo Hospitalario Universitario de Santiago (CHUS/SERGAS), Santiago de Compostela University (USC), Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Madrid, Spain
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Angel Diaz-Lagares
Angel Diaz-Lagares
Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain
Translational Medical Oncology Group (Oncomet), Instituto de Investigación Sanitaria (IDIS); Complejo Hospitalario Universitario de Santiago de Compostela (CHUS/SERGAS) and CIBER de Cancer (CIBERONC), Santiago de Compostela, Spain
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Translational Medical Oncology Group (Oncomet), Instituto de Investigación Sanitaria (IDIS); Complejo Hospitalario Universitario de Santiago de Compostela (CHUS/SERGAS) and CIBER de Cancer (CIBERONC), Santiago de Compostela, Spain
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Olafur A Stefansson
Olafur A Stefansson
Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain
Cancer Research Laboratory, Faculty of Medicine, University of Iceland, Reykjavic, Iceland
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Cancer Research Laboratory, Faculty of Medicine, University of Iceland, Reykjavic, Iceland
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Manuel Macias-Gonzalez
Manuel Macias-Gonzalez
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Madrid, Spain
Unidad de Gestión Clínica de Endocrinología y Nutrición, Instituto de Investigación Biomédica de Málaga (IBIMA), Complejo Hospitalario de Málaga (Virgen de la Victoria), Universidad de Málaga, Málaga, Spain
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Unidad de Gestión Clínica de Endocrinología y Nutrición, Instituto de Investigación Biomédica de Málaga (IBIMA), Complejo Hospitalario de Málaga (Virgen de la Victoria), Universidad de Málaga, Málaga, Spain
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Juan Sandoval
Juan Sandoval
Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain
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Juan Cueva
Juan Cueva
Translational Medical Oncology Group (Oncomet), Instituto de Investigación Sanitaria (IDIS); Complejo Hospitalario Universitario de Santiago de Compostela (CHUS/SERGAS) and CIBER de Cancer (CIBERONC), Santiago de Compostela, Spain
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Rafael Lopez-Lopez
Rafael Lopez-Lopez
Translational Medical Oncology Group (Oncomet), Instituto de Investigación Sanitaria (IDIS); Complejo Hospitalario Universitario de Santiago de Compostela (CHUS/SERGAS) and CIBER de Cancer (CIBERONC), Santiago de Compostela, Spain
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Sebastian Moran
Sebastian Moran
Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain
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Jon G Jonasson
Jon G Jonasson
Department of Pathology and the Icelandic Cancer Registry, Icelandic Cancer society and Landspitali University Hospital, Reykjavik, Iceland
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Laufey Tryggvadottir
Laufey Tryggvadottir
Department of Pathology and the Icelandic Cancer Registry, Icelandic Cancer society and Landspitali University Hospital, Reykjavik, Iceland
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Elinborg Olafsdottir
Elinborg Olafsdottir
Department of Pathology and the Icelandic Cancer Registry, Icelandic Cancer society and Landspitali University Hospital, Reykjavik, Iceland
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Francisco J Tinahones
Francisco J Tinahones
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Madrid, Spain
Unidad de Gestión Clínica de Endocrinología y Nutrición, Instituto de Investigación Biomédica de Málaga (IBIMA), Complejo Hospitalario de Málaga (Virgen de la Victoria), Universidad de Málaga, Málaga, Spain
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Unidad de Gestión Clínica de Endocrinología y Nutrición, Instituto de Investigación Biomédica de Málaga (IBIMA), Complejo Hospitalario de Málaga (Virgen de la Victoria), Universidad de Málaga, Málaga, Spain
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Marcos C Carreira
Marcos C Carreira
Laboratory of Molecular and Cellular Endocrinology, Instituto de Investigación Sanitaria (IDIS), Complejo Hospitalario Universitario de Santiago (CHUS/SERGAS), Santiago de Compostela University (USC), Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Madrid, Spain
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CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Madrid, Spain
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Felipe F Casanueva
Felipe F Casanueva
Laboratory of Molecular and Cellular Endocrinology, Instituto de Investigación Sanitaria (IDIS), Complejo Hospitalario Universitario de Santiago (CHUS/SERGAS), Santiago de Compostela University (USC), Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Madrid, Spain
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CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Madrid, Spain
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Manel Esteller
Manel Esteller
Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain
Department of Physiological Sciences II, School of Medicine, University of Barcelona and Instituto Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain
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Department of Physiological Sciences II, School of Medicine, University of Barcelona and Instituto Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain
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( Seidell & Halberstadt 2015 ). Breast cancer, the leading cause of cancer diagnosis in women, is among the co-disorders associated with obesity. Overweight or obesity is a known risk factor for breast cancer ( Lorincz & Sukumar 2006 ), especially in
Gavin P Vinson
Gavin P Vinson
School of Biological and Chemical Sciences, Queen Mary University of London, London E1 4NS, UK
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Stewart Barker
Stewart Barker
School of Biological and Chemical Sciences, Queen Mary University of London, London E1 4NS, UK
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John R Puddefoot
John R Puddefoot
School of Biological and Chemical Sciences, Queen Mary University of London, London E1 4NS, UK
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Introduction In the treatment of breast cancer, the various ways of removing the effects of oestrogen, first by surgery and then by the use of drugs, such as tamoxifen and the aromatase inhibitors, which block the actions of oestrogens or prevent
Claudia Lanari
Claudia Lanari
Laboratory of Hormonal Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME)-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Vuelta de Obligado 2490 C1428ADN, Buenos Aires, CF, Argentina
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Caroline A Lamb
Caroline A Lamb
Laboratory of Hormonal Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME)-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Vuelta de Obligado 2490 C1428ADN, Buenos Aires, CF, Argentina
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Victoria T Fabris
Victoria T Fabris
Laboratory of Hormonal Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME)-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Vuelta de Obligado 2490 C1428ADN, Buenos Aires, CF, Argentina
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Luisa A Helguero
Luisa A Helguero
Laboratory of Hormonal Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME)-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Vuelta de Obligado 2490 C1428ADN, Buenos Aires, CF, Argentina
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Rocío Soldati
Rocío Soldati
Laboratory of Hormonal Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME)-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Vuelta de Obligado 2490 C1428ADN, Buenos Aires, CF, Argentina
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María Cecilia Bottino
María Cecilia Bottino
Laboratory of Hormonal Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME)-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Vuelta de Obligado 2490 C1428ADN, Buenos Aires, CF, Argentina
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Sebastián Giulianelli
Sebastián Giulianelli
Laboratory of Hormonal Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME)-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Vuelta de Obligado 2490 C1428ADN, Buenos Aires, CF, Argentina
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Juan Pablo Cerliani
Juan Pablo Cerliani
Laboratory of Hormonal Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME)-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Vuelta de Obligado 2490 C1428ADN, Buenos Aires, CF, Argentina
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Victoria Wargon
Victoria Wargon
Laboratory of Hormonal Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME)-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Vuelta de Obligado 2490 C1428ADN, Buenos Aires, CF, Argentina
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Alfredo Molinolo
Alfredo Molinolo
Laboratory of Hormonal Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME)-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Vuelta de Obligado 2490 C1428ADN, Buenos Aires, CF, Argentina
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Introduction Breast cancer is the most frequent cancer in women (23% of all cancers), and it ranks second overall when both sexes are considered together ( Parkin et al . 2005 ). Most tumors are ductal infiltrating carcinomas expressing estrogen
