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Catherine Ory
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Nicolas Ugolin
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Céline Levalois
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Ludovic Lacroix CEA, Department of Nuclear Medicine and Endocrine Oncology, Inserm, Institut Gustave Roussy, Université Paris XI, INSERM ERI-21, University of Nice-Sophia Antipolis, Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA Tumour/Tissue Bank of Nice Area, Department of Otorhinolaryngology, Institut Curie, CNRS, Université Paris VI, DSV, IRCM, LCE, BP6, Fontenay-aux-Roses F-92265, France

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Bernard Caillou CEA, Department of Nuclear Medicine and Endocrine Oncology, Inserm, Institut Gustave Roussy, Université Paris XI, INSERM ERI-21, University of Nice-Sophia Antipolis, Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA Tumour/Tissue Bank of Nice Area, Department of Otorhinolaryngology, Institut Curie, CNRS, Université Paris VI, DSV, IRCM, LCE, BP6, Fontenay-aux-Roses F-92265, France

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Jean-Michel Bidart CEA, Department of Nuclear Medicine and Endocrine Oncology, Inserm, Institut Gustave Roussy, Université Paris XI, INSERM ERI-21, University of Nice-Sophia Antipolis, Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA Tumour/Tissue Bank of Nice Area, Department of Otorhinolaryngology, Institut Curie, CNRS, Université Paris VI, DSV, IRCM, LCE, BP6, Fontenay-aux-Roses F-92265, France

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Martin Schlumberger CEA, Department of Nuclear Medicine and Endocrine Oncology, Inserm, Institut Gustave Roussy, Université Paris XI, INSERM ERI-21, University of Nice-Sophia Antipolis, Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA Tumour/Tissue Bank of Nice Area, Department of Otorhinolaryngology, Institut Curie, CNRS, Université Paris VI, DSV, IRCM, LCE, BP6, Fontenay-aux-Roses F-92265, France

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Ibrahima Diallo CEA, Department of Nuclear Medicine and Endocrine Oncology, Inserm, Institut Gustave Roussy, Université Paris XI, INSERM ERI-21, University of Nice-Sophia Antipolis, Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA Tumour/Tissue Bank of Nice Area, Department of Otorhinolaryngology, Institut Curie, CNRS, Université Paris VI, DSV, IRCM, LCE, BP6, Fontenay-aux-Roses F-92265, France
CEA, Department of Nuclear Medicine and Endocrine Oncology, Inserm, Institut Gustave Roussy, Université Paris XI, INSERM ERI-21, University of Nice-Sophia Antipolis, Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA Tumour/Tissue Bank of Nice Area, Department of Otorhinolaryngology, Institut Curie, CNRS, Université Paris VI, DSV, IRCM, LCE, BP6, Fontenay-aux-Roses F-92265, France
CEA, Department of Nuclear Medicine and Endocrine Oncology, Inserm, Institut Gustave Roussy, Université Paris XI, INSERM ERI-21, University of Nice-Sophia Antipolis, Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA Tumour/Tissue Bank of Nice Area, Department of Otorhinolaryngology, Institut Curie, CNRS, Université Paris VI, DSV, IRCM, LCE, BP6, Fontenay-aux-Roses F-92265, France

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Florent de Vathaire CEA, Department of Nuclear Medicine and Endocrine Oncology, Inserm, Institut Gustave Roussy, Université Paris XI, INSERM ERI-21, University of Nice-Sophia Antipolis, Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA Tumour/Tissue Bank of Nice Area, Department of Otorhinolaryngology, Institut Curie, CNRS, Université Paris VI, DSV, IRCM, LCE, BP6, Fontenay-aux-Roses F-92265, France
CEA, Department of Nuclear Medicine and Endocrine Oncology, Inserm, Institut Gustave Roussy, Université Paris XI, INSERM ERI-21, University of Nice-Sophia Antipolis, Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA Tumour/Tissue Bank of Nice Area, Department of Otorhinolaryngology, Institut Curie, CNRS, Université Paris VI, DSV, IRCM, LCE, BP6, Fontenay-aux-Roses F-92265, France
CEA, Department of Nuclear Medicine and Endocrine Oncology, Inserm, Institut Gustave Roussy, Université Paris XI, INSERM ERI-21, University of Nice-Sophia Antipolis, Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA Tumour/Tissue Bank of Nice Area, Department of Otorhinolaryngology, Institut Curie, CNRS, Université Paris VI, DSV, IRCM, LCE, BP6, Fontenay-aux-Roses F-92265, France

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Paul Hofman CEA, Department of Nuclear Medicine and Endocrine Oncology, Inserm, Institut Gustave Roussy, Université Paris XI, INSERM ERI-21, University of Nice-Sophia Antipolis, Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA Tumour/Tissue Bank of Nice Area, Department of Otorhinolaryngology, Institut Curie, CNRS, Université Paris VI, DSV, IRCM, LCE, BP6, Fontenay-aux-Roses F-92265, France
CEA, Department of Nuclear Medicine and Endocrine Oncology, Inserm, Institut Gustave Roussy, Université Paris XI, INSERM ERI-21, University of Nice-Sophia Antipolis, Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA Tumour/Tissue Bank of Nice Area, Department of Otorhinolaryngology, Institut Curie, CNRS, Université Paris VI, DSV, IRCM, LCE, BP6, Fontenay-aux-Roses F-92265, France
CEA, Department of Nuclear Medicine and Endocrine Oncology, Inserm, Institut Gustave Roussy, Université Paris XI, INSERM ERI-21, University of Nice-Sophia Antipolis, Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA Tumour/Tissue Bank of Nice Area, Department of Otorhinolaryngology, Institut Curie, CNRS, Université Paris VI, DSV, IRCM, LCE, BP6, Fontenay-aux-Roses F-92265, France

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José Santini CEA, Department of Nuclear Medicine and Endocrine Oncology, Inserm, Institut Gustave Roussy, Université Paris XI, INSERM ERI-21, University of Nice-Sophia Antipolis, Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA Tumour/Tissue Bank of Nice Area, Department of Otorhinolaryngology, Institut Curie, CNRS, Université Paris VI, DSV, IRCM, LCE, BP6, Fontenay-aux-Roses F-92265, France

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Bernard Malfoy CEA, Department of Nuclear Medicine and Endocrine Oncology, Inserm, Institut Gustave Roussy, Université Paris XI, INSERM ERI-21, University of Nice-Sophia Antipolis, Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA Tumour/Tissue Bank of Nice Area, Department of Otorhinolaryngology, Institut Curie, CNRS, Université Paris VI, DSV, IRCM, LCE, BP6, Fontenay-aux-Roses F-92265, France
CEA, Department of Nuclear Medicine and Endocrine Oncology, Inserm, Institut Gustave Roussy, Université Paris XI, INSERM ERI-21, University of Nice-Sophia Antipolis, Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA Tumour/Tissue Bank of Nice Area, Department of Otorhinolaryngology, Institut Curie, CNRS, Université Paris VI, DSV, IRCM, LCE, BP6, Fontenay-aux-Roses F-92265, France
CEA, Department of Nuclear Medicine and Endocrine Oncology, Inserm, Institut Gustave Roussy, Université Paris XI, INSERM ERI-21, University of Nice-Sophia Antipolis, Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA Tumour/Tissue Bank of Nice Area, Department of Otorhinolaryngology, Institut Curie, CNRS, Université Paris VI, DSV, IRCM, LCE, BP6, Fontenay-aux-Roses F-92265, France

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Sylvie Chevillard
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some DNA mutations, we searched for RAS , RET/PTC , and BRAF genetic alterations in the learning/training set of tumors ( Tables 1 and 2 ). Mutations at codon 61 of NRAS , HRAS , or KRAS were found in one rFTA and two sFTA. RET

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-10-0205
Volume/Issue:
Volume 18: Issue 1
Open access
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Sung Gwe Ahn Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea

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Chang Ik Yoon Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea

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Jae Hoon Lee Department of Nuclear Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea

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Hye Sun Lee Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, Republic of Korea

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So Eun Park Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea

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Yoon Jin Cha Department of Pathology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea

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Chihwan Cha Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea

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Soong June Bae Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea

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Kyung-A Lee Department of Laboratory Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea

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Joon Jeong Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea

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that genetic alteration of the TP53 gene and dysregulated glucose metabolism partly involve low PR expression in ER-positive and HER2-negative breast cancer. Supplementary data This is linked to the online version of the paper at https

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-18-0281
Volume/Issue:
Volume 26: Issue 2
Open access
Gaëlle Prost Institut National de la Santé et de la Recherche Médicale, Faculté de Médecine Laennec, UMR 664, Lyon F-69372, France
Institut National de la Santé et de la Recherche Médicale, Faculté de Médecine Laennec, UMR 664, Lyon F-69372, France

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Françoise Bernier-Valentin Institut National de la Santé et de la Recherche Médicale, Faculté de Médecine Laennec, UMR 664, Lyon F-69372, France
Institut National de la Santé et de la Recherche Médicale, Faculté de Médecine Laennec, UMR 664, Lyon F-69372, France

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Martine Croset Institut National de la Santé et de la Recherche Médicale, Faculté de Médecine Laennec, UMR 664, Lyon F-69372, France
Institut National de la Santé et de la Recherche Médicale, Faculté de Médecine Laennec, UMR 664, Lyon F-69372, France

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Bernard Rousset Institut National de la Santé et de la Recherche Médicale, Faculté de Médecine Laennec, UMR 664, Lyon F-69372, France
Institut National de la Santé et de la Recherche Médicale, Faculté de Médecine Laennec, UMR 664, Lyon F-69372, France

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Bl/6 genetic background. The possibility of masked interferences between genetic alterations has been studied. We found that the level of expression of the E7 oncogene (data not shown) and the level of expression of RP3 oncogene ( Fig. 5 ) were

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-09-0091
Volume/Issue:
Volume 16: Issue 3
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Dimitra A Vassiliadi Department of Endocrinology, Diabetes, and Metabolism, Evangelismos Hospital, Athens, Greece

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Stylianos Tsagarakis Department of Endocrinology, Diabetes, and Metabolism, Evangelismos Hospital, Athens, Greece

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clinical stigmata of CS, consistent with a mild glucocorticoid resistance syndrome. Genetics As discussed, PBMAH may be associated with genetic alterations of the ACTH receptor MC2R (extremely rare), PRKACA and PDE11A . Rarely, PBMAH may be

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-19-0240
Volume/Issue:
Volume 26: Issue 10
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C D E Margetts
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D Astuti
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D C Gentle
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W N Cooper
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A Cascon
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D Catchpoole
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M Robledo
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H P H Neumann
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F Latif
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E R Maher
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neuroblastoma is rare and major susceptibility genes have not yet been isolated, many investigators have attempted to define the somatic genetic and epigenetic alterations associated with neuroblastoma development. Common genetic events include N

Article Type:
Research Article
DOI:
https://doi.org/10.1677/erc.1.00865
Volume/Issue:
Volume 12: Issue 1
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Luca Morandi Department of Biomedical and Neuromotor Sciences, Section of Anatomic Pathology ‘M. Malpighi’ at Bellaria Hospital, University of Bologna, Bologna, Italy

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Alberto Righi Department of Pathology, Rizzoli Institute, (IRCCS), Bologna, Italy

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Francesca Maletta Department of Medical Sciences, University of Turin, Turin, Italy

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Paola Rucci Section of Hygiene and Biostatistics, University of Bologna, Bologna, Italy

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Fabio Pagni Department of Pathology, University of Milano Bicocca, Monza, Italy

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Marco Gallo Oncological Endocrinology Unit, Department of Medical Sciences, AOU Città della Salute e della Scienza di Torino, University of Turin, Turin, Italy

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Sabrina Rossi Department of Pathology, Regional Hospital, Treviso, Italy

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Leonardo Caporali Istituto delle Scienze Neurologiche di Bologna (IRCCS), Bellaria Hospital, Bologna, Italy

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Anna Sapino Institute for Cancer Research and Treatment (IRCCS), Candiolo, Italy

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Ricardo V Lloyd University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA

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Sofia Asioli Department of Biomedical and Neuromotor Sciences, Section of Anatomic Pathology ‘M. Malpighi’ at Bellaria Hospital, University of Bologna, Bologna, Italy

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single-base substitutions at the promoter of hTERT . Forty-six out of 49 genetic alterations found in coding regions are recorded in the COSMIC databases. The remaining three were not previously described in solid tumors and they were detected in AKT1

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-16-0546
Volume/Issue:
Volume 24: Issue 2
Free access
Tobias Hofving Sahlgrenska Cancer Center, Department of Pathology and Genetics, Institute of Biomedicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

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Yvonne Arvidsson Sahlgrenska Cancer Center, Department of Pathology and Genetics, Institute of Biomedicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

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Bilal Almobarak Sahlgrenska Cancer Center, Department of Pathology and Genetics, Institute of Biomedicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

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Linda Inge Sahlgrenska Cancer Center, Department of Pathology and Genetics, Institute of Biomedicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

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Roswitha Pfragner Institute of Pathophysiology and Immunology, Center for Molecular Medicine, Medical University of Graz, Graz, Austria

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Marta Persson Sahlgrenska Cancer Center, Department of Pathology and Genetics, Institute of Biomedicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

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Göran Stenman Sahlgrenska Cancer Center, Department of Pathology and Genetics, Institute of Biomedicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

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Erik Kristiansson Department of Mathematical Sciences, Chalmers University of Technology, Gothenburg, Sweden

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Viktor Johanson Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

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Ola Nilsson Sahlgrenska Cancer Center, Department of Pathology and Genetics, Institute of Biomedicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

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-resolution analysis of genetic alterations in small bowel carcinoid tumors reveals areas of recurrent amplification and loss . Genes, Chromosomes and Cancer 47 591 – 603 . ( https://doi.org/10.1002/gcc.20561 ) 10.1002/gcc.20561 Kölby L Bernhardt P Ahlman H

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-17-0445
Volume/Issue:
Volume 25: Issue 3
Open access
Larry J Suva Departments of Orthopaedic Surgery, Physiology and Biophysics, Radiation Oncology, Breast Cancer Research Program, Hematology and Oncology, Barton Research Institute, Center for Orthopaedic Research
Departments of Orthopaedic Surgery, Physiology and Biophysics, Radiation Oncology, Breast Cancer Research Program, Hematology and Oncology, Barton Research Institute, Center for Orthopaedic Research
Departments of Orthopaedic Surgery, Physiology and Biophysics, Radiation Oncology, Breast Cancer Research Program, Hematology and Oncology, Barton Research Institute, Center for Orthopaedic Research

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Robert J Griffin Departments of Orthopaedic Surgery, Physiology and Biophysics, Radiation Oncology, Breast Cancer Research Program, Hematology and Oncology, Barton Research Institute, Center for Orthopaedic Research
Departments of Orthopaedic Surgery, Physiology and Biophysics, Radiation Oncology, Breast Cancer Research Program, Hematology and Oncology, Barton Research Institute, Center for Orthopaedic Research

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Issam Makhoul Departments of Orthopaedic Surgery, Physiology and Biophysics, Radiation Oncology, Breast Cancer Research Program, Hematology and Oncology, Barton Research Institute, Center for Orthopaedic Research
Departments of Orthopaedic Surgery, Physiology and Biophysics, Radiation Oncology, Breast Cancer Research Program, Hematology and Oncology, Barton Research Institute, Center for Orthopaedic Research

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environmental pressure, heterogeneity in gene expression develops within the population of tumor cells, for example due to the effects of genomic instability and the accumulation of mutations and other genetic aberrations. Clonal selection then determines that

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-09-0012
Volume/Issue:
Volume 16: Issue 3
Free access
Shalini Patiar Cancer Research UK Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK

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Adrian L Harris Cancer Research UK Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK

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between HIF-1 over-expression and poor patient outcome. The activity of HIF-1 is increased in response to intratumoural hypoxia and as a result of genetic alterations that activate oncogenes and inactivate tumour suppressor genes. HIF-1 plays a key role in

Article Type:
Research Article
DOI:
https://doi.org/10.1677/erc.1.01290
Volume/Issue:
Volume 13: Issue Supplement_1
Free access
F Frasca
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C Nucera Endocrinologia, Sezione di Endocrinologia, Unità Operativa di Anatomia Patologica, Servizio di Anatomia Patologica, Dana-Farber Cancer Institute, Sezione di Endocrinologia, Dipartimento di Medicina Sperimentale e Farmacologia, Endocrinologia, Dipartimento di Medicina Interna e Medicina Specialistica, University of Catania, PO Garibaldi Nesima, Via Palermo 636, 95122 Catania, Italy

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G Pellegriti
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P Gangemi Endocrinologia, Sezione di Endocrinologia, Unità Operativa di Anatomia Patologica, Servizio di Anatomia Patologica, Dana-Farber Cancer Institute, Sezione di Endocrinologia, Dipartimento di Medicina Sperimentale e Farmacologia, Endocrinologia, Dipartimento di Medicina Interna e Medicina Specialistica, University of Catania, PO Garibaldi Nesima, Via Palermo 636, 95122 Catania, Italy

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M Attard Endocrinologia, Sezione di Endocrinologia, Unità Operativa di Anatomia Patologica, Servizio di Anatomia Patologica, Dana-Farber Cancer Institute, Sezione di Endocrinologia, Dipartimento di Medicina Sperimentale e Farmacologia, Endocrinologia, Dipartimento di Medicina Interna e Medicina Specialistica, University of Catania, PO Garibaldi Nesima, Via Palermo 636, 95122 Catania, Italy

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M Stella Endocrinologia, Sezione di Endocrinologia, Unità Operativa di Anatomia Patologica, Servizio di Anatomia Patologica, Dana-Farber Cancer Institute, Sezione di Endocrinologia, Dipartimento di Medicina Sperimentale e Farmacologia, Endocrinologia, Dipartimento di Medicina Interna e Medicina Specialistica, University of Catania, PO Garibaldi Nesima, Via Palermo 636, 95122 Catania, Italy

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M Loda Endocrinologia, Sezione di Endocrinologia, Unità Operativa di Anatomia Patologica, Servizio di Anatomia Patologica, Dana-Farber Cancer Institute, Sezione di Endocrinologia, Dipartimento di Medicina Sperimentale e Farmacologia, Endocrinologia, Dipartimento di Medicina Interna e Medicina Specialistica, University of Catania, PO Garibaldi Nesima, Via Palermo 636, 95122 Catania, Italy

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V Vella
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C Giordano Endocrinologia, Sezione di Endocrinologia, Unità Operativa di Anatomia Patologica, Servizio di Anatomia Patologica, Dana-Farber Cancer Institute, Sezione di Endocrinologia, Dipartimento di Medicina Sperimentale e Farmacologia, Endocrinologia, Dipartimento di Medicina Interna e Medicina Specialistica, University of Catania, PO Garibaldi Nesima, Via Palermo 636, 95122 Catania, Italy

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F Trimarchi Endocrinologia, Sezione di Endocrinologia, Unità Operativa di Anatomia Patologica, Servizio di Anatomia Patologica, Dana-Farber Cancer Institute, Sezione di Endocrinologia, Dipartimento di Medicina Sperimentale e Farmacologia, Endocrinologia, Dipartimento di Medicina Interna e Medicina Specialistica, University of Catania, PO Garibaldi Nesima, Via Palermo 636, 95122 Catania, Italy

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E Mazzon Endocrinologia, Sezione di Endocrinologia, Unità Operativa di Anatomia Patologica, Servizio di Anatomia Patologica, Dana-Farber Cancer Institute, Sezione di Endocrinologia, Dipartimento di Medicina Sperimentale e Farmacologia, Endocrinologia, Dipartimento di Medicina Interna e Medicina Specialistica, University of Catania, PO Garibaldi Nesima, Via Palermo 636, 95122 Catania, Italy

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A Belfiore Endocrinologia, Sezione di Endocrinologia, Unità Operativa di Anatomia Patologica, Servizio di Anatomia Patologica, Dana-Farber Cancer Institute, Sezione di Endocrinologia, Dipartimento di Medicina Sperimentale e Farmacologia, Endocrinologia, Dipartimento di Medicina Interna e Medicina Specialistica, University of Catania, PO Garibaldi Nesima, Via Palermo 636, 95122 Catania, Italy

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R Vigneri
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excluded and has been attributed to either iodine supplementation ( Farahati et al . 2004 ) or exposure to radiation or other environmental endocrine disruptors, especially during childhood ( Tronko et al . 2006 ). Many genetic alterations have been

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-07-0212
Volume/Issue:
Volume 15: Issue 1
Free access