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Raquel Santana da Cruz
Raquel Santana da Cruz
Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia, USA
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Johan Clarke
Johan Clarke
Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia, USA
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Ana Cristina P Curi
Ana Cristina P Curi
Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia, USA
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Aseel Al-Yawar
Aseel Al-Yawar
Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia, USA
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Lu Jin
Lu Jin
Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia, USA
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Ali Baird
Ali Baird
Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia, USA
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M Idalia Cruz
M Idalia Cruz
Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia, USA
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Bhaskar Kallakury
Bhaskar Kallakury
Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia, USA
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Sonia de Assis
Sonia de Assis
Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia, USA
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accelerated development of high-grade PanIN and invasive PDAC in offspring carrying the Kras G12D/+ mutation. This phenotype was associated with increased rates of acinar-to-ductal reprogramming as well as increased desmoplasia and other alterations in the
Hiroki Ueda
Hiroki Ueda
Department of Molecular Oncology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
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Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
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Yoshimitsu Akiyama
Yoshimitsu Akiyama
Department of Molecular Oncology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
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Shu Shimada
Shu Shimada
Department of Molecular Oncology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
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Kaoru Mogushi
Kaoru Mogushi
Department of Molecular Oncology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
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Misaki Serizawa
Misaki Serizawa
Department of Molecular Oncology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
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Satoshi Matsumura
Satoshi Matsumura
Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
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Yusuke Mitsunori
Yusuke Mitsunori
Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
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Arihiro Aihara
Arihiro Aihara
Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
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Daisuke Ban
Daisuke Ban
Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
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Takanori Ochiai
Takanori Ochiai
Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
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Atsushi Kudo
Atsushi Kudo
Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
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Minoru Tanabe
Minoru Tanabe
Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
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Shinji Tanaka
Shinji Tanaka
Department of Molecular Oncology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
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Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
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univariate analysis indicated that WHO grade G1/G2, perineural invasion, lymphatic invasion, adjacent organ invasion, DAXX-low tumors and the combined expression signature of DAXX-low and STC2-high were significantly associated with poor prognosis, while ATRX
Nelson Rangel
Nelson Rangel
Department of Medical Sciences, University of Turin, Turin, Italy
Natural and Mathematical Sciences Faculty, Universidad del Rosario, Bogotá, Colombia
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Natural and Mathematical Sciences Faculty, Universidad del Rosario, Bogotá, Colombia
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Milena Rondon-Lagos
Milena Rondon-Lagos
School of Biological Sciences, Universidad Pedagógica y Tecnológica de Colombia, Tunja, Colombia
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Laura Annaratone
Laura Annaratone
Department of Medical Sciences, University of Turin, Turin, Italy
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Simona Osella-Abate
Simona Osella-Abate
Department of Medical Sciences, University of Turin, Turin, Italy
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Jasna Metovic
Jasna Metovic
Department of Medical Sciences, University of Turin, Turin, Italy
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Maria Piera Mano
Maria Piera Mano
Department of Surgical Sciences, University of Turin, Turin, Italy
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Luca Bertero
Luca Bertero
Department of Medical Sciences, University of Turin, Turin, Italy
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Paola Cassoni
Paola Cassoni
Department of Medical Sciences, University of Turin, Turin, Italy
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Anna Sapino
Anna Sapino
Department of Medical Sciences, University of Turin, Turin, Italy
Pathology Unit, Fondazione del Piemonte per l’Oncologia (FPO) Candiolo Cancer Institute (IRCCS), Candiolo, Italy
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Pathology Unit, Fondazione del Piemonte per l’Oncologia (FPO) Candiolo Cancer Institute (IRCCS), Candiolo, Italy
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Isabella Castellano
Isabella Castellano
Department of Medical Sciences, University of Turin, Turin, Italy
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. 2011 ) and approximately 75% of ER-positive (ER+) BCs are also AR positive (AR+). Several studies have shown that AR expression in luminal tumours (ER+) is associated with lower tumour grade, smaller tumour size, lower proliferative index (Ki67 level
Derek Raghavan
Derek Raghavan
Departments of Solid Tumor Oncology, Endocrinology, and Urologic Oncology, Levine, Cancer Institute, Charlotte, North Carolina, USA
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Antoinette R Tan
Antoinette R Tan
Departments of Solid Tumor Oncology, Endocrinology, and Urologic Oncology, Levine, Cancer Institute, Charlotte, North Carolina, USA
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E Shannon Story
E Shannon Story
Departments of Solid Tumor Oncology, Endocrinology, and Urologic Oncology, Levine, Cancer Institute, Charlotte, North Carolina, USA
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Earle F Burgess
Earle F Burgess
Departments of Solid Tumor Oncology, Endocrinology, and Urologic Oncology, Levine, Cancer Institute, Charlotte, North Carolina, USA
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Laura Musselwhite
Laura Musselwhite
Departments of Solid Tumor Oncology, Endocrinology, and Urologic Oncology, Levine, Cancer Institute, Charlotte, North Carolina, USA
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Edward S Kim
Edward S Kim
Departments of Solid Tumor Oncology, Endocrinology, and Urologic Oncology, Levine, Cancer Institute, Charlotte, North Carolina, USA
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Peter E Clark
Peter E Clark
Departments of Solid Tumor Oncology, Endocrinology, and Urologic Oncology, Levine, Cancer Institute, Charlotte, North Carolina, USA
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are more likely to become infected and are at high risk for severe clinical complications, such as the need for ventilation, intensive care unit admission, or death ( Liang et al . 2020 , Onder et al . 2020 , Yu et al . 2020 ). A review of
Matthew Saldana
Matthew Saldana
Department of Biochemistry and Molecular Medicine, UC Davis School of Medicine, UC Davis Comprehensive Cancer Center, Sacramento, California, USA
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Kacey VanderVorst
Kacey VanderVorst
Department of Biochemistry and Molecular Medicine, UC Davis School of Medicine, UC Davis Comprehensive Cancer Center, Sacramento, California, USA
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Anastasia L Berg
Anastasia L Berg
Department of Biochemistry and Molecular Medicine, UC Davis School of Medicine, UC Davis Comprehensive Cancer Center, Sacramento, California, USA
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Hyun Lee
Hyun Lee
Department of Biochemistry and Molecular Medicine, UC Davis School of Medicine, UC Davis Comprehensive Cancer Center, Sacramento, California, USA
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Kermit L Carraway III
Kermit L Carraway III
Department of Biochemistry and Molecular Medicine, UC Davis School of Medicine, UC Davis Comprehensive Cancer Center, Sacramento, California, USA
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axis as a promising therapeutic target. OTUB1 promotes invasion in glioma, colon, gastric and esophageal cancer via EMT Glioblastoma, a high-grade glioma, is the most deadly form of brain cancer, with a 5-year survival rate of 5% ( Goodenberger
N Burrows
N Burrows
School of Pharmacy and Pharmaceutical Sciences, Department of Endocrinology, Department of Pathology, Experimental and Surgical Oncology, Academic Department of Radiation Oncology, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK
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J Resch
J Resch
School of Pharmacy and Pharmaceutical Sciences, Department of Endocrinology, Department of Pathology, Experimental and Surgical Oncology, Academic Department of Radiation Oncology, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK
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R L Cowen
R L Cowen
School of Pharmacy and Pharmaceutical Sciences, Department of Endocrinology, Department of Pathology, Experimental and Surgical Oncology, Academic Department of Radiation Oncology, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK
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R von Wasielewski
R von Wasielewski
School of Pharmacy and Pharmaceutical Sciences, Department of Endocrinology, Department of Pathology, Experimental and Surgical Oncology, Academic Department of Radiation Oncology, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK
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C Hoang-Vu
C Hoang-Vu
School of Pharmacy and Pharmaceutical Sciences, Department of Endocrinology, Department of Pathology, Experimental and Surgical Oncology, Academic Department of Radiation Oncology, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK
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C M West
C M West
School of Pharmacy and Pharmaceutical Sciences, Department of Endocrinology, Department of Pathology, Experimental and Surgical Oncology, Academic Department of Radiation Oncology, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK
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K J Williams
K J Williams
School of Pharmacy and Pharmaceutical Sciences, Department of Endocrinology, Department of Pathology, Experimental and Surgical Oncology, Academic Department of Radiation Oncology, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK
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G Brabant
G Brabant
School of Pharmacy and Pharmaceutical Sciences, Department of Endocrinology, Department of Pathology, Experimental and Surgical Oncology, Academic Department of Radiation Oncology, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK
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thyroid tumours, the effect on radiation resistance is of high therapeutic relevance in these aggressive carcinomas. Previous data characterizing the potential role of HIF-1α in thyroid carcinomas are limited. In vitro studies have shown that
J Cros
J Cros
Department of Pathology, AP-HP, DHU UNITY, Beaujon University Hospital, Clichy, France
U1149 – University Paris Diderot, Paris, France
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U1149 – University Paris Diderot, Paris, France
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O Hentic
O Hentic
Department of Gastroenterology and Pancreatology, AP-HP, DHU UNITY, Beaujon University Hospital, Clichy, France
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V Rebours
V Rebours
U1149 – University Paris Diderot, Paris, France
Department of Gastroenterology and Pancreatology, AP-HP, DHU UNITY, Beaujon University Hospital, Clichy, France
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Department of Gastroenterology and Pancreatology, AP-HP, DHU UNITY, Beaujon University Hospital, Clichy, France
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M Zappa
M Zappa
Department of Radiology, AP-HP, DHU UNITY, Beaujon Hospital, Clichy, France
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N Gille
N Gille
Department of Pathology, AP-HP, DHU UNITY, Beaujon University Hospital, Clichy, France
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N Theou-Anton
N Theou-Anton
Department of Somatic Genetic, AP-HP, DHU UNITY, Bichat University Hospital, Paris, France
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D Vernerey
D Vernerey
Methodology and Quality of Life in Oncology Unit (EA 3181), University Hospital of Besançon, Besançon, France
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F Maire
F Maire
Department of Gastroenterology and Pancreatology, AP-HP, DHU UNITY, Beaujon University Hospital, Clichy, France
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P Lévy
P Lévy
U1149 – University Paris Diderot, Paris, France
Department of Gastroenterology and Pancreatology, AP-HP, DHU UNITY, Beaujon University Hospital, Clichy, France
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Department of Gastroenterology and Pancreatology, AP-HP, DHU UNITY, Beaujon University Hospital, Clichy, France
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P Bedossa
P Bedossa
Department of Pathology, AP-HP, DHU UNITY, Beaujon University Hospital, Clichy, France
U1149 – University Paris Diderot, Paris, France
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U1149 – University Paris Diderot, Paris, France
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V Paradis
V Paradis
Department of Pathology, AP-HP, DHU UNITY, Beaujon University Hospital, Clichy, France
U1149 – University Paris Diderot, Paris, France
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U1149 – University Paris Diderot, Paris, France
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P Hammel
P Hammel
U1149 – University Paris Diderot, Paris, France
Department of Digestive Oncology, AP-HP, DHU UNITY, Beaujon University Hospital, Clichy, France
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Department of Digestive Oncology, AP-HP, DHU UNITY, Beaujon University Hospital, Clichy, France
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P Ruszniewski
P Ruszniewski
U1149 – University Paris Diderot, Paris, France
Department of Gastroenterology and Pancreatology, AP-HP, DHU UNITY, Beaujon University Hospital, Clichy, France
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Department of Gastroenterology and Pancreatology, AP-HP, DHU UNITY, Beaujon University Hospital, Clichy, France
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A Couvelard
A Couvelard
U1149 – University Paris Diderot, Paris, France
Department of Pathology, AP-HP, DHU UNITY, Bichat University Hospital, Paris, France
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Department of Pathology, AP-HP, DHU UNITY, Bichat University Hospital, Paris, France
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characteristics of the patients and their tumors were collected from the surgical, clinical, and pathological files. Tumors were classified according to the 2010 WHO classification and the ENETS grading system ( Rindi et al. 2006 ). TEM-based regimens were
Lei Gu
Lei Gu
Cancer Biology, Medicina Sperimentale e Patologia, Biological Sciences, Pharmacy and Experimental Therapeutics, Institute for Pathology, Pathology, Urology, Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
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Paraskevi Vogiatzi
Paraskevi Vogiatzi
Cancer Biology, Medicina Sperimentale e Patologia, Biological Sciences, Pharmacy and Experimental Therapeutics, Institute for Pathology, Pathology, Urology, Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
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Martin Puhr
Martin Puhr
Cancer Biology, Medicina Sperimentale e Patologia, Biological Sciences, Pharmacy and Experimental Therapeutics, Institute for Pathology, Pathology, Urology, Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
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Ayush Dagvadorj
Ayush Dagvadorj
Cancer Biology, Medicina Sperimentale e Patologia, Biological Sciences, Pharmacy and Experimental Therapeutics, Institute for Pathology, Pathology, Urology, Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
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Jacqueline Lutz
Jacqueline Lutz
Cancer Biology, Medicina Sperimentale e Patologia, Biological Sciences, Pharmacy and Experimental Therapeutics, Institute for Pathology, Pathology, Urology, Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
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Amy Ryder
Amy Ryder
Cancer Biology, Medicina Sperimentale e Patologia, Biological Sciences, Pharmacy and Experimental Therapeutics, Institute for Pathology, Pathology, Urology, Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
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Sankar Addya
Sankar Addya
Cancer Biology, Medicina Sperimentale e Patologia, Biological Sciences, Pharmacy and Experimental Therapeutics, Institute for Pathology, Pathology, Urology, Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
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Paolo Fortina
Paolo Fortina
Cancer Biology, Medicina Sperimentale e Patologia, Biological Sciences, Pharmacy and Experimental Therapeutics, Institute for Pathology, Pathology, Urology, Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
Cancer Biology, Medicina Sperimentale e Patologia, Biological Sciences, Pharmacy and Experimental Therapeutics, Institute for Pathology, Pathology, Urology, Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
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Cancer Biology, Medicina Sperimentale e Patologia, Biological Sciences, Pharmacy and Experimental Therapeutics, Institute for Pathology, Pathology, Urology, Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
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Carlton Cooper
Carlton Cooper
Cancer Biology, Medicina Sperimentale e Patologia, Biological Sciences, Pharmacy and Experimental Therapeutics, Institute for Pathology, Pathology, Urology, Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
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Benjamin Leiby
Benjamin Leiby
Cancer Biology, Medicina Sperimentale e Patologia, Biological Sciences, Pharmacy and Experimental Therapeutics, Institute for Pathology, Pathology, Urology, Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
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Abhijit Dasgupta
Abhijit Dasgupta
Cancer Biology, Medicina Sperimentale e Patologia, Biological Sciences, Pharmacy and Experimental Therapeutics, Institute for Pathology, Pathology, Urology, Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
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Terry Hyslop
Terry Hyslop
Cancer Biology, Medicina Sperimentale e Patologia, Biological Sciences, Pharmacy and Experimental Therapeutics, Institute for Pathology, Pathology, Urology, Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
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Lukas Bubendorf
Lukas Bubendorf
Cancer Biology, Medicina Sperimentale e Patologia, Biological Sciences, Pharmacy and Experimental Therapeutics, Institute for Pathology, Pathology, Urology, Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
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Kalle Alanen
Kalle Alanen
Cancer Biology, Medicina Sperimentale e Patologia, Biological Sciences, Pharmacy and Experimental Therapeutics, Institute for Pathology, Pathology, Urology, Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
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Tuomas Mirtti
Tuomas Mirtti
Cancer Biology, Medicina Sperimentale e Patologia, Biological Sciences, Pharmacy and Experimental Therapeutics, Institute for Pathology, Pathology, Urology, Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
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Marja T Nevalainen
Marja T Nevalainen
Cancer Biology, Medicina Sperimentale e Patologia, Biological Sciences, Pharmacy and Experimental Therapeutics, Institute for Pathology, Pathology, Urology, Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
Cancer Biology, Medicina Sperimentale e Patologia, Biological Sciences, Pharmacy and Experimental Therapeutics, Institute for Pathology, Pathology, Urology, Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
Cancer Biology, Medicina Sperimentale e Patologia, Biological Sciences, Pharmacy and Experimental Therapeutics, Institute for Pathology, Pathology, Urology, Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
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Cancer Biology, Medicina Sperimentale e Patologia, Biological Sciences, Pharmacy and Experimental Therapeutics, Institute for Pathology, Pathology, Urology, Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
Cancer Biology, Medicina Sperimentale e Patologia, Biological Sciences, Pharmacy and Experimental Therapeutics, Institute for Pathology, Pathology, Urology, Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
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al . 2004 ). Stat5 activation is associated with high histological grade ( Li et al . 2004 , 2005 ), and is present in the majority of castration-resistant recurrent human prostate cancers ( Tan et al . 2008 ). The molecular mechanisms underlying
D Cecchin
D Cecchin
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F Lumachi
F Lumachi
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M C Marzola
M C Marzola
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G Opocher
G Opocher
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C Scaroni
C Scaroni
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P Zucchetta
P Zucchetta
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F Mantero
F Mantero
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F Bui
F Bui
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Introduction At present, the high spatial resolution of morphologic modalities (computed tomography (CT) or magnetic resonance imaging (MRI)) leads to an increasing number of incidentally discovered adrenal masses. Nearly 25% of
Yan Zhou
Yan Zhou
Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Beijing Key Laboratory of Tumor Invasion and Metastasis Research, Institute of Cancer Research, Capital Medical University, Beijing, China
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Gaoxiang Yang
Gaoxiang Yang
Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Beijing Key Laboratory of Tumor Invasion and Metastasis Research, Institute of Cancer Research, Capital Medical University, Beijing, China
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Hua Tian
Hua Tian
Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Beijing Key Laboratory of Tumor Invasion and Metastasis Research, Institute of Cancer Research, Capital Medical University, Beijing, China
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Yabin Hu
Yabin Hu
Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Beijing Key Laboratory of Tumor Invasion and Metastasis Research, Institute of Cancer Research, Capital Medical University, Beijing, China
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Sai Wu
Sai Wu
Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Beijing Key Laboratory of Tumor Invasion and Metastasis Research, Institute of Cancer Research, Capital Medical University, Beijing, China
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Yang Geng
Yang Geng
Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Beijing Key Laboratory of Tumor Invasion and Metastasis Research, Institute of Cancer Research, Capital Medical University, Beijing, China
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Kai Lin
Kai Lin
Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Beijing Key Laboratory of Tumor Invasion and Metastasis Research, Institute of Cancer Research, Capital Medical University, Beijing, China
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Wei Wu
Wei Wu
Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Beijing Key Laboratory of Tumor Invasion and Metastasis Research, Institute of Cancer Research, Capital Medical University, Beijing, China
Institute of Brain Tumor, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China
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Institute of Brain Tumor, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China
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), and their high expression in cancer tissues contributed to the grading of malignancy and poor prognosis ( Nemunaitis 2012 ). Reversely, low expression and phosphorylation of microtubule-destabilizing protein Stathmin-1 might cause microtubule over
