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Tiago Bordeira Gaspar i3S – Instituto de Investigação e Inovação em Saúde, Porto, Portugal
Ipatimup – Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Porto, Portugal
ICBAS – Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto, Porto, Portugal
FMUP – Faculdade de Medicina da Universidade do Porto, Porto, Portugal

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José Manuel Lopes i3S – Instituto de Investigação e Inovação em Saúde, Porto, Portugal
Ipatimup – Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Porto, Portugal
FMUP – Faculdade de Medicina da Universidade do Porto, Porto, Portugal
Department of Pathology, Centro Hospitalar e Universitário de São João, Porto, Portugal

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Paula Soares i3S – Instituto de Investigação e Inovação em Saúde, Porto, Portugal
Ipatimup – Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Porto, Portugal
FMUP – Faculdade de Medicina da Universidade do Porto, Porto, Portugal

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João Vinagre i3S – Instituto de Investigação e Inovação em Saúde, Porto, Portugal
Ipatimup – Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Porto, Portugal
FMUP – Faculdade de Medicina da Universidade do Porto, Porto, Portugal

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%) that could either be WD (PanNETs G3) or poorly differentiated (PD) pancreatic neuroendocrine carcinomas (PanNECs). Long-term survival is achieved in some PanNEN patients, although the overall 5-year and 10-year survival rates are 46 and 31

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-22-0166
Volume/Issue:
Volume 29: Issue 12
Free access
L Lemonnier
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R Lazarenko
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Y Shuba
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S Thebault
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M Roudbaraki
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G Lepage
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N Prevarskaya
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R Skryma
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21 8471 –8482. di Sant’Agnese PA 1992 Neuroendocrine differentiation in carcinoma of the prostate. Diagnostic, prognostic, and therapeutic implications. Cancer 70 254 –268. di Sant

Article Type:
Research Article
DOI:
https://doi.org/10.1677/erc.1.00898
Volume/Issue:
Volume 12: Issue 2
Free access
Gregory A Kaltsas
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Janet L Cunningham Department of Pathophysiology, Section of Endocrine Oncology, Department of Clinical Pathology and Cytology, Department of Genetics and Pathology, National University of Athens, Athens 11527, Greece

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Sture E Falkmer Department of Pathophysiology, Section of Endocrine Oncology, Department of Clinical Pathology and Cytology, Department of Genetics and Pathology, National University of Athens, Athens 11527, Greece

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Lars Grimelius Department of Pathophysiology, Section of Endocrine Oncology, Department of Clinical Pathology and Cytology, Department of Genetics and Pathology, National University of Athens, Athens 11527, Greece

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Apostolos V Tsolakis Department of Pathophysiology, Section of Endocrine Oncology, Department of Clinical Pathology and Cytology, Department of Genetics and Pathology, National University of Athens, Athens 11527, Greece

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( n =2)  Small-cell PDEC <3 60 0 25  Large-cell PDEC 90 90 0 90 Total ( n =38) NE, neuroendocrine; CgA, chromogranin A; IR; immunoreactive; NETs, neuroendocrine tumours; PDECs, poorly differentiated endocrine carcinomas. Within brackets the range

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-10-0026
Volume/Issue:
Volume 18: Issue 1
Free access
Martin Gotthardt
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Martin P Béhé
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Julia Grass
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Artur Bauhofer
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Anja Rinke
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Meike L Schipper
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Marc Kalinowski
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Rudolf Arnold
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Wim J G Oyen
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Thomas M Behr
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Introduction Somatostatin receptor scintigraphy (SRS) is a successful nuclear medicine procedure for the detection of neuroendocrine tumours (NET) and their metastases. It is considered as the diagnostic method of choice in several

Article Type:
Research Article
DOI:
https://doi.org/10.1677/erc.1.01245
Volume/Issue:
Volume 13: Issue 4
Free access
J R Strosberg Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA

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M Cives Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA

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J Hwang Department of Medicine and The UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA

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T Weber Department of Medicine and The UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA

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M Nickerson Department of Medicine and The UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA

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C E Atreya Department of Medicine and The UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA

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A Venook Department of Medicine and The UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA

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R K Kelley Department of Medicine and The UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA

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T Valone Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA

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B Morse Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA

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D Coppola Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA

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E K Bergsland Department of Medicine and The UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA

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Introduction Neuroendocrine tumors (NETs) comprise a heterogeneous spectrum of malignancies characterized by a relatively indolent rate of growth and the ability to secrete a variety of hormones resulting in characteristic clinical syndromes

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-16-0008
Volume/Issue:
Volume 23: Issue 5
Free access
Matti L Gild Human Oncology and Pathogenesis Program, Department of Medicine, Department of Pathology

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Iñigo Landa Human Oncology and Pathogenesis Program, Department of Medicine, Department of Pathology

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Mabel Ryder Human Oncology and Pathogenesis Program, Department of Medicine, Department of Pathology
Human Oncology and Pathogenesis Program, Department of Medicine, Department of Pathology

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Ronald A Ghossein Human Oncology and Pathogenesis Program, Department of Medicine, Department of Pathology

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Jeffrey A Knauf Human Oncology and Pathogenesis Program, Department of Medicine, Department of Pathology

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James A Fagin Human Oncology and Pathogenesis Program, Department of Medicine, Department of Pathology
Human Oncology and Pathogenesis Program, Department of Medicine, Department of Pathology

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& Saarma 2002 ). RET also plays a crucial role in thyroid tumorigenesis. Mutations in RET are highly prevalent in medullary thyroid carcinomas (MTCs), which stem from the parafollicular cells of the thyroid gland, and may occur as sporadic or hereditary

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-13-0085
Volume/Issue:
Volume 20: Issue 5
Free access
Ta-Chun Yuan
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Suresh Veeramani
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Fen-Fen Lin
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Dmitry Kondrikou
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Stanislav Zelivianski
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Tsukasa Igawa
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Dev Karan
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Surinder K. Batra
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Ming-Fong Lin
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of neuroendocrine differentiation in clinically localized prostatic carcinoma. Prostate Supplement 8 37 –42. Angelsen A , Syversen U, Stridsberg M, Haugen OA, Mjolnerod OK & Waldum HL 1997 Use of neuroendocrine serum

Article Type:
Research Article
DOI:
https://doi.org/10.1677/erc.1.01043
Volume/Issue:
Volume 13: Issue 1
Free access
Eva-Maria Duerr Gastrointestinal Unit, Department of Medicine, Cancer Center, Center for Computational and Integrative Biology, Department of Surgery, Department of Pathology, Department of Adult Oncology
Gastrointestinal Unit, Department of Medicine, Cancer Center, Center for Computational and Integrative Biology, Department of Surgery, Department of Pathology, Department of Adult Oncology

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Yusuke Mizukami Gastrointestinal Unit, Department of Medicine, Cancer Center, Center for Computational and Integrative Biology, Department of Surgery, Department of Pathology, Department of Adult Oncology
Gastrointestinal Unit, Department of Medicine, Cancer Center, Center for Computational and Integrative Biology, Department of Surgery, Department of Pathology, Department of Adult Oncology

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Aylwin Ng Gastrointestinal Unit, Department of Medicine, Cancer Center, Center for Computational and Integrative Biology, Department of Surgery, Department of Pathology, Department of Adult Oncology

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Ramnik J Xavier Gastrointestinal Unit, Department of Medicine, Cancer Center, Center for Computational and Integrative Biology, Department of Surgery, Department of Pathology, Department of Adult Oncology
Gastrointestinal Unit, Department of Medicine, Cancer Center, Center for Computational and Integrative Biology, Department of Surgery, Department of Pathology, Department of Adult Oncology
Gastrointestinal Unit, Department of Medicine, Cancer Center, Center for Computational and Integrative Biology, Department of Surgery, Department of Pathology, Department of Adult Oncology

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Hirotoshi Kikuchi Gastrointestinal Unit, Department of Medicine, Cancer Center, Center for Computational and Integrative Biology, Department of Surgery, Department of Pathology, Department of Adult Oncology
Gastrointestinal Unit, Department of Medicine, Cancer Center, Center for Computational and Integrative Biology, Department of Surgery, Department of Pathology, Department of Adult Oncology

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Vikram Deshpande Gastrointestinal Unit, Department of Medicine, Cancer Center, Center for Computational and Integrative Biology, Department of Surgery, Department of Pathology, Department of Adult Oncology

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Andrew L Warshaw  Gastrointestinal Unit, Department of Medicine, Cancer Center, Center for Computational and Integrative Biology, Department of Surgery, Department of Pathology, Department of Adult Oncology

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Jonathan Glickman Gastrointestinal Unit, Department of Medicine, Cancer Center, Center for Computational and Integrative Biology, Department of Surgery, Department of Pathology, Department of Adult Oncology

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Matthew H Kulke Gastrointestinal Unit, Department of Medicine, Cancer Center, Center for Computational and Integrative Biology, Department of Surgery, Department of Pathology, Department of Adult Oncology

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Daniel C Chung Gastrointestinal Unit, Department of Medicine, Cancer Center, Center for Computational and Integrative Biology, Department of Surgery, Department of Pathology, Department of Adult Oncology
Gastrointestinal Unit, Department of Medicine, Cancer Center, Center for Computational and Integrative Biology, Department of Surgery, Department of Pathology, Department of Adult Oncology
Gastrointestinal Unit, Department of Medicine, Cancer Center, Center for Computational and Integrative Biology, Department of Surgery, Department of Pathology, Department of Adult Oncology

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index, angioinvasion, and distant metastases, the World Health Organization (WHO) classifies these tumors into three groups: well-differentiated NETs (WDET), well-differentiated neuroendocrine carcinomas (WDEC), and poorly-differentiated neuroendocrine

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-07-0194
Volume/Issue:
Volume 15: Issue 1
Free access
Paul Benjamin Loughrey Patrick G Johnston Centre for Cancer Research, Queen’s University, Belfast, UK
Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast Health & Social Care Trust, Belfast, UK

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Federico Roncaroli Geoffrey Jefferson Brain Research Centre, Division of Neuroscience and Experimental Psychology, School of Medicine, Manchester University, Manchester, UK

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Estelle Healy Department of Cellular Pathology, Royal Victoria Hospital, Belfast Health & Social Care Trust, Belfast, UK

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Philip Weir Department of Neurosurgery, Royal Victoria Hospital, Belfast Health & Social Care Trust, Belfast, UK

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Madhu Basetti Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK

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Ruth T Casey Department of Endocrinology, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK

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Steven J Hunter Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast Health & Social Care Trust, Belfast, UK

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Márta Korbonits Centre for Endocrinology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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Introduction Primary tumours of adenohypophyseal cells recently suggested to be redefined as pituitary neuroendocrine tumours (PitNETs) can rarely occur in association with paraganglioma (PGL) or phaeochromocytoma. These tumours may develop in

Article Type:
Review Article
Collections:
Advances and Future Directions in Pheochromocytoma and Paraganglioma
DOI:
https://doi.org/10.1530/ERC-22-0157
Volume/Issue:
Volume 29: Issue 10
Open access
Emmanouil Saloustros Section on Endocrinology and Genetics, Program on Developmental Endocrinology & Genetics (PDEGEN) & Pediatric Endocrinology Inter-institute Training Program, Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, USA

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Paraskevi Salpea Section on Endocrinology and Genetics, Program on Developmental Endocrinology & Genetics (PDEGEN) & Pediatric Endocrinology Inter-institute Training Program, Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, USA

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Matthew Starost Diagnostic and Research Services Branch, Division of Veterinary Resources (DVR), Office of Research Services (ORS), National Institutes of Health (NIH), Bethesda, Maryland, USA

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Sissi Liu Section on Endocrinology and Genetics, Program on Developmental Endocrinology & Genetics (PDEGEN) & Pediatric Endocrinology Inter-institute Training Program, Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, USA

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Fabio R Faucz Section on Endocrinology and Genetics, Program on Developmental Endocrinology & Genetics (PDEGEN) & Pediatric Endocrinology Inter-institute Training Program, Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, USA

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Edra London Section on Endocrinology and Genetics, Program on Developmental Endocrinology & Genetics (PDEGEN) & Pediatric Endocrinology Inter-institute Training Program, Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, USA

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Eva Szarek Section on Endocrinology and Genetics, Program on Developmental Endocrinology & Genetics (PDEGEN) & Pediatric Endocrinology Inter-institute Training Program, Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, USA

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Woo-Jin Song Department of Pediatrics, Metabolism Division, John Hopkins University, Baltimore, Maryland, USA

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Mehboob Hussain Department of Pediatrics, Metabolism Division, John Hopkins University, Baltimore, Maryland, USA

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Constantine A Stratakis Section on Endocrinology and Genetics, Program on Developmental Endocrinology & Genetics (PDEGEN) & Pediatric Endocrinology Inter-institute Training Program, Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, USA

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neuroendocrine pancreatic neoplasms with an acinar component. This finding may support the role of PKA as a potential druggable target in the neuroendocrine tumors of the pancreatic gland. Materials and methods Animal studies All mice were housed

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-16-0443
Volume/Issue:
Volume 24: Issue 1
Free access