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Second Department of Medicine, Department of Genetics, First Department of Surgery, Department of Urology, Molecular Medicine Research Group, Gedeon Richter Ltd, Division of Endocrinology, Research Group of Inflammation Biology and Immunogenomics, Faculty of Medicine, Semmelweis University, Szentkirályi Street 46, H-1088 Budapest, Hungary
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alterations. GSEA determines whether a priori or a user-defined set of genes shows statistically significant, concordant differences between two biological states (e.g. phenotypes). GSEA analyses gene expression data by rank statistics, and determines
School of Medicine and Public Health Molecular and Environmental Toxicology Center
School of Medicine and Public Health University of Wisconsin Carbone Cancer Center, University of Wisconsin, 1111 Highland Avenue, Madison, Wisconsin 53705, USA
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School of Medicine and Public Health Molecular and Environmental Toxicology Center
School of Medicine and Public Health University of Wisconsin Carbone Cancer Center, University of Wisconsin, 1111 Highland Avenue, Madison, Wisconsin 53705, USA
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School of Medicine and Public Health Molecular and Environmental Toxicology Center
School of Medicine and Public Health University of Wisconsin Carbone Cancer Center, University of Wisconsin, 1111 Highland Avenue, Madison, Wisconsin 53705, USA
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School of Medicine and Public Health Molecular and Environmental Toxicology Center
School of Medicine and Public Health University of Wisconsin Carbone Cancer Center, University of Wisconsin, 1111 Highland Avenue, Madison, Wisconsin 53705, USA
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School of Medicine and Public Health Molecular and Environmental Toxicology Center
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School of Medicine and Public Health Molecular and Environmental Toxicology Center
School of Medicine and Public Health University of Wisconsin Carbone Cancer Center, University of Wisconsin, 1111 Highland Avenue, Madison, Wisconsin 53705, USA
McArdle Laboratory for Cancer Research Department of Oncology, School of Medicine and Public Health
School of Medicine and Public Health Molecular and Environmental Toxicology Center
School of Medicine and Public Health University of Wisconsin Carbone Cancer Center, University of Wisconsin, 1111 Highland Avenue, Madison, Wisconsin 53705, USA
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School of Medicine and Public Health Molecular and Environmental Toxicology Center
School of Medicine and Public Health University of Wisconsin Carbone Cancer Center, University of Wisconsin, 1111 Highland Avenue, Madison, Wisconsin 53705, USA
McArdle Laboratory for Cancer Research Department of Oncology, School of Medicine and Public Health
School of Medicine and Public Health Molecular and Environmental Toxicology Center
School of Medicine and Public Health University of Wisconsin Carbone Cancer Center, University of Wisconsin, 1111 Highland Avenue, Madison, Wisconsin 53705, USA
McArdle Laboratory for Cancer Research Department of Oncology, School of Medicine and Public Health
School of Medicine and Public Health Molecular and Environmental Toxicology Center
School of Medicine and Public Health University of Wisconsin Carbone Cancer Center, University of Wisconsin, 1111 Highland Avenue, Madison, Wisconsin 53705, USA
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treated ACI rats as well as to recent historical data from identically treated ACI and COP rats. Median latency was derived from Kaplan–Meier analyses. The log rank test was used to compare latencies between strains and to calculate the relative risk of
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variables. For ordered categorical variables, a trend P -value was calculated based on an ordinal variable corresponding to rank (lowest to highest). Logistic regression was used to calculate odds ratio (ORs) and 95% CIs for risk of total prostate cancer
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Breast Biology Group, Department of Medical Oncology, Breast Cancer Now Research Unit, Institute of Cancer Sciences, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK
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, including receptor activator of nuclear factor-kappa B ligand (RANKL) and WNT4, secreted from PR + sensor cells and acting on PR − stem cells, expressing the RANK receptor and Wnt receptors, such as Frizzled (FZD) and LRP5/6 ( Graham et al . 2009
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Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
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Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
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Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
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Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
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Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
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Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
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Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
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Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
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were compared using log-rank test. Overall survival was the period from the time of diagnosis until the end of follow-up or death of the patient. For overall survival analysis, survival was censored if patients were still alive at the end of the follow
Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden
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Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden
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Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden
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Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden
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Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden
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Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden
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Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden
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Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden
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Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden
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with survival was studied using Kaplan–Meier plots, and the curves for each group were compared by log-rank test. All the analyses were two-tailed and P values <0.05 were considered significant. Results Deregulated miRNAs in ACC In this study, we
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cells in bone, including receptor activator of nuclear factor-κB (RANK) ligand, PTH-related protein (PTHrP), interleukins 1 and 6, and macrophage inflammatory protein-1-alpha ( Roodman 2001 ). The activation of Oc induces bone resorption and release of
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Department of Pathology and Laboratory Medicine, Dan L. Duncan Cancer Center, Department of Pathology and Immunology, Department of Veterans Affairs, University of Texas Health Sciences Center Medical School, Houston, Texas, USA
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Department of Pathology and Laboratory Medicine, Dan L. Duncan Cancer Center, Department of Pathology and Immunology, Department of Veterans Affairs, University of Texas Health Sciences Center Medical School, Houston, Texas, USA
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variables as well as the panel of 46 previously studied TMA biomarkers was evaluated using Spearman's rank correlation. There was no formal adjustment for multiple comparisons, although a more stringent α =0.01 was used. Kaplan–Meier survival curves and log
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calculated using the log-rank test. Uni- and multivariate analyses were evaluated by a Cox’s proportional hazard model using PROC PHREG in our SAS software. Cells and chemicals MCF-7 human breast cancer cell line and LY
Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France
Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France
Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France
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Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France
Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France
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Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France
Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France
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Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France
Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France
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Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France
Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France
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Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France
Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France
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Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France
Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France
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Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France
Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France
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. Survival analysis was performed using the Kaplan–Meier method and curves were compared using the log-rank test. High and low expressions for miR-195 and miR-483-5p were defined with reference to the expression cutoff value determined by ROC analyses. A P