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Zsófia Tömböl
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Peter M Szabó
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Viktor Molnár Second Department of Medicine, Department of Genetics, First Department of Surgery, Department of Urology, Molecular Medicine Research Group, Gedeon Richter Ltd, Division of Endocrinology, Research Group of Inflammation Biology and Immunogenomics, Faculty of Medicine, Semmelweis University, Szentkirályi Street 46, H-1088 Budapest, Hungary

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Zoltán Wiener Second Department of Medicine, Department of Genetics, First Department of Surgery, Department of Urology, Molecular Medicine Research Group, Gedeon Richter Ltd, Division of Endocrinology, Research Group of Inflammation Biology and Immunogenomics, Faculty of Medicine, Semmelweis University, Szentkirályi Street 46, H-1088 Budapest, Hungary

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Gergely Tölgyesi Second Department of Medicine, Department of Genetics, First Department of Surgery, Department of Urology, Molecular Medicine Research Group, Gedeon Richter Ltd, Division of Endocrinology, Research Group of Inflammation Biology and Immunogenomics, Faculty of Medicine, Semmelweis University, Szentkirályi Street 46, H-1088 Budapest, Hungary

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János Horányi Second Department of Medicine, Department of Genetics, First Department of Surgery, Department of Urology, Molecular Medicine Research Group, Gedeon Richter Ltd, Division of Endocrinology, Research Group of Inflammation Biology and Immunogenomics, Faculty of Medicine, Semmelweis University, Szentkirályi Street 46, H-1088 Budapest, Hungary

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Peter Riesz Second Department of Medicine, Department of Genetics, First Department of Surgery, Department of Urology, Molecular Medicine Research Group, Gedeon Richter Ltd, Division of Endocrinology, Research Group of Inflammation Biology and Immunogenomics, Faculty of Medicine, Semmelweis University, Szentkirályi Street 46, H-1088 Budapest, Hungary

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Peter Reismann
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Attila Patócs Second Department of Medicine, Department of Genetics, First Department of Surgery, Department of Urology, Molecular Medicine Research Group, Gedeon Richter Ltd, Division of Endocrinology, Research Group of Inflammation Biology and Immunogenomics, Faculty of Medicine, Semmelweis University, Szentkirályi Street 46, H-1088 Budapest, Hungary

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István Likó Second Department of Medicine, Department of Genetics, First Department of Surgery, Department of Urology, Molecular Medicine Research Group, Gedeon Richter Ltd, Division of Endocrinology, Research Group of Inflammation Biology and Immunogenomics, Faculty of Medicine, Semmelweis University, Szentkirályi Street 46, H-1088 Budapest, Hungary

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Rolf-Christian Gaillard Second Department of Medicine, Department of Genetics, First Department of Surgery, Department of Urology, Molecular Medicine Research Group, Gedeon Richter Ltd, Division of Endocrinology, Research Group of Inflammation Biology and Immunogenomics, Faculty of Medicine, Semmelweis University, Szentkirályi Street 46, H-1088 Budapest, Hungary

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András Falus Second Department of Medicine, Department of Genetics, First Department of Surgery, Department of Urology, Molecular Medicine Research Group, Gedeon Richter Ltd, Division of Endocrinology, Research Group of Inflammation Biology and Immunogenomics, Faculty of Medicine, Semmelweis University, Szentkirályi Street 46, H-1088 Budapest, Hungary
Second Department of Medicine, Department of Genetics, First Department of Surgery, Department of Urology, Molecular Medicine Research Group, Gedeon Richter Ltd, Division of Endocrinology, Research Group of Inflammation Biology and Immunogenomics, Faculty of Medicine, Semmelweis University, Szentkirályi Street 46, H-1088 Budapest, Hungary

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Károly Rácz
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Peter Igaz
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alterations. GSEA determines whether a priori or a user-defined set of genes shows statistically significant, concordant differences between two biological states (e.g. phenotypes). GSEA analyses gene expression data by rank statistics, and determines

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Kirsten L Dennison McArdle Laboratory for Cancer Research Department of Oncology, School of Medicine and Public Health

School of Medicine and Public Health Molecular and Environmental Toxicology Center

School of Medicine and Public Health University of Wisconsin Carbone Cancer Center, University of Wisconsin, 1111 Highland Avenue, Madison, Wisconsin 53705, USA

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Nyssa Becker Samanas McArdle Laboratory for Cancer Research Department of Oncology, School of Medicine and Public Health

School of Medicine and Public Health Molecular and Environmental Toxicology Center

School of Medicine and Public Health University of Wisconsin Carbone Cancer Center, University of Wisconsin, 1111 Highland Avenue, Madison, Wisconsin 53705, USA

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Quincy Eckert Harenda McArdle Laboratory for Cancer Research Department of Oncology, School of Medicine and Public Health

School of Medicine and Public Health Molecular and Environmental Toxicology Center

School of Medicine and Public Health University of Wisconsin Carbone Cancer Center, University of Wisconsin, 1111 Highland Avenue, Madison, Wisconsin 53705, USA

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Maureen Peters Hickman McArdle Laboratory for Cancer Research Department of Oncology, School of Medicine and Public Health

School of Medicine and Public Health Molecular and Environmental Toxicology Center

School of Medicine and Public Health University of Wisconsin Carbone Cancer Center, University of Wisconsin, 1111 Highland Avenue, Madison, Wisconsin 53705, USA

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Nicole L Seiler McArdle Laboratory for Cancer Research Department of Oncology, School of Medicine and Public Health

School of Medicine and Public Health Molecular and Environmental Toxicology Center

School of Medicine and Public Health University of Wisconsin Carbone Cancer Center, University of Wisconsin, 1111 Highland Avenue, Madison, Wisconsin 53705, USA

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Lina Ding McArdle Laboratory for Cancer Research Department of Oncology, School of Medicine and Public Health

School of Medicine and Public Health Molecular and Environmental Toxicology Center

School of Medicine and Public Health University of Wisconsin Carbone Cancer Center, University of Wisconsin, 1111 Highland Avenue, Madison, Wisconsin 53705, USA
McArdle Laboratory for Cancer Research Department of Oncology, School of Medicine and Public Health

School of Medicine and Public Health Molecular and Environmental Toxicology Center

School of Medicine and Public Health University of Wisconsin Carbone Cancer Center, University of Wisconsin, 1111 Highland Avenue, Madison, Wisconsin 53705, USA

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James D Shull McArdle Laboratory for Cancer Research Department of Oncology, School of Medicine and Public Health

School of Medicine and Public Health Molecular and Environmental Toxicology Center

School of Medicine and Public Health University of Wisconsin Carbone Cancer Center, University of Wisconsin, 1111 Highland Avenue, Madison, Wisconsin 53705, USA
McArdle Laboratory for Cancer Research Department of Oncology, School of Medicine and Public Health

School of Medicine and Public Health Molecular and Environmental Toxicology Center

School of Medicine and Public Health University of Wisconsin Carbone Cancer Center, University of Wisconsin, 1111 Highland Avenue, Madison, Wisconsin 53705, USA
McArdle Laboratory for Cancer Research Department of Oncology, School of Medicine and Public Health

School of Medicine and Public Health Molecular and Environmental Toxicology Center

School of Medicine and Public Health University of Wisconsin Carbone Cancer Center, University of Wisconsin, 1111 Highland Avenue, Madison, Wisconsin 53705, USA

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treated ACI rats as well as to recent historical data from identically treated ACI and COP rats. Median latency was derived from Kaplan–Meier analyses. The log rank test was used to compare latencies between strains and to calculate the relative risk of

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Cindy H Chau Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA

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Cathee Till SWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

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Douglas K Price Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA

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Phyllis J Goodman SWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

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Marian L Neuhouser Cancer Prevention Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

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Michael N Pollak Department of Oncology and Medicine, McGill University, Montreal, Canada

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Ian M Thompson CHRISTUS Santa Rosa Hospital Medical Center, San Antonio, Texas, USA

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William D Figg Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA

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variables. For ordered categorical variables, a trend P  -value was calculated based on an ordinal variable corresponding to rank (lowest to highest). Logistic regression was used to calculate odds ratio (ORs) and 95% CIs for risk of total prostate cancer

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Bruno M Simões Breast Biology Group, Department of Medical Oncology, Breast Cancer Now Research Unit, Institute of Cancer Sciences, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK

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Denis G Alferez Breast Biology Group, Department of Medical Oncology, Breast Cancer Now Research Unit, Institute of Cancer Sciences, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK

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Sacha J Howell Breast Biology Group, Department of Medical Oncology, Breast Cancer Now Research Unit, Institute of Cancer Sciences, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK
Breast Biology Group, Department of Medical Oncology, Breast Cancer Now Research Unit, Institute of Cancer Sciences, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK

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Robert B Clarke Breast Biology Group, Department of Medical Oncology, Breast Cancer Now Research Unit, Institute of Cancer Sciences, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK

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, including receptor activator of nuclear factor-kappa B ligand (RANKL) and WNT4, secreted from PR + sensor cells and acting on PR − stem cells, expressing the RANK receptor and Wnt receptors, such as Frizzled (FZD) and LRP5/6 ( Graham et al . 2009

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Stefano Caramuta Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden

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Linkiat Lee Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden

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Deniz M Özata Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden

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Pinar Akçakaya Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden

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Hong Xie Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden

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Anders Höög Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden

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Jan Zedenius Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden

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Martin Bäckdahl Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden

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Catharina Larsson Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden

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Weng-Onn Lui Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden

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were compared using log-rank test. Overall survival was the period from the time of diagnosis until the end of follow-up or death of the patient. For overall survival analysis, survival was censored if patients were still alive at the end of the follow

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Deniz M Özata Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden
Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden

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Stefano Caramuta Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden
Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden

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David Velázquez-Fernández Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden
Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden

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Pinar Akçakaya Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden
Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden

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Hong Xie Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden
Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden

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Anders Höög Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden

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Jan Zedenius Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden
Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden

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Martin Bäckdahl Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden
Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden

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Catharina Larsson Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden
Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden

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Weng-Onn Lui Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden
Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden

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with survival was studied using Kaplan–Meier plots, and the curves for each group were compared by log-rank test. All the analyses were two-tailed and P values <0.05 were considered significant. Results Deregulated miRNAs in ACC In this study, we

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Caroline Wilson Academic Unit of Clinical Oncology, Weston Park Hospital, University of Sheffield, Sheffield, UK

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Hannah Brown Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK

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Ingunn Holen Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK

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cells in bone, including receptor activator of nuclear factor-κB (RANK) ligand, PTH-related protein (PTHrP), interleukins 1 and 6, and macrophage inflammatory protein-1-alpha ( Roodman 2001 ). The activation of Oc induces bone resorption and release of

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Gustavo Ayala Department of Pathology and Laboratory Medicine, Dan L. Duncan Cancer Center, Department of Pathology and Immunology, Department of Veterans Affairs, University of Texas Health Sciences Center Medical School, Houston, Texas, USA

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Anna Frolov Department of Pathology and Laboratory Medicine, Dan L. Duncan Cancer Center, Department of Pathology and Immunology, Department of Veterans Affairs, University of Texas Health Sciences Center Medical School, Houston, Texas, USA
Department of Pathology and Laboratory Medicine, Dan L. Duncan Cancer Center, Department of Pathology and Immunology, Department of Veterans Affairs, University of Texas Health Sciences Center Medical School, Houston, Texas, USA

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Deyali Chatterjee Department of Pathology and Laboratory Medicine, Dan L. Duncan Cancer Center, Department of Pathology and Immunology, Department of Veterans Affairs, University of Texas Health Sciences Center Medical School, Houston, Texas, USA

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Dandan He Department of Pathology and Laboratory Medicine, Dan L. Duncan Cancer Center, Department of Pathology and Immunology, Department of Veterans Affairs, University of Texas Health Sciences Center Medical School, Houston, Texas, USA

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Susan Hilsenbeck Department of Pathology and Laboratory Medicine, Dan L. Duncan Cancer Center, Department of Pathology and Immunology, Department of Veterans Affairs, University of Texas Health Sciences Center Medical School, Houston, Texas, USA

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Michael Ittmann Department of Pathology and Laboratory Medicine, Dan L. Duncan Cancer Center, Department of Pathology and Immunology, Department of Veterans Affairs, University of Texas Health Sciences Center Medical School, Houston, Texas, USA
Department of Pathology and Laboratory Medicine, Dan L. Duncan Cancer Center, Department of Pathology and Immunology, Department of Veterans Affairs, University of Texas Health Sciences Center Medical School, Houston, Texas, USA

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variables as well as the panel of 46 previously studied TMA biomarkers was evaluated using Spearman's rank correlation. There was no formal adjustment for multiple comparisons, although a more stringent α =0.01 was used. Kaplan–Meier survival curves and log

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Takashi Suzuki
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Akio Inoue
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Yasuhiro Miki
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Takuya Moriya
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Jun-ichi Akahira
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Takanori Ishida
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Hisashi Hirakawa
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Yuri Yamaguchi
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Shin-ichi Hayashi
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Hironobu Sasano
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calculated using the log-rank test. Uni- and multivariate analyses were evaluated by a Cox’s proportional hazard model using PROC PHREG in our SAS software. Cells and chemicals MCF-7 human breast cancer cell line and LY

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O Chabre Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France
Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France
Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France
Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France

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R Libé Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France
Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France
Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France

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G Assie Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France
Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France
Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France

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O Barreau Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France
Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France
Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France

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J Bertherat Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France
Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France
Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France

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X Bertagna Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France
Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France
Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France

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J-J Feige Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France
Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France
Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France

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N Cherradi Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France
Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France
Institut National de la Santé et de la Recherche Médicale, Department of Endocrinology, Commissariat à l'Energie Atomique, Lab. BCI, Paris Descartes University, Centre National de la Recherche Scientifique UMR 8104, Department of Endocrinology, Unité 1036, 17, Rue des Martyrs, F-38054 Grenoble Cedex 09, France

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. Survival analysis was performed using the Kaplan–Meier method and curves were compared using the log-rank test. High and low expressions for miR-195 and miR-483-5p were defined with reference to the expression cutoff value determined by ROC analyses. A P

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