Search Results
Division of Biomedical Informatics & Personalized Medicine, Department of Medicine, University of Colorado School of Medicine at Colorado Anschutz Medical Campus Aurora, Aurora, Colorado, USA
Search for other papers by Nikita Pozdeyev in
Google Scholar
PubMed
Division of Biomedical Informatics & Personalized Medicine, Department of Medicine, University of Colorado School of Medicine at Colorado Anschutz Medical Campus Aurora, Aurora, Colorado, USA
Search for other papers by Lauren Fishbein in
Google Scholar
PubMed
Search for other papers by Laurie M Gay in
Google Scholar
PubMed
Search for other papers by Ethan S Sokol in
Google Scholar
PubMed
Search for other papers by Ryan Hartmaier in
Google Scholar
PubMed
Departments of Pathology and Urology, Upstate Medical University, Syracuse, New York, USA
Search for other papers by Jeffrey S Ross in
Google Scholar
PubMed
Search for other papers by Sourat Darabi in
Google Scholar
PubMed
Translational Genomics Research Institute, Phoenix, Arizona, USA
Search for other papers by Michael J Demeure in
Google Scholar
PubMed
Search for other papers by Adwitiya Kar in
Google Scholar
PubMed
Search for other papers by Lindsey J Foust in
Google Scholar
PubMed
Search for other papers by Katrina Koc in
Google Scholar
PubMed
Search for other papers by Daniel W Bowles in
Google Scholar
PubMed
Search for other papers by Stephen Leong in
Google Scholar
PubMed
Research Service Veterans Affairs Medical Center, Aurora, Colorado, USA
Search for other papers by Margaret E Wierman in
Google Scholar
PubMed
Research Service Veterans Affairs Medical Center, Aurora, Colorado, USA
Search for other papers by Katja Kiseljak-Vassiliades in
Google Scholar
PubMed
identifying novel genetic alterations and understanding the percent targetable alterations for therapeutic intervention. Our analysis confirmed the commonly known pathway alterations in ACC and identified several novel somatic alterations. Importantly, we
Search for other papers by Soazig Le Pennec in
Google Scholar
PubMed
Search for other papers by Tomasz Konopka in
Google Scholar
PubMed
Search for other papers by David Gacquer in
Google Scholar
PubMed
Search for other papers by Danai Fimereli in
Google Scholar
PubMed
Search for other papers by Maxime Tarabichi in
Google Scholar
PubMed
Search for other papers by Gil Tomás in
Google Scholar
PubMed
IRIBHM, WELBIO, CHU d'Angers, EA 3143, Service d'Anatomie et Cytologie Pathologiques, Hôpital Pitié-Salpêtrière, Institut Jules Bordet, Université libre de Bruxelles (ULB), Campus Erasme, 808 Route de Lennik, 1070 Brussels, Belgium
Search for other papers by Frédérique Savagner in
Google Scholar
PubMed
Search for other papers by Myriam Decaussin-Petrucci in
Google Scholar
PubMed
Search for other papers by Christophe Trésallet in
Google Scholar
PubMed
Search for other papers by Guy Andry in
Google Scholar
PubMed
Search for other papers by Denis Larsimont in
Google Scholar
PubMed
Search for other papers by Vincent Detours in
Google Scholar
PubMed
IRIBHM, WELBIO, CHU d'Angers, EA 3143, Service d'Anatomie et Cytologie Pathologiques, Hôpital Pitié-Salpêtrière, Institut Jules Bordet, Université libre de Bruxelles (ULB), Campus Erasme, 808 Route de Lennik, 1070 Brussels, Belgium
Search for other papers by Carine Maenhaut in
Google Scholar
PubMed
the basis of multiple genetic alterations, i.e. non-synonymous single-nucleotide variants (nsSNVs), gene fusions, alternative transcripts, and loss of heterozygosity (LOH). Materials and methods Case description A 71-year-old male was diagnosed with a
Search for other papers by Iñigo Landa in
Google Scholar
PubMed
Search for other papers by Cristina Montero-Conde in
Google Scholar
PubMed
Hereditary Endocrine Cancer Group, University Magna Graecia, Institute for Genetic Research IRGS, Genotyping Unit, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Human Cancer Genetics Programme, Spanish National Cancer Centre, Centro Nacional de Investigaciones Oncológicas (CNIO), Calle Melchor Fernández Almagro, 3, 28029 Madrid, Spain
Search for other papers by Donatella Malanga in
Google Scholar
PubMed
Search for other papers by Silvia De Gisi in
Google Scholar
PubMed
Search for other papers by Guillermo Pita in
Google Scholar
PubMed
Search for other papers by Luis-Javier Leandro-García in
Google Scholar
PubMed
Search for other papers by Lucía Inglada-Pérez in
Google Scholar
PubMed
Search for other papers by Rocío Letón in
Google Scholar
PubMed
Hereditary Endocrine Cancer Group, University Magna Graecia, Institute for Genetic Research IRGS, Genotyping Unit, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Human Cancer Genetics Programme, Spanish National Cancer Centre, Centro Nacional de Investigaciones Oncológicas (CNIO), Calle Melchor Fernández Almagro, 3, 28029 Madrid, Spain
Search for other papers by Carmela De Marco in
Google Scholar
PubMed
Hereditary Endocrine Cancer Group, University Magna Graecia, Institute for Genetic Research IRGS, Genotyping Unit, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Human Cancer Genetics Programme, Spanish National Cancer Centre, Centro Nacional de Investigaciones Oncológicas (CNIO), Calle Melchor Fernández Almagro, 3, 28029 Madrid, Spain
Search for other papers by Cristina Rodríguez-Antona in
Google Scholar
PubMed
Hereditary Endocrine Cancer Group, University Magna Graecia, Institute for Genetic Research IRGS, Genotyping Unit, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Human Cancer Genetics Programme, Spanish National Cancer Centre, Centro Nacional de Investigaciones Oncológicas (CNIO), Calle Melchor Fernández Almagro, 3, 28029 Madrid, Spain
Search for other papers by Giuseppe Viglietto in
Google Scholar
PubMed
Hereditary Endocrine Cancer Group, University Magna Graecia, Institute for Genetic Research IRGS, Genotyping Unit, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Human Cancer Genetics Programme, Spanish National Cancer Centre, Centro Nacional de Investigaciones Oncológicas (CNIO), Calle Melchor Fernández Almagro, 3, 28029 Madrid, Spain
Search for other papers by Mercedes Robledo in
Google Scholar
PubMed
tumours (3%), referred to as ‘medullary thyroid carcinoma’ (MTC), arise from a different cell lineage, the parafollicular or C-cells, which are involved in calcitonin secretion ( Randolph & Maniar 2000 ). Different genetic alterations, all of them
Search for other papers by Susan J Hsiao in
Google Scholar
PubMed
Search for other papers by Yuri E Nikiforov in
Google Scholar
PubMed
discussed in further detail below. Utility of mutational molecular markers in preoperative FNA samples BRAF and RAS point mutations and RET/PTC and PAX8/PPARγ rearrangements are the most common genetic alterations found in thyroid cancer and have been
Institute of Pathology and Immunology of the University of Porto (IPATIMUP), Department of Pathology, Portugese Institute of Oncology, Department of Pathology, Rua Roberto Frias s/n, 4200-465 Porto, Portugal
Search for other papers by Valdemar Máximo in
Google Scholar
PubMed
Institute of Pathology and Immunology of the University of Porto (IPATIMUP), Department of Pathology, Portugese Institute of Oncology, Department of Pathology, Rua Roberto Frias s/n, 4200-465 Porto, Portugal
Search for other papers by Jorge Lima in
Google Scholar
PubMed
Institute of Pathology and Immunology of the University of Porto (IPATIMUP), Department of Pathology, Portugese Institute of Oncology, Department of Pathology, Rua Roberto Frias s/n, 4200-465 Porto, Portugal
Search for other papers by Hugo Prazeres in
Google Scholar
PubMed
Institute of Pathology and Immunology of the University of Porto (IPATIMUP), Department of Pathology, Portugese Institute of Oncology, Department of Pathology, Rua Roberto Frias s/n, 4200-465 Porto, Portugal
Search for other papers by Paula Soares in
Google Scholar
PubMed
Institute of Pathology and Immunology of the University of Porto (IPATIMUP), Department of Pathology, Portugese Institute of Oncology, Department of Pathology, Rua Roberto Frias s/n, 4200-465 Porto, Portugal
Institute of Pathology and Immunology of the University of Porto (IPATIMUP), Department of Pathology, Portugese Institute of Oncology, Department of Pathology, Rua Roberto Frias s/n, 4200-465 Porto, Portugal
Search for other papers by Manuel Sobrinho-Simões in
Google Scholar
PubMed
divided for the sake of simplicity into two categories: genetic alterations that are linked with the three main histotypes of follicular cell-derived thyroid carcinomas (FTC, PTC, and PDTC) and the genetic alterations that are linked to the acquisition of
Department of Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden
Search for other papers by C Christofer Juhlin in
Google Scholar
PubMed
Endocrine Oncology Site, Princess Margaret Cancer Centre, Toronto, ON, Canada
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
Search for other papers by Ozgur Mete in
Google Scholar
PubMed
Search for other papers by Zubair W Baloch in
Google Scholar
PubMed
signaling, indicating a relationship between FTCs and FVPTCs ( Wong et al. 2021 ). In the process of dedifferentiation, additional genetic alterations are usually seen in DHGTCs and PDTCs, including TERT promoter and TP53 gene mutations ( Paulsson et
Search for other papers by Y M H Jonkers in
Google Scholar
PubMed
Search for other papers by S M H Claessen in
Google Scholar
PubMed
Search for other papers by A Perren in
Google Scholar
PubMed
Search for other papers by A M Schmitt in
Google Scholar
PubMed
Search for other papers by L J Hofland in
Google Scholar
PubMed
Search for other papers by W de Herder in
Google Scholar
PubMed
Search for other papers by R R de Krijger in
Google Scholar
PubMed
Search for other papers by A A J Verhofstad in
Google Scholar
PubMed
Search for other papers by A R Hermus in
Google Scholar
PubMed
Search for other papers by J A Kummer in
Google Scholar
PubMed
Search for other papers by B Skogseid in
Google Scholar
PubMed
Search for other papers by M Volante in
Google Scholar
PubMed
Search for other papers by A C Voogd in
Google Scholar
PubMed
Search for other papers by F C S Ramaekers in
Google Scholar
PubMed
Search for other papers by E J M Speel in
Google Scholar
PubMed
the most optimal indicator of tumor-specific death in the other EPTs. From previous studies, it has become clear that malignant progression of EPTs is associated with an accumulation of genetic alterations ( Speel et al. 1999 , 2001
Search for other papers by Raffaele Ciampi in
Google Scholar
PubMed
Search for other papers by Thomas J Giordano in
Google Scholar
PubMed
Search for other papers by Kathryn Wikenheiser-Brokamp in
Google Scholar
PubMed
Search for other papers by Ronald J Koenig in
Google Scholar
PubMed
Search for other papers by Yuri E Nikiforov in
Google Scholar
PubMed
Introduction Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer and accounts for ~80% of all thyroid malignancies ( Hundahl et al. 2000 ). Genetic alterations along the RET/RAS/BRAF/ MAPK signaling
Search for other papers by Katarina Edfeldt in
Google Scholar
PubMed
Search for other papers by Tanveer Ahmad in
Google Scholar
PubMed
Search for other papers by Göran Åkerström in
Google Scholar
PubMed
Search for other papers by Eva Tiensuu Janson in
Google Scholar
PubMed
Search for other papers by Per Hellman in
Google Scholar
PubMed
Search for other papers by Peter Stålberg in
Google Scholar
PubMed
Search for other papers by Peyman Björklund in
Google Scholar
PubMed
Search for other papers by Gunnar Westin in
Google Scholar
PubMed
endocrine tumors . Genes, Chromosomes & Cancer 47 84 – 92 . ( doi:10.1002/gcc.20510 ). Kulke MH Freed E Chiang DY Philips J Zahrieh D Glickman JN Shivdasani RA 2008 High-resolution analysis of genetic alterations in small bowel
Search for other papers by Nitya Raj in
Google Scholar
PubMed
Search for other papers by Youyun Zheng in
Google Scholar
PubMed
Search for other papers by Haley Hauser in
Google Scholar
PubMed
Search for other papers by Joanne Chou in
Google Scholar
PubMed
Search for other papers by Johnathan Rafailov in
Google Scholar
PubMed
Search for other papers by Jad Bou-Ayache in
Google Scholar
PubMed
Search for other papers by Peter Sawan in
Google Scholar
PubMed
Search for other papers by Jamie Chaft in
Google Scholar
PubMed
Search for other papers by Jennifer Chan in
Google Scholar
PubMed
Search for other papers by Kimberly Perez in
Google Scholar
PubMed
Search for other papers by Charles Rudin in
Google Scholar
PubMed
Search for other papers by Laura Tang in
Google Scholar
PubMed
Search for other papers by Diane Reidy-Lagunes in
Google Scholar
PubMed
during treatment with ribociclib and everolimus. In correlative analyses, there was no association between genetic alterations in the tumor of patients experiencing disease stabilization vs progressive disease during treatment with this drug combination