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Carla Colombo Division of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy

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Marina Muzza Laboratory of Endocrine and Metabolic Research, Istituto Auxologico Italiano IRCCS, Milan, Italy

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Gabriele Pogliaghi Laboratory of Endocrine and Metabolic Research, Istituto Auxologico Italiano IRCCS, Milan, Italy

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Sonia Palazzo Pathology Unit, Istituto Auxologico Italiano IRCCS, Milan, Italy

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Guia Vannucchi Division of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy

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Leonardo Vicentini Endocrine Surgery Unit, Istituto Auxologico Italiano IRCCS, Milan, Italy

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Luca Persani Division of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy
Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy

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Giacomo Gazzano Pathology Unit, Istituto Auxologico Italiano IRCCS, Milan, Italy

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Laura Fugazzola Division of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy

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localization . Molecular and Cellular Endocrinology 399 288 – 295 . ( https://doi.org/10.1016/j.mce.2014.10.019 ) Muzza M Colombo C Pogliaghi G Karapanou O Fugazzola L 2020 Molecular markers for the classification of cytologically indeterminate

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-20-0511
Volume/Issue:
Volume 28: Issue 4
Restricted access
Pei-Pei Xu Department of Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China

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Su Zeng Department of Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China

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Xiao-Tian Xia Department of Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China

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Zi-Heng Ye Department of Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China

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Mei-Fang Li Department of Emergency, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China

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Ming-Yun Chen Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Clinical Center for Diabetes, Shanghai, China

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Tian Xia CAS Key Laboratory of Molecular Virology and Immunology, Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China

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Jing-Jing Xu Department of Pathology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China

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Qiong Jiao Department of Pathology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China

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Liang Liu Department of Pathology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China

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Lian-Xi Li Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Clinical Center for Diabetes, Shanghai, China

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Ming-Gao Guo Department of Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China

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highly expressed in FTC tissues, and plays an important role in the carcinogenesis of FTC via Erk1/2 and JNK pathways. Based on FANB and IHC, FAM172A may be a potential molecular marker to differentially diagnose FTC and benign/borderline thyroid

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-20-0181
Volume/Issue:
Volume 27: Issue 11
Open access
Roberto Bellelli Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy

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Maria Domenica Castellone Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy

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Ginesa Garcia-Rostan Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy

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Clara Ugolini Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy

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Carmelo Nucera Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy

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Peter M Sadow Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy

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Tito Claudio Nappi Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy

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Paolo Salerno Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy

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Maria Carmela Cantisani Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy

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Fulvio Basolo Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy

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Tomas Alvarez Gago Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy

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Giuliana Salvatore Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy

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Massimo Santoro Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy

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upregulated in a fraction (28.4%) of PTCs and correlated with aggressive PTC variants (tall-cell) and expression of molecular markers of invasiveness, such as metalloproteases. Here, we show that FOXM1 is significantly increased in ATCs compared with WDTCs

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-12-0031
Volume/Issue:
Volume 19: Issue 5
Free access
Maria Theresa E Montales Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

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Stepan B Melnyk Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
Arkansas Children’s Hospital Research Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

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Shi J Liu Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

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Frank A Simmen Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
The Winthrop P Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

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Y Lucy Liu The Winthrop P Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

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Rosalia C M Simmen Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
The Winthrop P Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

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expression of CDO and HFDO tumors Tumors from CDO and HFDO were further assessed for molecular markers of early pathologic response to Dox, given the comparable numbers of CDO (5 of 12) and HFDO (6 of 12) whose tumors did not decrease in volume with Dox

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-16-0136
Volume/Issue:
Volume 23: Issue 9
Free access
Thais Biude Mendes Genetic Bases of Thyroid Tumors Laboratory, Division of Genetics, Department of Morphology and Genetics, Universidade Federal de São Paulo, São Paulo, Brazil

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Bruno Heidi Nozima Genetic Bases of Thyroid Tumors Laboratory, Division of Genetics, Department of Morphology and Genetics, Universidade Federal de São Paulo, São Paulo, Brazil

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Alexandre Budu Enzymology Laboratory, Department of Biophysics, Universidade Federal de São Paulo, São Paulo, Brazil

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Rodrigo Barbosa de Souza Genetic Bases of Thyroid Tumors Laboratory, Division of Genetics, Department of Morphology and Genetics, Universidade Federal de São Paulo, São Paulo, Brazil

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Marcia Helena Braga Catroxo Laboratory of Electron Microscopy, Center for Research and Development of Animal Health, Instituto Biológico, São Paulo, Brazil

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Rosana Delcelo Department of Pathology, Universidade Federal de São Paulo, São Paulo, Brazil

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Marcos Leoni Gazarini Cell Signaling Laboratory in Plasmodium, Department of Biosciences, Universidade Federal de São Paulo, Santos, São Paulo, Brazil

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Janete Maria Cerutti Genetic Bases of Thyroid Tumors Laboratory, Division of Genetics, Department of Morphology and Genetics, Universidade Federal de São Paulo, São Paulo, Brazil

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). Indeterminate nodules often undergo surgical excision for a definitive diagnosis. For better classification of a disease state and improved clinical decision-making, preoperative molecular markers have been considered. We have previously identified four

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-16-0181
Volume/Issue:
Volume 23: Issue 9
Free access
Jens Waldmann Department of Surgery, Division of Gastroenterology, Department of Pathology, Department of Pathology, Institute of Molecular Biology and Tumor Research, Department of Surgery, University Giessen, Department of Surgery, Center for Minimally Invasive Surgery, Philipps-Universität Marburg, Baldingerstraße, D-35043 Marburg, Germany

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Volker Fendrich Department of Surgery, Division of Gastroenterology, Department of Pathology, Department of Pathology, Institute of Molecular Biology and Tumor Research, Department of Surgery, University Giessen, Department of Surgery, Center for Minimally Invasive Surgery, Philipps-Universität Marburg, Baldingerstraße, D-35043 Marburg, Germany

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Julia Holler Department of Surgery, Division of Gastroenterology, Department of Pathology, Department of Pathology, Institute of Molecular Biology and Tumor Research, Department of Surgery, University Giessen, Department of Surgery, Center for Minimally Invasive Surgery, Philipps-Universität Marburg, Baldingerstraße, D-35043 Marburg, Germany

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Malte Buchholz Department of Surgery, Division of Gastroenterology, Department of Pathology, Department of Pathology, Institute of Molecular Biology and Tumor Research, Department of Surgery, University Giessen, Department of Surgery, Center for Minimally Invasive Surgery, Philipps-Universität Marburg, Baldingerstraße, D-35043 Marburg, Germany

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Ernst Heinmöller Department of Surgery, Division of Gastroenterology, Department of Pathology, Department of Pathology, Institute of Molecular Biology and Tumor Research, Department of Surgery, University Giessen, Department of Surgery, Center for Minimally Invasive Surgery, Philipps-Universität Marburg, Baldingerstraße, D-35043 Marburg, Germany

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Peter Langer Department of Surgery, Division of Gastroenterology, Department of Pathology, Department of Pathology, Institute of Molecular Biology and Tumor Research, Department of Surgery, University Giessen, Department of Surgery, Center for Minimally Invasive Surgery, Philipps-Universität Marburg, Baldingerstraße, D-35043 Marburg, Germany

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Annette Ramaswamy Department of Surgery, Division of Gastroenterology, Department of Pathology, Department of Pathology, Institute of Molecular Biology and Tumor Research, Department of Surgery, University Giessen, Department of Surgery, Center for Minimally Invasive Surgery, Philipps-Universität Marburg, Baldingerstraße, D-35043 Marburg, Germany

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Birgit Samans Department of Surgery, Division of Gastroenterology, Department of Pathology, Department of Pathology, Institute of Molecular Biology and Tumor Research, Department of Surgery, University Giessen, Department of Surgery, Center for Minimally Invasive Surgery, Philipps-Universität Marburg, Baldingerstraße, D-35043 Marburg, Germany

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Martin K Walz Department of Surgery, Division of Gastroenterology, Department of Pathology, Department of Pathology, Institute of Molecular Biology and Tumor Research, Department of Surgery, University Giessen, Department of Surgery, Center for Minimally Invasive Surgery, Philipps-Universität Marburg, Baldingerstraße, D-35043 Marburg, Germany

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Matthias Rothmund Department of Surgery, Division of Gastroenterology, Department of Pathology, Department of Pathology, Institute of Molecular Biology and Tumor Research, Department of Surgery, University Giessen, Department of Surgery, Center for Minimally Invasive Surgery, Philipps-Universität Marburg, Baldingerstraße, D-35043 Marburg, Germany

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Detlef K Bartsch Department of Surgery, Division of Gastroenterology, Department of Pathology, Department of Pathology, Institute of Molecular Biology and Tumor Research, Department of Surgery, University Giessen, Department of Surgery, Center for Minimally Invasive Surgery, Philipps-Universität Marburg, Baldingerstraße, D-35043 Marburg, Germany

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Emily P Slater Department of Surgery, Division of Gastroenterology, Department of Pathology, Department of Pathology, Institute of Molecular Biology and Tumor Research, Department of Surgery, University Giessen, Department of Surgery, Center for Minimally Invasive Surgery, Philipps-Universität Marburg, Baldingerstraße, D-35043 Marburg, Germany

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benign from malignant PC is not reliable. Malignancy is only proven by the presence of distant or lymph node metastases. Efforts have been made to establish molecular markers for malignancy such as overexpression of HSP90, human telomerase reverse

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-09-0118
Volume/Issue:
Volume 17: Issue 3
Free access
Segolene Hescot Department of Nuclear Medicine, Institut Curie, Saint-Cloud, France

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Abir Al Ghuzlan Department of Pathology, Gustave Roussy and Paris Saclay University, Villejuif, France

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Theophraste Henry Department of Nuclear Medicine and Endocrine Oncology, Gustave Roussy and Paris Saclay University, Villejuif, France

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Hala Sheikh-Alard Department of Pathology, Gustave Roussy and Paris Saclay University, Villejuif, France

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Livia Lamartina Department of Nuclear Medicine and Endocrine Oncology, Gustave Roussy and Paris Saclay University, Villejuif, France

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Isabelle Borget Department of Biostatistics, Gustave Roussy and Paris Saclay University, Villejuif, France

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Julien Hadoux Department of Nuclear Medicine and Endocrine Oncology, Gustave Roussy and Paris Saclay University, Villejuif, France

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Eric Baudin Department of Nuclear Medicine and Endocrine Oncology, Gustave Roussy and Paris Saclay University, Villejuif, France

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Corinne Dupuy UMR 8200 CNRS, Gustave Roussy and Paris Saclay University, Villejuif, France

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Alyaksandr V Nikitski Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

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Yuri E Nikiforov Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

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Martin Schlumberger Department of Nuclear Medicine and Endocrine Oncology, Gustave Roussy and Paris Saclay University, Villejuif, France

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Marina N Nikiforova Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

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Sophie Leboulleux Department of Nuclear Medicine and Endocrine Oncology, Gustave Roussy and Paris Saclay University, Villejuif, France
Department of Endocrinology, Hôpitaux Universitaires de Genève, Geneva, Switzerland

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profiles in this study revealed the presence of molecular markers that can be potentially used for targeted therapies. Among them, two tumors carried NTRK3 fusions, which are targetable by specific and NTRK inhibitors (entrectinib, larotrectinib) with

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-22-0151
Volume/Issue:
Volume 29: Issue 11
Restricted access
Li Cong
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Jessica Gasser
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Jessica Zhao
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Baofeng Yang
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Fanghong Li
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Allan Z Zhao
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correlated with its poor prognosis ( Nikaido et al. 1996 ). Similarly, one of the molecular markers of endometrial cancer cells is the elevated level of cyclin E2 ( Oshita et al. 2002 ), which also helps to propel the progression from G 1 - to S

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-07-0065
Volume/Issue:
Volume 14: Issue 3
Free access
Stephen Hiscox
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L Morgan
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Tim Green
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Robert I Nicholson
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. Tovey S , Dunne B, Witton CJ, Forsyth A, Cooke TG & Bartlett JM 2005 Can molecular markers predict when to implement treatment with aromatase inhibitors in invasive breast cancer? Clinical Cancer Research 11 4835 –4842

Article Type:
Research Article
DOI:
https://doi.org/10.1677/erc.1.01297
Volume/Issue:
Volume 13: Issue Supplement_1
Free access
Lauren N Pontius Duke University Medical Center, Durham, North Carolina, USA

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Linda M Youngwirth Duke University Medical Center, Durham, North Carolina, USA

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Samantha M Thomas Duke University Medical Center, Durham, North Carolina, USA

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Randall P Scheri Duke University Medical Center, Durham, North Carolina, USA

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Sanziana A Roman Duke University Medical Center, Durham, North Carolina, USA

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Julie A Sosa Duke University Medical Center, Durham, North Carolina, USA

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audited. An additional limitation of this study is that NCDB only reports overall survival, without disease-specific survival or recurrence data. Also, the NCDB does not include novel predictors of outcomes, such as molecular markers. As this study is

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-16-0123
Volume/Issue:
Volume 23: Issue 7
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