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M C F Mulders Department of Internal Medicine, ENETS Center of Excellence, Section of Endocrinology, Erasmus Medical Center and Erasmus Medical Center Cancer Institute, Rotterdam, The Netherlands

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Q G de Lussanet de la Sablonière Department of Radiology and Nuclear Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

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M L F van Velthuysen Department of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands

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E M Roes Department of Gynecologic Oncology, Erasmus Medical Center Cancer Institute, Rotterdam, The Netherlands

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J Hofland Department of Internal Medicine, ENETS Center of Excellence, Section of Endocrinology, Erasmus Medical Center and Erasmus Medical Center Cancer Institute, Rotterdam, The Netherlands

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W W de Herder Department of Internal Medicine, ENETS Center of Excellence, Section of Endocrinology, Erasmus Medical Center and Erasmus Medical Center Cancer Institute, Rotterdam, The Netherlands

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were either having histologically proven NOM or somatostatin receptor (SSTR) functional imaging suggesting the presence of NOM. Patients with neuroendocrine carcinomas and those with a non-midgut primary origin (including ovarian) were excluded. For

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-23-0035
Volume/Issue:
Volume 30: Issue 8
Restricted access
Mohid S Khan Neuroendocrine Tumour Unit, Centre for Gastroenterology, Royal Free Hospital, 10th Floor, London NW3 2QG, UK

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Martyn E Caplin Neuroendocrine Tumour Unit, Centre for Gastroenterology, Royal Free Hospital, 10th Floor, London NW3 2QG, UK

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Efficacy of radionuclide treatment DOTATATE Y-90 in patients with progressive metastatic gastroenteropancreatic neuroendocrine carcinomas (GEP-NETs): a phase II study . Annals of Oncology 21 787 – 794 . doi:10.1093/annonc/mdp372 . Cybulla M Weiner

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-10-0271
Volume/Issue:
Volume 18: Issue S1
Free access
Bristi Basu Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK

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Bhawna Sirohi Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK

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Pippa Corrie Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK

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S Giannetta L Cerea G Pedrazzoli P Schiavetto I Napolitano M Veronese S Bramerio E Gambacorta M Vanzulli A 2005 Treatment of metastatic neuroendocrine carcinomas based on WHO classification

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-09-0108
Volume/Issue:
Volume 17: Issue 1
Free access
Tiago Bordeira Gaspar i3S – Instituto de Investigação e Inovação em Saúde, Porto, Portugal
Ipatimup – Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Porto, Portugal
ICBAS – Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto, Porto, Portugal
FMUP – Faculdade de Medicina da Universidade do Porto, Porto, Portugal

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José Manuel Lopes i3S – Instituto de Investigação e Inovação em Saúde, Porto, Portugal
Ipatimup – Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Porto, Portugal
FMUP – Faculdade de Medicina da Universidade do Porto, Porto, Portugal
Department of Pathology, Centro Hospitalar e Universitário de São João, Porto, Portugal

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Paula Soares i3S – Instituto de Investigação e Inovação em Saúde, Porto, Portugal
Ipatimup – Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Porto, Portugal
FMUP – Faculdade de Medicina da Universidade do Porto, Porto, Portugal

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João Vinagre i3S – Instituto de Investigação e Inovação em Saúde, Porto, Portugal
Ipatimup – Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Porto, Portugal
FMUP – Faculdade de Medicina da Universidade do Porto, Porto, Portugal

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%) that could either be WD (PanNETs G3) or poorly differentiated (PD) pancreatic neuroendocrine carcinomas (PanNECs). Long-term survival is achieved in some PanNEN patients, although the overall 5-year and 10-year survival rates are 46 and 31

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-22-0166
Volume/Issue:
Volume 29: Issue 12
Free access
Annemiek Walenkamp
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Guillermo Crespo Department of Medical Oncology, Department of Medical Oncology, Department of Endocrine Oncology, Department of Cancer Research and Molecular Medicine, 2nd Department of Medicine, Department of Gastroenterology, Department of General Internal Medicine, Department of Clinical Sciences and Community Health (DISCCO), Laboratory of Endocrine and Metabolic Research, Department of Endocrine Oncology, UCL Cancer Institute, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands

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Felipe Fierro Maya Department of Medical Oncology, Department of Medical Oncology, Department of Endocrine Oncology, Department of Cancer Research and Molecular Medicine, 2nd Department of Medicine, Department of Gastroenterology, Department of General Internal Medicine, Department of Clinical Sciences and Community Health (DISCCO), Laboratory of Endocrine and Metabolic Research, Department of Endocrine Oncology, UCL Cancer Institute, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands

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Reidar Fossmark Department of Medical Oncology, Department of Medical Oncology, Department of Endocrine Oncology, Department of Cancer Research and Molecular Medicine, 2nd Department of Medicine, Department of Gastroenterology, Department of General Internal Medicine, Department of Clinical Sciences and Community Health (DISCCO), Laboratory of Endocrine and Metabolic Research, Department of Endocrine Oncology, UCL Cancer Institute, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands

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Peter Igaz Department of Medical Oncology, Department of Medical Oncology, Department of Endocrine Oncology, Department of Cancer Research and Molecular Medicine, 2nd Department of Medicine, Department of Gastroenterology, Department of General Internal Medicine, Department of Clinical Sciences and Community Health (DISCCO), Laboratory of Endocrine and Metabolic Research, Department of Endocrine Oncology, UCL Cancer Institute, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands

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Anja Rinke Department of Medical Oncology, Department of Medical Oncology, Department of Endocrine Oncology, Department of Cancer Research and Molecular Medicine, 2nd Department of Medicine, Department of Gastroenterology, Department of General Internal Medicine, Department of Clinical Sciences and Community Health (DISCCO), Laboratory of Endocrine and Metabolic Research, Department of Endocrine Oncology, UCL Cancer Institute, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands

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Gianluca Tamagno Department of Medical Oncology, Department of Medical Oncology, Department of Endocrine Oncology, Department of Cancer Research and Molecular Medicine, 2nd Department of Medicine, Department of Gastroenterology, Department of General Internal Medicine, Department of Clinical Sciences and Community Health (DISCCO), Laboratory of Endocrine and Metabolic Research, Department of Endocrine Oncology, UCL Cancer Institute, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands

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Giovanni Vitale Department of Medical Oncology, Department of Medical Oncology, Department of Endocrine Oncology, Department of Cancer Research and Molecular Medicine, 2nd Department of Medicine, Department of Gastroenterology, Department of General Internal Medicine, Department of Clinical Sciences and Community Health (DISCCO), Laboratory of Endocrine and Metabolic Research, Department of Endocrine Oncology, UCL Cancer Institute, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
Department of Medical Oncology, Department of Medical Oncology, Department of Endocrine Oncology, Department of Cancer Research and Molecular Medicine, 2nd Department of Medicine, Department of Gastroenterology, Department of General Internal Medicine, Department of Clinical Sciences and Community Health (DISCCO), Laboratory of Endocrine and Metabolic Research, Department of Endocrine Oncology, UCL Cancer Institute, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands

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Kjell Öberg Department of Medical Oncology, Department of Medical Oncology, Department of Endocrine Oncology, Department of Cancer Research and Molecular Medicine, 2nd Department of Medicine, Department of Gastroenterology, Department of General Internal Medicine, Department of Clinical Sciences and Community Health (DISCCO), Laboratory of Endocrine and Metabolic Research, Department of Endocrine Oncology, UCL Cancer Institute, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands

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Tim Meyer Department of Medical Oncology, Department of Medical Oncology, Department of Endocrine Oncology, Department of Cancer Research and Molecular Medicine, 2nd Department of Medicine, Department of Gastroenterology, Department of General Internal Medicine, Department of Clinical Sciences and Community Health (DISCCO), Laboratory of Endocrine and Metabolic Research, Department of Endocrine Oncology, UCL Cancer Institute, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands

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-cadherin junctions and gain of cell motility and invasiveness in several tumour types. Moreover, E-cadherin loss was identified in 13 out of 17 (76.5%) gastric neuroendocrine carcinomas (NECs) and was significantly associated with lymph node metastasis; however, it

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-14-0106
Volume/Issue:
Volume 21: Issue 6
Free access
Georgios K Dimitriadis The Arden NET CoE, Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospitals of Coventry and Warwickshire NHS Trust, Coventry, UK

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Anna Angelousi Division of Pathophysiology, National and Kapodistrian University of Athens Medical School, Athens, Greece

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Martin O Weickert The Arden NET CoE, Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospitals of Coventry and Warwickshire NHS Trust, Coventry, UK

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Harpal S Randeva The Arden NET CoE, Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospitals of Coventry and Warwickshire NHS Trust, Coventry, UK

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Gregory Kaltsas The Arden NET CoE, Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospitals of Coventry and Warwickshire NHS Trust, Coventry, UK
Division of Pathophysiology, National and Kapodistrian University of Athens Medical School, Athens, Greece
Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK

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Ashley Grossman Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK

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tumour-to-background uptake ratios of radioactivity, and is also low in NETs with a high Ki-67 index or neuroendocrine carcinomas (NECs), reflecting dedifferentiation and loss of sstr expression ( Sundin et al. 2012 ). 68 Ga-DOTATATE or 68 Ga

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-17-0036
Volume/Issue:
Volume 24: Issue 6
Free access
Maria Chiara Zatelli Department of Medical Sciences, Section of Endocrinology and Internal Medicine, University of Ferrara, Ferrara, Italy

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Erika Maria Grossrubatscher Endocrine Unit, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy

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Elia Guadagno Department of Advanced Biomedical Sciences, Pathology Section, University of Naples Federico II, Naples, Italy

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Concetta Sciammarella IOS & COLEMAN Srl, Naples, Italy

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Antongiulio Faggiano Thyroid and Parathyroid Surgery Unit, Istituto Nazionale per lo Studio e la Cura Dei Tumori ‘Fondazione G. Pascale’ – IRCCS, Naples, Italy

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Annamaria Colao IOS & COLEMAN Srl, Naples, Italy

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basis of their close correlation to tumor development and progression, in a series of 63 lung NENs, including 19 typical carcinoids (TC), 6 atypical carcinoids (AT), 19 large cell neuroendocrine carcinomas (LCNEC) and 19 SCLC. The results showed that miR

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-17-0091
Volume/Issue:
Volume 24: Issue 6
Free access
A Karpathakis University College London Cancer Institute, Neuroendocrine Tumour Unit, 72 Huntley Street, London WC1E 6BT, UK
University College London Cancer Institute, Neuroendocrine Tumour Unit, 72 Huntley Street, London WC1E 6BT, UK

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H Dibra University College London Cancer Institute, Neuroendocrine Tumour Unit, 72 Huntley Street, London WC1E 6BT, UK

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C Thirlwell University College London Cancer Institute, Neuroendocrine Tumour Unit, 72 Huntley Street, London WC1E 6BT, UK
University College London Cancer Institute, Neuroendocrine Tumour Unit, 72 Huntley Street, London WC1E 6BT, UK

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carcinomas including a group of 16 mostly low-grade primary intestinal NETs ( Magerl et al . 2010 ). Up to 100% of neuroendocrine carcinomas exhibited strong immunostaining for Ash2 and LSD1, while H3K4diMe was strongly expressed in 93% of neuroendocrine

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-12-0338
Volume/Issue:
Volume 20: Issue 3
Free access
Nicté Figueroa-Vega Service of Endocrinology, Department of Immunology, Department of Medical Sciences, Service of Endocrinology and Nutrition, Service of Pathology, Service of Endocrinology, Service of Immunology, Service of Digestive Surgery, Service of Digestive Diseases and CIBEREHD, Hospital Universitario de la Princesa, Universidad Autónoma de Madrid, Instituto de Investigación Sanitaria Princesa, C/Diego de León 62, Madrid 28006, Spain
Service of Endocrinology, Department of Immunology, Department of Medical Sciences, Service of Endocrinology and Nutrition, Service of Pathology, Service of Endocrinology, Service of Immunology, Service of Digestive Surgery, Service of Digestive Diseases and CIBEREHD, Hospital Universitario de la Princesa, Universidad Autónoma de Madrid, Instituto de Investigación Sanitaria Princesa, C/Diego de León 62, Madrid 28006, Spain
Service of Endocrinology, Department of Immunology, Department of Medical Sciences, Service of Endocrinology and Nutrition, Service of Pathology, Service of Endocrinology, Service of Immunology, Service of Digestive Surgery, Service of Digestive Diseases and CIBEREHD, Hospital Universitario de la Princesa, Universidad Autónoma de Madrid, Instituto de Investigación Sanitaria Princesa, C/Diego de León 62, Madrid 28006, Spain

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Ángel Díaz Service of Endocrinology, Department of Immunology, Department of Medical Sciences, Service of Endocrinology and Nutrition, Service of Pathology, Service of Endocrinology, Service of Immunology, Service of Digestive Surgery, Service of Digestive Diseases and CIBEREHD, Hospital Universitario de la Princesa, Universidad Autónoma de Madrid, Instituto de Investigación Sanitaria Princesa, C/Diego de León 62, Madrid 28006, Spain

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Magdalena Adrados Service of Endocrinology, Department of Immunology, Department of Medical Sciences, Service of Endocrinology and Nutrition, Service of Pathology, Service of Endocrinology, Service of Immunology, Service of Digestive Surgery, Service of Digestive Diseases and CIBEREHD, Hospital Universitario de la Princesa, Universidad Autónoma de Madrid, Instituto de Investigación Sanitaria Princesa, C/Diego de León 62, Madrid 28006, Spain

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Cristina Álvarez-Escolá Service of Endocrinology, Department of Immunology, Department of Medical Sciences, Service of Endocrinology and Nutrition, Service of Pathology, Service of Endocrinology, Service of Immunology, Service of Digestive Surgery, Service of Digestive Diseases and CIBEREHD, Hospital Universitario de la Princesa, Universidad Autónoma de Madrid, Instituto de Investigación Sanitaria Princesa, C/Diego de León 62, Madrid 28006, Spain

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Amalia Paniagua Service of Endocrinology, Department of Immunology, Department of Medical Sciences, Service of Endocrinology and Nutrition, Service of Pathology, Service of Endocrinology, Service of Immunology, Service of Digestive Surgery, Service of Digestive Diseases and CIBEREHD, Hospital Universitario de la Princesa, Universidad Autónoma de Madrid, Instituto de Investigación Sanitaria Princesa, C/Diego de León 62, Madrid 28006, Spain

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Julián Aragonés Service of Endocrinology, Department of Immunology, Department of Medical Sciences, Service of Endocrinology and Nutrition, Service of Pathology, Service of Endocrinology, Service of Immunology, Service of Digestive Surgery, Service of Digestive Diseases and CIBEREHD, Hospital Universitario de la Princesa, Universidad Autónoma de Madrid, Instituto de Investigación Sanitaria Princesa, C/Diego de León 62, Madrid 28006, Spain

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Elena Martín-Pérez Service of Endocrinology, Department of Immunology, Department of Medical Sciences, Service of Endocrinology and Nutrition, Service of Pathology, Service of Endocrinology, Service of Immunology, Service of Digestive Surgery, Service of Digestive Diseases and CIBEREHD, Hospital Universitario de la Princesa, Universidad Autónoma de Madrid, Instituto de Investigación Sanitaria Princesa, C/Diego de León 62, Madrid 28006, Spain

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Susanna Leskela Service of Endocrinology, Department of Immunology, Department of Medical Sciences, Service of Endocrinology and Nutrition, Service of Pathology, Service of Endocrinology, Service of Immunology, Service of Digestive Surgery, Service of Digestive Diseases and CIBEREHD, Hospital Universitario de la Princesa, Universidad Autónoma de Madrid, Instituto de Investigación Sanitaria Princesa, C/Diego de León 62, Madrid 28006, Spain

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Ricardo Moreno-Otero Service of Endocrinology, Department of Immunology, Department of Medical Sciences, Service of Endocrinology and Nutrition, Service of Pathology, Service of Endocrinology, Service of Immunology, Service of Digestive Surgery, Service of Digestive Diseases and CIBEREHD, Hospital Universitario de la Princesa, Universidad Autónoma de Madrid, Instituto de Investigación Sanitaria Princesa, C/Diego de León 62, Madrid 28006, Spain

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Roberto González-Amaro Service of Endocrinology, Department of Immunology, Department of Medical Sciences, Service of Endocrinology and Nutrition, Service of Pathology, Service of Endocrinology, Service of Immunology, Service of Digestive Surgery, Service of Digestive Diseases and CIBEREHD, Hospital Universitario de la Princesa, Universidad Autónoma de Madrid, Instituto de Investigación Sanitaria Princesa, C/Diego de León 62, Madrid 28006, Spain

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Mónica Marazuela Service of Endocrinology, Department of Immunology, Department of Medical Sciences, Service of Endocrinology and Nutrition, Service of Pathology, Service of Endocrinology, Service of Immunology, Service of Digestive Surgery, Service of Digestive Diseases and CIBEREHD, Hospital Universitario de la Princesa, Universidad Autónoma de Madrid, Instituto de Investigación Sanitaria Princesa, C/Diego de León 62, Madrid 28006, Spain

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neuroendocrine tumors . Oncology Reports 21 769 – 775 doi:10.3892/or_00000283 . Rindi G Bordi C Rappel S La Rosa S Stolte M Solcia E 1996 Gastric carcinoids and neuroendocrine carcinomas: pathogenesis, pathology, and behavior . World Journal

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-10-0020
Volume/Issue:
Volume 17: Issue 4
Free access
Georgios K Dimitriadis The Arden NET CoE, Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism, University Hospitals of Coventry and Warwickshire NHS Trust, Coventry, UK
Division of Translational and Experimental Medicine, Warwick Medical School, University of Warwick, Coventry, UK
Division of Endocrinology and Investigative Medicine, Imperial College London, Hammersmith Campus, London, UK

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Martin O Weickert The Arden NET CoE, Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism, University Hospitals of Coventry and Warwickshire NHS Trust, Coventry, UK
Division of Translational and Experimental Medicine, Warwick Medical School, University of Warwick, Coventry, UK
Centre for Applied Biological and Exercise Sciences, Coventry University, Coventry, UK

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Harpal S Randeva The Arden NET CoE, Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism, University Hospitals of Coventry and Warwickshire NHS Trust, Coventry, UK
Division of Translational and Experimental Medicine, Warwick Medical School, University of Warwick, Coventry, UK
Centre for Applied Biological and Exercise Sciences, Coventry University, Coventry, UK

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Gregory Kaltsas The Arden NET CoE, Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism, University Hospitals of Coventry and Warwickshire NHS Trust, Coventry, UK
Division of Pathophysiology, National and Kapodistrian University of Athens Medical School, Athens, Greece
Oxford Center for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK

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Ashley Grossman Oxford Center for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK

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. Journal of Clinical Oncology 21 2689 – 2696 . ( doi:10.1200/JCO.2003.12.142 ) Fazio N de Braud F Delle Fave G Oberg K 2007 Interferon–alpha and somatostatin analog in patients with gastroenetropancreatic neuroendocrine carcinoma

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-16-0200
Volume/Issue:
Volume 23: Issue 9
Free access