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Introduction Neuroendocrine neoplasms (NENs) of the gastroenteropancreatic (GEP) system are a heterogeneous group of rare malignancies. While the incidence of NENs was relatively low, with 6.98 cases per 100,000 adults in 2012, the incidence
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Division of Endocrinology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
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Introduction The classification of neuroendocrine neoplasms (NENs) relies on differentiation (well-differentiated neuroendocrine tumors (NETs) or poorly-differentiated neuroendocrine carcinomas (NECs)) and the proliferation index, which is
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Laboratoire GReD, Université Clermont Auvergne, Clermont-Ferrand, France
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Faculté de Médecine, Université Paris Saclay, Le Kremlin-Bicêtre, France
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Faculté de Médecine, Université Paris Saclay, Le Kremlin-Bicêtre, France
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Patients This was a multicentre retrospective study of seven tertiary centres of the French expert network for the management of neuroendocrine neoplasms ENDOCAN-RENATEN (approved by the French National Cancer Institute, INCa). Patients were diagnosed
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Introduction Neuroendocrine neoplasms (NEN) are a heterogenous group of malignancies, most commonly arising from gastroenteropancreatic (GEP) sites, with increasing incidence and prevalence worldwide ( Dasari et al. 2017 , Das & Dasari 2021
Division of Cancer Sciences, University of Manchester, Manchester, UK
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Université Paris Sud, Faculté de Médecine de Bicêtre, Le Kremlin-Bicêtre, France
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al . 2016 , McNamara et al . 2019 ). There has been recent progress in the pathological diagnosis of high grade neuroendocrine neoplasms (NENs) ( Lloyd et al . 2017 , Rindi et al . 2018 a ) and in the description of their molecular and immune
Université de Paris, Centre de Recherche sur l’Inflammation, INSERM, Paris, France
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Department of Pathology, ENETS Centre of Excellence, Bichat/Beaujon University Hospital, Paris/Clichy, France
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Université de Paris, Centre de Recherche sur l’Inflammation, INSERM, Paris, France
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Department of Pathology, ENETS Centre of Excellence, Bichat/Beaujon University Hospital, Paris/Clichy, France
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Université de Paris, Centre de Recherche sur l’Inflammation, INSERM, Paris, France
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, 2018 Correlation between MGMT promoter methylation and response to temozolomide-based therapy in neuroendocrine neoplasms: an observational retrospective multicenter study . Endocrine 60 490 – 498 . ( https://doi.org/10.1007/s12020
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Klinik für Nuklearmedizin, Universitätklinikum Ulm, Ulm, Germany
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Innere Medizin und Gastroenterologie, Asklepios Klinik St. Georg, Asklepios Medical School, Hamburg, Germany
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Medizinische Klinik 1, Gastroenterologie, Pneumologie und Endokrinologie, Universitätsklinikum der Friedrich-Alexander Universität Erlangen, Erlangen, Germany
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Klinik für Allgemein-, Viszeral- und Transplantationschirurgie, Uinversitätsklinikum Münster, Münster, Germany
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Innere Medizin und Gastroenterologie, Asklepios Klinik St. Georg, Asklepios Medical School, Hamburg, Germany
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G Fazio N , et al . 2016 Clinical management of patients with gastric neuroendocrine neoplasms associated with chronic atrophic gastritis: a retrospective, multicentre study . Endocrine 51 . ( https://doi.org/10.1007/s12020-015-0584-z
Department of Endocrine Oncology, Department of Medical Sciences, University Hospital, Entrance 78, SE-751 85 Uppsala, Sweden
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classification and the pathology of gastro-entero-pancreatic neuroendocrine neoplasms is discussed by Prof. Günter Klöppel ( Klöppel 2011 ). A number of biomarkers has been developed during the last decades based on development of the immunoassays for various gut
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-endocrine manifestations (i.e., adrenocortical neoplasm, thymic and bronchial neuroendocrine neoplasms, breast and soft tissue tumors) beyond the parathyroid adenoma, gastrinoma and prolactinoma described originally, and also to understand the genetic, epigenetic and post
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small bowel neuroendocrine neoplasms . Endocrine 67 718 – 726 . ( https://doi.org/10.1007/s12020-019-02107-4 ) Laskaratos FM Walker M Wilkins D Tuck A Ramakrishnan S Phillips E Gertner J Megapanou M Papantoniou D Shah R , 2018