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Lucas Leite Cunha Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Federal University of São Paulo, São Paulo, Brazil

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Laura Sterian Ward Laboratory of Cancer Molecular Genetics, Faculty of Medical Sciences, University of Campinas (Unicamp), Campinas, Brazil

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infiltration of CD8 cells by immunohistochemistry as independent prognostic markers of relapse-free time ( Cunha et al. 2015 ). The inclusion of immunological parameters (COX2/CD8) in the score system significantly improved the prognosticator capacity of pTNM

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-21-0414
Volume/Issue:
Volume 29: Issue 6
Free access
Jennifer Munkley Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, UK

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combined in a scoring system . Journal of Cancer 7 297 – 303 . ( doi:10.7150/jca.12771 ) Alur M Nguyen MM Eggener SE Jiang F Dadras SS Stern J Kimm S Roehl K Kozlowski J Pins M 2009 Suppressive roles of

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-16-0569
Volume/Issue:
Volume 24: Issue 3
Free access
Paola Romeo Molecular Mechanisms Unit, Research Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

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Carla Colombo Division of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, Milan, Italy
Department of Pathophysiology and Transplantation, University of Milan, Milan, Ital

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Roberta Granata Department of Head and Neck Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

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Giuseppina Calareso Department of Radiology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

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Ambra Vittoria Gualeni Department of Diagnostic Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

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Matteo Dugo Functional Genomics and Bioinformatics Unit, Department of Applied Research and Technology Development, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

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Loris De Cecco Functional Genomics and Bioinformatics Unit, Department of Applied Research and Technology Development, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

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Maria Grazia Rizzetti Molecular Mechanisms Unit, Research Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

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Angela Zanframundo Department of Diagnostic Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

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Antonella Aiello Department of Diagnostic Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

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Maria Luisa Carcangiu Department of Diagnostic Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

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Annunziata Gloghini Department of Diagnostic Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

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Stefano Ferrero Department of Pathophysiology and Transplantation, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy

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Lisa Licitra Department of Head and Neck Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
Department of Medical Oncology, University of Milan, Milan, Italy

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Angela Greco Molecular Mechanisms Unit, Research Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

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Laura Fugazzola Division of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, Milan, Italy
Department of Pathophysiology and Transplantation, University of Milan, Milan, Ital

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Laura Deborah Locati Department of Head and Neck Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

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Maria Grazia Borrello Molecular Mechanisms Unit, Research Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

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staining. Positive signals appeared as brown dots usually localized in the cytoplasm. Signals were quantified using a scoring system from 0 to 16 obtained by multiplying the number of dots/cell (0 = no signal, 1 = 1–3 dots/cell, 2 = 4–6 dots/cell, 3 = 7

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-17-0389
Volume/Issue:
Volume 25: Issue 3
Free access
Hannah Nieto Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston, Birmingham, UK
Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK

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Kristien Boelaert Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston, Birmingham, UK
Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK

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the UK, cytology results are reported using the THY classification ( The Royal College of Pathologists 2009 ), whereas in the US, the Bethesda scoring system ( Bongiovanni et al . 2012 ) is used. Despite accuracy of diagnosis in the majority of

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-16-0328
Volume/Issue:
Volume 23: Issue 11
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Maria Cristina De Martino
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Richard A Feelders
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Wouter W de Herder
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Peter M van Koetsveld
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Fadime Dogan
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Joseph A M J L Janssen
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A Marlijn Waaijers
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Claudia Pivonello Department of Internal Medicine Division of Endocrinology, Erasmus Medical Center, Rotterdam, The Netherlands

Dipartimento di Medicina Clinica e Chirurgia Sezione di Endocrinologia, Università Federico II, Naples, Italy

Department of Pathology Erasmus Medical Center, Rotterdam and Reinier de Graaf Gasthuis, Delft, The Netherlands

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Steven W J Lamberts
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Annamaria Colao Department of Internal Medicine Division of Endocrinology, Erasmus Medical Center, Rotterdam, The Netherlands

Dipartimento di Medicina Clinica e Chirurgia Sezione di Endocrinologia, Università Federico II, Naples, Italy

Department of Pathology Erasmus Medical Center, Rotterdam and Reinier de Graaf Gasthuis, Delft, The Netherlands

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Ronald R de Krijger Department of Internal Medicine Division of Endocrinology, Erasmus Medical Center, Rotterdam, The Netherlands

Dipartimento di Medicina Clinica e Chirurgia Sezione di Endocrinologia, Università Federico II, Naples, Italy

Department of Pathology Erasmus Medical Center, Rotterdam and Reinier de Graaf Gasthuis, Delft, The Netherlands

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Rosario Pivonello Department of Internal Medicine Division of Endocrinology, Erasmus Medical Center, Rotterdam, The Netherlands

Dipartimento di Medicina Clinica e Chirurgia Sezione di Endocrinologia, Università Federico II, Naples, Italy

Department of Pathology Erasmus Medical Center, Rotterdam and Reinier de Graaf Gasthuis, Delft, The Netherlands

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Leo J Hofland
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. The staining was evaluated independently by two investigators and any discrepancy was resolved by a consensus review. In tumor specimens (ACAs and ACCs), the results were interpreted in a semiquantitative manner using an intensity-proportion scoring

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-13-0112
Volume/Issue:
Volume 21: Issue 4
Free access
Tae Hyuk Kim Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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Young-Eun Kim Green Cross Genome, Yongin, Korea

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Soomin Ahn Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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Ji-Youn Kim Center for Clinical Medicine, Samsung Biomedical Research Institute, Samsung Medical Center, Seoul, Korea

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Chang-Seok Ki Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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Young Lyun Oh Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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Kyunga Kim Biostatistics and Clinical Epidemiology Center, Research Institute for Future Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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Jae Won Yun Samsung Genome Institute, Samsung Medical Center, Seoul, Korea
Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Korea

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Woong-Yang Park Samsung Genome Institute, Samsung Medical Center, Seoul, Korea
Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Korea

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Jun-Ho Choe Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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Jung-Han Kim Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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Jee Soo Kim Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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Sun Wook Kim Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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Jae Hoon Chung Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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. ( doi:10.1002/(sici)1097-0258(19960229)15:4<361::aid-sim168
>3.0.co;2-4 ) Hay ID Bergstralh EJ Goellner JR Ebersold JR Grant CS 1993 Predicting outcome in papillary thyroid carcinoma: development of a reliable prognostic scoring

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-16-0219
Volume/Issue:
Volume 23: Issue 10
Free access
Athanasios Bikas Division of Endocrinology, Department of Pediatrics, Biomedical Instrumental Center, Center for Endocrine Surgery, Department of Surgery, Department of Medicine, Medstar Washington Hospital Center, 110 Irving Street Northwest, Washington, District of Columbia 20010, USA

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Kirk Jensen Division of Endocrinology, Department of Pediatrics, Biomedical Instrumental Center, Center for Endocrine Surgery, Department of Surgery, Department of Medicine, Medstar Washington Hospital Center, 110 Irving Street Northwest, Washington, District of Columbia 20010, USA

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Aneeta Patel Division of Endocrinology, Department of Pediatrics, Biomedical Instrumental Center, Center for Endocrine Surgery, Department of Surgery, Department of Medicine, Medstar Washington Hospital Center, 110 Irving Street Northwest, Washington, District of Columbia 20010, USA

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John Costello Jr Division of Endocrinology, Department of Pediatrics, Biomedical Instrumental Center, Center for Endocrine Surgery, Department of Surgery, Department of Medicine, Medstar Washington Hospital Center, 110 Irving Street Northwest, Washington, District of Columbia 20010, USA

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Dennis McDaniel Division of Endocrinology, Department of Pediatrics, Biomedical Instrumental Center, Center for Endocrine Surgery, Department of Surgery, Department of Medicine, Medstar Washington Hospital Center, 110 Irving Street Northwest, Washington, District of Columbia 20010, USA

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Joanna Klubo-Gwiezdzinska Division of Endocrinology, Department of Pediatrics, Biomedical Instrumental Center, Center for Endocrine Surgery, Department of Surgery, Department of Medicine, Medstar Washington Hospital Center, 110 Irving Street Northwest, Washington, District of Columbia 20010, USA

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Olexander Larin Division of Endocrinology, Department of Pediatrics, Biomedical Instrumental Center, Center for Endocrine Surgery, Department of Surgery, Department of Medicine, Medstar Washington Hospital Center, 110 Irving Street Northwest, Washington, District of Columbia 20010, USA

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Victoria Hoperia Division of Endocrinology, Department of Pediatrics, Biomedical Instrumental Center, Center for Endocrine Surgery, Department of Surgery, Department of Medicine, Medstar Washington Hospital Center, 110 Irving Street Northwest, Washington, District of Columbia 20010, USA

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Kenneth D Burman Division of Endocrinology, Department of Pediatrics, Biomedical Instrumental Center, Center for Endocrine Surgery, Department of Surgery, Department of Medicine, Medstar Washington Hospital Center, 110 Irving Street Northwest, Washington, District of Columbia 20010, USA

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Lisa Boyle Division of Endocrinology, Department of Pediatrics, Biomedical Instrumental Center, Center for Endocrine Surgery, Department of Surgery, Department of Medicine, Medstar Washington Hospital Center, 110 Irving Street Northwest, Washington, District of Columbia 20010, USA

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Leonard Wartofsky Division of Endocrinology, Department of Pediatrics, Biomedical Instrumental Center, Center for Endocrine Surgery, Department of Surgery, Department of Medicine, Medstar Washington Hospital Center, 110 Irving Street Northwest, Washington, District of Columbia 20010, USA

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Vasyl Vasko Division of Endocrinology, Department of Pediatrics, Biomedical Instrumental Center, Center for Endocrine Surgery, Department of Surgery, Department of Medicine, Medstar Washington Hospital Center, 110 Irving Street Northwest, Washington, District of Columbia 20010, USA

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Kit (DAKO, Carpinteria, CA, USA). Negative controls were performed as described earlier except that the primary antisera were not included. We adopted the semi-quantitative scoring system in considering the staining intensity and area extent. Every

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-15-0402
Volume/Issue:
Volume 22: Issue 6
Free access
Fernanda Vaisman
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Denise P Carvalho Endocrinology Service, Laboratório de Fosiologia Endócrina Doris Rosental, Endocrinology Service, National Cancer Institute, Brazil Praça da Cruz Vermelha, 23, 8° Floor, Centro, Rio de Janeiro, Rio de Janeiro, 20230-130, Brazil

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Mario Vaisman Endocrinology Service, Laboratório de Fosiologia Endócrina Doris Rosental, Endocrinology Service, National Cancer Institute, Brazil Praça da Cruz Vermelha, 23, 8° Floor, Centro, Rio de Janeiro, Rio de Janeiro, 20230-130, Brazil

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scoring system in a cohort of 1779 patients surgically treated at one institution during 1940 through 1989 . Surgery 114 1050 – 1057 . (discussion 1057–1058) Ho AL Grewal RK Leboeuf R Sherman EJ Pfister DG Deandreis D Pentlow KS

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DOI:
https://doi.org/10.1530/ERC-15-0300
Volume/Issue:
Volume 22: Issue 6
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Eduardo Vilar
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Ramón Salazar
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Jose Pérez-García
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Javier Cortes
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Kjell Öberg
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Josep Tabernero
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survival after adjusting for functional status and tumor size. Jorda et al. (2003) used a semiquantitative scoring system to explore its application for assessing the metastatic behavior of PET. All metastatic tumors expressed at least an intermediate

Article Type:
Review Article
DOI:
https://doi.org/10.1677/ERC-06-0074
Volume/Issue:
Volume 14: Issue 2
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N Sarwar
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J-S Kim
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J Jiang
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D Peston
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H D Sinnett
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P Madden
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J M Gee
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R I Nicholson
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A E Lykkesfeldt
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S Shousha
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R C Coombes
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S Ali
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(PR, cat. no. MU328-UC; Biogenex, USA) and a rabbit polyclonal antibody for c-erbB2 (cat. no. A 0485; Dako). P-S118 levels were scored by a trained histopathologist, using the modified McCarty’s H-scoring system, which was based on the percentage of

Article Type:
Research Article
DOI:
https://doi.org/10.1677/erc.1.01123
Volume/Issue:
Volume 13: Issue 3
Free access