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, especially breast cancer ( Godinho & Pellman 2014 ). At least 75% of malignant breast tumors exhibit CA, although the proportion of intratumoral cells with CA varies widely, from 1 to 100% ( Chan 2011 ). Centrosome abnormalities are classified as voluminous
Division of Molecular Carcinogenesis, the Netherlands Cancer Institute, Amsterdam, the Netherlands
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Introduction Male breast cancer is rare, accounting for around 1% of all breast cancers ( Siegel et al. 2016 ) and is frequently positive for ERα (91–95%) and/or PR (80–81%) ( Giordano et al. 2004 , Anderson et al. 2010 , Nilsson et
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Introduction Breast cancer contributes to one-third of cancers in the female population of UK. Its incidence has continued to increase with latest data showing 41 000 newly diagnosed cases and 13 000 deaths per year ( Cancer Research
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Introduction Breast cancer is the leading type of cancer among women today and the incidence of this disease is increasing in all industrialized countries. In spite of the increasing incidence, mortality has been rather stable for
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Introduction Despite recent progress in treatment and therapeutic strategies, breast cancer incidence, morbidity and mortality remain a major problem in Western countries. Recent trials with selective oestrogen receptor modulators
Cell Biology and Biotherapy Unit, Pharmacogenomic Laboratory, Clinical Trials Unit, INT-Fondazione Pascale, 80131 Naples, Italy
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treatment without a major increase in side effects. Breast cancer is a complex and heterogeneous disease. The development of high throughput technologies has recently underscored such complexity by revealing the existence of different subtypes of breast
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KU Leuven, University Hospitals Leuven, University Hospitals Leuven, Department of Oncology, Leuven, Belgium
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KU Leuven, University Hospitals Leuven, University Hospitals Leuven, Department of Oncology, Leuven, Belgium
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KU Leuven, University Hospitals Leuven, University Hospitals Leuven, Department of Oncology, Leuven, Belgium
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Introduction Breast cancer is the most common type of cancer in women and the main cause of female cancer-related deaths worldwide ( Jemal et al . 2011 ). About 80% of primary breast cancers are hormone sensitive as they contain estrogen receptor
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Introduction Improvements in the use of traditional breast cancer therapies have decreased the morbidity and mortality of breast cancer treatment, and improved the overall survival of women with early stage disease (American Cancer
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Introduction The rarity of male breast cancer (MBC) has severely impeded the investigation of this disease so that compared with female breast cancer (FBC), our knowledge is rudimentary. There is however some evidence that the incidence is
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Deeley Research Centre, Translational Gastroenterology Unit, Department of Biochemistry and Medical Genetics and the Manitoba Institute of Cell Biology, Department of Biochemistry and Microbiology, Department of Pathology and Laboratory Medicine, British Columbia Cancer Agency, 2410 Lee Avenue, Victoria, British Columbia, Canada V8R 6V5
Deeley Research Centre, Translational Gastroenterology Unit, Department of Biochemistry and Medical Genetics and the Manitoba Institute of Cell Biology, Department of Biochemistry and Microbiology, Department of Pathology and Laboratory Medicine, British Columbia Cancer Agency, 2410 Lee Avenue, Victoria, British Columbia, Canada V8R 6V5
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Introduction The association between inflammation and cancer has long been established. Inflammatory cells are commonly found in tumour tissues and chronic inflammation is associated with many cancers, including breast cancer, and is capable of
