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Cancer Genetics, Department of Surgery, Department of Biochemistry, Hormones and Cancer, Kolling Institute of Medical Research, University of Sydney, Level 9, Kolling Building, Royal North Shore Hospital, St Leonards, Sydney, New South Wales, Australia
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microenvironment and play a role in pathological and molecular events in human breast cancers ( Bronisz et al . 2012 ). miR-148a has been found to be significantly down-regulated in CAFs of endometrial cancer compared with matched normal fibroblasts. Up
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The University of Sydney Nano Institute, The University of Sydney, Sydney, New South Wales, Australia
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affinity to GnRH and its analogs), endometrial and ovarian adenocarcinomas (80%), breast cancer (50%), renal cancer (80%), and pancreatic cancer (50%) ( Nagy & Schally 2005 , Gründker et al. 2011 ). On a short arm of chromosome 8 (region 8p11.2, p21
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. A variety of polymorphisms have been described in CYP19A1 , and these have been evaluated in association with breast cancer ( Haiman et al . 2003 , 2007 , Cai et al . 2008 ), endometrial cancer ( Paynter et al . 2005 , Tao et al . 2007 ), and
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treatment confers a two- to sevenfold increased risk of developing endometrial pathologies ( Cohen et al. 1993 , McGonigle et al. 2006 ), including endometrial cancer ( Fisher et al. 1998 , Cohen 2004 ). Type 1 endometrial tumours are
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tamoxifen differentially regulates human telomerase reverse transcriptase (hTERT) gene expression in breast and endometrial cancer cells, and this activity has been associated with the presence of an estrogen-sensitive element in the hTERT gene. The
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rates of endometrial cancer were seen in all prevention studies with a consensus relative risk of 2.4 (1.5–4.0; P = 0.0005). Most excess risk is seen in cases with age 50 or older. Thus far, no increase in endometrial cancer but similar thromboembolic
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the adjuvant setting. Long-term treatment with tamoxifen, however, is well known to have side-effects related to the partial agonistic activity of this compound, especially the increased risk of endometrial cancer and thromboembolic events
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Molecular and Cellular Biology Program, Ohio University, Athens, Ohio, USA
Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA
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irradiation challenge was consistent with that observed in non-tumor cells, as is reported in (i) GH treatment-induced post-irradiation survival and DNA damage repair in breast and endometrial cancer cells ( Bougen et al. 2012 ), (ii) suppression of GH
School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of
School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of
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School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of
School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of
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School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of
School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of
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School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of
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School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of
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School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of
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Tjønneland A Olsen A Overvad K Jakobsen MU Chajés V 2007 Metabolic syndrome, plasma lipid, lipoprotein and glucose levels, and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) . Endocrine
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, colorectal, kidney, bladder, endometrial and breast cancers, and non-Hodgkin's lymphoma) is elevated in diabetic patients ( Table 1 ). Evidence for the association of diabetes with other cancers is not available, while for prostate cancer, a reduced incidence