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Meng Ji Department of General Surgery (Department of Pancreatic-Biliary Surgery), Shanghai Changzheng Hospital, The Second Military Medical University, Shanghai, China

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Yanli Yao Glycochemistry & Glycobiology Lab, Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Shanghai, China
University of the Chinese Academy of Sciences, Beijing, China

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Anan Liu Department of General Surgery (Department of Pancreatic-Biliary Surgery), Shanghai Changzheng Hospital, The Second Military Medical University, Shanghai, China

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Ligang Shi Department of General Surgery (Department of Pancreatic-Biliary Surgery), Shanghai Changzheng Hospital, The Second Military Medical University, Shanghai, China

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Danlei Chen Department of General Surgery (Department of Pancreatic-Biliary Surgery), Shanghai Changzheng Hospital, The Second Military Medical University, Shanghai, China

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Liang Tang Department of General Surgery (Department of Pancreatic-Biliary Surgery), Shanghai Changzheng Hospital, The Second Military Medical University, Shanghai, China

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Guang Yang Department of General Surgery (Department of Pancreatic-Biliary Surgery), Shanghai Changzheng Hospital, The Second Military Medical University, Shanghai, China

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Xing Liang Department of General Surgery (Department of Pancreatic-Biliary Surgery), Shanghai Changzheng Hospital, The Second Military Medical University, Shanghai, China

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Junfeng Peng Department of General Surgery (Department of Pancreatic-Biliary Surgery), Shanghai Changzheng Hospital, The Second Military Medical University, Shanghai, China

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Chenghao Shao Department of General Surgery (Department of Pancreatic-Biliary Surgery), Shanghai Changzheng Hospital, The Second Military Medical University, Shanghai, China

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Introduction Neuroendocrine neoplasms (NENs) arise from neuroendocrine systems and often occur in tissues, such as lung, pancreas and pituitary tissues ( Ohki et al. 2014 , Gao et al. 2018 ). However, due to the low incidence and the lack

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Krystallenia I Alexandraki Department of Surgery, Medical School, National and Kapodistrian University of Athens, Athens, Greece

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Gregory A Kaltsas Department of Propaedeutic Internal Medicine, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece

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Simona Grozinsky-Glasberg Department of Endocrinology and Metabolism, Neuroendocrine Tumor Unit, ENETS Center of Excellence, Hadassah Medical Organization and Faculty of Medicine, the Hebrew University, Jerusalem, Israel

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Introduction Pancreatic neuroendocrine neoplasms (panNENs) are considered rare malignancies despite a steady increase in their incidence as shown by recent epidemiological studies ( Dasari et al. 2017 ). PanNENs are considered slow

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Cecile N Chougnet Departments of Nuclear Medicine and Endocrine Tumors, Medical Imaging, Biostatistics and Epidemiology, Pathology, Oncologic Surgery, Department of Endocrinology, Departments of Medical Oncology, Digestive Oncology

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Sophie Leboulleux Departments of Nuclear Medicine and Endocrine Tumors, Medical Imaging, Biostatistics and Epidemiology, Pathology, Oncologic Surgery, Department of Endocrinology, Departments of Medical Oncology, Digestive Oncology

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Caroline Caramella Departments of Nuclear Medicine and Endocrine Tumors, Medical Imaging, Biostatistics and Epidemiology, Pathology, Oncologic Surgery, Department of Endocrinology, Departments of Medical Oncology, Digestive Oncology

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Jean Lumbroso Departments of Nuclear Medicine and Endocrine Tumors, Medical Imaging, Biostatistics and Epidemiology, Pathology, Oncologic Surgery, Department of Endocrinology, Departments of Medical Oncology, Digestive Oncology

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Isabelle Borget Departments of Nuclear Medicine and Endocrine Tumors, Medical Imaging, Biostatistics and Epidemiology, Pathology, Oncologic Surgery, Department of Endocrinology, Departments of Medical Oncology, Digestive Oncology

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Désirée Déandreis Departments of Nuclear Medicine and Endocrine Tumors, Medical Imaging, Biostatistics and Epidemiology, Pathology, Oncologic Surgery, Department of Endocrinology, Departments of Medical Oncology, Digestive Oncology

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Pierre Duvillard Departments of Nuclear Medicine and Endocrine Tumors, Medical Imaging, Biostatistics and Epidemiology, Pathology, Oncologic Surgery, Department of Endocrinology, Departments of Medical Oncology, Digestive Oncology

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Dominique Elias Departments of Nuclear Medicine and Endocrine Tumors, Medical Imaging, Biostatistics and Epidemiology, Pathology, Oncologic Surgery, Department of Endocrinology, Departments of Medical Oncology, Digestive Oncology

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Thierry de Baere Departments of Nuclear Medicine and Endocrine Tumors, Medical Imaging, Biostatistics and Epidemiology, Pathology, Oncologic Surgery, Department of Endocrinology, Departments of Medical Oncology, Digestive Oncology

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Fritz-Line Vélayoudom-Céphise Departments of Nuclear Medicine and Endocrine Tumors, Medical Imaging, Biostatistics and Epidemiology, Pathology, Oncologic Surgery, Department of Endocrinology, Departments of Medical Oncology, Digestive Oncology

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Joël Guigay Departments of Nuclear Medicine and Endocrine Tumors, Medical Imaging, Biostatistics and Epidemiology, Pathology, Oncologic Surgery, Department of Endocrinology, Departments of Medical Oncology, Digestive Oncology

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Michel Ducreux Departments of Nuclear Medicine and Endocrine Tumors, Medical Imaging, Biostatistics and Epidemiology, Pathology, Oncologic Surgery, Department of Endocrinology, Departments of Medical Oncology, Digestive Oncology

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Martin Schlumberger Departments of Nuclear Medicine and Endocrine Tumors, Medical Imaging, Biostatistics and Epidemiology, Pathology, Oncologic Surgery, Department of Endocrinology, Departments of Medical Oncology, Digestive Oncology

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Eric Baudin Departments of Nuclear Medicine and Endocrine Tumors, Medical Imaging, Biostatistics and Epidemiology, Pathology, Oncologic Surgery, Department of Endocrinology, Departments of Medical Oncology, Digestive Oncology

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Introduction Functional imaging has become critical for gastro–entero–pancreatic neuroendocrine neoplasm (GEP NEN) ( Krenning et al . 1994 , Baudin 2007 ). Somatostatin receptors (sst) are expressed by these tumors, and somatostatin receptor

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Claudio Ricci Department of Internal Medicine and Surgery (DIMEC), Alma Mater Studiorum, University of Bologna, S.Orsola-Malpighi Hospital, Bologna, Italy

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Stefano Partelli Pancreatic Surgery Unit, Pancreas Translational and Clinical Research Center, San Raffaele Scientific Institute, Milan, Italy
‘Vita-Salute’ San Raffaele University, Milan, Italy

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Carlo Ingaldi Department of Internal Medicine and Surgery (DIMEC), Alma Mater Studiorum, University of Bologna, S.Orsola-Malpighi Hospital, Bologna, Italy

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Valentina Andreasi Pancreatic Surgery Unit, Pancreas Translational and Clinical Research Center, San Raffaele Scientific Institute, Milan, Italy
‘Vita-Salute’ San Raffaele University, Milan, Italy

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Davide Campana Department of Internal Medicine and Surgery (DIMEC), Alma Mater Studiorum, University of Bologna, S.Orsola-Malpighi Hospital, Bologna, Italy

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Francesca Muffatti Pancreatic Surgery Unit, Pancreas Translational and Clinical Research Center, San Raffaele Scientific Institute, Milan, Italy
‘Vita-Salute’ San Raffaele University, Milan, Italy

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Laura Alberici Department of Internal Medicine and Surgery (DIMEC), Alma Mater Studiorum, University of Bologna, S.Orsola-Malpighi Hospital, Bologna, Italy

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Cecilia Giorgi Pancreatic Surgery Unit, Pancreas Translational and Clinical Research Center, San Raffaele Scientific Institute, Milan, Italy
‘Vita-Salute’ San Raffaele University, Milan, Italy

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Riccardo Casadei Department of Internal Medicine and Surgery (DIMEC), Alma Mater Studiorum, University of Bologna, S.Orsola-Malpighi Hospital, Bologna, Italy

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Massimo Falconi Pancreatic Surgery Unit, Pancreas Translational and Clinical Research Center, San Raffaele Scientific Institute, Milan, Italy
‘Vita-Salute’ San Raffaele University, Milan, Italy

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OR pancreatic neuroendocrine neoplasm OR pancreatic neuroendocrine neoplasms OR Adenomas, Islet Cell OR Islet Cell Adenoma OR Islet Cell Adenomas OR Islet Cell Tumor OR Islet Cell Tumors OR Tumor, Islet Cell OR Tumors, Islet Cell OR Island Cell Tumor

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Anela Blažević Department of Internal Medicine, Sector Endocrinology, ENETS Centre of Excellence, Erasmus University Medical Center (Erasmus MC) and Erasmus MC Cancer Institute, Rotterdam, Netherlands

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Johannes Hofland Department of Internal Medicine, Sector Endocrinology, ENETS Centre of Excellence, Erasmus University Medical Center (Erasmus MC) and Erasmus MC Cancer Institute, Rotterdam, Netherlands

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Leo J Hofland Department of Internal Medicine, Sector Endocrinology, ENETS Centre of Excellence, Erasmus University Medical Center (Erasmus MC) and Erasmus MC Cancer Institute, Rotterdam, Netherlands

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Richard A Feelders Department of Internal Medicine, Sector Endocrinology, ENETS Centre of Excellence, Erasmus University Medical Center (Erasmus MC) and Erasmus MC Cancer Institute, Rotterdam, Netherlands

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Wouter W de Herder Department of Internal Medicine, Sector Endocrinology, ENETS Centre of Excellence, Erasmus University Medical Center (Erasmus MC) and Erasmus MC Cancer Institute, Rotterdam, Netherlands

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Introduction Small intestinal neuroendocrine tumours (SI-NETs) are rare and mostly slow-growing neoplasms originating from the enterochromaffin (EC) cells of the intestine ( de Herder 2005 , Yao et al . 2008 ). EC cells are chemo- and

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Nele Garbrecht
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Martin Anlauf
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Anja Schmitt Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany

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Tobias Henopp
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Bence Sipos
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Andreas Raffel Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany

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Claus F Eisenberger Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany

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Wolfram T Knoefel Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany

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Marianne Pavel Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany

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Christian Fottner Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany

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Thomas J Musholt Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany

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Anja Rinke Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany

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Rudolf Arnold Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany

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Uta Berndt Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany

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Ursula Plöckinger Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany

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Bertram Wiedenmann Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany

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Holger Moch Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany

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Philipp U Heitz Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany

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Paul Komminoth Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany
Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany

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Aurel Perren Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany
Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany

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Günter Klöppel
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Introduction Neuroendocrine tumors (NETs) of the stomach, intestine, and pancreas are heterogeneous, as far as their morphology, function, and biology are concerned. The WHO classification therefore distinguishes the gastroenteropancreatic NETs

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Nora Sahnane Section of Anatomic Pathology, CRIBI Biotechnology Center, Department of Molecular Medicine, Department of Pathology, Department of Surgical and Morphological Sciences, University of Insubria, Via O. Rossi, 9, 21100 Varese, Italy

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Daniela Furlan Section of Anatomic Pathology, CRIBI Biotechnology Center, Department of Molecular Medicine, Department of Pathology, Department of Surgical and Morphological Sciences, University of Insubria, Via O. Rossi, 9, 21100 Varese, Italy

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Matilde Monti Section of Anatomic Pathology, CRIBI Biotechnology Center, Department of Molecular Medicine, Department of Pathology, Department of Surgical and Morphological Sciences, University of Insubria, Via O. Rossi, 9, 21100 Varese, Italy

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Chiara Romualdi Section of Anatomic Pathology, CRIBI Biotechnology Center, Department of Molecular Medicine, Department of Pathology, Department of Surgical and Morphological Sciences, University of Insubria, Via O. Rossi, 9, 21100 Varese, Italy

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Alessandro Vanoli Section of Anatomic Pathology, CRIBI Biotechnology Center, Department of Molecular Medicine, Department of Pathology, Department of Surgical and Morphological Sciences, University of Insubria, Via O. Rossi, 9, 21100 Varese, Italy

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Emanuela Vicari Section of Anatomic Pathology, CRIBI Biotechnology Center, Department of Molecular Medicine, Department of Pathology, Department of Surgical and Morphological Sciences, University of Insubria, Via O. Rossi, 9, 21100 Varese, Italy

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Enrico Solcia Section of Anatomic Pathology, CRIBI Biotechnology Center, Department of Molecular Medicine, Department of Pathology, Department of Surgical and Morphological Sciences, University of Insubria, Via O. Rossi, 9, 21100 Varese, Italy

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Carlo Capella Section of Anatomic Pathology, CRIBI Biotechnology Center, Department of Molecular Medicine, Department of Pathology, Department of Surgical and Morphological Sciences, University of Insubria, Via O. Rossi, 9, 21100 Varese, Italy

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Fausto Sessa Section of Anatomic Pathology, CRIBI Biotechnology Center, Department of Molecular Medicine, Department of Pathology, Department of Surgical and Morphological Sciences, University of Insubria, Via O. Rossi, 9, 21100 Varese, Italy

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Stefano La Rosa Section of Anatomic Pathology, CRIBI Biotechnology Center, Department of Molecular Medicine, Department of Pathology, Department of Surgical and Morphological Sciences, University of Insubria, Via O. Rossi, 9, 21100 Varese, Italy

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patients had a history of primary pulmonary neuroendocrine neoplasms. Clinical information including sex, age, type of surgery, clinical history, the presence of distant metastases, and follow-up findings was collected by consulting clinical charts. This

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Judith A Gilbert Department of Molecular Pharmacology and Experimental Therapeutics, Department of Laboratory Medicine and Pathology, Department of Oncology, Oncology Drug Discovery, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA

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Laura J Adhikari Department of Molecular Pharmacology and Experimental Therapeutics, Department of Laboratory Medicine and Pathology, Department of Oncology, Oncology Drug Discovery, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA

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Ricardo V Lloyd Department of Molecular Pharmacology and Experimental Therapeutics, Department of Laboratory Medicine and Pathology, Department of Oncology, Oncology Drug Discovery, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA

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Joseph Rubin Department of Molecular Pharmacology and Experimental Therapeutics, Department of Laboratory Medicine and Pathology, Department of Oncology, Oncology Drug Discovery, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA

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Paul Haluska Department of Molecular Pharmacology and Experimental Therapeutics, Department of Laboratory Medicine and Pathology, Department of Oncology, Oncology Drug Discovery, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA

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Joan M Carboni Department of Molecular Pharmacology and Experimental Therapeutics, Department of Laboratory Medicine and Pathology, Department of Oncology, Oncology Drug Discovery, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA

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Marco M Gottardis Department of Molecular Pharmacology and Experimental Therapeutics, Department of Laboratory Medicine and Pathology, Department of Oncology, Oncology Drug Discovery, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA

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Matthew M Ames Department of Molecular Pharmacology and Experimental Therapeutics, Department of Laboratory Medicine and Pathology, Department of Oncology, Oncology Drug Discovery, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA

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Introduction Neuroendocrine (carcinoid) tumors (NETs) are neoplasms of the endocrine system arising predominantly in the gastrointestinal (GI) tract and respiratory system. These neoplasms originate in cells of the diffuse neuroendocrine system, and

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Giovanni Vitale Department of Clinical Sciences and Community Health (DISCCO), Laboratory of Endocrine and Metabolic Research, Department of Biosciences, Endocrinology Unit, University of Milan, Milan, Italy
Department of Clinical Sciences and Community Health (DISCCO), Laboratory of Endocrine and Metabolic Research, Department of Biosciences, Endocrinology Unit, University of Milan, Milan, Italy

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Germano Gaudenzi Department of Clinical Sciences and Community Health (DISCCO), Laboratory of Endocrine and Metabolic Research, Department of Biosciences, Endocrinology Unit, University of Milan, Milan, Italy

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Alessandra Dicitore Department of Clinical Sciences and Community Health (DISCCO), Laboratory of Endocrine and Metabolic Research, Department of Biosciences, Endocrinology Unit, University of Milan, Milan, Italy

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Franco Cotelli Department of Clinical Sciences and Community Health (DISCCO), Laboratory of Endocrine and Metabolic Research, Department of Biosciences, Endocrinology Unit, University of Milan, Milan, Italy

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Diego Ferone Department of Clinical Sciences and Community Health (DISCCO), Laboratory of Endocrine and Metabolic Research, Department of Biosciences, Endocrinology Unit, University of Milan, Milan, Italy

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Luca Persani Department of Clinical Sciences and Community Health (DISCCO), Laboratory of Endocrine and Metabolic Research, Department of Biosciences, Endocrinology Unit, University of Milan, Milan, Italy
Department of Clinical Sciences and Community Health (DISCCO), Laboratory of Endocrine and Metabolic Research, Department of Biosciences, Endocrinology Unit, University of Milan, Milan, Italy

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a model in cancer research, focusing on potential applications in neuroendocrine tumors (NETs). Zebrafish as a cancer model Although fish do not have certain organs found in mammals (breast, prostate, and lung), zebrafish spontaneously develops

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J R Strosberg Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA

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M Cives Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA

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J Hwang Department of Medicine and The UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA

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T Weber Department of Medicine and The UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA

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A Venook Department of Medicine and The UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA

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T Valone Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA

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501 – 513 . ( doi:10.1056/NEJMoa1003825 ) 19 Rindi G Arnold R 2010 Nomenclature and classification of neuroendocrine neoplasms of the digestive system. In World Health Organization Classification of Tumours of the Digestive

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