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Wei Zhang Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang City, Liaoning Province, China

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Hang Zhang Department of Otorhinolaryngology, Shengjing Hospital of China Medical University, Shenyang City, Liaoning Province, China

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Xudong Zhao Department of Otorhinolaryngology, Shengjing Hospital of China Medical University, Shenyang City, Liaoning Province, China

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involved in the maintenance of stem features in anaplastic thyroid cancer ( Arancio et al . 2015 ) and plays a pivotal role in the resistance of anaplastic thyroid cancer to chemotherapy ( Carina et al . 2013 ). In the present study, we found out that

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Patrick Brest INSERM ERI‐21, University of Nice Sophia‐Antipolis, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, CNRS UMR 6097, Département d'otorhinolaryngologie, Centre Antoine‐Lacassagne, Department of Microbiology, EA4319, Nice, France
INSERM ERI‐21, University of Nice Sophia‐Antipolis, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, CNRS UMR 6097, Département d'otorhinolaryngologie, Centre Antoine‐Lacassagne, Department of Microbiology, EA4319, Nice, France

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Sandra Lassalle INSERM ERI‐21, University of Nice Sophia‐Antipolis, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, CNRS UMR 6097, Département d'otorhinolaryngologie, Centre Antoine‐Lacassagne, Department of Microbiology, EA4319, Nice, France
INSERM ERI‐21, University of Nice Sophia‐Antipolis, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, CNRS UMR 6097, Département d'otorhinolaryngologie, Centre Antoine‐Lacassagne, Department of Microbiology, EA4319, Nice, France
INSERM ERI‐21, University of Nice Sophia‐Antipolis, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, CNRS UMR 6097, Département d'otorhinolaryngologie, Centre Antoine‐Lacassagne, Department of Microbiology, EA4319, Nice, France
INSERM ERI‐21, University of Nice Sophia‐Antipolis, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, CNRS UMR 6097, Département d'otorhinolaryngologie, Centre Antoine‐Lacassagne, Department of Microbiology, EA4319, Nice, France

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Veronique Hofman INSERM ERI‐21, University of Nice Sophia‐Antipolis, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, CNRS UMR 6097, Département d'otorhinolaryngologie, Centre Antoine‐Lacassagne, Department of Microbiology, EA4319, Nice, France
INSERM ERI‐21, University of Nice Sophia‐Antipolis, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, CNRS UMR 6097, Département d'otorhinolaryngologie, Centre Antoine‐Lacassagne, Department of Microbiology, EA4319, Nice, France
INSERM ERI‐21, University of Nice Sophia‐Antipolis, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, CNRS UMR 6097, Département d'otorhinolaryngologie, Centre Antoine‐Lacassagne, Department of Microbiology, EA4319, Nice, France
INSERM ERI‐21, University of Nice Sophia‐Antipolis, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, CNRS UMR 6097, Département d'otorhinolaryngologie, Centre Antoine‐Lacassagne, Department of Microbiology, EA4319, Nice, France

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Olivier Bordone INSERM ERI‐21, University of Nice Sophia‐Antipolis, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, CNRS UMR 6097, Département d'otorhinolaryngologie, Centre Antoine‐Lacassagne, Department of Microbiology, EA4319, Nice, France

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Virginie Gavric Tanga INSERM ERI‐21, University of Nice Sophia‐Antipolis, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, CNRS UMR 6097, Département d'otorhinolaryngologie, Centre Antoine‐Lacassagne, Department of Microbiology, EA4319, Nice, France

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Christelle Bonnetaud INSERM ERI‐21, University of Nice Sophia‐Antipolis, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, CNRS UMR 6097, Département d'otorhinolaryngologie, Centre Antoine‐Lacassagne, Department of Microbiology, EA4319, Nice, France

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Chimene Moreilhon INSERM ERI‐21, University of Nice Sophia‐Antipolis, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, CNRS UMR 6097, Département d'otorhinolaryngologie, Centre Antoine‐Lacassagne, Department of Microbiology, EA4319, Nice, France
INSERM ERI‐21, University of Nice Sophia‐Antipolis, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, CNRS UMR 6097, Département d'otorhinolaryngologie, Centre Antoine‐Lacassagne, Department of Microbiology, EA4319, Nice, France
INSERM ERI‐21, University of Nice Sophia‐Antipolis, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, CNRS UMR 6097, Département d'otorhinolaryngologie, Centre Antoine‐Lacassagne, Department of Microbiology, EA4319, Nice, France

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Geraldine Rios INSERM ERI‐21, University of Nice Sophia‐Antipolis, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, CNRS UMR 6097, Département d'otorhinolaryngologie, Centre Antoine‐Lacassagne, Department of Microbiology, EA4319, Nice, France
INSERM ERI‐21, University of Nice Sophia‐Antipolis, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, CNRS UMR 6097, Département d'otorhinolaryngologie, Centre Antoine‐Lacassagne, Department of Microbiology, EA4319, Nice, France

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José Santini INSERM ERI‐21, University of Nice Sophia‐Antipolis, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, CNRS UMR 6097, Département d'otorhinolaryngologie, Centre Antoine‐Lacassagne, Department of Microbiology, EA4319, Nice, France
INSERM ERI‐21, University of Nice Sophia‐Antipolis, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, CNRS UMR 6097, Département d'otorhinolaryngologie, Centre Antoine‐Lacassagne, Department of Microbiology, EA4319, Nice, France
INSERM ERI‐21, University of Nice Sophia‐Antipolis, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, CNRS UMR 6097, Département d'otorhinolaryngologie, Centre Antoine‐Lacassagne, Department of Microbiology, EA4319, Nice, France

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Pascal Barbry INSERM ERI‐21, University of Nice Sophia‐Antipolis, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, CNRS UMR 6097, Département d'otorhinolaryngologie, Centre Antoine‐Lacassagne, Department of Microbiology, EA4319, Nice, France
INSERM ERI‐21, University of Nice Sophia‐Antipolis, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, CNRS UMR 6097, Département d'otorhinolaryngologie, Centre Antoine‐Lacassagne, Department of Microbiology, EA4319, Nice, France

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Catharina Svanborg INSERM ERI‐21, University of Nice Sophia‐Antipolis, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, CNRS UMR 6097, Département d'otorhinolaryngologie, Centre Antoine‐Lacassagne, Department of Microbiology, EA4319, Nice, France

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Baharia Mograbi INSERM ERI‐21, University of Nice Sophia‐Antipolis, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, CNRS UMR 6097, Département d'otorhinolaryngologie, Centre Antoine‐Lacassagne, Department of Microbiology, EA4319, Nice, France
INSERM ERI‐21, University of Nice Sophia‐Antipolis, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, CNRS UMR 6097, Département d'otorhinolaryngologie, Centre Antoine‐Lacassagne, Department of Microbiology, EA4319, Nice, France

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Bernard Mari INSERM ERI‐21, University of Nice Sophia‐Antipolis, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, CNRS UMR 6097, Département d'otorhinolaryngologie, Centre Antoine‐Lacassagne, Department of Microbiology, EA4319, Nice, France
INSERM ERI‐21, University of Nice Sophia‐Antipolis, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, CNRS UMR 6097, Département d'otorhinolaryngologie, Centre Antoine‐Lacassagne, Department of Microbiology, EA4319, Nice, France

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Paul Hofman INSERM ERI‐21, University of Nice Sophia‐Antipolis, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, CNRS UMR 6097, Département d'otorhinolaryngologie, Centre Antoine‐Lacassagne, Department of Microbiology, EA4319, Nice, France
INSERM ERI‐21, University of Nice Sophia‐Antipolis, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, CNRS UMR 6097, Département d'otorhinolaryngologie, Centre Antoine‐Lacassagne, Department of Microbiology, EA4319, Nice, France
INSERM ERI‐21, University of Nice Sophia‐Antipolis, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, CNRS UMR 6097, Département d'otorhinolaryngologie, Centre Antoine‐Lacassagne, Department of Microbiology, EA4319, Nice, France
INSERM ERI‐21, University of Nice Sophia‐Antipolis, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, Centre Hospitalier Universitaire de Nice, CNRS UMR 6097, Département d'otorhinolaryngologie, Centre Antoine‐Lacassagne, Department of Microbiology, EA4319, Nice, France

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of thyroid cancers harboring different oncogenes. It has been shown that vorinostat induces cell death in FRO81-2 anaplastic thyroid cancer cells (BRAF V600E) by activation of caspase and degradation of Bcl-2 family proteins. ( Mitsiades et al . 2005

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Yushan Mao Laboratory for Cellular and Molecular Thyroid Research, Division of Endocrinology, Diabetes and Metabolism, Johns Hopkins University School of Medicine, Maryland, MD, USA

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Mingzhao Xing Laboratory for Cellular and Molecular Thyroid Research, Division of Endocrinology, Diabetes and Metabolism, Johns Hopkins University School of Medicine, Maryland, MD, USA

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. 2015 ). Other types of thyroid cancer include relatively uncommon follicular thyroid cancer (FTC), anaplastic thyroid cancer (ATC), and medullary thyroid cancer (MTC) ( Xing 2013 ). PTC can be histologically classified into several variants, and the

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Myriem Boufraqech Endocrine Oncology Branch Laboratory of Pathology National Cancer Institute, National Institutes of Health, Center for Cancer Research, Bethesda, Maryland 20892, USA

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Lisa Zhang Endocrine Oncology Branch Laboratory of Pathology National Cancer Institute, National Institutes of Health, Center for Cancer Research, Bethesda, Maryland 20892, USA

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Meenu Jain Endocrine Oncology Branch Laboratory of Pathology National Cancer Institute, National Institutes of Health, Center for Cancer Research, Bethesda, Maryland 20892, USA

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Dhaval Patel Endocrine Oncology Branch Laboratory of Pathology National Cancer Institute, National Institutes of Health, Center for Cancer Research, Bethesda, Maryland 20892, USA

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Ryan Ellis Endocrine Oncology Branch Laboratory of Pathology National Cancer Institute, National Institutes of Health, Center for Cancer Research, Bethesda, Maryland 20892, USA

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Yin Xiong Endocrine Oncology Branch Laboratory of Pathology National Cancer Institute, National Institutes of Health, Center for Cancer Research, Bethesda, Maryland 20892, USA

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Mei He Endocrine Oncology Branch Laboratory of Pathology National Cancer Institute, National Institutes of Health, Center for Cancer Research, Bethesda, Maryland 20892, USA

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Naris Nilubol Endocrine Oncology Branch Laboratory of Pathology National Cancer Institute, National Institutes of Health, Center for Cancer Research, Bethesda, Maryland 20892, USA

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Maria J Merino Endocrine Oncology Branch Laboratory of Pathology National Cancer Institute, National Institutes of Health, Center for Cancer Research, Bethesda, Maryland 20892, USA

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Electron Kebebew Endocrine Oncology Branch Laboratory of Pathology National Cancer Institute, National Institutes of Health, Center for Cancer Research, Bethesda, Maryland 20892, USA

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Introduction The most common types of thyroid cancer are of follicular cell origin and can be classified as well-differentiated thyroid cancer (WDTC), poorly differentiated thyroid cancer (PDTC), and anaplastic thyroid cancer (ATC). Although WDTC

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Shu-Fu Lin Department of Internal Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan
Chang Gung University, Taoyuan, Taiwan

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Jen-Der Lin Department of Internal Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan
Chang Gung University, Taoyuan, Taiwan

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Chuen Hsueh Chang Gung University, Taoyuan, Taiwan
Department of Pathology, Chang Gung Memorial Hospital, Taoyuan, Taiwan

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Ting-Chao Chou Laboratory of Preclinical Pharmacology Core, Memorial Sloan-Kettering Cancer Center, New York, New York, USA

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Richard J Wong Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York, USA

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, promotes caspase-3 activity and stimulates apoptosis in vitro . Oral administration of roniciclib has potent efficacy in impeding tumor growth of cervical, lung and anaplastic thyroid cancer xenografts, with favorable safety profiles in animal models

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Roberto Bellelli Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy

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Maria Domenica Castellone Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy

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Ginesa Garcia-Rostan Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy

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Clara Ugolini Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy

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Carmelo Nucera Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy

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Peter M Sadow Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy

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Tito Claudio Nappi Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy

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Paolo Salerno Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy

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Maria Carmela Cantisani Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy

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Fulvio Basolo Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy

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Tomas Alvarez Gago Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy

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Giuliana Salvatore Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy

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Massimo Santoro Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy

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kinase and mammalian target of rapamycin in differentiated and anaplastic thyroid cancer . Journal of Clinical Endocrinology and Metabolism 94 4107 – 4112 . ( doi:10.1210/jc.2009-0662 ). Jin N Jiang T Rosen DM Nelkin BD Ball DW 2011

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Alessandro Antonelli Department of Internal Medicine, Department of Surgery, Pathology Unit, Clinical Biochemistry Unit, Department of Endocrinology, Department of Experimental Pathology

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Silvia Martina Ferrari Department of Internal Medicine, Department of Surgery, Pathology Unit, Clinical Biochemistry Unit, Department of Endocrinology, Department of Experimental Pathology

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Poupak Fallahi Department of Internal Medicine, Department of Surgery, Pathology Unit, Clinical Biochemistry Unit, Department of Endocrinology, Department of Experimental Pathology

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Silvia Frascerra Department of Internal Medicine, Department of Surgery, Pathology Unit, Clinical Biochemistry Unit, Department of Endocrinology, Department of Experimental Pathology

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Simona Piaggi Department of Internal Medicine, Department of Surgery, Pathology Unit, Clinical Biochemistry Unit, Department of Endocrinology, Department of Experimental Pathology

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Stefania Gelmini Department of Internal Medicine, Department of Surgery, Pathology Unit, Clinical Biochemistry Unit, Department of Endocrinology, Department of Experimental Pathology

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Cristiana Lupi Department of Internal Medicine, Department of Surgery, Pathology Unit, Clinical Biochemistry Unit, Department of Endocrinology, Department of Experimental Pathology

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Michele Minuto Department of Internal Medicine, Department of Surgery, Pathology Unit, Clinical Biochemistry Unit, Department of Endocrinology, Department of Experimental Pathology

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Piero Berti Department of Internal Medicine, Department of Surgery, Pathology Unit, Clinical Biochemistry Unit, Department of Endocrinology, Department of Experimental Pathology

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Salvatore Benvenga Department of Internal Medicine, Department of Surgery, Pathology Unit, Clinical Biochemistry Unit, Department of Endocrinology, Department of Experimental Pathology

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Fulvio Basolo Department of Internal Medicine, Department of Surgery, Pathology Unit, Clinical Biochemistry Unit, Department of Endocrinology, Department of Experimental Pathology

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Claudio Orlando Department of Internal Medicine, Department of Surgery, Pathology Unit, Clinical Biochemistry Unit, Department of Endocrinology, Department of Experimental Pathology

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Paolo Miccoli Department of Internal Medicine, Department of Surgery, Pathology Unit, Clinical Biochemistry Unit, Department of Endocrinology, Department of Experimental Pathology

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-activated receptor-γ agonists induce partial reversion of epithelial–mesenchymal transition in anaplastic thyroid cancer cells . Endocrinology 147 4463 – 4475 . Andrews NC Faller DV 1991 A rapid micropreparation technique for extraction of DNA

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Segolene Hescot Department of Nuclear Medicine, Institut Curie, Saint-Cloud, France

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Abir Al Ghuzlan Department of Pathology, Gustave Roussy and Paris Saclay University, Villejuif, France

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Theophraste Henry Department of Nuclear Medicine and Endocrine Oncology, Gustave Roussy and Paris Saclay University, Villejuif, France

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Hala Sheikh-Alard Department of Pathology, Gustave Roussy and Paris Saclay University, Villejuif, France

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Livia Lamartina Department of Nuclear Medicine and Endocrine Oncology, Gustave Roussy and Paris Saclay University, Villejuif, France

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Isabelle Borget Department of Biostatistics, Gustave Roussy and Paris Saclay University, Villejuif, France

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Julien Hadoux Department of Nuclear Medicine and Endocrine Oncology, Gustave Roussy and Paris Saclay University, Villejuif, France

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Eric Baudin Department of Nuclear Medicine and Endocrine Oncology, Gustave Roussy and Paris Saclay University, Villejuif, France

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Corinne Dupuy UMR 8200 CNRS, Gustave Roussy and Paris Saclay University, Villejuif, France

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Alyaksandr V Nikitski Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

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Yuri E Nikiforov Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

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Martin Schlumberger Department of Nuclear Medicine and Endocrine Oncology, Gustave Roussy and Paris Saclay University, Villejuif, France

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Marina N Nikiforova Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

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Sophie Leboulleux Department of Nuclear Medicine and Endocrine Oncology, Gustave Roussy and Paris Saclay University, Villejuif, France
Department of Endocrinology, Hôpitaux Universitaires de Genève, Geneva, Switzerland

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Lam AK Papotti M Tallini G 2021 Molecular pathology of poorly differentiated and anaplastic thyroid cancer: what do pathologists need to know? Endocrine Pathology 32 63 – 76 . ( https://doi.org/10.1007/s12022-021-09665-2 ) Wong KS Lorch JH

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R Malaguarnera Endocrinologia, Dipartimento di Medicina Interna e Medicina Specialistica, Università di Catania, PO Garibaldi Nesima, Via Palermo 636, 95122 Catania, Italy

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V Vella Endocrinologia, Dipartimento di Medicina Interna e Medicina Specialistica, Università di Catania, PO Garibaldi Nesima, Via Palermo 636, 95122 Catania, Italy

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R Vigneri Endocrinologia, Dipartimento di Medicina Interna e Medicina Specialistica, Università di Catania, PO Garibaldi Nesima, Via Palermo 636, 95122 Catania, Italy

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F Frasca Endocrinologia, Dipartimento di Medicina Interna e Medicina Specialistica, Università di Catania, PO Garibaldi Nesima, Via Palermo 636, 95122 Catania, Italy

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( Blagosklonny et al. 1998 , Ceraline et al. 2003 , Hassan et al. 2006 ). Several reports indicate that wild-type p53 gene delivery into anaplastic thyroid cancer cells induces a partial differentiation, with the re-expression of thyroid specific

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Samantha Peiling Yang Endocrinology Division, Department of Medicine, National University Hospital of Singapore, Singapore, Singapore
Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

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Joanne Ngeow Cancer Genetics Service, Division of Medical Oncology, National Cancer Centre, Singapore, Singapore
Oncology Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore

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-degree relatives, in the absence of predisposing environmental factors. Among FNMTC, PTC is the commonest (85–91%) histological sub-type, followed by follicular thyroid cancer (6–9.7%), anaplastic thyroid cancer (1.6%) and Hurthle cell cancer ( Loh 1997 , Vriens

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