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third ( Early Breast Cancer Trialists’ Collaborative Group 2005 ). However, this drug has been associated with increased risks of potentially life-threatening events, such as endometrial cancer ( Bergman et al. 2000 ), uterine sarcoma ( Wickerham
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Tjønneland A Olsen A Overvad K Jakobsen MU Chajés V 2007 Metabolic syndrome, plasma lipid, lipoprotein and glucose levels, and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) . Endocrine
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Institute of Biosciences and Technology, Department of Veterinary Physiology and Pharmacology, Dow Chemical Company, Texas A&M Health Science Center, 2121 Holcombe Boulevard, Houston, Texas 77030, USA
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-resistant tumors and there is evidence that long term use of tamoxifen increases the risk for endometrial cancer ( Clarke et al . 2001 , Vogel et al . 2006 ). Some early stage and most later stage mammary tumors are ER-negative and patients with ER
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tamoxifen differentially regulates human telomerase reverse transcriptase (hTERT) gene expression in breast and endometrial cancer cells, and this activity has been associated with the presence of an estrogen-sensitive element in the hTERT gene. The
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association between obesity and type 2 diabetes and an increased cancer risk and mortality of both epithelial such as colon, breast, endometrial cancers and nonsolid tumors, such as lymphomas ( Haslam & James 2005 , Onitilo et al . 2012 ). Of the numerous
Departments of Cardiac Surgery , Cardiovascular Research, Obstetrics and Gynecology, Medical University of Vienna and Comprehensive Cancer Center, Waehringer Guertel 18-20, A-1090 Vienna, Austria
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chemoresistance of human mammary tumor xenografts in immunodeficient mice ( Aharinejad et al . 2004 , Paulus et al . 2006 ). In the clinical setting, serum CSF1 concentrations are higher in breast, ovarian, and endometrial cancer patients when compared with
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Department of Animal Biology and Physiology, Biomedical Research Center, Department of Biomedical Sciences, Laboratory of Cytometry, Department of Veterinary Anatomy, Optometry, University of Yaoundé 1, PO Box 812, Yaoundé, Cameroon
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revealed that type 2 diabetes is the third major risk factor for this disease ( Li 2012 ). A recent meta-analysis of observational studies has revealed that insulin resistance is a significant risk factor for endometrial cancer, particularly when associated
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the adjuvant setting. Long-term treatment with tamoxifen, however, is well known to have side-effects related to the partial agonistic activity of this compound, especially the increased risk of endometrial cancer and thromboembolic events
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, endometrial cancer, colon cancer, esophageal adenocarcinoma, kidney cancer, liver cancer, pancreatic cancer, prostate cancer, thyroid cancers, leukemia, non-Hodgkin lymphoma, and myeloma are related to overweight and obesity with respect to development
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cancer and longer adjuvant therapy (5 years) was better than shorter (1–2 years) therapy. Concern about an increased incidence of fatal endometrial cancer was calculated to be manageable. A gynaecological examination before adjuvant tamoxifen therapy