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Daniela Gallo
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third ( Early Breast Cancer Trialists’ Collaborative Group 2005 ). However, this drug has been associated with increased risks of potentially life-threatening events, such as endometrial cancer ( Bergman et al. 2000 ), uterine sarcoma ( Wickerham

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Cheng-Chieh Lin School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of
School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of
School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of

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Chia-Ing Li School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of
School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of
School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of

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Chiu-Shong Liu School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of
School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of
School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of

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Wen-Yuan Lin School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of
School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of

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Ching-Chu Chen School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of

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Sing-Yu Yang School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of

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Cheng-Chun Lee School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of
School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of

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Tsai-Chung Li School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of
School of Medicine, Medical Research, Department of Public Health, Division of Endocrinology and Metabolism, College of Public Health, Department of Neurology, Department of Healthcare Administration, College of Medicine, China Medical University, Taichung, Taiwan Departments of

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Tjønneland A Olsen A Overvad K Jakobsen MU Chajés V 2007 Metabolic syndrome, plasma lipid, lipoprotein and glucose levels, and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) . Endocrine

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Shu Zhang Institute of Biosciences and Technology, Department of Veterinary Physiology and Pharmacology, Dow Chemical Company, Texas A&M Health Science Center, 2121 Holcombe Boulevard, Houston, Texas 77030, USA

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Ping Lei Institute of Biosciences and Technology, Department of Veterinary Physiology and Pharmacology, Dow Chemical Company, Texas A&M Health Science Center, 2121 Holcombe Boulevard, Houston, Texas 77030, USA

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Xinyi Liu Institute of Biosciences and Technology, Department of Veterinary Physiology and Pharmacology, Dow Chemical Company, Texas A&M Health Science Center, 2121 Holcombe Boulevard, Houston, Texas 77030, USA

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Xiangrong Li Institute of Biosciences and Technology, Department of Veterinary Physiology and Pharmacology, Dow Chemical Company, Texas A&M Health Science Center, 2121 Holcombe Boulevard, Houston, Texas 77030, USA

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Kelcey Walker Institute of Biosciences and Technology, Department of Veterinary Physiology and Pharmacology, Dow Chemical Company, Texas A&M Health Science Center, 2121 Holcombe Boulevard, Houston, Texas 77030, USA

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Leela Kotha Institute of Biosciences and Technology, Department of Veterinary Physiology and Pharmacology, Dow Chemical Company, Texas A&M Health Science Center, 2121 Holcombe Boulevard, Houston, Texas 77030, USA

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Craig Rowlands Institute of Biosciences and Technology, Department of Veterinary Physiology and Pharmacology, Dow Chemical Company, Texas A&M Health Science Center, 2121 Holcombe Boulevard, Houston, Texas 77030, USA

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Stephen Safe Institute of Biosciences and Technology, Department of Veterinary Physiology and Pharmacology, Dow Chemical Company, Texas A&M Health Science Center, 2121 Holcombe Boulevard, Houston, Texas 77030, USA
Institute of Biosciences and Technology, Department of Veterinary Physiology and Pharmacology, Dow Chemical Company, Texas A&M Health Science Center, 2121 Holcombe Boulevard, Houston, Texas 77030, USA

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-resistant tumors and there is evidence that long term use of tamoxifen increases the risk for endometrial cancer ( Clarke et al . 2001 , Vogel et al . 2006 ). Some early stage and most later stage mammary tumors are ER-negative and patients with ER

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N Angelopoulos
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V Barbounis
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S Livadas
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D Kaltsas
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G Tolis
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tamoxifen differentially regulates human telomerase reverse transcriptase (hTERT) gene expression in breast and endometrial cancer cells, and this activity has been associated with the presence of an estrogen-sensitive element in the hTERT gene. The

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Zara Zelenko Division of Endocrinology, Diabetes and Bone Diseases, Icahn School of Medicine at Mount Sinai, New York, New York, USA

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Emily Jane Gallagher Division of Endocrinology, Diabetes and Bone Diseases, Icahn School of Medicine at Mount Sinai, New York, New York, USA

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Irini Markella Antoniou Division of Endocrinology, Diabetes and Bone Diseases, Icahn School of Medicine at Mount Sinai, New York, New York, USA

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Deepali Sachdev Department of Medicine and Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA

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Anupma Nayak Department of Pathology and Laboratory Medicine, The Mount Sinai Hospital and Icahn School of Medicine at Mount Sinai, New York, New York, USA

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Douglas Yee Department of Medicine and Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA

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Derek LeRoith Division of Endocrinology, Diabetes and Bone Diseases, Icahn School of Medicine at Mount Sinai, New York, New York, USA

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association between obesity and type 2 diabetes and an increased cancer risk and mortality of both epithelial such as colon, breast, endometrial cancers and nonsolid tumors, such as lymphomas ( Haslam & James 2005 , Onitilo et al . 2012 ). Of the numerous

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Seyedhossein Aharinejad Departments of Cardiac Surgery , Cardiovascular Research, Obstetrics and Gynecology, Medical University of Vienna and Comprehensive Cancer Center, Waehringer Guertel 18-20, A-1090 Vienna, Austria
Departments of Cardiac Surgery , Cardiovascular Research, Obstetrics and Gynecology, Medical University of Vienna and Comprehensive Cancer Center, Waehringer Guertel 18-20, A-1090 Vienna, Austria

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Mohamed Salama Departments of Cardiac Surgery , Cardiovascular Research, Obstetrics and Gynecology, Medical University of Vienna and Comprehensive Cancer Center, Waehringer Guertel 18-20, A-1090 Vienna, Austria
Departments of Cardiac Surgery , Cardiovascular Research, Obstetrics and Gynecology, Medical University of Vienna and Comprehensive Cancer Center, Waehringer Guertel 18-20, A-1090 Vienna, Austria

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Patrick Paulus Departments of Cardiac Surgery , Cardiovascular Research, Obstetrics and Gynecology, Medical University of Vienna and Comprehensive Cancer Center, Waehringer Guertel 18-20, A-1090 Vienna, Austria

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Karin Zins Departments of Cardiac Surgery , Cardiovascular Research, Obstetrics and Gynecology, Medical University of Vienna and Comprehensive Cancer Center, Waehringer Guertel 18-20, A-1090 Vienna, Austria

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Andreas Berger Departments of Cardiac Surgery , Cardiovascular Research, Obstetrics and Gynecology, Medical University of Vienna and Comprehensive Cancer Center, Waehringer Guertel 18-20, A-1090 Vienna, Austria

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Christian F Singer Departments of Cardiac Surgery , Cardiovascular Research, Obstetrics and Gynecology, Medical University of Vienna and Comprehensive Cancer Center, Waehringer Guertel 18-20, A-1090 Vienna, Austria

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chemoresistance of human mammary tumor xenografts in immunodeficient mice ( Aharinejad et al . 2004 , Paulus et al . 2006 ). In the clinical setting, serum CSF1 concentrations are higher in breast, ovarian, and endometrial cancer patients when compared with

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Sefirin Djiogue Department of Animal Biology and Physiology, Biomedical Research Center, Department of Biomedical Sciences, Laboratory of Cytometry, Department of Veterinary Anatomy, Optometry, University of Yaoundé 1, PO Box 812, Yaoundé, Cameroon

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Armel Hervé Nwabo Kamdje Department of Animal Biology and Physiology, Biomedical Research Center, Department of Biomedical Sciences, Laboratory of Cytometry, Department of Veterinary Anatomy, Optometry, University of Yaoundé 1, PO Box 812, Yaoundé, Cameroon
Department of Animal Biology and Physiology, Biomedical Research Center, Department of Biomedical Sciences, Laboratory of Cytometry, Department of Veterinary Anatomy, Optometry, University of Yaoundé 1, PO Box 812, Yaoundé, Cameroon

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Lorella Vecchio Department of Animal Biology and Physiology, Biomedical Research Center, Department of Biomedical Sciences, Laboratory of Cytometry, Department of Veterinary Anatomy, Optometry, University of Yaoundé 1, PO Box 812, Yaoundé, Cameroon

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Maulilio John Kipanyula Department of Animal Biology and Physiology, Biomedical Research Center, Department of Biomedical Sciences, Laboratory of Cytometry, Department of Veterinary Anatomy, Optometry, University of Yaoundé 1, PO Box 812, Yaoundé, Cameroon

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Mohammed Farahna Department of Animal Biology and Physiology, Biomedical Research Center, Department of Biomedical Sciences, Laboratory of Cytometry, Department of Veterinary Anatomy, Optometry, University of Yaoundé 1, PO Box 812, Yaoundé, Cameroon

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Yousef Aldebasi Department of Animal Biology and Physiology, Biomedical Research Center, Department of Biomedical Sciences, Laboratory of Cytometry, Department of Veterinary Anatomy, Optometry, University of Yaoundé 1, PO Box 812, Yaoundé, Cameroon

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Paul Faustin Seke Etet Department of Animal Biology and Physiology, Biomedical Research Center, Department of Biomedical Sciences, Laboratory of Cytometry, Department of Veterinary Anatomy, Optometry, University of Yaoundé 1, PO Box 812, Yaoundé, Cameroon

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revealed that type 2 diabetes is the third major risk factor for this disease ( Li 2012 ). A recent meta-analysis of observational studies has revealed that insulin resistance is a significant risk factor for endometrial cancer, particularly when associated

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F Labrie Molecular Endocrinology and Oncology Research Center, Laval University Hospital Research Center (CRCHUL) and Laval University, 2705, Laurier Boulevard, Quebec City, Quebec G1V 4G2, Canada

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the adjuvant setting. Long-term treatment with tamoxifen, however, is well known to have side-effects related to the partial agonistic activity of this compound, especially the increased risk of endometrial cancer and thromboembolic events

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Marjory Alana Marcello Laboratory of Cancer Molecular Genetics (Gemoca), Faculty of Medical Sciences, University of Campinas (FCM- Unicamp), Rua Tessália Vieira de Camargo 126, Barão Geraldo, Campinas, São Paulo 13083-970, Brazil

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Lucas Leite Cunha Laboratory of Cancer Molecular Genetics (Gemoca), Faculty of Medical Sciences, University of Campinas (FCM- Unicamp), Rua Tessália Vieira de Camargo 126, Barão Geraldo, Campinas, São Paulo 13083-970, Brazil

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Fernando Assis Batista Laboratory of Cancer Molecular Genetics (Gemoca), Faculty of Medical Sciences, University of Campinas (FCM- Unicamp), Rua Tessália Vieira de Camargo 126, Barão Geraldo, Campinas, São Paulo 13083-970, Brazil

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Laura Sterian Ward Laboratory of Cancer Molecular Genetics (Gemoca), Faculty of Medical Sciences, University of Campinas (FCM- Unicamp), Rua Tessália Vieira de Camargo 126, Barão Geraldo, Campinas, São Paulo 13083-970, Brazil

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, endometrial cancer, colon cancer, esophageal adenocarcinoma, kidney cancer, liver cancer, pancreatic cancer, prostate cancer, thyroid cancers, leukemia, non-Hodgkin lymphoma, and myeloma are related to overweight and obesity with respect to development

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V Craig Jordan Dallas/Ft. Worth Living Legend Chair of Cancer Research, Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA

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cancer and longer adjuvant therapy (5 years) was better than shorter (1–2 years) therapy. Concern about an increased incidence of fatal endometrial cancer was calculated to be manageable. A gynaecological examination before adjuvant tamoxifen therapy

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